Jian Zhao

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates
    Jian Zhao
    Department of Oncology Pathology, Karolinska Institutet, CCK R8 05, Karolinska University Hospital Solna, 171 76, Stockholm, Sweden
    Cell Mol Life Sci 70:951-76. 2013
  2. doi request reprint Identification and expression analysis of an N-terminally truncated isoform of human PDGF-C
    Jian Zhao
    Department of Oncology Pathology, Karolinska Institutet, CCK R8 05, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Exp Cell Res 314:2529-43. 2008
  3. pmc Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
    Jian Zhao
    Department of Oncology Pathology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    EMBO J 30:2762-78. 2011
  4. ncbi request reprint Conspicuous accumulation of transcription elongation repressor hrp130/CA150 on the intron-rich Balbiani ring 3 gene
    Xin Sun
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, 17177 Stockholm, Sweden
    Chromosoma 113:244-57. 2004
  5. ncbi request reprint A novel Ded1-like RNA helicase interacts with the Y-box protein ctYB-1 in nuclear mRNP particles and in polysomes
    Dmitri Nashchekin
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Biol Chem 281:14263-72. 2006
  6. ncbi request reprint A p50-like Y-box protein with a putative translational role becomes associated with pre-mRNA concomitant with transcription
    Teresa Soop
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Cell Sci 116:1493-503. 2003
  7. doi request reprint The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics
    Tong Liu
    Department of Oncology Pathology, Karolinska Institutet, CCK R8 05, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Exp Cell Res 319:2893-904. 2013
  8. doi request reprint The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation
    Jian Zhao
    Department of Oncology Pathology, Karolinska Institutet, CCK R8 05, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    J Cell Sci 122:2252-62. 2009
  9. ncbi request reprint A novel protein localized to the fibrillar compartment of the nucleolus and to the brush border of a secretory cell
    Xin Sun
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, Stockholm, Sweden
    Eur J Cell Biol 81:125-37. 2002
  10. pmc The mRNA export factor Dbp5 is associated with Balbiani ring mRNP from gene to cytoplasm
    Jian Zhao
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, SE 17177 Stockholm, Sweden
    EMBO J 21:1177-87. 2002

Collaborators

  • Xin Sun
  • Neus Visa
  • Christer Ericsson
  • Lars Wieslander
  • Per Uhlen
  • Zhaoxu Liu
  • B Lu
  • Li Yu
  • L Li
  • Lei Zhao
  • Bin Liu
  • Zhong Ying Shen
  • Jian Bing Fan
  • Robert Abraham
  • M Frodin
  • Bohua Li
  • Hao Wang
  • Weizhu Qian
  • Yajun Guo
  • Jianxin Dai
  • Dapeng Zhang
  • Sheng Hou
  • Monica Nister
  • Huajing Wang
  • Zhiguo Cao
  • Salah Eldin Gadalla
  • Tong Liu
  • Dmitri Nashchekin
  • Huafeng Wei
  • Kexing Fan
  • Xiaopeng Zhang
  • Mei Cao
  • Sujun Liu
  • Xin Huang
  • Ming Min Zhao
  • Changjun Zhu
  • Yan Zhang
  • Xia Zhang
  • Rose Marie Lindgren
  • Bertil Daneholt
  • Yong Jun Zhang
  • Vlada V Philimonenko
  • Teresa Soop
  • Patricia Lara Vasquez
  • Shao Bo Jin
  • Rong Yu
  • Karin Ojemalm
  • Ingmarie Nilsson
  • Urban Lendahl
  • Liwei Han
  • Guanghui Ji
  • Kexin Fan
  • Lin Peng
  • Shu Shi
  • Lei Zheng
  • Wei Chen
  • Yong Qiu Mao
  • Geng Kou
  • Jie Zhang
  • Song Lei
  • Lin yu Fan
  • Rongxian Zhang
  • Zhen yu Ding
  • Shaoqiong Yi
  • Changming Yu
  • Hong Xin Deng
  • Shuichuan Song
  • Daxu Li
  • Xun Luo
  • Shuling Liu
  • Ling Fu
  • Yan jun Wen
  • Yu Quan Wei
  • Ting Yu
  • Jiong Li
  • Yu Jiang
  • Liang Tian
  • Wei Liu
  • Xin Song
  • Guang Hua Huang
  • Jiang Ye Chen
  • Zu Hua He
  • Jingliang Yang
  • Yuquan Wei
  • De Rong An
  • Yuming Wen
  • Qin Ping Liao
  • Joel D Leverson
  • Chun Ling Chen
  • Hanna Berglind

Detail Information

Publications32

  1. pmc Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates
    Jian Zhao
    Department of Oncology Pathology, Karolinska Institutet, CCK R8 05, Karolinska University Hospital Solna, 171 76, Stockholm, Sweden
    Cell Mol Life Sci 70:951-76. 2013
    ....
  2. doi request reprint Identification and expression analysis of an N-terminally truncated isoform of human PDGF-C
    Jian Zhao
    Department of Oncology Pathology, Karolinska Institutet, CCK R8 05, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Exp Cell Res 314:2529-43. 2008
    ..Based on these findings, we suggest that PDGF-Cb might act as a dominant negative molecule regulating the secretion of PDGF-C, and that deregulation of full-length PDGF-C is involved in RCC tumorigenesis...
  3. pmc Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
    Jian Zhao
    Department of Oncology Pathology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    EMBO J 30:2762-78. 2011
    ..As MIEF1 is vertebrate-specific, these data also reveal important differences between yeast and vertebrates in the regulation of mitochondrial dynamics...
  4. ncbi request reprint Conspicuous accumulation of transcription elongation repressor hrp130/CA150 on the intron-rich Balbiani ring 3 gene
    Xin Sun
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, 17177 Stockholm, Sweden
    Chromosoma 113:244-57. 2004
    ....
  5. ncbi request reprint A novel Ded1-like RNA helicase interacts with the Y-box protein ctYB-1 in nuclear mRNP particles and in polysomes
    Dmitri Nashchekin
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Biol Chem 281:14263-72. 2006
    ..As both Ded1 and YB-1 are known to regulate the initiation of translation, we propose that the RNA helicase-Y-box protein complex affects the efficiency of mRNA translation, presumably by modulating the conformation of the mRNP template...
  6. ncbi request reprint A p50-like Y-box protein with a putative translational role becomes associated with pre-mRNA concomitant with transcription
    Teresa Soop
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Cell Sci 116:1493-503. 2003
    ..Given that the p40/p50 protein, presumably with a role in translation, is loaded onto the primary transcript concomitant with transcription, an early programming of the cytoplasmic fate of mRNA is indicated...
  7. doi request reprint The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics
    Tong Liu
    Department of Oncology Pathology, Karolinska Institutet, CCK R8 05, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Exp Cell Res 319:2893-904. 2013
    ..In conclusion, our data suggest that the mitochondrial regulators MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics. ..
  8. doi request reprint The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation
    Jian Zhao
    Department of Oncology Pathology, Karolinska Institutet, CCK R8 05, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    J Cell Sci 122:2252-62. 2009
    ..In conclusion, we suggest that MTGM is an integral mitochondrial inner-membrane protein that coordinately regulates mitochondrial morphology and cell proliferation...
  9. ncbi request reprint A novel protein localized to the fibrillar compartment of the nucleolus and to the brush border of a secretory cell
    Xin Sun
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, Stockholm, Sweden
    Eur J Cell Biol 81:125-37. 2002
    ....
  10. pmc The mRNA export factor Dbp5 is associated with Balbiani ring mRNP from gene to cytoplasm
    Jian Zhao
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, SE 17177 Stockholm, Sweden
    EMBO J 21:1177-87. 2002
    ..Finally, the addition of the export factor Dbp5 to the growing transcript highlights the importance of the co-transcriptional loading process in determining the fate of mRNA...
  11. doi request reprint EpCAM associates with endoplasmic reticulum aminopeptidase 2 (ERAP2) in breast cancer cells
    Salah Eldin Gadalla
    Department of Oncology Pathology, Karolinska Institutet, Cancer Center Karolinska, R8 04 Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden Electronic address
    Biochem Biophys Res Commun 439:203-8. 2013
    ..The association between ERAP2 and EpCAM is a unique and novel finding that provides new ideas on EpCAM processing and on how antigen presentation may be regulated in cancer. ..
  12. ncbi request reprint Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain
    Rose Marie Lindgren
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Gene 348:143-55. 2005
    ..1 seems more efficiently translated. Based on their structural features, NCX3-tN.1 and NCX3-tN.2 proteins are potentially involved in regulation of Na+/Ca2+ homeostasis...
  13. ncbi request reprint TIP30/CC3 expression in breast carcinoma: relation to metastasis, clinicopathologic parameters, and P53 expression
    Jian Zhao
    International Joint Cancer Institute and Eastern Hospital of Hepatobiliary Surgery, The Second Military Medical University, Shanghai 200433, PR China
    Hum Pathol 38:293-8. 2007
    ..In summary, the decrease in expression of TIP30/CC3 is related to metastasis and may represent a new prognosticator in breast carcinoma...
  14. ncbi request reprint Serum proteomics study of the squamous cell carcinoma antigen 1 in tongue cancer
    Xin Huang
    State Key Laboratory of Biotherapy, Sichuan University, Guoxuexiang 37, Chendu City 610041, PR China
    Oral Oncol 42:26-31. 2006
    ..These results indicate that squamous cell carcinoma antigen 1 may be of great potential as the biomarker of tongue cancer and as the potential therapeutic target for gene therapy...
  15. doi request reprint Thirty-kilodalton Tat-interacting protein suppresses tumor metastasis by inhibition of osteopontin transcription in human hepatocellular carcinoma
    Jian Zhao
    International Joint Cancer Institute and Eastern Hospital of Hepatobiliary Surgery, Second Military Medical University, Shanghai, People s Republic of China
    Hepatology 48:265-75. 2008
    ..Moreover, expression of TIP30 was inversely associated with OPN expression in HCC tissue samples as detected by immunohistochemistry assay...
  16. doi request reprint Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis
    Jian Zhao
    International Cancer Institute and Eastern Hospital of Hepatobiliary Surgery, Second Military Medical University, Shanghai, People s Republic of China
    Gastroenterology 135:956-68. 2008
    ..The mechanisms by which osteopontin promotes tumor cell survival remain unclear. Here we used short-hairpin RNA-mediated gene silencing to investigate the antitumor effects by osteopontin depletion in hepatocellular carcinoma (HCC)...
  17. doi request reprint A novel functional motif of osteopontin for human lymphocyte migration and survival
    Zhiguo Cao
    School of Medicine and School of Pharmacy, Jiao Tong University, Shanghai 200025, China
    Mol Immunol 45:3683-92. 2008
    ..These results suggest that this novel epitope of OPN may provide a potential therapeutic target for the treatment of T cell-mediated immune diseases...
  18. ncbi request reprint [Effects of tumor suppressing gene TIP30/CC3 on the growth of tumor cells]
    Xia Zhang
    Nanjing Command, Fuzhou General Hospital, Fuzhou 350025, China
    Zhonghua Gan Zang Bing Za Zhi 13:38-41. 2005
    ..The growth and cell cycles were studied with the clones stably expressing TIP30/CC3 or anti-TIP30/CC3, and the effects of TIP30/CC3 gene on hepatoma cells were analyzed...
  19. ncbi request reprint [Studies on transformation of human esophageal fibroblasts mediated by a retroviral vector containing the E6E7 ORFs of human papillomavirus type 16]
    Yong Jun Zhang
    Department of Oncogenic Virus and HIV, National Institute for Viral Disease and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 18:223-6. 2004
    ..To study the etiological role of human papillomavirus type 16 (HPV16) infection in the development of esophageal cancers...
  20. ncbi request reprint Nuclear actin and myosin I are required for RNA polymerase I transcription
    Vlada V Philimonenko
    Department of Cell Ultrastructure and Molecular Biology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague 14220, Czech Republic
    Nat Cell Biol 6:1165-72. 2004
    ..The association with Pol I requires phosphorylation of TIF-IA at Ser 649 by RSK kinase, indicating a role for NMI in the growth-dependent regulation of rRNA synthesis...
  21. ncbi request reprint ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
    Jian Zhao
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120, Heidelberg, Germany
    Mol Cell 11:405-13. 2003
    ..The results provide a link between growth factor signaling, ribosome production, and cell growth, and may have a major impact on the mechanism of cell transformation...
  22. doi request reprint Cancer immunotherapy using in vitro genetically modified targeted dendritic cells
    Huafeng Wei
    International Joint Cancer Institute, The Second Military Medical University, and Shanghai Center for Cell Engineering and Antibody, Shanghai, People s Republic of China
    Cancer Res 68:3854-62. 2008
    ..These results support the concept that genetic modification of DC with tumor-associated antigen-specific CD40 chimeric receptor might be a useful strategy for treatment of human cancers...
  23. doi request reprint Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity
    Bohua Li
    International Joint Cancer Institute, Second Military Medical University, Shanghai, People s Republic of China
    Cancer Res 68:2400-8. 2008
    ....
  24. ncbi request reprint Transiently expressed short hairpin RNA targeting 126 kDa protein of tobacco mosaic virus interferes with virus infection
    Ming Min Zhao
    College of Plant Protection, Northwest Science and Technology University of Agriculture and Forestry, Yangling 712100, China
    Acta Biochim Biophys Sin (Shanghai) 38:22-8. 2006
    ..We propose that a combination of the RNAi technique and Agrobacterium-mediated transient expression could be employed as a potent antiviral treatment in plants.nt antiviral treatment in plants...
  25. pmc Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference
    Changjun Zhu
    The Burnham Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 16:3187-99. 2005
    ..Using immunofluorescence analysis, time-lapse microscopy, and rescue experiments, we investigate the roles of these 12 kinesins in detail...
  26. ncbi request reprint TIP30 inhibits growth of HCC cell lines and inhibits HCC xenografts in mice in combination with 5-FU
    Jian Zhao
    International Joint Cancer Institute and Eastern Hospital of Hepatobiliary Surgery, Second Military Medical University, Shanghai, China
    Hepatology 44:205-15. 2006
    ..Overexpression of TIP30 might be a promising candidate as a treatment for HCC that would increase sensitivity to chemotherapeutic drugs...
  27. ncbi request reprint [Study on the modulation of estrogen receptor isoforms alpha in endometrial carcinoma cells using antisense oligodeoxyribonucleotides]
    Yan Zhang
    Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 37:155-8. 2005
    ....
  28. ncbi request reprint Vaccination with a DNA vaccine based on human PSCA and HSP70 adjuvant enhances the antigen-specific CD8+ T-cell response and inhibits the PSCA+ tumors growth in mice
    Xiaopeng Zhang
    State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dongdajie, Fengtai, Beijing 100071, China
    J Gene Med 9:715-26. 2007
    ....
  29. ncbi request reprint Anticancer activity and quantitative analysis of flavone of Cirsium japonicum DC
    Sujun Liu
    Leshan Teacher s College, Leshan, 614004, PR China
    Nat Prod Res 21:915-22. 2007
    ..Our research shows that these two flavones greatly inhibit cancer cell growth. The rate of inhibiting S180 mice was 55.77% at 50 mg kg( - 1), and the rate of life lengthening was 99.13% at 50 mg kg( - 1) in H22 mice...
  30. ncbi request reprint Antitumour activity of cationic-liposome-conjugated adenovirus containing the CCL19 [chemokine (C-C motif) ligand 19] gene
    Mei Cao
    Key Laboratory of Biological Resource and Ecological Environment of the Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, People s Republic of China
    Biotechnol Appl Biochem 48:109-16. 2007
    ..The results demonstrated that PEG-PE-cationic-liposome-conjugated adenovirus could prolong the expression of the therapeutic gene in vivo and may enhance the antitumour efficacy...
  31. ncbi request reprint Expression, purification, and characterization of an immunotoxin containing a humanized anti-CD25 single-chain fragment variable antibody fused to a modified truncated Pseudomonas exotoxin A
    Huajing Wang
    International Joint Cancer Institute, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Protein Expr Purif 58:140-7. 2008
    ..The protein expression, purification, and refolding system established in this paper is important for further study on immunotoxin CD25-PE38KDELKQK...
  32. ncbi request reprint Treatment of hepatocellular carcinoma in a mouse xenograft model with an immunotoxin which is engineered to eliminate vascular leak syndrome
    Hao Wang
    International Joint Cancer Institute, Second Military Medical University, Shanghai, PR China
    Cancer Immunol Immunother 56:1775-83. 2007
    ..Both wt and mut1 were effective in inhibiting the tumor growth but mut1 showed improved therapeutic efficacy. These studies suggest mut1 may be a novel PE-based immunotoxin with much less toxicity for clinical use...