Per O Ljungdahl

Summary

Country: Sweden

Publications

  1. pmc Membrane chaperone Shr3 assists in folding amino acid permeases preventing precocious ERAD
    Jhansi Kota
    Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
    J Cell Biol 176:617-28. 2007
  2. pmc Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae
    Per O Ljungdahl
    Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Genetics 190:885-929. 2012
  3. doi request reprint Amino-acid-induced signalling via the SPS-sensing pathway in yeast
    Per O Ljungdahl
    Wenner Gren Institute, Department of Cell Biology, S 10691 Stockholm, Sweden
    Biochem Soc Trans 37:242-7. 2009
  4. ncbi request reprint Inner nuclear membrane proteins Asi1, Asi2, and Asi3 function in concert to maintain the latent properties of transcription factors Stp1 and Stp2
    Arezou Zargari
    Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm, Sweden
    J Biol Chem 282:594-605. 2007
  5. pmc Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER
    Jhansi Kota
    Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
    J Cell Biol 168:79-88. 2005
  6. pmc Dal81 enhances Stp1- and Stp2-dependent transcription necessitating negative modulation by inner nuclear membrane protein Asi1 in Saccharomyces cerevisiae
    Mirta Boban
    Ludwig Institute for Cancer Research, Box 240, S 171 77 Stockholm, Sweden
    Genetics 176:2087-97. 2007
  7. pmc The N-terminal regulatory domain of Stp1p is modular and, fused to an artificial transcription factor, confers full Ssy1p-Ptr3p-Ssy5p sensor control
    Claes Andréasson
    Ludwig Institute for Cancer Research, Box 240, S 171 77 Stockholm, Sweden
    Mol Cell Biol 24:7503-13. 2004
  8. pmc A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5
    Deike J Omnus
    Wenner Gren Institute, Stockholm University, S 106 91 Stockholm, Sweden
    Mol Biol Cell 22:2754-65. 2011
  9. pmc Regulation of transcription factor latency by receptor-activated proteolysis
    Claes Andréasson
    Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
    Genes Dev 20:1563-8. 2006
  10. pmc The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1
    Thorsten Pfirrmann
    Stockholm University, Wenner Gren Institute, S 106 91 Stockholm, Sweden
    Mol Cell Biol 30:3299-309. 2010

Collaborators

  • Claes Andréasson
  • Etienne P A Neve
  • Deike J Omnus
  • Jhansi Kota
  • Mirta Boban
  • Paula Martinez
  • Thorsten Pfirrmann
  • Stijn Heessen
  • Arezou Zargari
  • Monica M Davis
  • Johan Thyberg
  • Bjorn Rozell
  • Francisco J Alvarez
  • Ylva Engstrom
  • Asa A Holm
  • Kicki Ryman
  • Hanna Forsberg
  • C Fredrik Gilstring
  • Monika Melin-Larsson

Detail Information

Publications19

  1. pmc Membrane chaperone Shr3 assists in folding amino acid permeases preventing precocious ERAD
    Jhansi Kota
    Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
    J Cell Biol 176:617-28. 2007
    ..Consequently, in cells with impaired ERAD, AAPs are able to attain functional conformations independent of Shr3. These findings illustrate that folding and degradation are tightly coupled processes during membrane protein biogenesis...
  2. pmc Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae
    Per O Ljungdahl
    Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Genetics 190:885-929. 2012
    ..Thanks to the remarkable sophistication offered by the yeast experimental system, a picture of the intimate connections between the metabolomic and the transcriptome is becoming clear...
  3. doi request reprint Amino-acid-induced signalling via the SPS-sensing pathway in yeast
    Per O Ljungdahl
    Wenner Gren Institute, Department of Cell Biology, S 10691 Stockholm, Sweden
    Biochem Soc Trans 37:242-7. 2009
    ....
  4. ncbi request reprint Inner nuclear membrane proteins Asi1, Asi2, and Asi3 function in concert to maintain the latent properties of transcription factors Stp1 and Stp2
    Arezou Zargari
    Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm, Sweden
    J Biol Chem 282:594-605. 2007
    ..This study documents additional components of a novel mechanism controlling transcription in eukaryotic cells...
  5. pmc Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER
    Jhansi Kota
    Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
    J Cell Biol 168:79-88. 2005
    ....
  6. pmc Dal81 enhances Stp1- and Stp2-dependent transcription necessitating negative modulation by inner nuclear membrane protein Asi1 in Saccharomyces cerevisiae
    Mirta Boban
    Ludwig Institute for Cancer Research, Box 240, S 171 77 Stockholm, Sweden
    Genetics 176:2087-97. 2007
    ..Conversely, the high levels of processed Stp1 and Stp2 that accumulate in the nucleus of induced cells activate transcription in the absence of Dal81...
  7. pmc The N-terminal regulatory domain of Stp1p is modular and, fused to an artificial transcription factor, confers full Ssy1p-Ptr3p-Ssy5p sensor control
    Claes Andréasson
    Ludwig Institute for Cancer Research, Box 240, S 171 77 Stockholm, Sweden
    Mol Cell Biol 24:7503-13. 2004
    ..The N-terminal domain of Stp1p is functionally autonomous and transferable to other transcription factors, where its presence confers ASI1-dependent nuclear exclusion and SPS sensor-induced proteolytic processing...
  8. pmc A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5
    Deike J Omnus
    Wenner Gren Institute, Stockholm University, S 106 91 Stockholm, Sweden
    Mol Biol Cell 22:2754-65. 2011
    ....
  9. pmc Regulation of transcription factor latency by receptor-activated proteolysis
    Claes Andréasson
    Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
    Genes Dev 20:1563-8. 2006
    ..Our findings demonstrate that gene expression can be controlled by regulating the enzymatic activity of an intracellular endoprotease...
  10. pmc The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1
    Thorsten Pfirrmann
    Stockholm University, Wenner Gren Institute, S 106 91 Stockholm, Sweden
    Mol Cell Biol 30:3299-309. 2010
    ..Our results define a regulatory mechanism that is novel for eukaryotic proteases functioning within cells...
  11. pmc Rts1-protein phosphatase 2A antagonizes Ptr3-mediated activation of the signaling protease Ssy5 by casein kinase I
    Deike J Omnus
    Department of Molecular Biosciences, Wenner Gren Institute, Stockholm University, S 106 91 Stockholm, Sweden
    Mol Biol Cell 24:1480-92. 2013
    ....
  12. pmc Asi1 is an inner nuclear membrane protein that restricts promoter access of two latent transcription factors
    Mirta Boban
    Ludwig Institute for Cancer Research, S 171 77 Stockholm, Sweden
    J Cell Biol 173:695-707. 2006
    ..These findings reveal an unanticipated role of inner nuclear membrane proteins in controlling gene expression...
  13. pmc Ssh4, Rcr2 and Rcr1 affect plasma membrane transporter activity in Saccharomyces cerevisiae
    Jhansi Kota
    Ludwig Institute for Cancer Research, S 171 77 Stockholm, Sweden
    Genetics 175:1681-94. 2007
    ....
  14. pmc Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control
    Paula Martinez
    Ludwig Institute for Cancer Research, Box 240, S 171 77 Stockholm, Sweden
    Mol Cell Biol 25:9435-46. 2005
    ..These results define the hierarchy of regulatory mechanisms that differentially control two discrete pathways for the assimilation of nitrogen...
  15. ncbi request reprint Four permeases import proline and the toxic proline analogue azetidine-2-carboxylate into yeast
    Claes Andréasson
    Ludwig Institute for Cancer Research, Box 240, S 171 77 Stockholm, Sweden
    Yeast 21:193-9. 2004
    ..These findings have implications for the interpretation of studies using AzC to characterize nitrogen source-dependent regulation of amino acid uptake and of post-Golgi targeting and localization of amino acid permeases in yeast...
  16. pmc Wild-type Drosophila melanogaster as a model host to analyze nitrogen source dependent virulence of Candida albicans
    Monica M Davis
    Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
    PLoS ONE 6:e27434. 2011
    ..By contrast, Stp2, which activates genes required for amino acid uptake, is dispensable for virulence. These results indicate that nutrient availability within infected hosts directly influences C. albicans virulence...
  17. ncbi request reprint Host-pathogen interactions and the pathological consequences of acute systemic Candida albicans infections in mice
    Bjorn Rozell
    Developmental Biology, The Wenner Gren Institute, Stockholm University, SE 10691 Stockholm, Sweden
    Curr Drug Targets 7:483-94. 2006
    ..albicans. The interplay between defined pathogen and host specific responses are discussed. Additionally, we provide experimental data on the pathological consequences resulting from acute systemic infections of C. albicans in mice...
  18. pmc Receptor-mediated endoproteolytic activation of two transcription factors in yeast
    Claes Andréasson
    Ludwig Institute for Cancer Research, S 171 77 Stockholm, Sweden
    Genes Dev 16:3158-72. 2002
    ..These results define a completely unique and streamline metabolic control pathway that directly routes environmental signals initiated at the plasma membrane to transcriptional activation in the nucleus of yeast...
  19. ncbi request reprint An ER packaging chaperone determines the amino acid uptake capacity and virulence of Candida albicans
    Paula Martinez
    Ludwig Institute for Cancer Research, Box 24, SE 17177 Stockholm, Sweden
    Mol Microbiol 51:371-84. 2004
    ..These results strongly suggest that C. albicans cells use amino acids, presumably as nitrogen sources, during growth in mammalian hosts...