Juleen R Zierath


Affiliation: Karolinska Institutet
Country: Sweden


  1. Borg M, Massart J, Schönke M, de Castro Barbosa T, Guo L, Wade M, et al. Modified Ucn2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice. Diabetes. 2019;: pubmed publisher
    ..Our results demonstrate that modified Ucn2 peptides may be efficacious in the treatment of type 2 diabetes by acting as an insulin sensitizer in skeletal muscle. ..
  2. Gabriel B, Zierath J. Circadian rhythms and exercise - re-setting the clock in metabolic disease. Nat Rev Endocrinol. 2019;15:197-206 pubmed publisher
    ..In this Review, we discuss the literature regarding diurnal skeletal muscle metabolism and the interaction with exercise bouts at different times of the day to combat metabolic disease. ..
  3. Lundell L, Massart J, Altıntaş A, Krook A, Zierath J. Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle. Mol Metab. 2019;20:79-88 pubmed publisher
    ..FOXO1 and FOXO3 regulate glucose metabolism and markers of inflammation in skeletal muscle, implicating transcriptional control governing "immunometabolic" dynamics. ..
  4. Lassiter D, Sjögren R, Gabriel B, Krook A, Zierath J. AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle. Mol Metab. 2018;16:12-23 pubmed publisher
    ..We describe a role for GDAP1 in regulating mitochondrial proteins, circadian genes, and metabolic flux in skeletal muscle. Collectively, our results implicate GDAP1 in the circadian control of metabolism. ..
  5. Al Khalili L, de Castro Barbosa T, Ostling J, Massart J, Cuesta P, Osler M, et al. Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes. Am J Physiol Cell Physiol. 2014;307:C774-87 pubmed publisher
    ..Our results highlight the existence of a confounding inherent abnormality in cellular protein dynamics in metabolic disease, which is uncovered through concurrent inhibition of the proteasome system. ..
  6. Riedl I, Osler M, Benziane B, Chibalin A, Zierath J. Association of the ACTN3 R577X polymorphism with glucose tolerance and gene expression of sarcomeric proteins in human skeletal muscle. Physiol Rep. 2015;3: pubmed publisher
  7. Osler M, Fritz T, Caidahl K, Krook A, Zierath J, Wallberg Henriksson H. Changes in gene expression in responders and nonresponders to a low-intensity walking intervention. Diabetes Care. 2015;38:1154-60 pubmed publisher
    ..However, for individuals presenting with a greater derangement in glycemia, the potential for clinical and metabolic improvements after this low-intensity unsupervised exercise protocol appears to be limited. ..
  8. Mannerås Holm L, Kirchner H, Björnholm M, Chibalin A, Zierath J. mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance. Physiol Rep. 2015;3: pubmed publisher
    ..DGK isoforms likely have divergent functional roles in distinct tissues, which may contribute to metabolic dysfunction. ..
  9. Zierath J, Wallberg Henriksson H. Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us?. Cell Metab. 2015;22:25-30 pubmed publisher
    ..The ultimate goal will be to understand how these system-wide, tissue-specific exercise-induced changes lead to measurable physiological outcomes at the whole-body level to improve health and well-being. ..

More Information


  1. Kirchner H, Sinha I, Gao H, Ruby M, Schönke M, Lindvall J, et al. Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients. Mol Metab. 2016;5:171-183 pubmed publisher
    ..Obesity appears to shift the epigenetic program of the liver towards increased glycolysis and lipogenesis, which may exacerbate the development of insulin resistance. ..
  2. Schönke M, Massart J, Zierath J. Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism. J Lipid Res. 2018;59:1276-1282 pubmed publisher
    ..In conclusion, this technique allows for the assessment of the effect of pharmaceutical agents, as well as gene mutations, on whole-body FA oxidation in mice. ..
  3. Hawley J, Hargreaves M, Joyner M, Zierath J. Integrative biology of exercise. Cell. 2014;159:738-49 pubmed publisher
  4. Zierath J. Building Bridges through Scientific Conferences. Cell. 2016;167:1155-1158 pubmed publisher
    ..How conferences are serving the community, what their current challenges are, and what is in store for the future of conferences are the topics covered in this Commentary. ..
  5. Boon H, Sjögren R, Massart J, Egan B, Kostovski E, Iversen P, et al. MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression. Physiol Rep. 2015;3: pubmed publisher
    ..Our results implicate that microRNA-208b modulates myostatin expression and this may play a role in the regulation of skeletal muscle mass following spinal cord injury. ..
  6. Mudry J, Lassiter D, Nylén C, García Calzón S, Naslund E, Krook A, et al. Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle. Diabetes. 2017;66:651-662 pubmed publisher
    ..Furthermore, insulin and glucose modulate DAPK3 DNA methylation in a reciprocal manner, suggesting a feedback loop in the control of the epigenome. ..
  7. Ruby M, Massart J, Hunerdosse D, Schönke M, Correia J, Louie S, et al. Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance. Cell Rep. 2017;18:636-646 pubmed publisher
    ..Thus, decreased CES2 is a conserved feature of obesity and plays a causative role in the pathogenesis of obesity-related metabolic disturbances. ..
  8. Gabriel B, Zierath J. The Limits of Exercise Physiology: From Performance to Health. Cell Metab. 2017;25:1000-1011 pubmed publisher
    ..In this perspective, we review some of the historical milestones of exercise physiology, discuss how these inform contemporary knowledge, and speculate on future questions. ..
  9. Ruby M, Riedl I, Massart J, Åhlin M, Zierath J. Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2017;313:E483-E491 pubmed publisher
    ..Identification of PKN2 as a novel regulator of insulin and AMPK signaling may provide an avenue for manipulation of skeletal muscle metabolism. ..
  10. Benziane B, Borg M, Tom R, Riedl I, Massart J, Björnholm M, et al. DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism. J Lipid Res. 2017;58:2324-2333 pubmed publisher
    ..DGKζ plays a role in the control of growth and metabolic processes, further highlighting specialized functions of DGK isoforms in type 2 diabetes pathophysiology. ..
  11. Nascimento E, Mannerås Holm L, Chibalin A, Björnholm M, Zierath J. Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet. J Lipid Res. 2018;59:273-282 pubmed publisher
    ..Our results suggest DGKα aids in modulating the early immune response of adipose tissue following an acute exposure to HFD, possibly through modulation of acute T-cell action. ..
  12. Cartee G, Hepple R, Bamman M, Zierath J. Exercise Promotes Healthy Aging of Skeletal Muscle. Cell Metab. 2016;23:1034-1047 pubmed publisher
    ..This review focuses on mechanisms by which exercise promotes "healthy aging" by inducing modifications in skeletal muscle. ..
  13. Riedl I, Osler M, Björnholm M, Egan B, Nader G, Chibalin A, et al. AMPKγ3 is dispensable for skeletal muscle hypertrophy induced by functional overload. Am J Physiol Endocrinol Metab. 2016;310:E461-72 pubmed publisher
    ..Mechanical loading can override signaling pathways that act as negative effectors of mTOR signaling and consequently promote skeletal muscle hypertrophy. ..
  14. Jiang L, de Castro Barbosa T, Massart J, Deshmukh A, Löfgren L, Duque Guimarães D, et al. Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics. Am J Physiol Endocrinol Metab. 2016;310:E51-60 pubmed publisher
    ..DGKδ deficiency also influences skeletal muscle energetics, which may lead to low physical activity levels in type 2 diabetes. ..
  15. Mannerås Holm L, Schönke M, Brozinick J, Vetterli L, Bui H, Sanders P, et al. Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice. J Lipid Res. 2017;58:907-915 pubmed publisher
    ..In conclusion, DGKε plays a role in glucose and energy homeostasis by modulating lipid metabolism in skeletal muscle. ..
  16. Lassiter D, Nylén C, Sjögren R, Chibalin A, Wallberg Henriksson H, Naslund E, et al. FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle. Diabetologia. 2018;61:424-432 pubmed publisher
    ..Further exploration of the interaction between AMPK and FAK may lead to novel therapeutic strategies for diabetes and other chronic conditions associated with an altered metabolic homeostasis. ..