M Lindqvist

Summary

Country: Sweden

Publications

  1. ncbi request reprint Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23
    Malin Lindqvist
    Division of Clinical Pharmacology, Department of Medicine and Care, Faculty of Health Sciences, Linkoping, Sweden
    Pharmacogenet Genomics 17:891-5. 2007
  2. ncbi request reprint Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression
    Malin Lindqvist
    Department of Medicine and Care, Division of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, 58185 Linkoping, Sweden
    Eur J Clin Pharmacol 59:207-11. 2003
  3. ncbi request reprint Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity
    Malin Lindqvist
    Department of Medicine and Care, Division of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    Pharmacogenetics 14:261-5. 2004
  4. ncbi request reprint No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease
    M Lindqvist
    Department of Medicine and Care, Division of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Nucleosides Nucleotides Nucleic Acids 25:1033-7. 2006
  5. ncbi request reprint Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease
    Sofie Haglund
    Division of Research and Development in Laboratory Medicine, Ryhov County Hospital, SE 551 85 Jonkoping, Sweden
    Clin Chem 50:288-95. 2004
  6. ncbi request reprint Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines
    Alan Kambiz Fotoohi
    Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute, Stockholm, Sweden
    Biochem Biophys Res Commun 343:208-15. 2006

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23
    Malin Lindqvist
    Division of Clinical Pharmacology, Department of Medicine and Care, Faculty of Health Sciences, Linkoping, Sweden
    Pharmacogenet Genomics 17:891-5. 2007
    ..We conclude that this novel variant allele affects enzyme activity, as the individuals carrying it had almost undetectable TPMT activity...
  2. ncbi request reprint Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression
    Malin Lindqvist
    Department of Medicine and Care, Division of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, 58185 Linkoping, Sweden
    Eur J Clin Pharmacol 59:207-11. 2003
    ....
  3. ncbi request reprint Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity
    Malin Lindqvist
    Department of Medicine and Care, Division of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    Pharmacogenetics 14:261-5. 2004
    ..His father was genotyped as TPMT*1/*3A (6.0 U/ml pRBC). Hence, we report the identification of two novel sequence variants, present in highly conserved nucleotide positions of the human TPMT gene, resulting in a loss of enzyme activity...
  4. ncbi request reprint No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease
    M Lindqvist
    Department of Medicine and Care, Division of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Nucleosides Nucleotides Nucleic Acids 25:1033-7. 2006
    ..TPMT heterozygous individuals had a lower probability of remaining in the study on the predetermined dose (p = 0.039). The ITPA 94C > A polymorphism was not predictive of adverse events (p = 0.35)...
  5. ncbi request reprint Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease
    Sofie Haglund
    Division of Research and Development in Laboratory Medicine, Ryhov County Hospital, SE 551 85 Jonkoping, Sweden
    Clin Chem 50:288-95. 2004
    ..Patients with inflammatory bowel disease (n = 24) and healthy volunteers (n = 6), selected on the basis of TPMT enzymatic activity, were investigated for all 10 SNPs to determine the relationship between TPMT genotype and phenotype...
  6. ncbi request reprint Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines
    Alan Kambiz Fotoohi
    Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute, Stockholm, Sweden
    Biochem Biophys Res Commun 343:208-15. 2006
    ..From a clinical point of view determination of CNT3 and ENT2 levels in leukemia cells may be useful in predicting the efficacy of thiopurine treatment...