Ulf H Lerner

Summary

Country: Sweden

Publications

  1. pmc Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients
    Martin K Andersson
    Department of Orthopaedic Surgery, Karolinska Hospital, Karolinska Institute, 171 76, Stockholm, Sweden
    Arthritis Res Ther 9:R18. 2007
  2. ncbi request reprint Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
    J Dent Res 85:596-607. 2006
  3. ncbi request reprint Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    J Musculoskelet Neuronal Interact 6:87-95. 2006
  4. ncbi request reprint Bone remodeling in post-menopausal osteoporosis
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
    J Dent Res 85:584-95. 2006
  5. ncbi request reprint [Bone remodeling]
    Ulf H Lerner
    Avdelningen för oral cellbiologi, Medicinska fakulteten, Umea Universitet
    Lakartidningen 103:2972-5. 2006
  6. ncbi request reprint [Serotonin reuptake inhibitors may increase the risk of osteoporosis]
    Ulf H Lerner
    Medicinska fakulteten, Umea Universitet
    Lakartidningen 102:2746-9. 2005
  7. ncbi request reprint Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    J Musculoskelet Neuronal Interact 8:154-65. 2008
  8. ncbi request reprint [The skeletal protein osteocalcin is also an endocrine hormone. Possible significance for type 2 diabetes and the metabolic syndrome]
    Ulf H Lerner
    Medicinska fakulteten, Umea Universitet
    Lakartidningen 105:2264-6. 2008
  9. ncbi request reprint Glucocorticoid regulation of osteoclast differentiation and expression of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand, osteoprotegerin, and receptor activator of NF-kappaB in mouse calvarial bones
    Charlotte Swanson
    Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
    Endocrinology 147:3613-22. 2006
  10. doi request reprint Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases
    Anna Bernhold Brechter
    Oral Cell Biology, Umea University, Umea, Sweden
    Bone 43:72-83. 2008

Collaborators

Detail Information

Publications46

  1. pmc Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients
    Martin K Andersson
    Department of Orthopaedic Surgery, Karolinska Hospital, Karolinska Institute, 171 76, Stockholm, Sweden
    Arthritis Res Ther 9:R18. 2007
    ..The data indicate that SFs from patients with a loose prosthesis or with OA stimulate bone resorption and that SFs from patients with OA are more prone to enhance bone formation...
  2. ncbi request reprint Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
    J Dent Res 85:596-607. 2006
    ..In the present paper, the evidence for and against this hypothesis is presented...
  3. ncbi request reprint Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    J Musculoskelet Neuronal Interact 6:87-95. 2006
    ..Thus, our understanding of the role of the CT family of peptides has been changed dramatically and much more data have to be gained before we fully understand the roles these peptides have in bone biology...
  4. ncbi request reprint Bone remodeling in post-menopausal osteoporosis
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
    J Dent Res 85:584-95. 2006
    ....
  5. ncbi request reprint [Bone remodeling]
    Ulf H Lerner
    Avdelningen för oral cellbiologi, Medicinska fakulteten, Umea Universitet
    Lakartidningen 103:2972-5. 2006
  6. ncbi request reprint [Serotonin reuptake inhibitors may increase the risk of osteoporosis]
    Ulf H Lerner
    Medicinska fakulteten, Umea Universitet
    Lakartidningen 102:2746-9. 2005
    ..These observations raise the possibility that patients treated with SSRIs may have an increased risk for secondary osteoporosis and skeletal fractures...
  7. ncbi request reprint Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    J Musculoskelet Neuronal Interact 8:154-65. 2008
    ..The evidence for these observations is summarized in the present paper...
  8. ncbi request reprint [The skeletal protein osteocalcin is also an endocrine hormone. Possible significance for type 2 diabetes and the metabolic syndrome]
    Ulf H Lerner
    Medicinska fakulteten, Umea Universitet
    Lakartidningen 105:2264-6. 2008
  9. ncbi request reprint Glucocorticoid regulation of osteoclast differentiation and expression of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand, osteoprotegerin, and receptor activator of NF-kappaB in mouse calvarial bones
    Charlotte Swanson
    Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
    Endocrinology 147:3613-22. 2006
    ..The synergistic stimulation of RANKL by dexamethasone and D3 offers an explanation of how glucocorticoids and D3 interact to potentiate bone resorption...
  10. doi request reprint Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases
    Anna Bernhold Brechter
    Oral Cell Biology, Umea University, Umea, Sweden
    Bone 43:72-83. 2008
    ..These mechanisms might help to explain the enhanced bone resorption associated with inflammatory disorders, including periodontitis and rheumatoid arthritis...
  11. ncbi request reprint Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway
    Py Palmqvist
    Departments of Oral Cell Biology and Periodontics, Umea University, Umeå S 901 87, Sweden
    J Biol Chem 281:2414-29. 2006
    ..The data indicate that IL-4 and IL-13, via a STAT6-dependent pathway, inhibit osteoclast differentiation and bone resorption by activating receptors on osteoblasts and osteoclasts that affect the RANKL/RANK/OPG system...
  12. ncbi request reprint The neuropeptide VIP potentiates IL-6 production induced by proinflammatory osteotropic cytokines in calvarial osteoblasts and the osteoblastic cell line MC3T3-E1
    Emma Persson
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    Biochem Biophys Res Commun 335:705-11. 2005
    ..All effects, except for that of TNF-alpha, were synergistically potentiated by VIP. These findings further support the role of neuropeptides, and the presence of neuro-immunological interactions, in bone metabolism...
  13. doi request reprint Expression of the calcitonin receptor, calcitonin receptor-like receptor, and receptor activity modifying proteins during osteoclast differentiation
    Susanne Granholm
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    J Cell Biochem 104:920-33. 2008
    ..We also show, for the first time, that the CTR is not only down regulated by signaling through the CTR but also by the peptides signaling through CLR/RAMPs...
  14. ncbi request reprint Gutta-percha-stimulated mouse macrophages release factors that activate the bone resorptive system of mouse calvarial bone
    U Sjogren
    Department of Endodontics, Umea University, Sweden
    Eur J Oral Sci 106:872-81. 1998
    ..These experiments show that mouse peritoneal macrophages, when exposed to gutta-percha particles, release factors which have a bone resorbing activity that is primarily due to enhanced production of IL-1alpha...
  15. doi request reprint Comparisons between the effects of calcitonin receptor-stimulating peptide and intermedin and other peptides in the calcitonin family on bone resorption and osteoclastogenesis
    Susanne Granholm
    Department of Molecular Periodontology, Umea University, S 901 87 Umea, Sweden
    J Cell Biochem 112:3300-12. 2011
    ..Finally, the findings indicate that activation by CGRP, AMY, and IMD may include activation of both CT and CT receptor-like receptors...
  16. doi request reprint Cysteine proteinase inhibitors regulate human and mouse osteoclastogenesis by interfering with RANK signaling
    Fredrik Strålberg
    Department of Molecular Periodontology, Umea University, SE 901 87 Umea, Sweden
    FASEB J 27:2687-701. 2013
    ..These data show that cystatin C inhibits osteoclast differentiation and formation by interfering intracellularly with signaling pathways downstream RANK...
  17. doi request reprint The neuropeptide VIP regulates the expression of osteoclastogenic factors in osteoblasts
    Emma Persson
    Division of Molecular Periodontology, Umea University, Umea, Sweden
    J Cell Biochem 112:3732-41. 2011
    ..These observations demonstrate that activation of VPAC(2) receptors in osteoblasts enhances the RANKL/OPG ratio by mechanisms mediated by cyclic AMP and ERK pathways suggesting an important role for VIP in bone remodeling...
  18. ncbi request reprint Gingival crevicular fluid from patients with periodontitis contains bone resorbing activity
    U H Lerner
    Department of Oral Cell Biology, Umea University, Sweden
    Eur J Oral Sci 106:778-87. 1998
    ..The data indicate that other factors, such as IL-1, may play key roles in the stimulation of osteoclastic activity by gingival crevicular washings...
  19. doi request reprint Interleukin-4 and interleukin-13 inhibit the expression of leukemia inhibitory factor and interleukin-11 in fibroblasts
    Pedro P C Souza
    Department of Molecular Periodontology, Umea University, Umea, Sweden
    Mol Immunol 49:601-10. 2012
    ..A negative modulatory role of IL-4 and IL-13 in osteotropic cytokine production could be a mechanism playing an important inhibitory role in inflammation induced periodontitis...
  20. doi request reprint Osteoclast progenitor cells present in significant amounts in mouse calvarial osteoblast isolations and osteoclastogenesis increased by BMP-2
    Susanne Granholm
    Department of Molecular Periodontology, Umea University, Umea, Sweden
    Bone 52:83-92. 2013
    ..Moreover, the data show that BMP-2 not only stimulates osteoblastic differentiation but can also induce osteoclastogenesis through increased RANKL...
  21. ncbi request reprint Neuro-hormonal control of bone metabolism: vasoactive intestinal peptide stimulates alkaline phosphatase activity and mRNA expression in mouse calvarial osteoblasts as well as calcium accumulation mineralized bone nodules
    P Lundberg
    Department of Oral Cell Biology, Umea University, Sweden
    Regul Pept 85:47-58. 1999
    ..Our observations suggest a possibility that anabolic processes in bone are under neurohormonal control...
  22. ncbi request reprint Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts
    Emma Persson
    Department of Oral Cell Biology, Umea University, SE 901 87 Umea, Sweden
    Bone 37:513-29. 2005
    ....
  23. ncbi request reprint Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression
    Anna Bernhold Brechter
    Umea University, Umea, Sweden
    Arthritis Rheum 56:910-23. 2007
    ....
  24. doi request reprint Establishment and validation of an in vitro co-culture model to study the interactions between bone and prostate cancer cells
    Annika Nordstrand
    Department of Radiation Sciences, Oncology, Umea University, 901 85, Umea, Sweden
    Clin Exp Metastasis 26:945-53. 2009
    ..Our results show that the model can be used to follow tumor-induced bone remodeling, and by measuring changes in gene expression in the tumor cells we can also study how they respond to the bone microenvironment...
  25. ncbi request reprint Calcitonin inhibits osteoclast formation in mouse haematopoetic cells independently of transcriptional regulation by receptor activator of NF-{kappa}B and c-Fms
    Susanne Granholm
    Department of Oral Cell Biology, Umea University, S 901 87 Umea, Sweden
    J Endocrinol 195:415-27. 2007
    ....
  26. doi request reprint Stimulation of IL-6 cytokines in fibroblasts by toll-like receptors 2
    P P C Souza
    Department of Oral Cell Biology, Umea University, 901 87 Umea, Sweden
    J Dent Res 89:802-7. 2010
    ..Analysis of these data suggests that signaling through the innate immune system controls the expression of osteotropic cytokines in human gingival fibroblasts...
  27. ncbi request reprint Osteoclastogenesis is decreased by cysteine proteinase inhibitors
    Monica Brage
    Department of Oral Cell Biology, Umea University, S 90187 Umea, Sweden
    Bone 34:412-24. 2004
    ..It is concluded that cysteine proteinase inhibitors decrease formation of osteoclasts by interfering at a late stage of pre-osteoclast differentiation...
  28. ncbi request reprint Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction
    Pernilla Lundberg
    Department of Odontology, Section for Oral Cell Biology, Umea University, Sweden
    Biochem Biophys Res Commun 352:444-8. 2007
    ..We conclude that the CD47/SIRPalpha interaction is important for M-CSF/RANKL-stimulated osteoclast formation both in vivo and in vitro, and that absence of CD47 results in decreased numbers of osteoclasts in CD47-/- mice...
  29. ncbi request reprint Interleukin-6 promoter polymorphism is associated with bone quality assessed by calcaneus ultrasound and previous fractures in a cohort of 75-year-old women
    Anna Nordström
    Sports Medicine, Department of Surgical and Perioperative Sciences, Umea University Hospital, 901 85, Umea, Sweden
    Osteoporos Int 15:820-6. 2004
    ..This association may be related primarily to an altered bone quality identified by QUS and not a lower bone mass. This is also the first demonstration of association of IL-6 gene polymorphism to calcaneal QUS...
  30. ncbi request reprint IL-1beta and TNF-alpha regulate IL-6-type cytokines in gingival fibroblasts
    P Palmqvist
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    J Dent Res 87:558-63. 2008
    ....
  31. ncbi request reprint Cytokine responses of human gingival fibroblasts to Actinobacillus actinomycetemcomitans cytolethal distending toxin
    G N Belibasakis
    Division of Oral Microbiology, Department of Odontology, S 901 87 Umeå University, Umea, Sweden
    Cytokine 30:56-63. 2005
    ..actinomycetemcomitans induces IL-6 production in GF by a mechanism largely independent of its Cdt and b) A. actinomycetemcomitans-induced RANKL expression in GF occurs independently of IL-1, IL-6, TNF-alpha, or PGE(2)...
  32. ncbi request reprint Microisolated mouse osteoclasts express VIP-1 and PACAP receptors
    M Ransjö
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    Biochem Biophys Res Commun 274:400-4. 2000
    ..In this study, we show that mouse osteoclasts express VIP-1 and PACAP, but not VIP-2, receptor mRNA...
  33. ncbi request reprint Vasoactive intestinal peptide regulates osteoclast activity via specific binding sites on both osteoclasts and osteoblasts
    P Lundberg
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    Bone 27:803-10. 2000
    ....
  34. ncbi request reprint Vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide receptor subtypes in mouse calvarial osteoblasts: presence of VIP-2 receptors and differentiation-induced expression of VIP-1 receptors
    P Lundberg
    Department of Odontology, Oral Cell Biology, Umea University, Umea, Sweden
    Endocrinology 142:339-47. 2001
    ..Taken together, these data demonstrate that mouse calvarial osteoblasts express functional VIP-2R with higher affinity binding for PACAP than for VIP and that the VIP-1R expression is induced during osteoblastic differentiation...
  35. ncbi request reprint Bone-resorbing activity from cholesterol-exposed macrophages due to enhanced expression of interleukin-1alpha
    U Sjogren
    Department of Endodontics, Umea University, Sweden
    J Dent Res 81:11-6. 2002
    ..These findings indicate that frustrated phagocytosis by macrophages exposed to cholesterol crystals results in release of factors stimulating osteoclastic bone resorption, primarily due to increased transcription of the IL-1alpha gene...
  36. pmc The cytolethal distending toxin induces receptor activator of NF-kappaB ligand expression in human gingival fibroblasts and periodontal ligament cells
    G N Belibasakis
    Divisions of Oral Microbiology and Oral Cell Biology, Department of Odontology, Umea University, S 901 87 Umea, Sweden
    Infect Immun 73:342-51. 2005
    ..Cdt is crucial for this induction and may therefore be involved in the pathological bone resorption during the process of localized aggressive periodontitis...
  37. ncbi request reprint Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones
    J Ahlen
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    Bone 31:242-51. 2002
    ..In addition, IL-11 was not found to play an essential role in resorption stimulated by other calciotropic agents in calvariae...
  38. ncbi request reprint IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae
    Py Palmqvist
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    J Immunol 169:3353-62. 2002
    ....
  39. ncbi request reprint Expression and regulatory role of receptors for vasoactive intestinal peptide in bone cells
    Pernilla Lundberg
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    Microsc Res Tech 58:98-103. 2002
    ..In addition, deletion of signalling molecules has been shown to alter bone metabolism. In the present review, these studies are summarized with a focus on distribution and effects of vasoactive intestinal peptide...
  40. ncbi request reprint Different cysteine proteinases involved in bone resorption and osteoclast formation
    M Brage
    Department of Oral Cell Biology, Umea University, S 90187 Umea, Sweden
    Calcif Tissue Int 76:439-47. 2005
    ....
  41. ncbi request reprint Calcium sensing receptor gene polymorphism, circulating calcium concentrations and bone mineral density in healthy adolescent girls
    M Lorentzon
    Sports Medicine, Department of Surgical and Perioperative Sciences, Umea University, Sweden
    Eur J Endocrinol 144:257-61. 2001
    ..We investigated whether this polymorphism was related to BMD, circulating calcium and parathyroid hormone (PTH) concentrations in girls...
  42. ncbi request reprint TNF-alpha gene polymorphism and plasma TNF-alpha levels are related to lumbar spine bone area in healthy female Caucasian adolescents
    P Wennberg
    Sports Medicine, Department of Surgical and Perioperative Sciences, Umea University, 901 85, Sweden
    Eur J Endocrinol 146:629-34. 2002
    ..We investigated whether these polymorphisms and circulating TNF-alpha levels were related to bone mineral density and bone area in adolescent girls...
  43. ncbi request reprint High extracellular calcium affects osteoclastogenesis in mouse bone marrow cell culture
    Etsuko Takahashi
    Oral Surgery, Department of Oral Restitution, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 49:109-20. 2002
    ..In conclusion, high Ca affects osteoclastogenesis in a manner depending on the stage of osteoclastogenesis, which is partly mediated via the RANKL-RANK-OPG regulatory system...
  44. ncbi request reprint Bone resorbing activity and cytokine levels in gingival crevicular fluid before and after treatment of periodontal disease
    Anders Holmlund
    Department of Periodontology, The County Hospital of Gävle Sandviken, Centre for Research and Development Uppsala University, Gävleborg, Sweden
    J Clin Periodontol 31:475-82. 2004
    ..These assessments were performed before and after periodontal treatment...
  45. ncbi request reprint cDNA-arrays and real-time quantitative PCR techniques in the investigation of chronic Achilles tendinosis
    Håkan Alfredson
    Department of Surgical and Perioperative Science, Sports Medicine Unit, University of Umea, S 901 87 Umea, Sweden
    J Orthop Res 21:970-5. 2003
    ..In conclusion, cDNA-arrays and real-time PCR can be used to study differences in gene expression levels between tendinosis and control tendon tissue...
  46. ncbi request reprint Characterization of bradykinin receptors in a human osteoblastic cell line
    Anna Bernhold Brechter
    Department of Odontology, Oral Cell Biology, Umea University, SE 901 87, Umea, Sweden
    Regul Pept 103:39-51. 2002
    ....