Research Topics
Species | Per LindstromSummaryCountry: Sweden Publications
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Detail Information
Publications
The physiology of obese-hyperglycemic mice [ob/ob mice]Per Lindstrom
Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
ScientificWorldJournal 7:666-85. 2007..ob/ob Mice are well suited for studies on the interaction between leptin and insulin, and for studies on initial aspects of metabolic disturbances leading to type-2 diabetes...
beta-cell function in obese-hyperglycemic mice [ob/ob Mice]Per Lindstrom
Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, S 901 87 Umea, Sweden
Adv Exp Med Biol 654:463-77. 2010..ob/ob Mice can perhaps be described as a model for the prediabetic state. The large capacity for islet growth and insulin release makes ob/ob mice a good model for studies on how beta-cells can cope with prolonged functional stress...
Vasoactive intestinal polypeptide and pituitary adenylate cyclase activating polypeptide: effects on insulin release in isolated mouse islets in relation to metabolic status and ageSolveig Persson-Sjögren
Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, SE 901 87 Umea, Sweden
Neuropeptides 40:283-90. 2006..We suggest that VIP and PACAP contribute to the developing metabolic syndrome in ob/ob mice by aggravating hyperinsulinemia...
Cell specificity of the cytoplasmic Ca2+ response to tolbutamide is impaired in beta-cells from hyperglycemic miceNatalia Gustavsson
Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umeå S 901 87, Sweden
J Endocrinol 190:461-70. 2006..The loss of temporal cell specificity for the response to tolbutamide in single beta-cells from hyperglycemic mice may be a sign of K(ATP)- or voltage-dependent calcium channel dysfunction...
Effects of cholinergic m-receptor agonists on insulin release in islets from obese and lean mice of different ages: the importance of bicarbonateSolveig Persson-Sjögren
Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
Pancreas 29:e90-9. 2004..We have studied the age-related effects of M-receptor agonism on insulin release in islets isolated from female ob/ ob and lean mice...
Pancreatic beta cells from db/db mice show cell-specific [Ca2+]i and NADH responses to glucose but not to alpha-ketoisocaproic acidNatalia Gustavsson
Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
Pancreas 31:242-50. 2005..Besides glucose, we studied the effects of glyceraldehyde, a glycolytic intermediate, and alpha-ketoisocaproic acid (KIC), a mitochondrial substrate...
