Research Topics
| Börje J LjungbergSummaryCountry: Sweden Publications
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Publications
The role of metastasectomy in renal cell carcinoma in the era of targeted therapyBorje Ljungberg
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
Curr Urol Rep 14:19-25. 2013..Patients with metastatic renal cell carcinoma should be considered for multimodal therapy, including surgery of metastatic lesions. A proportion of patients will achieve long-term survival with aggressive surgical resection...
High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomasMaria V Yusenko
Laboratory of Molecular Oncology, Medical Faculty, Ruprecht Karls University, Heidelberg, Germany
BMC Cancer 9:152. 2009..The diagnosis of benign renal oncocytomas (RO) and chromophobe renal cell carcinomas (RCC) based on their morphology remains uncertain in several cases...
Prognostic factors in renal cell carcinomaB Ljungberg
Department of Surgical and Perioperative Sciences, Urology and Andrology, , Ume, Sweden
Scand J Surg 93:118-25. 2004
Nephron-sparing surgery--strategies for partial nephrectomy in renal cell carcinomaB Ljungberg
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
Scand J Surg 93:126-31. 2004..Albeit these facts, there is convincing evidence justifying nephron-sparing surgery to be used routinely for patients with a small renal cell carcinoma and a normal functioning contralateral kidney...
Different vascular endothelial growth factor (VEGF), VEGF-receptor 1 and -2 mRNA expression profiles between clear cell and papillary renal cell carcinomaBörje J Ljungberg
Urology and Andrology, Department of Surgical and Perioperative Sciences, Umea University, Umea, Sweden
BJU Int 98:661-7. 2006....
Renal cell carcinoma guidelineBorje Ljungberg
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden, and Department of Urology, Lister Hospital, Stevenage, UK
Eur Urol 51:1502-10. 2007....
Prognostic markers in renal cell carcinomaBorje Ljungberg
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
Curr Opin Urol 17:303-8. 2007..This article reviews recent reports on prognostic markers in renal cell carcinoma...
Contemporary status of open nephron-sparing surgery in renal cell carcinomaBorje Ljungberg
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Sweden
Arch Ital Urol Androl 81:61-4. 2009....
EAU guidelines on renal cell carcinoma: the 2010 updateBorje Ljungberg
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
Eur Urol 58:398-406. 2010....
The epidemiology of renal cell carcinomaBorje Ljungberg
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
Eur Urol 60:615-21. 2011..Globally, about 270 000 cases of kidney cancer are diagnosed yearly and 116 000 people die from the disease. Approximately 90% of all kidney cancers are renal cell carcinomas (RCC)...
Tumour vascular endothelial growth factor (VEGF) mRNA in relation to serum VEGF protein levels and tumour progression in human renal cell carcinomaBorje Ljungberg
Department of Surgical and Perioperative Sciences, Umea University, 90185 Umea, Sweden
Urol Res 31:335-40. 2003..The association with tumour progression shows that VEGF is a promising angiogenic factor especially important in conventional RCCs. VEGF expression might possibly be of help to identify RCCs susceptible for anti-angiogenic therapies...
Follow-up guidelines for nonmetastatic renal cell carcinoma based on the occurrence of metastases after radical nephrectomyB Ljungberg
Department of Urology, Umea University, Umea, Sweden
BJU Int 84:405-11. 1999..To define guidelines for the follow-up management of nonmetastatic renal cell carcinoma (RCC), by assessing tumour recurrences and the clinical course in patients who had undergone radical nephrectomy...
Factors of importance for prediction of survival in patients with metastatic renal cell carcinoma, treated with or without nephrectomyB Ljungberg
Department of Surgical and Perioperative Science, Urology and Andrology, Umea University, Sweden
Scand J Urol Nephrol 34:246-51. 2000..A number of variables were analysed to identify factors that might predict the survival time, and these factors were used to obtain guidance as to which patients might benefit from palliative nephrectomy...
p53 expression in correlation to clinical outcome in patients with renal cell carcinomaB Ljungberg
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Sweden
Scand J Urol Nephrol 35:15-20. 2001..The aim of this study was to evaluate the role of p53 as prognostic factor in renal cell carcinoma (RCC) and its relation to clinicopathological factors...
Impact of serum basic fibroblast growth factor on prognosis in human renal cell carcinomaT Rasmuson
Department of Radiation Sciences, Oncology, Umea University, Sweden
Eur J Cancer 37:2199-203. 2001..001). Furthermore, patients with tumours with vein invasion had a worse prognosis compared with those without invasion. After multivariate analysis, only tumour stage and grade remained as independent prognostic factors...
Serum beta 2-microglobulin and prognosis of patients with renal cell carcinomaT Rasmuson
Department of Oncology, , Sweden
Acta Oncol 35:479-82. 1996..Weaker factors were age and cell type, whereas the prognostic value of serum beta 2-M disappeared. However, if tumour cell type was excluded from the analysis, serum beta 2-M was identified as a prognostic factor...
Prognostic significance of the Heidelberg classification of renal cell carcinomaB Ljungberg
Department of Urology and Andrology, Umea University, Umea, Sweden
Eur Urol 36:565-9. 1999..In a large material of patients, the prognostic and clinical information of these different tumour types were evaluated...
Expression of vascular endothelial growth factor protein in human renal cell carcinomaJ Jacobsen
Department of Surgical and Perioperative Sciences, Urology and Andrology, , Ume, Sweden
BJU Int 93:297-302. 2004..There was no difference in VEGF expression among the different RCC types. The correlation between VEGF expression and tumour stage and with prognosis indicates the significance of VEGF within tumour growth and progression in RCC...
Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarrayY Hedberg
Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
Br J Cancer 88:1417-23. 2003..In summary, we have shown that G1/S regulatory defects are present in RCC and are associated with clinico-pathological parameters. The pattern of cell cycle regulatory defects also differed between RCC subtypes...
Sentinel node detection in renal cell carcinoma. A feasibility study for detection of tumour-draining lymph nodesAmir M Sherif
Department of Urology, Karolinska University Hospital, Stockholm, Sweden
BJU Int 109:1134-9. 2012..To evaluate the feasibility of performing sentinel node detection in patients with renal cell carcinoma (RCC)...
Increased serum cortisol levels are associated with high tumour grade in patients with renal cell carcinomaT Rasmuson
Department of Radiation Sciences, Oncology, Umea University, Sweden
Acta Oncol 40:83-7. 2001..In a multivariate analysis, disease stage and tumour grade were independent predictors of prognosis. Age, gender and serum levels of cortisol and DHEAS were of limited value for prognosis...
Prognostic importance of serum vascular endothelial growth factor in relation to platelet and leukocyte counts in human renal cell carcinomaJ Jacobsen
Department of Surgical and Perioperative Sciences, Urology and Andrology, , S-901 85 Ume, Sweden
Eur J Cancer Prev 11:245-52. 2002..Only stage and grade remained as independent prognostic factors. Both VEGF levels and platelet counts gave prognostic information but VEGF was more reliable as predictor of survival in patients with RCC...
Soluble ectodomain of c-erbB-2 oncoprotein in relation to tumour stage and grade in human renal cell carcinomaT Rasmuson
Department of Oncology, , Sweden
Br J Cancer 75:1674-7. 1997..003). In a multivariate analysis, c-erbB-2 oncoprotein lost its prognostic information, while tumour stage and tumour grade were identified as independent prognostic factors...
Cyclin-D1 expression in human renal-cell carcinomaY Hedberg
Department of Pathology, Umea University, Sweden
Int J Cancer 84:268-72. 1999..005 and 0.002 respectively), as compared with highly aggressive tumours with low cyclin-D1 levels...
Neuroendocrine differentiation in renal cell carcinoma--evaluation of chromogranin A and neuron-specific enolaseT Rasmuson
Department of Oncology, Umea University, Sweden
Acta Oncol 38:623-8. 1999..In a multivariate analysis, tumour stage, grade, and serum NSE, but not chromogranin A, were significant predictors of prognosis...
LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT--PCR and immunohistochemical analysisM Thomasson
Department of Radiation Sciences, Oncology, Umea University Hospital, Umea, Sweden
Br J Cancer 89:1285-9. 2003..Further studies are justified to elucidate the explicit role of LRIG1 in the oncogenesis of RCC...
Diagnosis of renal cell carcinoma by bone marrow aspiration biopsyB Ljungberg
Department of Surgical and Perioperative Science, Urology and Andrology, Umea University, Sweden
Scand J Urol Nephrol 35:334-6. 2001..A computerized tomography confirmed the diagnosis. The patient progressed rapidly and died of widespread metastatic papillary renal cell carcinoma...
Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathwaysR T Sitaram
Department of Medical Biosciences and Pathology, Umea University, Umea, Sweden
Br J Cancer 103:1255-62. 2010..Wilms' tumour 1 (WT1) gene was discovered as a tumour suppressor gene. Later findings have suggested that WT1 also can be oncogenic. This complexity is partly explained by the fact that WT1 has a number of target genes...
Excretion of pseudouridine as an independent prognostic factor in renal cell carcinomaT Rasmuson
Department of Oncology, University Hospital, , Sweden
Acta Oncol 30:11-5. 1991..The level of pseudouridine correlated to tumor grade and tumor size. Using Cox's proportional hazard model, only clinical stage and level of pseudouridine excretion were independent predictors of prognosis...
An image analysis method for prostate tissue classification: preliminary validation with resonance sensor dataP L Lindberg
Department of Applied Physics and Electronics, Umea University, Umea, Sweden
J Med Eng Technol 33:18-24. 2009..001). Thus it can be concluded that there existed a linear relationship between the impression depth and the tissue classes. The new image analysis method was easy to handle and decreased the classification time by 80%...
Similar rates of exponential decrease in serum concentrations of free prostate-specific antigen (PSA), PSA complexed to alpha-1-antichymotrypsin, and human glandular kallikrein 2 (hK2) in prostate cancer patients treated with GnRH-analoguesT Bjork
Department of Urology, Malmö and Lund University Hospitals, Lund University, Malmo, Sweden
Prostate 47:14-20. 2001..In addition, serum concentrations of hK2, the activator of proPSA, were measured...
