Research Topics
| M LindhSummaryCountry: Sweden Publications
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Publications
Virological response to interferon therapy of chronic hepatitis B as measured by a highly sensitive assayM Lindh
Department of Clinical Virology, Goteborg University, Goteborg, Sweden
J Viral Hepat 8:349-57. 2001..0 (PPV=92%). The potential value of differentiating the therapy of chronic hepatitis B on the basis of viraemia levels, as measured by highly sensitive assays, should be further investigated...
Genotype mixtures of hepatitis B virus in patients treated with interferonCharles Hannoun
Department of Clinical Virology, , , Sweden
J Infect Dis 186:752-9. 2002..This should be considered when tracing the source of HBV infection...
Dichotomy of glycoprotein g gene in herpes simplex virus type 1 isolatesElham Rekabdar
Department of Clinical Virology, Goteborg University, Goteborg, Sweden
J Clin Microbiol 40:3245-51. 2002....
Comparison of HIV-1 pol and env sequences of blood, CSF, brain and spleen isolates collected ante-mortem and post-mortemE C Caragounis
Department of Clinical Virology, The Sahlgrenska Academy at Goteborg University, Gothenburg, Sweden
Acta Neurol Scand 117:108-16. 2008..The aim of this study was to investigate HIV-1 evolution in the CNS and the origin of HIV-1 in CSF...
High cytokine levels in perforated acute otitis media exudates containing live bacteriaS Skovbjerg
Department of Infectious Medicine Clinical Bacteriology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
Clin Microbiol Infect 16:1382-8. 2010..IL-6 and PGE2, however, remain after bacterial disintegration, and may play a role in the resolution phase...
Dynamic tailoring of treatment durations improves efficiency of hepatitis C treatment with pegylated interferon and ribavirinM Lindh
Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden
J Viral Hepat 20:e82-9. 2013..The outcome parameter treatment weeks per cured patient could become a useful tool for comparing treatment efficiency also in the era of directly acting antivirals...
Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trialRobin Brittain-Long
Department of Infectious Diseases, Sahlgrenska University Hospital, Smörslottsgatan 1, Gothenburg, Sweden
BMC Med 9:44. 2011....
Real-time PCR detection of human herpesvirus 1-5 in patients lacking clinical signs of a viral CNS infectionBirgitta Sundén
Div Clinical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, Sweden
BMC Infect Dis 11:220. 2011..The aim of this study was to investigate if herpes- or enterovirus can be detected in cerebrospinal fluid (CSF) from patients without symptoms...
Core mutations, IL28B polymorphisms and response to peginterferon/ribavirin treatment in Swedish patients with hepatitis C virus genotype 1 infectionErik Alestig
Department of Infection and Virology, University of Gothenburg, Gothenburg, Sweden
BMC Infect Dis 11:124. 2011..In the present study, the impact of these mutations on response kinetics and treatment outcome was explored in Caucasian patients...
Monitoring treatment response by the hepatitis C virus core antigen assayM Lindh
Department of Clinical Virology, , Guldhedsgatan 10B, 41346, , Sweden
Eur J Clin Microbiol Infect Dis 24:230-2. 2005
Dynamic range and reproducibility of hepatitis B virus (HBV) DNA detection and quantification by Cobas Taqman HBV, a real-time semiautomated assayMagnus Lindh
Department of Clinical Virology, Goteborg University, Guldhedsgatan 10B, 413 46 Goteborg, Sweden
J Clin Microbiol 43:4251-4. 2005..The coefficient of variation was 1.2% at > or =1,000 IU/ml and 22.0% at 10 IU/ml. In 97 clinical samples, the log HBV DNA/ml differed by 0.11 between Cobas Amplicor and Cobas Taqman (r2 = 0.97)...
Genotyping of hepatitis C virus by Taqman real-time PCRMagnus Lindh
Department of Clinical Virology, Guldhedsgatan 10 B, 413 46 Goteborg, Sweden
J Clin Virol 34:108-14. 2005..Genotype of hepatitis C virus (HCV) is of major importance for the outcome of treatment. The response rate is considerably lower for genotype 1, the predominant genotype in western countries...
Lamivudine resistance of hepatitis B virus masked by coemergence of mutations in probe region of the COBAS AMPLICOR assayMagnus Lindh
Department of Clinical Virology, Goteborg University, Guldhedsgatan 10 B, 413 46 Goteborg, Sweden
J Clin Microbiol 44:2587-9. 2006..However, the assay failed to recognize increasing viremia levels when YMDD mutations were paralleled by mutations in the segment targeted by the COBAS AMPLICOR probe...
Real-time Taqman PCR targeting 14 human papilloma virus typesMagnus Lindh
Department of Virology, The Sahlgrenska Academy, Goteborg University, Sweden
J Clin Virol 40:321-4. 2007..Subtyping of human papilloma virus (HPV) may enhance the precision of vaginal cytological assessments and will be important for investigating the effect of the recently introduced vaccine against types 16 and 18...
IL28B polymorphisms determine early viral kinetics and treatment outcome in patients receiving peginterferon/ribavirin for chronic hepatitis C genotype 1M Lindh
Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden
J Viral Hepat 18:e325-31. 2011..A combined assessment of these SNPs in conjunction with other response predictors may better predict outcome in difficult-to-treat patients...
Novel method for genotyping hepatitis B virus on the basis of TaqMan real-time PCRSebastian Malmström
Department of Infectious Diseases, Section for Clinical Virology, Guldhedsgatan 10 B, 413 46 Goteborg, Sweden
J Clin Microbiol 48:1105-11. 2010..We conclude that this new assay represents a significant advancement for both diagnostics and clinical research because it is accurate, practical, and based on a technique that is well established in many virological laboratories...
Interleukin 28B gene variation at rs12979860 determines early viral kinetics during treatment in patients carrying genotypes 2 or 3 of hepatitis C virusMagnus Lindh
Department of Infectious Diseases, University of Gothenburg, Sweden
J Infect Dis 203:1748-52. 2011..The results indicate that IL28B gene testing may identify patients carrying genotype 2 or 3 who could benefit from extended treatment...
Response prediction and treatment tailoring for chronic hepatitis C virus genotype 1 infectionMagnus Lindh
Department of Infection and Virology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
J Clin Microbiol 45:2439-45. 2007..On the basis of these findings, we propose a model of tailored treatment which takes into account the second-phase slope and the amount of HCV RNA after 21 days of treatment...
Mutation of nucleotide 1,762 in the core promoter region during hepatitis B e seroconversion and its relation to liver damage in hepatitis B e antigen carriersM Lindh
Department of Clinical Virology, Goteborg University, Sweden
J Med Virol 55:185-90. 1998..The presence of a T-1,762 mutant in the HBeAg+ phase may be useful for identifying immunoactivation in previously immunotolerant carriers, which could be valuable for selecting patients for interferon therapy...
Genotyping of hepatitis B virus by restriction pattern analysis of a pre-S ampliconM Lindh
Department of Clinical Virology, Goteborg University, Sweden
J Virol Methods 72:163-74. 1998..This method should be useful for epidemiological investigations and for studying the potential influence of genotype on the course of infection...
Treatment of chronic hepatitis B infection: an update of Swedish recommendationsMagnus Lindh
Department of Infectious Diseases, Sahlgrenska University Hospital, Goteborg, Sweden
Scand J Infect Dis 40:436-50. 2008..mpa.se and www.rav.nu.se) including 7 separate papers based on thorough literature search. The complete reference list can be received from the Medical Products Agency upon request...
Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriersM Lindh
Department of Clinical Virology, Goteborg University, S 413 46 Goteborg, Sweden
J Infect Dis 179:775-82. 1999....
Acute hepatitis B in Western Sweden--genotypes and transmission routesM Lindh
Dept of Clinical Virology, Goteborg University, Sweden
Infection 28:161-3. 2000....
Hepatitis C treatment response kinetics and impact of baseline predictorsM Lindh
Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden
J Viral Hepat 18:400-7. 2011..The kinetic patterns and the high relapse rate in genotype 2/3 patients without RVR suggest that this group might benefit from treatment durations longer than 24weeks...
Monitoring virological responses to interferon-ribavirin and interferon monotherapy of chronic hepatitis C re-treated due to relapse or non-responseJ Westin
Department of Infectious Diseases, Sahlgrenska University Hospital, , Sweden
Scand J Infect Dis 33:110-5. 2001..Loss of viremia at week 4 of IFN was associated with a sustained response to IFN-RBV and was seen in 11 of 13 patients (85%) with genotypes 2 or 3, as compared with one of seven patients (14%) with genotype 1 (p = 0.0044)...
Phylogenetic origin of hepatitis B virus strains with precore C-1858 variantE Alestig
Department of Clinical Virology, , , Sweden
J Clin Microbiol 39:3200-3. 2001..Further study of the distribution of this variant is warranted...
Hepatitis B virus genotypes in Mongols and Australian AboriginesE Alestig
Department of Clinical Virology, , Sweden
Arch Virol 146:2321-9. 2001..By preS analysis, they were however clearly of genotype C. The 6-7% nucleotide difference from published Asian genotype C sequences suggests that they diverged from Asian genotype C branch more than 1000 years ago...
Moderate alcohol intake increases fibrosis progression in untreated patients with hepatitis C virus infectionJohan Westin
Department of Infectious Diseases, Goteborg University, Göteborg Sweden
J Viral Hepat 9:235-41. 2002..From that point of view, total abstention ought to be recommended. If this is not achieved, occasional use of alcohol is probably less harmful than daily drinking for patients with low or moderate alcohol consumption...
Histologic activity of childhood chronic hepatitis B related to viremia levels, genotypes, mutations, and epidemiologic factorsAnn Soderstrom
Department of Infectious Diseases, Goteborg University, Sweden
J Pediatr Gastroenterol Nutr 35:487-94. 2002..Despite the absence of biochemical abnormalities in these patients, there is still a risk for long-term complications. The pathogenic importance of viral load and genetic variability is less well studied in children than in adults...
Mutations in the X region and core promoter are rare and have little impact on response to interferon therapy for chronic hepatitis BCharles Hannoun
Department of Clinical Virology, , , Sweden
J Med Virol 66:171-8. 2002..The low frequency of mutations indicates that analysis of this region is of limited clinical value and that emerging mutations in this region are not major determinants of response to treatment with IFN-alpha...
Simple method for detection of mutations causing hereditary fructose intoleranceC Kullberg-Lindh
Department of Pediatrics, Goteborg University, Sweden
J Inherit Metab Dis 25:571-5. 2002..The method might be useful for screening of these mutations, which may account for more than 70% of the mutations causing HFI...
Opportunistic virus DNA levels after pediatric stem cell transplantation: serostatus matching, anti-thymocyte globulin, and total body irradiation are additive risk factorsC Kullberg-Lindh
Department of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
Transpl Infect Dis 13:122-30. 2011..We conclude that DNAemia levels help to distinguish significant viral infections, and that surveillance and prophylactic measures should be focused on patients with risk factors in whom viral complications rapidly can become fatal...
Treatment of hepatitis C virus infection: updated Swedish Consensus recommendationsMartin Lagging
Department of Infectious Diseases and Virology, Sahlgrenska University Hospital, Goteborg
Scand J Infect Dis 41:389-402. 2009..For liver transplant patients pre-emptive therapy is not recommended; hence, treatment should be deferred until histological recurrence...
Varicella-zoster virus CNS disease--viral load, clinical manifestations and sequelsAnna Persson
Department of Infectious Diseases, Sahlgrenska University Hospital, Ostra, SE 416 85, Gothenburg, Sweden
J Clin Virol 46:249-53. 2009..The VZV viral load in the CSF obtained from VZV-related neurological syndromes is not known...
Phylogenetic analysis of clinical herpes simplex virus type 1 isolates identified three genetic groups and recombinant virusesPeter Norberg
Department of Virology, University of Goteborg, Guldhedsgatan 10 B, S 413 46 Goteborg, Sweden
J Virol 78:10755-64. 2004..The presence of polymorphic tandem repeat regions and the different genogroup identities can be used for molecular epidemiology studies and for further detection of recombination in the HSV-1 genome...
A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicalsFredrik Thoren
Department of Clinical Virology, Goteborg University, Guldhedsgatan 10B, S 413 46 Goteborg, Sweden
J Leukoc Biol 76:1180-6. 2004....
Detection and typing of Herpes Simplex virus (HSV) in mucocutaneous samples by TaqMan PCR targeting a gB segment homologous for HSV types 1 and 2Lilly Namvar
Department of Clinical Virology, , Guldhedsgatan 10B, , Sweden
J Clin Microbiol 43:2058-64. 2005..HSV-1 constituted 40% of genital infections and was associated with lower mean age (29.2 versus 36.4 years), probably reflecting the fact that recurrent genital HSV-1 infections are rare...
Mutation analysis of lamivudine resistant hepatitis B virus strains by TaqMan PCRSebastian Malmström
Department of Clinical Virology, Goteborg University, Guldhedsgatan 10 B, 413 46 Goteborg, Sweden
J Virol Methods 143:147-52. 2007..This method is rapid, cost effective, and should prove useful for monitoring patients treated with lamivudine...
Comparison of serum and whole blood levels of cytomegalovirus and Epstein-Barr virus DNAC Kullberg-Lindh
Department of Paediatrics, Queen Silvia Children s Hospital, Goteborg University, Goteborg, Sweden
Transpl Infect Dis 10:308-15. 2008..Identification of PTLD may require EBV DNA testing in both specimen types or complementary tests...
Progression of fibrosis in untreated patients with hepatitis C virus infectionL Martin Lagging
Department of Clinical Virology, Goteborg University, Goteborg, Sweden, Department of Infectious Diseases, Goteborg University, Sweden
Liver 22:136-44. 2002..If moderate interface hepatitis early in the course of the disease is followed by less interface hepatitis later there is less fibrosis; and if moderate interface hepatitis persists, there is more fibrosis eventually...
Predictive factors and virological response to interferon treatment in children with chronic hepatitis BAnn Soderstrom
Department of Infectious Diseases, Goteborg University, Sweden
Scand J Infect Dis 37:40-7. 2005..Thus, pretreatment HBV DNA levels were associated with IFN response, and the virological response at week 12 predicts SR and may be useful in the decision to continue or modify therapy...
Comparison of serum hepatitis C virus RNA and core antigen concentrations and determination of whether levels are associated with liver histology or affected by specimen storage timeL Martin Lagging
Department of Clinical Virology, Goteborg University, Goteborg, Sweden
J Clin Microbiol 40:4224-9. 2002..0 years) and 4.41 for the sera obtained at the time of the second biopsy (median storage time, 6.6 years) compared to 5.96, the median for 102 different routine clinical patient samples...
Hepatitis B virus DNA during pregnancy and post partum: aspects on vertical transmissionAnn Soderstrom
Department of Infectious Diseases, Sahlgrenska University Hospital, Ostra, Goteborg, Sweden
Scand J Infect Dis 35:814-9. 2003..Vertical transmission was only seen in HBeAg-positive mothers with very high levels of viremia. The value of measuring HBV DNA in the pregnant woman to modify immunoprophylaxis to her infant needs further study...
Epstein-Barr viremia levels after pediatric liver transplantation as measured by real-time polymerase chain reactionCarola Kullberg-Lindh
Department of Pediatrics, Queen Silvia Children s Hospital, Goteborg, Sweden
Pediatr Transplant 10:83-9. 2006..The data suggest that quantitative analysis of EBV DNA in serum by real-time PCR is useful for identification of EBV-related disease...
Nosocomial transmission of HCV in a cardiology ward during the window phase of infection: an epidemiological and molecular investigationL Martin Lagging
Department of Infectious Diseases, Goteborg University, Sweden
Scand J Infect Dis 34:580-2. 2002..It may, therefore, be prudent to restrict the use of such vials, in addition to promoting vigorous adherence to standard hygiene procedures in order to prevent the recurrence of similar outbreaks in the future...
Excess mortality following community-onset norovirus enteritis in the elderlyL Gustavsson
Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
J Hosp Infect 79:27-31. 2011..001). In conclusion, community-onset NVE requiring hospitalization was associated with higher mortality compared with hospital-onset NVE and matched controls in hospitalized elderly patients...
Real time PCR for monitoring regulation of host gene expression in herpes simplex virus type 1-infected human diploid cellsKristina Nyström
Clinical Virology, University of Goteborg, Guldhedsgatan 10B, S 413 46 Goteborg, Sweden
J Virol Methods 118:83-94. 2004..By applying these procedures, it was shown that the transcription of FUT5 was increased by 50-fold 5-24h after HSV-1 infection and 200-fold by the inhibition of viral DNA replication in HSV-infected cells...
Quantitative analysis of CMV DNA in children the first year after liver transplantationCarola Kullberg-Lindh
Departments of Pediatrics and Clinical Virology, Goteborg University, Goteborg, Sweden
Pediatr Transplant 7:296-301. 2003..The data suggest that quantitative analysis of CMV DNA may be of value in early identification of CMV disease and for avoiding unnecessary antiviral treatment...
Neutralization of pseudotyped vesicular stomatitis virus expressing hepatitis C virus envelope glycoprotein 1 or 2 by serum from patientsL Martin Lagging
Department of Clinical Virology, Goteborg University, Guldhedsgatan 10B, S 413 46 Goteborg, Sweden
J Infect Dis 185:1165-9. 2002....
Oxygen radical production and severity of the Guillain--Barré syndromeNatalia Mossberg
Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Goteborg, Sweden
J Neuroimmunol 192:186-91. 2007....
Phylogeny of African complete genomes reveals a West African genotype A subtype of hepatitis B virus and relatedness between Somali and Asian A1 sequencesCharles Hannoun
Department of Clinical Virology, , Guldhedsgatan 10B, , Sweden
J Gen Virol 86:2163-7. 2005....
Multiplex real-time PCR for detection of respiratory tract infectionsRobin Brittain-Long
Department of Infection, The Sahlgrenska Academy, Goteborg University, 416 85 Goteborg, Sweden
J Clin Virol 41:53-6. 2008..Broad diagnostics of respiratory infection by molecular assays has not yet won acceptance due to technical difficulties and high costs...
Excellent booster response 4 to 8 years after a single primary dose of an inactivated hepatitis A vaccineSten Iwarson
Department of Infectious Diseases, Sahlgrenska University Hospital, , Sweden
J Travel Med 11:120-1. 2004
Virus-induced transcriptional activation of host FUT genes associated with neo-expression of Ley in cytomegalovirus-infected and sialyl-Lex in varicella-zoster virus-infected diploid human cellsKristina Nyström
Department of Virology, University of Goteborg, Goteborg, Sweden
Glycobiology 17:355-66. 2007..The induced carbohydrate antigens in CMV- and VZV-infected cells could be of significance for virus spread and possible escape from immune responses...
Prospective evaluation of a novel multiplex real-time PCR assay for detection of fifteen respiratory pathogens-duration of symptoms significantly affects detection rateRobin Brittain-Long
Department of Infectious Diseases, Sahlgrenska University Hospital, Ostra, Gothenburg, Sweden
J Clin Virol 47:263-7. 2010..We have evaluated a multiplex real-time PCR method for the detection of 13 respiratory viruses and 2 bacteria (Mycoplasma and Chlamydophila) in a clinical setting...
Demonstration of an association between detection of IgG antibody reactivity towards the C-terminal region of the preS1 protein of hepatitis B virus and the capacity to respond to interferon therapy in chronic hepatitis BUlla Hellstrom
Department of Communicable Disease Control and Prevention, Karolinska Hospital, Stockholm, Sweden
J Gastroenterol Hepatol 23:804-10. 2008....
Simultaneous quantification and genotyping of hepatitis B virus for genotypes A to G by real-time PCR and two-step melting curve analysisWen-Chun Liu
Institute of Basic Medical Sciences, Department of Medicine, National Cheng Kung University, Tainan City 704, Taiwan, Republic of China, and Liver Unit, Hospital General Universitari Vall d'Hebron, Barcelona, Spain
J Clin Microbiol 44:4491-7. 2006..3% of 441 samples were accurately genotyped by the current assay. The method should be useful for genotyping and quantification of HBV DNA in areas where all genotypes exist...
HBV genotype G-an odd genotype of unknown originMagnus Lindh
J Clin Virol 34:315-6. 2005
