Yaofeng Zhao

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Artiodactyl IgD: the missing link
    Yaofeng Zhao
    Center for Biotechnology, Department of Bioscience at Novum, Karolinska Institute, SE 14157 Huddinge, Sweden
    J Immunol 169:4408-16. 2002
  2. pmc Lack of association of the CIITA -168A→G promoter SNP with myasthenia gravis and its role in autoimmunity
    Ryan Ramanujam
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    BMC Med Genet 11:147. 2010
  3. pmc Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis
    Yaofeng Zhao
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, People s Republic of China
    Proc Natl Acad Sci U S A 103:12087-92. 2006
  4. doi request reprint Extensive diversification of IgD-, IgY-, and truncated IgY(δFc)-encoding genes in the red-eared turtle (Trachemys scripta elegans)
    Lingxiao Li
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, People s Republic of China
    J Immunol 189:3995-4004. 2012
  5. pmc Immunoglobulin genomics in the guinea pig (Cavia porcellus)
    Yongchen Guo
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 7:e39298. 2012
  6. pmc Analysis of immunoglobulin transcripts in the ostrich Struthio camelus, a primitive avian species
    Tian Huang
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 7:e34346. 2012
  7. doi request reprint Ornithorhynchus anatinus (platypus) links the evolution of immunoglobulin genes in eutherian mammals and nonmammalian tetrapods
    Yaofeng Zhao
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People s Republic of China
    J Immunol 183:3285-93. 2009
  8. ncbi request reprint Genomic organization of the immunoglobulin light chain gene loci in Xenopus tropicalis: evolutionary implications
    Tong Qin
    State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100094, PR China
    Dev Comp Immunol 32:156-65. 2008
  9. doi request reprint Characterization of the MHC class II α-chain gene in ducks
    Liming Ren
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, People s Republic of China
    Immunogenetics 63:667-78. 2011
  10. doi request reprint Clenbuterol upregulates histone demethylase JHDM2a via the β2-adrenoceptor/cAMP/PKA/p-CREB signaling pathway
    Yang Li
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100193, China
    Cell Signal 24:2297-306. 2012

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Artiodactyl IgD: the missing link
    Yaofeng Zhao
    Center for Biotechnology, Department of Bioscience at Novum, Karolinska Institute, SE 14157 Huddinge, Sweden
    J Immunol 169:4408-16. 2002
    ..The presence of Cdelta genes in artiodactyls, possibly in most mammals, suggests that IgD may have some as yet unknown biological properties, distinct from those of IgM, conferring a survival advantage...
  2. pmc Lack of association of the CIITA -168A→G promoter SNP with myasthenia gravis and its role in autoimmunity
    Ryan Ramanujam
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    BMC Med Genet 11:147. 2010
    ..In order to determine if allelic variants of rs3087456 increase predisposition to MG, we analyzed this SNP in our Swedish cohort of 446 MG patients and 1866 controls...
  3. pmc Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis
    Yaofeng Zhao
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, People s Republic of China
    Proc Natl Acad Sci U S A 103:12087-92. 2006
    ..The IgH locus of X. tropicalis shows a 5' V(H)-D(H)-J(H)-C(mu)-C(delta)-C(chi)-C(upsilon)-C(phi) 3' organization, suggesting that the mammalian and amphibian Ig heavy-chain loci share a common ancestor...
  4. doi request reprint Extensive diversification of IgD-, IgY-, and truncated IgY(δFc)-encoding genes in the red-eared turtle (Trachemys scripta elegans)
    Lingxiao Li
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, People s Republic of China
    J Immunol 189:3995-4004. 2012
    ..Although a single μ gene was identified, the α gene was not identified in this species...
  5. pmc Immunoglobulin genomics in the guinea pig (Cavia porcellus)
    Yongchen Guo
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 7:e39298. 2012
    ..Therefore, this species may generate antibody diversity via a gene conversion-like mechanism associated with its pseudogene reserves...
  6. pmc Analysis of immunoglobulin transcripts in the ostrich Struthio camelus, a primitive avian species
    Tian Huang
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 7:e34346. 2012
    ....
  7. doi request reprint Ornithorhynchus anatinus (platypus) links the evolution of immunoglobulin genes in eutherian mammals and nonmammalian tetrapods
    Yaofeng Zhao
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People s Republic of China
    J Immunol 183:3285-93. 2009
    ....
  8. ncbi request reprint Genomic organization of the immunoglobulin light chain gene loci in Xenopus tropicalis: evolutionary implications
    Tong Qin
    State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100094, PR China
    Dev Comp Immunol 32:156-65. 2008
    ....
  9. doi request reprint Characterization of the MHC class II α-chain gene in ducks
    Liming Ren
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, People s Republic of China
    Immunogenetics 63:667-78. 2011
    ..Otherwise, we found that the duck gene is located next to class II β genes, which is the same as in humans but different from the situation in chickens...
  10. doi request reprint Clenbuterol upregulates histone demethylase JHDM2a via the β2-adrenoceptor/cAMP/PKA/p-CREB signaling pathway
    Yang Li
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100193, China
    Cell Signal 24:2297-306. 2012
    ....
  11. pmc Pituitary-specific overexpression of porcine follicle-stimulating hormone leads to improvement of female fecundity in BAC transgenic mice
    Mingjun Bi
    State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China
    PLoS ONE 7:e42335. 2012
    ..Therefore, our TG mouse model provides exciting insights for investigating the actions of pFSH in vivo...
  12. pmc A preliminary analysis of the immunoglobulin genes in the African elephant (Loxodonta africana)
    Yongchen Guo
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 6:e16889. 2011
    ..Our results provide insights into the immunoglobulin genes in a placental mammal that is evolutionarily distant from humans, mice, and domestic animals...
  13. doi request reprint The duck genome and transcriptome provide insight into an avian influenza virus reservoir species
    Yinhua Huang
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China
    Nat Genet 45:776-83. 2013
    ..These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses. ..
  14. ncbi request reprint Evidence of IgY subclass diversification in snakes: evolutionary implications
    Tao Wang
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100094, People s Republic of China
    J Immunol 189:3557-65. 2012
    ..We also identified the μ and δ genes, but no α gene, in both snakes. This study provides valuable clues for our understanding of Ig gene evolution in tetrapods...
  15. pmc Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
    Qiang Pan-Hammarstrom
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, SE 14186 Stockholm, Sweden
    J Exp Med 203:99-110. 2006
    ..These data suggest that the role of ATR is partially overlapping with that of ataxia telangiectasia-mutated protein, but that the former is also endowed with unique functional properties in the repair processes during CSR and SHM...
  16. doi request reprint Construction of a transgenic pig model overexpressing polycystic kidney disease 2 (PKD2) gene
    Jin He
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100193, People s Republic of China
    Transgenic Res 22:861-7. 2013
    ..The transgenic pigs continue to show no significant alteration in kidney function; it is estimated that 1-2 more years may be required for manifestation of renal cystogenesis in these pigs. ..
  17. doi request reprint Impacts of human lysozyme transgene on the microflora of pig feces and the surrounding soil
    Jie Zhao
    State Key Laboratory for Agrobiotechnology, College of Biological Science, China Agricultural University, Haidian District, Beijing 100193, People s Republic of China
    J Biotechnol 161:437-44. 2012
    ..Finally, TN and TP contents were not significantly different in pig manure or soils taken at different distances from the pig site (P>0.25)...
  18. doi request reprint Genome-scale gene expression characteristics define the follicular initiation and developmental rules during folliculogenesis
    Kerong Shi
    State Key Laboratory for Agrobiotechnology, College of Biological Science, China Agricultural University, No 2 Yuan Ming Yuan West Road, Haidian District, Beijing, 100193, China
    Mamm Genome 24:266-75. 2013
    ..Transcriptional regulatory circuitries in certain follicular stages are expected to be found among the identified differentially expressed gene groups. ..
  19. pmc Lats2 Modulates Adipocyte Proliferation and Differentiation via Hippo Signaling
    Yang An
    State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China
    PLoS ONE 8:e72042. 2013
    ..Interestingly, our study provides evidence that Lats2 not only negatively modulates cell proliferation but also positively regulates cell differentiation. ..
  20. ncbi request reprint Pig large tumor suppressor 2 (Lats2), a novel gene that may regulate the fat reduction in adipocyte
    Qiuyue Liu
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100193, China
    BMB Rep 43:97-102. 2010
    ..Our results suggested that Lats2 may involve in Hippo pathway regulating the fat reduction by inhibiting adipocyte differentiation and growth...
  21. doi request reprint Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum
    Ran Zhang
    State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, People s Republic of China
    Anim Biotechnol 20:242-6. 2009
    ..Haplotype 5 was found to be significantly associated with a high IgG level ([OR] = 9.90, 95%CI = 1.11-88.34, p = 0.016) and haplotype 2 exhibited a similar trend ([OR] = 2.89, 95%CI = 1.17-7.11, p = 0.019)...
  22. doi request reprint Analysis of Ig gene hypermutation in Ung(-/-)Polh(-/-) mice suggests that UNG and A:T mutagenesis pathway target different U:G lesions
    Shuyin Li
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Mol Immunol 53:214-7. 2013
    ....
  23. pmc Genome-wide mapping of DNA methylation in chicken
    Qinghe Li
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 6:e19428. 2011
    ..Promoter methylation is negatively correlated with the gene expression level, indicating its suppressive role in regulating gene transcription. This work contributes to our understanding of epigenetics in birds...
  24. pmc Over-expression of human lipoprotein lipase in mouse mammary glands leads to reduction of milk triglyceride and delayed growth of suckling pups
    Yuanyuan Wang
    State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China
    PLoS ONE 6:e20895. 2011
    ....
  25. pmc Cloning of the complete rat immunoglobulin delta gene: evolutionary implications
    Yaofeng Zhao
    Center for Biotechnology and Center for Oral Biology, Department of Bioscience at Novum, Karolinska Institutet, SE 14157 Huddinge, Sweden
    Immunology 108:288-95. 2003
    ..Phylogenetic analysis supports that the Cdelta gene appeared early in the evolution of vertebrates, and it was probably duplicated from the C micro gene more than 400 million years ago...
  26. ncbi request reprint ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region
    Qiang Pan-Hammarstrom
    Division of Clinical Immunology, IMPI, Karolinska Institute at Huddinge Hospital, Stockholm, Sweden
    J Immunol 170:3707-16. 2003
    ..ATM may thus be one of the factors that is not shared by the CSR and SHM processes...
  27. ncbi request reprint Identification of the activation-induced cytidine deaminase gene from zebrafish: an evolutionary analysis
    Yaofeng Zhao
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Huddinge Hospital, SE 141 86 Stockholm, Sweden
    Dev Comp Immunol 29:61-71. 2005
    ..Furthermore, an aa deletion, and extensive substitutions in the C terminal end of AID from bony fish indicate that the molecule may not yet have developed a capacity to recruit the specific cofactor(s) needed to initiate CSR...
  28. ncbi request reprint The bovine antibody repertoire
    Yaofeng Zhao
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital at Huddinge, SE 14186 Stockholm, Sweden
    Dev Comp Immunol 30:175-86. 2006
    ....
  29. ncbi request reprint Physical mapping of the giant panda immunoglobulin heavy chain constant region genes
    Zhihui Zhao
    State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, PR China, and Department of Laboratory Medicine, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    Dev Comp Immunol 31:1034-49. 2007
    ..It is the most compact mammalian IGHC locus known thus far, encompassing only 120 kb of DNA. Fluorescent in situ hybridization showed that the panda locus is localized on tip of the short arm of chromosome 12...
  30. ncbi request reprint Lactobacilli expressing variable domain of llama heavy-chain antibody fragments (lactobodies) confer protection against rotavirus-induced diarrhea
    Neha Pant
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska Huddinge, Stockholm, Sweden
    J Infect Dis 194:1580-8. 2006
    ..We therefore developed a system for passive immunotherapy in which recombinant lactobacilli constitutively express neutralizing variable domain of llama heavy-chain (VHH) antibody fragments against rotavirus...
  31. ncbi request reprint Physical mapping of the bovine immunoglobulin heavy chain constant region gene locus
    Yaofeng Zhao
    Center for Biotechnology, Department of Bioscience at Novum, Karolinska, Institutet, SE 14157, Huddinge, Sweden
    J Biol Chem 278:35024-32. 2003
    ..A further sequence comparison revealed that the bovine IGHC genes display an extensive polymorphism leading to expression of multiple antibody allotypes...
  32. ncbi request reprint The porcine Ig delta gene: unique chimeric splicing of the first constant region domain in its heavy chain transcripts
    Yaofeng Zhao
    Center for Biotechnology, Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    J Immunol 171:1312-8. 2003
    ..However, the exon could be spliced into most of the expressed transcripts in vitro in cell transfection experiments after introduction of a single T nucleotide to restore the branchpoint sequence upstream of the putative H2 exon...
  33. ncbi request reprint Cloning and characterization of the dromedary (Camelus dromedarius) neonatal Fc receptor (drFcRn)
    Imre Kacskovics
    Department of Physiology and Biochemistry, Faculty of Veterinary Science, Szent Istvan University, Istvan utca 2 H 1078, Budapest, Hungary
    Dev Comp Immunol 30:1203-15. 2006
    ....
  34. ncbi request reprint Presence of the di-leucine motif in the cytoplasmic tail of the pig FcRn alpha chain
    Yaofeng Zhao
    Department of Biosciences at Novum, Center for Biotechnology, Karolinska Institute, S 141 57 Huddinge, Sweden
    Vet Immunol Immunopathol 96:229-33. 2003
    ....
  35. ncbi request reprint Lack of association between human switch recombination breakpoints and the secondary structure of targeted DNA regions
    Qiang Pan-Hammarstrom
    J Immunol 172:2727. 2004
  36. pmc AID from bony fish catalyzes class switch recombination
    Vasco M Barreto
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 202:733-8. 2005
    ....
  37. ncbi request reprint Selective IgG2 deficiency due to a point mutation causing abnormal splicing of the Cgamma2 gene
    Yaofeng Zhao
    Division of Clinical Immunology, Department of Laboratory Medicine, F79, Karolinska University Hospital Huddinge, Karolinska Institute, SE 141 86, Stockholm, Sweden
    Int Immunol 17:95-101. 2005
    ..These findings suggest a novel genetic mechanism as the cause of IgG subclass deficiency in selected patients...
  38. ncbi request reprint Class switch recombination: a comparison between mouse and human
    Qiang Pan-Hammarstrom
    Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska University Hospital Huddinge, SE 14186 Stockholm, Sweden
    Adv Immunol 93:1-61. 2007
    ..We have also compared pathways/factors that are involved in CSR. Although there are remarkable similarities in the cellular machinery involved in CSR, there are also a number of unique features in each species...