D G Joakim Larsson

Summary

Country: Sweden

Publications

  1. ncbi Effluent from drug manufactures contains extremely high levels of pharmaceuticals
    D G Joakim Larsson
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    J Hazard Mater 148:751-5. 2007
  2. pmc Pyrosequencing of antibiotic-contaminated river sediments reveals high levels of resistance and gene transfer elements
    Erik Kristiansson
    Department of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    PLoS ONE 6:e17038. 2011
  3. pmc Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment
    Amy Pruden
    Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, Virginia, USA
    Environ Health Perspect 121:878-85. 2013
  4. doi Functional verification of computationally predicted qnr genes
    Carl Fredrik Flach
    Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden
    Ann Clin Microbiol Antimicrob 12:34. 2013
  5. doi Transparency throughout the production chain--a way to reduce pollution from the manufacturing of pharmaceuticals?
    D G Joakim Larsson
    Department of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Box 434, SE 405 30 Goteborg, Sweden
    Regul Toxicol Pharmacol 53:161-3. 2009
  6. ncbi Characterization of putative ligands for a fish gonadal androgen receptor in a pulp mill effluent
    D G Joakim Larsson
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, 78373 Texas, USA
    Environ Toxicol Chem 25:419-27. 2006
  7. pmc Male-biased sex ratios of fish embryos near a pulp mill: temporary recovery after a short-term shutdown
    D G Joakim Larsson
    Department of Zoology Zoophysiology, Goteborg University, Goteborg, Sweden
    Environ Health Perspect 110:739-42. 2002
  8. doi Pharmaceutical industry effluent diluted 1:500 affects global gene expression, cytochrome P450 1A activity, and plasma phosphate in fish
    Lina Gunnarsson
    Department of Neuroscience and Physiology, the Sahlgrenska Academy at University of Göteborg, Goteborg, Sweden
    Environ Toxicol Chem 28:2639-47. 2009
  9. pmc Distribution and hormonal regulation of membrane progesterone receptors beta and gamma in ciliated epithelial cells of mouse and human fallopian tubes
    Magdalena Nutu
    Department of Neurosciences and Physiology, The Sahlgrenska Academy, University of Gothenburg, and Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Box 434, SE 40530, Gothenburg, Sweden
    Reprod Biol Endocrinol 7:89. 2009
  10. doi Hepatic transcriptome profiling indicates differential mRNA expression of apoptosis and immune related genes in eelpout (Zoarces viviparus) caught at Göteborg harbor, Sweden
    Noomi Asker
    Department of Biological and Environmental Sciences, University of Gothenburg, Gothenburg, Sweden
    Aquat Toxicol 130:58-67. 2013

Detail Information

Publications38

  1. ncbi Effluent from drug manufactures contains extremely high levels of pharmaceuticals
    D G Joakim Larsson
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    J Hazard Mater 148:751-5. 2007
    ..The results from the present study call for an increased focus on the potential release of active pharmaceutical ingredients from production facilities in different regions...
  2. pmc Pyrosequencing of antibiotic-contaminated river sediments reveals high levels of resistance and gene transfer elements
    Erik Kristiansson
    Department of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    PLoS ONE 6:e17038. 2011
    ..The entire life-cycle of antibiotic substances, both before, under and after usage, should therefore be considered to fully evaluate their role in the promotion of resistance...
  3. pmc Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment
    Amy Pruden
    Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, Virginia, USA
    Environ Health Perspect 121:878-85. 2013
    ..There is growing concern worldwide about the role of polluted soil and water environments in the development and dissemination of antibiotic resistance...
  4. doi Functional verification of computationally predicted qnr genes
    Carl Fredrik Flach
    Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden
    Ann Clin Microbiol Antimicrob 12:34. 2013
    ..We recently developed and applied probabilistic models to identify tentative novel qnr genes in large public collections of DNA sequence data including fragmented metagenomes...
  5. doi Transparency throughout the production chain--a way to reduce pollution from the manufacturing of pharmaceuticals?
    D G Joakim Larsson
    Department of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Box 434, SE 405 30 Goteborg, Sweden
    Regul Toxicol Pharmacol 53:161-3. 2009
    ..We propose that increased transparency throughout the production chain would be one of several important steps to reducing pollution from the manufacturing of drugs...
  6. ncbi Characterization of putative ligands for a fish gonadal androgen receptor in a pulp mill effluent
    D G Joakim Larsson
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, 78373 Texas, USA
    Environ Toxicol Chem 25:419-27. 2006
    ..The detection of multiple fractions with significant binding activity indicates that a variety of compounds in effluents have the potential to masculinize fish near pulp mills via an androgen receptor-mediated mechanism...
  7. pmc Male-biased sex ratios of fish embryos near a pulp mill: temporary recovery after a short-term shutdown
    D G Joakim Larsson
    Department of Zoology Zoophysiology, Goteborg University, Goteborg, Sweden
    Environ Health Perspect 110:739-42. 2002
    ..The repeatedly identified male bias at the investigated mill, the normalization after mill shutdown, and the reappearance the following year indicate that pulp mill effluents also can affect sex ratios of nearby fish...
  8. doi Pharmaceutical industry effluent diluted 1:500 affects global gene expression, cytochrome P450 1A activity, and plasma phosphate in fish
    Lina Gunnarsson
    Department of Neuroscience and Physiology, the Sahlgrenska Academy at University of Göteborg, Goteborg, Sweden
    Environ Toxicol Chem 28:2639-47. 2009
    ..The pattern of regulated genes may contribute to the identification of mechanisms of sublethal toxicity, as well as illuminate possible causative agents...
  9. pmc Distribution and hormonal regulation of membrane progesterone receptors beta and gamma in ciliated epithelial cells of mouse and human fallopian tubes
    Magdalena Nutu
    Department of Neurosciences and Physiology, The Sahlgrenska Academy, University of Gothenburg, and Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Box 434, SE 40530, Gothenburg, Sweden
    Reprod Biol Endocrinol 7:89. 2009
    ..Here, we investigated the possible presence of a related receptor, mPR beta, in the fallopian tubes of mice and women as well as the possible hormonal regulation of mPR beta and gamma...
  10. doi Hepatic transcriptome profiling indicates differential mRNA expression of apoptosis and immune related genes in eelpout (Zoarces viviparus) caught at Göteborg harbor, Sweden
    Noomi Asker
    Department of Biological and Environmental Sciences, University of Gothenburg, Gothenburg, Sweden
    Aquat Toxicol 130:58-67. 2013
    ....
  11. doi Global hepatic gene expression in rainbow trout exposed to sewage effluents: a comparison of different sewage treatment technologies
    Filip Cuklev
    Institute of Neuroscience and Physiology, Department of Physiology, The Sahlgrenska Academy at the University of Gothenburg, Box 434, SE 405 30 Goteborg, Sweden
    Sci Total Environ 427:106-14. 2012
    ..Taken together, granular activated carbon showed the highest potential of reducing responses in fish induced by exposure to sewage effluents...
  12. ncbi Diclofenac in fish: blood plasma levels similar to human therapeutic levels affect global hepatic gene expression
    Filip Cuklev
    Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    Environ Toxicol Chem 30:2126-34. 2011
    ..In contrast to some previously reported results, the bioconcentration factor was found to be stable (4.02 ± 0.75 for blood plasma and 2.54 ± 0.36 for liver) regardless of the water concentration...
  13. doi Does ketoprofen or diclofenac pose the lowest risk to fish?
    Filip Cuklev
    Institute for Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    J Hazard Mater 229:100-6. 2012
    ....
  14. doi Physiology and mRNA expression in rainbow trout (Oncorhynchus mykiss) after long-term exposure to the new antifoulant medetomidine
    Anna Lennquist
    Department of Zoology Zoophysiology, University of Gothenburg, Sweden
    Comp Biochem Physiol C Toxicol Pharmacol 154:234-41. 2011
    ..Taken together, the results suggest that medetomidine at investigated concentrations could interfere with carbohydrate metabolism of exposed fish but without any clear consequences for growth...
  15. doi Transcriptional effects of progesterone receptor antagonist in rat granulosa cells
    P Anders Friberg
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Mol Cell Endocrinol 315:121-30. 2010
    ..This study expands our knowledge of events that occur during the processes of ovulation and luteinization...
  16. pmc Rapid effects of progesterone on ciliary beat frequency in the mouse fallopian tube
    Anna Bylander
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SE 405 30 Goteborg, Sweden
    Reprod Biol Endocrinol 8:48. 2010
    ..The aims of this study were to establish methodology for studying fallopian tube CBF in the mouse, as it is an important model species, and to investigate if progesterone rapidly affects the CBF of mice at nM concentrations...
  17. doi Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis
    P Anders Friberg
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenurg, Gothenburg, Sweden
    Biol Reprod 80:1160-7. 2009
    ..Neither anti-PGRMC1 nor P4 or cyanoketone affected apoptosis of immature granulosa cells. In conclusion, we show that P4 regulates apoptosis in periovulatory granulosa cells by acting via the classic nuclear receptor...
  18. ncbi Evolutionary conservation of human drug targets in organisms used for environmental risk assessments
    Lina Gunnarsson
    Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 434, SE 405 30 Goteborg, Sweden
    Environ Sci Technol 42:5807-13. 2008
    ..Moreover, we suggest that the results can be used to interpret the relevance of existing ecotoxicity data...
  19. doi Reproducible (1)H NMR-based metabolomic responses in fish exposed to different sewage effluents in two separate studies
    Linda M Samuelsson
    Institute of Neuroscience and Physiology, Department of Physiology, The Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Environ Sci Technol 45:1703-10. 2011
    ..To conclude, (1)H NMR metabolomics proved suitable for identifying physiological responses not identified by more targeted assays used in parallel studies. Whether these changes are linked to adverse effects remains to be tested...
  20. pmc A novel method for cross-species gene expression analysis
    Erik Kristiansson
    Department of Mathematical Statistics, Chalmers University of Technology University of Gothenburg, Gothenburg, Sweden
    BMC Bioinformatics 14:70. 2013
    ..However, due to evolutionary events such as gene duplication, there is no one-to-one correspondence between genes from different species which makes comparison of their expression profiles complex...
  21. ncbi Oral exposure to industrial effluent with exceptionally high levels of drugs does not indicate acute toxic effects in rats
    Carolin Rutgersson
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Environ Toxicol Chem 32:577-84. 2013
    ....
  22. pmc Characterization of the Zoarces viviparus liver transcriptome using massively parallel pyrosequencing
    Erik Kristiansson
    Department of Zoology, University of Gothenburg, Goteborg, Sweden
    BMC Genomics 10:345. 2009
    ..The scarce information about this species genome has however restrained the use of efficient molecular-level assays, such as gene expression microarrays...
  23. pmc Acquired genetic mechanisms of a multiresistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production
    Anna Johnning
    Institute of Biomedicine, Department of Infectious Diseases, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Appl Environ Microbiol 79:7256-63. 2013
    ..Our results highlight that WWTPs serving antibiotic manufacturing may provide nearly ideal conditions for the recruitment of resistance genes into human commensal and pathogenic bacteria...
  24. ncbi Using NMR metabolomics to identify responses of an environmental estrogen in blood plasma of fish
    Linda M Samuelsson
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    Aquat Toxicol 78:341-9. 2006
    ..This adds confidence to the approach of using NMR metabolomics to identify environmental effects of pharmaceuticals and other contaminants...
  25. doi The impact of temperature on the metabolome and endocrine metabolic signals in Atlantic salmon (Salmo salar)
    Andreas Kullgren
    Fish Endocrinology Laboratory, Department of Biological and Environmental Sciences, Box 463, University of Gothenburg, S 40530, Gothenburg, Sweden
    Comp Biochem Physiol A Mol Integr Physiol 164:44-53. 2013
    ....
  26. doi Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy?
    Anna Holmberg
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Box 434, SE 405 30 Goteborg, Sweden
    J Hazard Mater 187:596-9. 2011
    ..This may be explained by a relatively low uptake of citalopram from water to fish...
  27. pmc A novel method to discover fluoroquinolone antibiotic resistance (qnr) genes in fragmented nucleotide sequences
    Fredrik Boulund
    Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Goteborg, SE 412 96, Sweden
    BMC Genomics 13:695. 2012
    ..The vast amount of data generated by shotgun metagenomics can therefore be used to explore the diversity of qnr genes in more detail...
  28. pmc Sensitive and robust gene expression changes in fish exposed to estrogen--a microarray approach
    Lina Gunnarsson
    Department of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    BMC Genomics 8:149. 2007
    ..Induction of zona pellucida genes may be more sensitive but their specificities are not as clear. The objective of this study was to find additional sensitive and robust candidate biomarkers of estrogenic exposure...
  29. ncbi Studies of masculinization, detoxification, and oxidative stress responses in guppies (Poecilia reticulata) exposed to effluent from a pulp mill
    D G Joakim Larsson
    Department of Zoology Zoophysiology, Goteborg University, SE 405 30 Goteborg, Sweden
    Ecotoxicol Environ Saf 52:13-20. 2002
    ..There were no indications that either effluent caused oxidative stress since hepatic glutathione reductase, glutathione S-transferase and DT-diaphorase activities remained unchanged compared with controls...
  30. ncbi Regulation of androgen receptors in Atlantic croaker brains by testosterone and estradiol
    D G Joakim Larsson
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Gen Comp Endocrinol 128:224-30. 2002
    ..These results suggest that gonadal factors, including both androgens and estrogens, are involved in the physiological regulation of brain androgen receptors in a teleost species during the reproductive cycle...
  31. ncbi Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube
    Magdalena Nutu
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Mol Reprod Dev 74:843-50. 2007
    ..The presence of mPRgamma in lung and liver of mice suggests that the receptor mediates the actions of progesterone outside the reproductive tract as well...
  32. ncbi Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma
    Jeffrey N Brown
    The Institute for Neuroscience and Physiology, Department of Physiology Endocrinology, The Sahlgrenska Academy at Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    Environ Toxicol Pharmacol 24:267-74. 2007
    ....
  33. ncbi Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro
    Emilia Rung
    Department of Physiology and Pharmacology, Goteborg, Sweden
    Biol Reprod 72:538-45. 2005
    ..These results show that PR antagonists reduce cholesterol synthesis in periovulatory granulosa cells and that cholesterol synthesis is important for granulosa cell survival...
  34. ncbi Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced protein isoprenylation
    P Anders Friberg
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Mol Reprod Dev 74:1317-26. 2007
    ..In conclusion, we demonstrate that the PGR antagonist inhibits cholesterol synthesis in granulosa cells but reduced protein isoprenylation is not the mediating mechanism of increased apoptosis as previously hypothesized...
  35. ncbi Contributions from metabolomics to fish research
    Linda M Samuelsson
    University of Gothenburg, Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Physiology, Division of Endocrinology, P O Box 432, SE 405 30 Goteborg, Sweden
    Mol Biosyst 4:974-9. 2008
    ..It is already clear that metabolomics has contributed new knowledge about fish in areas such as basic physiology and development, disease, water pollution and aspects concerning fish as foodstuffs...
  36. pmc BacMet: antibacterial biocide and metal resistance genes database
    Chandan Pal
    Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, SE 413 46, Sweden, Department of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, DK 1871, Denmark and Department of Mathematical Sciences, Chalmers University of Technology, SE 412 96, Gothenburg, Sweden
    Nucleic Acids Res 42:D737-43. 2014
    ..All resistance genes in the BacMet database have been organized according to their molecular function and induced resistance phenotype...
  37. ncbi Seasonal variations of vitelline envelope proteins, vitellogenin, and sex steroids in male and female eelpout (Zoarces viviparus)
    D G Joakim Larsson
    Department of Physiology Endocrinology, Goteborg University, Goteberg, S 405 30, Sweden
    Gen Comp Endocrinol 125:184-96. 2002
    ..This suggests that the VTG induction by estradiol may be modulated by other factors in the eelpout...
  38. ncbi Fish models in toxicology
    Michael J Carvan
    Great Lakes Wisconsin Aquaculture Technology and Environmental Research WATER Institute, University of Wisconsin Milwaukee, 600 E Greenfield Avenue, Milwaukee, WI 53204, USA
    Zebrafish 4:9-20. 2007