Affiliation: Karolinska Institutet
Li D, Kular L, Vij M, Herter E, Li X, Wang A, et al
. Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
..Collectively, we have identified a lncRNA important for keratinocyte migration, whose deficiency may be involved in the pathogenesis of chronic wounds. ..
Herter E, Li D, Toma M, Vij M, Li X, Visscher D, et al
. WAKMAR2, a Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines. J Invest Dermatol. 2018;: pubmed publisher
..In summary, our data suggest that WAKMAR2 is an important regulator of skin wound healing and its deficiency may contribute to the pathogenesis of chronic wounds. ..
Li J, Chen H, Ren J, Song J, Zhang F, Zhang J, et al
. Effects of statin on circulating microRNAome and predicted function regulatory network in patients with unstable angina. BMC Med Genomics. 2015;8:12 pubmed publisher
..Our study suggest that statin induces the expression of multiple miRNAs in the circulation of UA patient, which play important roles by regulating signal pathways critical for the pathogenesis of UA. ..
Landén N, Li D, Stahle M. Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci. 2016;73:3861-85 pubmed publisher
..We propose that identification of such mechanisms will reveal promising targets for development of more effective therapies. ..
Xu N, Meisgen F, Butler L, Han G, Wang X, Soderberg Naucler C, et al
. MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40. J Immunol. 2013;190:678-88 pubmed publisher
..Our data indicate that inhibition of miR-31 may be a potential therapeutic option in psoriasis...
Li D, Li X, Wang A, Meisgen F, Pivarcsi A, Sonkoly E, et al
. MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration. J Invest Dermatol. 2015;135:1676-1685 pubmed publisher
..Collectively, we identify miR-31 as a key regulator for promoting keratinocyte proliferation and migration during wound healing. ..
Cheung L, Fisher R, Kuzmina N, Li D, Li X, Werngren O, et al
. Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue. J Invest Dermatol. 2016;136:640-648 pubmed publisher
..We conclude that this miRNA may serve as a mechanistic link between psoriatic skin inflammation and its systemic comorbidities. ..
Li X, Li D, Wikstrom J, Pivarcsi A, Sonkoly E, Stahle M, et al
. MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing. Sci Rep. 2017;7:7797 pubmed publisher
..Silencing of RASA1 phenocopied the pro-migratory effect of miR-132. Collectively, our study reveals an important role for miR-132 in HDFs during wound healing and indicates a therapeutic potential of miR-132 in hard-to-heal skin wounds. ..
Li X, Li D, Wang A, Chu T, Lohcharoenkal W, Zheng X, et al
. MicroRNA-132 with Therapeutic Potential in Chronic Wounds. J Invest Dermatol. 2017;137:2630-2638 pubmed publisher
..Together, our study showed the therapeutic potential of miR-132 in chronic wounds, which warrants further evaluation in controlled clinical trials. ..