H Lennernas

Summary

Country: Sweden

Publications

  1. ncbi Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences
    H Lennernas
    Department of Pharmacy, Uppsala University, Sweden
    Clin Pharmacokinet 32:403-25. 1997
  2. ncbi The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum: experience from a regional perfusion technique
    H Lennernas
    Department of Pharmacy, Box 580, BMC, Uppsala University, S 751 23, Sweden
    Eur J Pharm Sci 15:271-7. 2002
  3. doi The effect of acute administration of rifampicin and imatinib on the enterohepatic transport of rosuvastatin in vivo
    E Bergman
    Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Xenobiotica 40:558-68. 2010
  4. doi Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model
    E M Persson
    Department of Pharmacy, Uppsala University, Box 580, S 751 23, and Department of Surgery, University Hospital, Uppsala, Sweden
    Eur J Pharm Sci 34:22-9. 2008
  5. ncbi Human intestinal permeability
    H Lennernas
    Department of Pharmacy, Group of Biopharmaceutics, Uppsala University, Sweden
    J Pharm Sci 87:403-10. 1998
  6. ncbi A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: in-vivo permeability estimation
    H Lennernas
    Department of Pharmacy, Uppsala University, Sweden
    J Pharm Pharmacol 49:682-6. 1997
  7. ncbi High in situ rat intestinal permeability of artemisinin unaffected by multiple dosing and with no evidence of P-glycoprotein involvement
    U S Svensson
    Department of Pharmacy, Division of Biopharmaceutics and Pharmacokinetics, Uppsala University, Uppsala, Sweden
    Drug Metab Dispos 27:227-32. 1999
  8. ncbi Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement
    N G Schipper
    Department of Pharmaceutics, Uppsala University, Biomedical Center, P O Box 580, S 75123, Uppsala, Sweden
    Eur J Pharm Sci 8:335-43. 1999
  9. ncbi Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers
    N Petri
    Department of Pharmacy, Biopharmaceutics Research Group Uppsala University, Uppsala, Sweden
    Int J Clin Pharmacol Ther 44:71-9. 2006
  10. ncbi Intestinal permeability and its relevance for absorption and elimination
    H Lennernas
    Biopharmaceutics, Uppsala University, Uppsala, Sweden
    Xenobiotica 37:1015-51. 2007

Collaborators

Detail Information

Publications12

  1. ncbi Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences
    H Lennernas
    Department of Pharmacy, Uppsala University, Sweden
    Clin Pharmacokinet 32:403-25. 1997
    ..Estimates of liver extraction in humans for lovastatin and simvastatin are poorly reported, which makes a direct comparison difficult...
  2. ncbi The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum: experience from a regional perfusion technique
    H Lennernas
    Department of Pharmacy, Box 580, BMC, Uppsala University, S 751 23, Sweden
    Eur J Pharm Sci 15:271-7. 2002
    ..63+/-0.51 x 10(-4) cm/s which predicts an intestinal absorption of more than 90%. Following the BCS amoxicillin was classified as a low P(eff) drug, and amiloride had no acute effect on the in vivo jejunal P(eff) of amoxicillin...
  3. doi The effect of acute administration of rifampicin and imatinib on the enterohepatic transport of rosuvastatin in vivo
    E Bergman
    Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Xenobiotica 40:558-68. 2010
    ..Rifampicin significantly affected the hepatobiliary transport of rosuvastatin, however imatinib did not alter the plasma exposure of rosuvastatin...
  4. doi Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model
    E M Persson
    Department of Pharmacy, Uppsala University, Box 580, S 751 23, and Department of Surgery, University Hospital, Uppsala, Sweden
    Eur J Pharm Sci 34:22-9. 2008
    ..In addition, the partition into different colloidal structures seems to play a major role in the dissolution and absorption of poorly soluble drugs...
  5. ncbi Human intestinal permeability
    H Lennernas
    Department of Pharmacy, Group of Biopharmaceutics, Uppsala University, Sweden
    J Pharm Sci 87:403-10. 1998
    ..It will also be important to study the effect of antitransport mechanisms (multidrug resistance, MDR), such as efflux by P-glycoprotein(s) and gut wall metabolism, for example CYP 3A4, on bioavailability...
  6. ncbi A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: in-vivo permeability estimation
    H Lennernas
    Department of Pharmacy, Uppsala University, Sweden
    J Pharm Pharmacol 49:682-6. 1997
    ....
  7. ncbi High in situ rat intestinal permeability of artemisinin unaffected by multiple dosing and with no evidence of P-glycoprotein involvement
    U S Svensson
    Department of Pharmacy, Division of Biopharmaceutics and Pharmacokinetics, Uppsala University, Uppsala, Sweden
    Drug Metab Dispos 27:227-32. 1999
    ..It seems more likely attributed to increased hepatocellular activity. Furthermore, artemisinin exhibits high jejunal permeability and is neither a substrate nor inducer of P-glycoprotein...
  8. ncbi Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement
    N G Schipper
    Department of Pharmaceutics, Uppsala University, Biomedical Center, P O Box 580, S 75123, Uppsala, Sweden
    Eur J Pharm Sci 8:335-43. 1999
    ..This effect may be overcome by increasing the local concentrations of both chitosan and drug, i.e,. through formulation of the chitosan into a particulate dosage form...
  9. ncbi Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers
    N Petri
    Department of Pharmacy, Biopharmaceutics Research Group Uppsala University, Uppsala, Sweden
    Int J Clin Pharmacol Ther 44:71-9. 2006
    ..To investigate the in vivo intestinal absorption mechanism(s) and systemic availability of fexofenadine in the jejunum, ileum and colon in humans...
  10. ncbi Intestinal permeability and its relevance for absorption and elimination
    H Lennernas
    Biopharmaceutics, Uppsala University, Uppsala, Sweden
    Xenobiotica 37:1015-51. 2007
    ..This would stimulate the development of more relevant and complex in vitro absorption models and form the basis for an accurate physiologically based pharmacokinetic modelling of oral drug absorption...
  11. ncbi The influence of caprate on rectal absorption of phenoxymethylpenicillin: experience from an in-vivo perfusion in humans
    H Lennernas
    Department of Pharmacy, Uppsala University, Sweden
    J Pharm Pharmacol 54:499-508. 2002
    ....
  12. ncbi CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies
    H A Engman
    Department of Pharmacy, Uppsala University, Box 580, SE 751 23 Uppsala, Sweden
    J Pharm Sci 90:1736-51. 2001
    ....