B Winblad

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study
    Bengt Winblad
    Karolinska Institutet Alzheimer Disease Research Centre and Clinical Trial Unit, Geriatric Clinic, Karolinska University Hospital, Huddinge, Sweden
    Lancet Neurol 11:597-604. 2012
  2. pmc Validation of the relevant outcome scale for Alzheimer's disease: a novel multidomain assessment for daily medical practice
    Vjera A Holthoff
    Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, University of Technology, Fetscherstraße 74, Dresden 01307, Germany
    Alzheimers Res Ther 3:27. 2011
  3. pmc Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice
    Xing Mei Zhang
    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
    J Neuroinflammation 7:26. 2010
  4. pmc Review of Alzheimer's disease scales: is there a need for a new multi-domain scale for therapy evaluation in medical practice?
    Philippe Robert
    Memory Center, CHU University of Nice Sophia Antipolis, hopital de Cimiez, 4 av Victoria, 06000 Nice, France
    Alzheimers Res Ther 2:24. 2010
  5. ncbi request reprint Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease
    Bengt Winblad
    Karolinska Institutet Alzheimer Research Center, Huddinge, Sweden
    Int J Geriatr Psychiatry 22:485-91. 2007
  6. ncbi request reprint A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease--rivastigmine patch versus capsule
    Bengt Winblad
    Karolinska Institutet Alzheimer Research Center, Stockholm, Sweden
    Int J Geriatr Psychiatry 22:456-67. 2007
  7. ncbi request reprint Therapeutic use of nicergoline
    Bengt Winblad
    Karolinska Institute Alzheimer Disease Research Center, Stockholm, Sweden
    Clin Drug Investig 28:533-52. 2008
  8. ncbi request reprint Use of rivastigmine transdermal patch in the treatment of Alzheimer's disease
    Bengt Winblad
    Karolinska Institutet Alzheimer s Disease Research Center KI ADRC, Floor 5, S 14157, Novum, Huddinge, Sweden
    Expert Opin Drug Deliv 5:1377-86. 2008
  9. ncbi request reprint Memantine benefits functional abilities in moderate to severe Alzheimer's disease
    B Winblad
    Karolinska Institutet, Alzheimer Disease Research Center KI ADRC NOVUM, Huddinge, Sweden
    J Nutr Health Aging 14:770-4. 2010
  10. doi request reprint Donepezil in severe Alzheimer's disease
    Bengt Winblad
    Karolinska Institutet, Stockholm, Sweden
    Am J Alzheimers Dis Other Demen 24:185-92. 2009

Collaborators

Detail Information

Publications158 found, 100 shown here

  1. doi request reprint Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study
    Bengt Winblad
    Karolinska Institutet Alzheimer Disease Research Centre and Clinical Trial Unit, Geriatric Clinic, Karolinska University Hospital, Huddinge, Sweden
    Lancet Neurol 11:597-604. 2012
    ..We aimed to assess the safety and tolerability of CAD106, a novel active Aβ immunotherapy for patients with Alzheimer's disease, designed to induce N-terminal Aβ-specific antibodies without an Aβ-specific T-cell response...
  2. pmc Validation of the relevant outcome scale for Alzheimer's disease: a novel multidomain assessment for daily medical practice
    Vjera A Holthoff
    Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, University of Technology, Fetscherstraße 74, Dresden 01307, Germany
    Alzheimers Res Ther 3:27. 2011
    ..The validity and reliability of ROSA as well as sensitivity to changes due to intervention were examined in an open-label, single-arm, multicenter clinical study in patients with Alzheimer's disease (AD)...
  3. pmc Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice
    Xing Mei Zhang
    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
    J Neuroinflammation 7:26. 2010
    ..Additionally, IL-18 participates in fundamental inflammatory processes that increase during aging. In the present study, we were interested in the role of IL-18 in KA-induced neurodegeneration in aged female C57BL/6 mice...
  4. pmc Review of Alzheimer's disease scales: is there a need for a new multi-domain scale for therapy evaluation in medical practice?
    Philippe Robert
    Memory Center, CHU University of Nice Sophia Antipolis, hopital de Cimiez, 4 av Victoria, 06000 Nice, France
    Alzheimers Res Ther 2:24. 2010
    ....
  5. ncbi request reprint Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease
    Bengt Winblad
    Karolinska Institutet Alzheimer Research Center, Huddinge, Sweden
    Int J Geriatr Psychiatry 22:485-91. 2007
    ..Transdermal patches may offer advantages over conventional oral formulations...
  6. ncbi request reprint A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease--rivastigmine patch versus capsule
    Bengt Winblad
    Karolinska Institutet Alzheimer Research Center, Stockholm, Sweden
    Int J Geriatr Psychiatry 22:456-67. 2007
    ..To compare the efficacy, safety and tolerability of a novel rivastigmine transdermal patch with conventional rivastigmine capsules and placebo in patients with Alzheimer's disease (AD)...
  7. ncbi request reprint Therapeutic use of nicergoline
    Bengt Winblad
    Karolinska Institute Alzheimer Disease Research Center, Stockholm, Sweden
    Clin Drug Investig 28:533-52. 2008
    ....
  8. ncbi request reprint Use of rivastigmine transdermal patch in the treatment of Alzheimer's disease
    Bengt Winblad
    Karolinska Institutet Alzheimer s Disease Research Center KI ADRC, Floor 5, S 14157, Novum, Huddinge, Sweden
    Expert Opin Drug Deliv 5:1377-86. 2008
    ..The apparent success of rivastigmine patch, in terms of clinical utility and patient acceptability, suggests that it may mark the next generation of dementia treatment...
  9. ncbi request reprint Memantine benefits functional abilities in moderate to severe Alzheimer's disease
    B Winblad
    Karolinska Institutet, Alzheimer Disease Research Center KI ADRC NOVUM, Huddinge, Sweden
    J Nutr Health Aging 14:770-4. 2010
    ....
  10. doi request reprint Donepezil in severe Alzheimer's disease
    Bengt Winblad
    Karolinska Institutet, Stockholm, Sweden
    Am J Alzheimers Dis Other Demen 24:185-92. 2009
    ..Donepezil has strong data throughout the Alzheimer's disease spectrum and, therefore, represents a first-line monotherapy that can provide benefits to patients in all stages of Alzheimer's disease...
  11. ncbi request reprint 3-year study of donepezil therapy in Alzheimer's disease: effects of early and continuous therapy
    B Winblad
    Karolinska University Hospital Huddinge, Stockholm, Sweden
    Dement Geriatr Cogn Disord 21:353-63. 2006
    ..These data support the long-term efficacy and safety of donepezil...
  12. doi request reprint Donepezil treatment in severe Alzheimer's disease: a pooled analysis of three clinical trials
    Bengt Winblad
    Department of NVS, Karolinska Institutet Alzheimer Disease Research Center, Huddinge, Sweden
    Curr Med Res Opin 25:2577-87. 2009
    ..Data were pooled from three randomized, placebo-controlled trials of donepezil for severe AD to further evaluate treatment effects and overall tolerability/safety...
  13. ncbi request reprint IDEAL: a 6-month, double-blind, placebo-controlled study of the first skin patch for Alzheimer disease
    B Winblad
    Karolinska Institutet Alzheimer Research Center, Stockholm, Sweden
    Neurology 69:S14-22. 2007
    ..Local skin tolerability was good. The transdermal patch with rivastigmine may offer additional therapeutic benefits and may prove to be the best delivery system for this drug to treat AD...
  14. doi request reprint Gender differences in susceptibility to kainic acid-induced neurodegeneration in aged C57BL/6 mice
    Xing Mei Zhang
    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
    Neurotoxicology 29:406-12. 2008
    ..These results denote the disparity of aging and gender in KA-induced hippocampal neurodegeneration and aged female mice are more sensitive to the excitotoxicity...
  15. doi request reprint Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study
    B Hooshmand
    Aging Research Center, KarolinskaInstitutet, Stockholm, Sweden
    J Intern Med 271:204-12. 2012
    ....
  16. doi request reprint Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study
    B Hooshmand
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet, Gavlegatan 16, S 113 30, Stockholm, Sweden
    Neurology 75:1408-14. 2010
    ..To examine the relation between serum levels of homocysteine (tHcy) and holotranscobalamin (holoTC), the active fraction of vitamin B12, and risk of incident Alzheimer disease (AD) in a sample of Finnish community-dwelling elderly...
  17. ncbi request reprint Institutionalization in the elderly: the role of chronic diseases and dementia. Cross-sectional and longitudinal data from a population-based study
    H Aguero-Torres
    Stockholm Gerontology Research Center, Neurotec, Karolinska Institutet, Stockholm, Sweden
    J Clin Epidemiol 54:795-801. 2001
    ..This study confirms that dementia and cognitive impairment are the main contributors to institutionalization in the elderly, independently of their sociodemographic status, social network, or functional status...
  18. ncbi request reprint A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD
    B Winblad
    Karolinska Institutet, Alzheimer s Disease Research Center, Division of Geriatric Medicine, Huddinge Hospital B, Stockholm, Sweden
    Neurology 57:489-95. 2001
    ..To evaluate the long-term clinical efficacy and safety of donepezil versus placebo over 1 year in patients with mild to moderate AD...
  19. doi request reprint Occurrence of cognitive impairment and dementia in the community: a 9-year-long prospective study
    B Caracciolo
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurology 70:1778-85. 2008
    ....
  20. ncbi request reprint Association of stroke with dementia, cognitive impairment, and functional disability in the very old: a population-based study
    L Zhu
    Stockholm Gerontology Research Center and Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Stroke 29:2094-9. 1998
    ..BACKGROUND and..
  21. ncbi request reprint Lead concentrations in elderly urban people related to blood pressure and mental performance: results from a population-based study
    M Nordberg
    Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Am J Ind Med 38:290-4. 2000
    ..The Kungsholmen project is a longitudinal study of ageing and dementia conducted in Stockholm in 1987. In a 1994-96 follow-up, 804 subjects had their blood samples analyzed for lead...
  22. ncbi request reprint Nicergoline stimulates protein kinase C mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells
    A Cedazo-Minguez
    Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
    Neurochem Int 35:307-15. 1999
    ..These results indicate that nicergoline can modulate alpha-secretase APP processing by a PKC dependent mechanism that is likely to involve the gamma and epsilon isoforms of this enzyme...
  23. doi request reprint The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population
    B Caracciolo
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, Stockholm 113 30, Sweden
    J Neurol Neurosurg Psychiatry 82:788-93. 2011
    ..To investigate the symptom of low mood as a predictor of mild cognitive impairment (MCI) and its progression to dementia, taking into account: (i) MCI severity, (ii) time of assessment and (iii) interaction with other factors...
  24. ncbi request reprint CD28-B7 costimulation: a critical role for initiation and development of experimental autoimmune neuritis in C57BL/6 mice
    Y Zhu
    Division of Geriatric Medicine B84, Department of Clinical Neuroscience, Karolinska Institutet, Huddinge University Hospital, S 141 86 Huddinge, Stockholm, Sweden
    J Neuroimmunol 114:114-21. 2001
    ..Evidently, CD28 is required for interaction with B7 to regulate the activation of T and B cells that initiates development of EAN...
  25. ncbi request reprint Increased expression of mRNA encoding interleukin-1beta and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration
    C Eriksson
    Division of Geriatric Medicine, Neurotec, Karolinska Institute, Huddinge Hospital, Novum, Huddinge, Sweden
    J Neurosci Res 60:266-79. 2000
    ....
  26. ncbi request reprint IL-1beta and ICE mRNA are not altered upon beta-amyloid(25-35) induced neurotoxicity in human neuroblastoma cells
    A Diana
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Geriatric Medicine, Karolinska Institute, Novum, KFC, S 141 86, Huddinge, Sweden
    Int J Dev Neurosci 18:237-46. 2000
    ..It is conceivable that in the absence of glial elements, such as in the present neuroblastoma cell line, beta-amyloid triggers the toxicity through a direct action and/or through the production of other harmful molecules...
  27. ncbi request reprint Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice
    Zhiguo Chen
    Neurotec, Division of Experimental Geriatrics, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Brain Res 931:135-45. 2002
    ..This animal model could provide a valuable tool for exploring the role of excitotoxicity in neuropathological conditions and should be further evaluated in gene-targeting studies of neurodegenerative diseases...
  28. ncbi request reprint Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice
    Rui Sheng Duan
    Division of Experimental Geriatrics Novum, plan 5, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Exp Neurol 202:373-80. 2006
    ..05). Taken together, these findings imply that apoE modulates hippocampal damage induced by KA and found early in the sequence of human Alzheimer's brain changes, by modulating microglial activation...
  29. ncbi request reprint Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade enhances incidence and severity of experimental autoimmune neuritis in resistant mice
    J Zhu
    Division of Geriatric Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 115:111-7. 2001
    ..Thus, manipulation of CTLA-4/B7 costimulatory pathway by CTLA-4 blockade can promote autoreactivity and break the relative tolerance to peripheral autoantigen P0 in resistant B6 mice...
  30. ncbi request reprint PTEN, Akt, and GSK3beta signalling in rat primary cortical neuronal cultures following tumor necrosis factor-alpha and trans-4-hydroxy-2-nonenal treatments
    A Rickle
    Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Center KASPAC, NVS, Novum, Huddinge, Sweden
    J Neurosci Res 84:596-605. 2006
    ..In conclusion, PTEN inhibition gives a mild reversal of TNFalpha- but not HNE-induced cell death via the PI3K pathway...
  31. pmc Clinical trials in mild cognitive impairment: lessons for the future
    V Jelic
    Karolinska Institutet, Neurotec Department, Division of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 77:429-38. 2006
    ....
  32. ncbi request reprint Preclinical symptoms of major depression in very old age: a prospective longitudinal study
    A K Berger
    Stockholm Gerontology Research Center and the Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Stockholm, Sweden
    Am J Psychiatry 155:1039-43. 1998
    ..The authors' goal was to examine whether individuals diagnosed as having major depression experienced greater levels of depressive symptoms and cognitive dysfunction up to 3 years before the clinical diagnosis was rendered...
  33. ncbi request reprint Quantitative autoradiography of [3H]forskolin binding sites in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits
    A Garcia-Jimenez
    Karolinska Institutet, Neurotec, Huddinge, Sweden
    Brain Res 850:104-17. 1999
    ..The specific change in the effect of a low concentration of Gpp[NH]p on the binding could indicate the loss of Ca2+/calmodulin-sensitive AC isoforms in AD...
  34. doi request reprint Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer's disease
    Ewa Kloskowska
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    J Cell Mol Med 14:1816-23. 2010
    ..The Tg6590 transgenic rat line should prove a suitable model of early AD for advanced studies including serial cerebrospinal fluid sampling, electrophysiology, neuroimaging or complex behavioural testing...
  35. ncbi request reprint Pulse pressure and risk of Alzheimer disease in persons aged 75 years and older: a community-based, longitudinal study
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Stroke 34:594-9. 2003
    ..Elevated blood pressure has been found to increase the risk of dementia, including Alzheimer disease. We sought to investigate whether pulse pressure was predictive of Alzheimer disease and dementia...
  36. ncbi request reprint IL-18 deficiency aggravates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice due to an overcompensation by IL-12
    Xing Mei Zhang
    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital in Huddinge, Stockholm, Sweden
    Exp Neurol 205:64-73. 2007
    ..These results suggest that the role of IL-18 in excitotoxic injury in IL-18 deficient mice may be overcompensated by increased IL-12 secretion...
  37. doi request reprint Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study
    W L Xu
    Department of Neurobiology, Aging Research Center, Care Sciences and Society, Stockholm Gerontology Research Center, Karolinska Institutet, Stockholm, Sweden
    Diabetologia 52:1031-9. 2009
    ..We aimed to clarify the association of diabetes with different dementing disorders taking into account glycaemic control, and to explore the link between glucose dysregulation and neurodegeneration...
  38. ncbi request reprint Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
    E Arnaiz
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy, and Elderly Care Research NEUROTEC, Huddinge University Hospital, Sweden
    Neuroreport 12:851-5. 2001
    ..Measures of temporoparietal cerebral metabolism and visuospatial function may aid in predicting the evolution to AD for patients with MCI...
  39. ncbi request reprint Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
    A Cedazo-Minguez
    Karolinska Institutet, Neurotec, Section for Geriatric Medicine, Novum, KFC, Plan 4, S 141 86 Huddinge, Sweden
    Neurochem Int 38:615-25. 2001
    ..These effects could contribute to the reported PKC alterations seen in AD. However, it is unlikely that the contribution of different apoE isoforms to AD pathology occurs via effects on APP processing...
  40. ncbi request reprint Incidence of dementia in relation to stroke and the apolipoprotein E epsilon4 allele in the very old. Findings from a population-based longitudinal study
    L Zhu
    Stockholm Gerontology Research Center, Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Stroke 31:53-60. 2000
    ..Both stroke and the apolipoprotein E (APOE) epsilon4 allele increase the risk of dementia. However, the interaction between stroke and APOE on dementia is still unclear. We addressed this topic by using a longitudinal design...
  41. doi request reprint Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen Project
    Anita Karp
    Aging Research Center, Karolinska Institutet, and the Stockholm Gerontology Research Center, Gavlegatan 16, Stockholm, Sweden
    Am J Geriatr Psychiatry 17:227-36. 2009
    ..This study aimed to explore the association between work complexity factors at midlife and dementia risk in late life under the hypothesis that high work complexity may modulate the increased dementia risk due to low education...
  42. ncbi request reprint Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's disease
    S Akterin
    Section of Experimental Geriatrics, Neurotec Department, Karolinska Institutet, Kliniskt Forskningscentrum KFC, Novum, Huddinge, Sweden
    Cell Death Differ 13:1454-65. 2006
    ..Thus, Abeta neurotoxicity might be mediated by oxidation of GRX1 or TRX1 and subsequent activation of the ASK1 cascade. Deregulation of GRX1 and TRX1 antioxidant systems could be important events in AD pathogenesis...
  43. ncbi request reprint Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer's disease
    V Jelic
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine, B 84, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    Neurobiol Aging 21:533-40. 2000
    ....
  44. ncbi request reprint Interaction between estrogen receptor 1 and the epsilon4 allele of apolipoprotein E increases the risk of familial Alzheimer's disease in women
    K M Mattila
    Alzheimer s Disease Research Centre, KFC, Novum, Karolinska Institutet, S 14186, Huddinge, Sweden
    Neurosci Lett 282:45-8. 2000
    ..Furthermore, the Pp genotype frequency was found to be significantly increased in Finnish women with sporadic AD. We, thus, conclude that the ESR1 gene may have a role in the development of AD in females...
  45. ncbi request reprint Psychotropic drug use in elderly people with and without dementia
    M S Giron
    Division of Geriatric Medicine, Neurotec, Karolinska Institute, Stockholm, Sweden
    Int J Geriatr Psychiatry 16:900-6. 2001
    ..To determine the prevalence of psychotropic drug use in very old persons with and without dementia in two time periods, and describe the patterns of psychotropic drug use between institutions and non-institutions...
  46. ncbi request reprint Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells
    B O Popescu
    Karolinska Institute, Neurotec, Division of Geriatric Medicine, KFC, Novum, Huddinge, Sweden
    J Neurosci Res 66:122-34. 2001
    ..e., PARP and gelsolin), simultaneous with minimum detectable caspase-3 activation. Therefore, alternative cleavage of PS1 may play an important role for the regulation of the proteolytic cascade activated during apoptosis...
  47. ncbi request reprint Aging and the occurrence of dementia: findings from a population-based cohort with a large sample of nonagenarians
    E von Strauss
    Stockholm Gerontology Research Center, Division of Geriatric Medicine, Neurotec, Karolinska Institute, Stockholm, Sweden
    Arch Neurol 56:587-92. 1999
    ..This question is relevant both for understanding the pathogenetic mechanism of the dementias and for the public health prospective because of the increasing number of 85-year-old or older persons in our population...
  48. ncbi request reprint Calcium ionophore A23187 specifically decreases the secretion of beta-secretase cleaved amyloid precursor protein during apoptosis in primary rat cortical cultures
    K Sennvik
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine, KFC Novum, Huddinge, Sweden
    J Neurosci Res 63:429-37. 2001
    ..We conclude that calcium homeostasis is an important apoptotic effector specifically affecting the beta-secretase cleavage of APP...
  49. ncbi request reprint Amyloid beta pathology in Alzheimer's disease and schizophrenia
    Dorota Religa
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Karolinska Institutet, 141 86 Huddinge, Sweden
    Am J Psychiatry 160:867-72. 2003
    ..Biochemical and genetic studies suggest that amyloid beta-peptide is central in Alzheimer's disease. The authors examined the possible involvement of amyloid beta-peptide in cognitive impairment in schizophrenia...
  50. pmc Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
    Am J Pathol 163:591-607. 2003
    ..A p70 S6 kinase modulated up-regulation of tau translation might contribute to PHF-tau accumulation in neurons with neurofibrillary changes...
  51. ncbi request reprint Alpha-MSH rescues neurons from excitotoxic cell death
    Asa Forslin Aronsson
    Division of Neurodegeneration and Neuroinflammation, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    J Mol Neurosci 33:239-51. 2007
    ..Furthermore, the administration of alpha-MSH resulted in a similar increase in cell viability, supporting the hypothesis that administration of alpha-MSH has rescuing effects on neurons subjected to excitotoxic insults...
  52. ncbi request reprint Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
    Camilla A Hansson
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Novum, SE 141 57 Huddinge, Sweden
    J Biol Chem 279:51654-60. 2004
    ..This novel localization of NCT, PS1, APH-1, and PEN-2 expands the role and importance of gamma-secretase activity to mitochondria...
  53. ncbi request reprint Assessing the societal impact of acetylcholinesterase inhibitor therapies
    B Winblad
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care, Karolinska Institute, Stockholm, Sweden
    Alzheimer Dis Assoc Disord 13:S9-19. 1999
    ..Thus, the health economics of dementia is an extremely complex area of study that is rapidly growing, due to the likelihood that cost-effectiveness will form the basis for future reimbursement decisions...
  54. ncbi request reprint Maintaining functional and behavioral abilities in Alzheimer disease
    B Winblad
    Karolinska Institutet, Alzheimer Disease Research Center, Huddinge Hospital, Sweden
    Alzheimer Dis Assoc Disord 15:S34-40. 2001
    ..These behavioral benefits were associated with reduced caregiver distress and translated into reduced caregiver time. These benefits would be expected to make an important difference to the quality of life of patients and caregivers...
  55. ncbi request reprint Vitamin B(12) and folate in relation to the development of Alzheimer's disease
    H X Wang
    Stockholm Gerontology Research Center and Division of Geriatric Medicine, Neurotec, Karolinska Institutet, Stockholm
    Neurology 56:1188-94. 2001
    ..To explore the associations of low serum levels of vitamin B(12) and folate with AD occurrence...
  56. pmc Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex
    C Qiu
    Ageing Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and the Stockholm Gerontology Research Centre, Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 75:828-33. 2004
    ..The risk effect of APOE epsilon 4 allele for Alzheimer's disease is acknowledged, whereas the putative protective effect of epsilon 2 allele remains in debate...
  57. ncbi request reprint Predictors of progression from mild cognitive impairment to Alzheimer disease
    K Palmer
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Neurology 68:1596-602. 2007
    ..To determine the occurrence of neuropsychiatric symptomatology and the relation to future development of Alzheimer disease (AD) in persons with and without mild cognitive impairment (MCI)...
  58. ncbi request reprint Incidence of stroke in relation to cognitive function and dementia in the Kungsholmen Project
    L Zhu
    Stockholm Gerontology Research Center and Department of Geriatric Medicine, Neurotec, Karolinska Institute, Stockholm, Sweden
    Neurology 54:2103-7. 2000
    ..To investigate whether cognitive function is related to incidence of stroke...
  59. ncbi request reprint Elevated cortical zinc in Alzheimer disease
    D Religa
    Neurotec, Experimental Geriatrics, Karolinska Institutet, Stockholm, Sweden
    Neurology 67:69-75. 2006
    ..To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta) burden and dementia severity...
  60. ncbi request reprint Protective effect of Rolipram in experimental autoimmune neuritis: protection is associated with down-regulation of IFN-gamma and inflammatory chemokines as well as up-regulation of IL-4 in peripheral nervous system
    N Abbas
    Dept of Clinical Neuroscience, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
    Autoimmunity 32:93-9. 2000
    ..These observations call for further studies on the potential role of Rolipram in the treatment of autoimmune diseases...
  61. doi request reprint Personality and lifestyle in relation to dementia incidence
    H X Wang
    Aging Research Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet, Gavlegatan 16, 113 30 Stockholm, Sweden
    Neurology 72:253-9. 2009
    ..The aim of the current study was to explore the separate and combined effects of neuroticism and extraversion on the risk of dementia, and to examine whether lifestyle factors may modify this association...
  62. ncbi request reprint Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
    Suvi Rovio
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 4:705-11. 2005
    ..The aim of our study was to investigate the association between leisure-time physical activity at midlife and the subsequent development of dementia and Alzheimer's disease (AD)...
  63. ncbi request reprint Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study
    Bengt Winblad
    Karolinska Institutet, Alzheimer s Disease Research Center, Department of Neurotec, Division of Geriatric Medicine, Karolinska University Hospital, Huddinge, 14186 Stockholm, Sweden
    Lancet 367:1057-65. 2006
    ..Our aim was to ascertain the effectiveness of donepezil in patients with severe Alzheimer's disease, by focusing primarily on cognition and activities of daily living...
  64. ncbi request reprint The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid-induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3
    Zhiguo Chen
    Division of Geriatric Medicine, Department of Neurotec, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Neurochem 86:61-8. 2003
    ..The roles of CCR5 in excitotoxic injury in CCR5 deficient mice are compensated by increased CCR2 and CCR3 expression, which share the common MCP-2 ligand with CCR5...
  65. ncbi request reprint APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations
    Anna Bergman
    Karolinska Institutet, Neurotec, Section for Experimental Geriatrics, Novum, SE 141 86, Huddinge, Sweden
    Exp Cell Res 287:1-9. 2003
    ..These findings indicate that there are very similar routes for Abeta and AICD formation but that FAD-linked mutations in APP primarily affect gamma-secretase-mediated Abeta42 formation, and not AICD signaling...
  66. doi request reprint Genetic association to the amyloid plaque associated protein gene COL25A1 in Alzheimer's disease
    Charlotte Forsell
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KASPAC, Novum, S 141 57 Huddinge, Sweden
    Neurobiol Aging 31:409-15. 2010
    ..Thus, in addition to the biochemical data, there is now genetic evidence of association between COL25A1 and risk for Alzheimer's disease...
  67. ncbi request reprint Cytokine production by a human microglial cell line: effects of beta-amyloid and alpha-melanocyte-stimulating hormone
    Catharina Lindberg
    Karolinska Institutet, Neurotec Department, Division of Experimental Geriatrics, Karolinska University Hospital Huddinge, Novum, SE 141 86 Stockholm, Sweden
    Neurotox Res 8:267-76. 2005
    ..RT-PCR showed the expression of MCR1, MCR3, MCR4 and MCR5 mRNA. The combined data suggest that the effect of alpha-MSH in increasing IL-6 release from the human microglial cell line is mediated by MCR3 or MCR5...
  68. ncbi request reprint Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
    Xin Wen Zhou
    Karolinska Institutet, Department of Neurotec, Geriatric lab, Novum Plan 5, S 14157, Huddinge, Sweden
    Neurobiol Dis 22:657-68. 2006
    ..Assessments of levels of these abnormal proteins by dot blots may serve as a useful complement to the morphological evaluations in diagnosis of AD...
  69. doi request reprint Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain
    Mikio Aoki
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum Plan 5, Huddinge, Sweden
    Neuroreport 19:1085-9. 2008
    ..We speculate that intracellular accumulation of Abeta42 increase vulnerability of cornu ammonis 1 pyramidal neurons in Alzheimer's disease...
  70. ncbi request reprint Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
    ....
  71. ncbi request reprint Education and dementia: what lies behind the association?
    T Ngandu
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, 11330 Stockholm, Sweden
    Neurology 69:1442-50. 2007
    ..People with low education have unhealthier lifestyles and more cardiovascular risk factors, but it is unclear how this affects the association between education and dementia...
  72. ncbi request reprint White matter lesions impair initiation of FAS flow
    S E Fernaeus
    Department of Clinical Neuroscience and Family Medicine, Division of Geriatric Medicine, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 12:52-6. 2001
    ..The initial FAS performance was related to anterior WMH, in particular left frontal or lateral periventricular hyperintensities, whereas the late FAS performance was not related to any index of WMH...
  73. doi request reprint The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study
    A Marengoni
    NVS Department, Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 265:288-95. 2009
    ..We aimed to disentangle the effect of chronic multimorbidity and disability on 3-year functional decline and survival in the elderly...
  74. ncbi request reprint The interplay of institution and family caregiving: relations between patient hassles, nursing home hassles and caregivers' burnout
    B Almberg
    Stockholm Gerontology Research Center and Department of Clinical Neuroscience and Family Medicine Division of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Int J Geriatr Psychiatry 15:931-9. 2000
    ..All subscales except basic ADL were correlated to burnout. However, regression analysis showed the nursing home hassles to be the most important stresses explaining variance in burnout among family caregivers...
  75. ncbi request reprint Neuroglia in the inferior olivary nucleus during normal aging and Alzheimer's disease
    H Lasn
    Section for Clinical Geriatric, NEUROTEC Institutionen, Karolinska Institutet, Stockholm, Sweden
    J Cell Mol Med 10:145-56. 2006
    ..Using a novel unbiased quantitative method, we were able to describe significant oligodendroglial loss in the PO but the pathogenic mechanism behind remains unknown...
  76. ncbi request reprint IPECAD5--Fifth International Pharmaco-Economic Conference on Alzheimer's Disease
    A Gustavsson
    KI Alzheimer s Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum Plan 5, 141 86 Stockholm, Sweden
    J Nutr Health Aging 14:358-60. 2010
    ....
  77. ncbi request reprint Influence of social network on occurrence of dementia: a community-based longitudinal study
    L Fratiglioni
    Stockholm Gerontology Research Centre, and Division of Geriatric Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Lancet 355:1315-9. 2000
    ..Few data are available on the effect of social ties on dementia development. This study explored whether single social network components and different degrees of the social connections affect dementia incidence...
  78. ncbi request reprint Transgenic overexpression of interleukin-1 receptor antagonist in the CNS influences behaviour, serum corticosterone and brain monoamines
    Mircea Oprica
    Division of Experimental Geriatrics, Neurotec Department, Karolinska Institutet, Novum, KFC, 4th Floor, Karolinska University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Brain Behav Immun 19:223-34. 2005
    ..Finally, the activation of hypothalamo-pituitary-adrenal (HPA)-axis was comparable in the two genotypes, however Tg hsIL-1ra(+/+) mice had a modified metabolism of brain monoamines as compared to WT mice...
  79. ncbi request reprint Effects of statins on microglia
    Catharina Lindberg
    Karolinska Institutet, Neurotec Department, Division of Experimental Geriatrics, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Neurosci Res 82:10-9. 2005
    ..The data indicate the importance of also considering the microglial responses to statins in evaluation of their effects in AD and other neurodegenerative disorders with an inflammatory component...
  80. doi request reprint Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
    Xin Wen Zhou
    Karolinska Institutet, KI Alzheimer Disease Research Center KI ADRC, Novum, Huddinge, Sweden
    Neurobiol Dis 31:386-94. 2008
    ....
  81. ncbi request reprint Women are more disabled in basic activities of daily living than men only in very advanced ages: a study on disability, morbidity, and mortality from the Kungsholmen Project
    Eva von Strauss
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    J Clin Epidemiol 56:669-77. 2003
    ..We explored the effect of morbidity, mortality, and occurrence of new disability on gender differences in activities of daily living (ADL) functioning in different age groups in the elderly population...
  82. ncbi request reprint IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice
    Zhiguo Chen
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Neurobiol Dis 17:171-8. 2004
    ..In summary, this study indicates that IL-12 may play a critical role in excitotoxin-induced brain injury...
  83. ncbi request reprint Increased susceptibility to experimental autoimmune neuritis after upregulation of the autoreactive T cell response to peripheral myelin antigen in apolipoprotein E-deficient mice
    Shuo Yu
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Neuropathol Exp Neurol 63:120-8. 2004
    ..These data may aid the development of new and more effective therapeutic strategies for inflammatory and demyelinating diseases such as Guillain-Barré syndrome...
  84. ncbi request reprint Caspase cleaved presenilin-1 is part of active gamma-secretase complexes
    Camilla A Hansson
    Karolinska Institutet, Neurotec, Section for Experimental Geriatrics, Huddinge, Sweden
    J Neurochem 97:356-64. 2006
    ..Together, the data show that gamma-secretase complexes containing PS1-caspCTF are active, and suggest that this proteolytic activity is also important in dying cells and may affect the progression of AD...
  85. ncbi request reprint A longitudinal study integrating population, care and social services data. The Swedish National study on Aging and Care (SNAC)
    Marten Lagergren
    Stockholm Gerontology Research Center, Stockholm, Sweden
    Aging Clin Exp Res 16:158-68. 2004
    ..A large, national, long-term, longitudinal, multi-purpose study has been launched in Sweden--the Swedish National study on Aging and Care (SNAC). The study involves four research centers collecting data in four different areas of Sweden...
  86. ncbi request reprint Combined effects of APOE genotype, blood pressure, and antihypertensive drug use on incident AD
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and the Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurology 61:655-60. 2003
    ..To study the hypotheses that APOE-epsilon4 allele may interact with blood pressure to affect Alzheimer's disease (AD) occurrence and that antihypertensive therapy could modify such an effect...
  87. ncbi request reprint Molecular identification of AMY, an Alzheimer disease amyloid-associated protein
    Linda Söderberg
    Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
    J Neuropathol Exp Neurol 62:1108-17. 2003
    ..Therefore, we conclude that the AMY immunoreactivity seen in association with amyloid in AD brain is due to the presence of the CLAC protein...
  88. ncbi request reprint The age-dependent relation of blood pressure to cognitive function and dementia
    Chengxuan Qiu
    Aging Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institute and Stockholm Gerontology Research Centre, Stockholm, Sweden
    Lancet Neurol 4:487-99. 2005
    ....
  89. doi request reprint Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology
    R Liu
    Karolinska Institutet, KI Alzheimer Disease Research Center KI ADRC, Novum, Huddinge, Sweden
    J Cell Mol Med 12:241-57. 2008
    ....
  90. ncbi request reprint Cerebrovascular diseases and depression: epidemiology, mechanisms and treatment
    F Göthe
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Panminerva Med 54:161-70. 2012
    ..There is emerging evidence that treatment of cardiovascular disease and risk-factors can reduce the risk for late-life depression, but more studies are needed to test this hypothesis...
  91. ncbi request reprint Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population
    C Cornelius
    Aging Research Centre, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm Gerontology Research Centre, Stockholm, Sweden
    Neuroepidemiology 23:135-43. 2004
    ..23; 95% CI 0.03-1.68). This could be due to the small samples in our study, or to comorbidity contributing to the development of dementia in this elderly population...
  92. ncbi request reprint Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study
    W L Xu
    Aging Research Center, Neurotec, Karolinska Institutet, Sweden
    Neurology 63:1181-6. 2004
    ..The authors investigated the relationship between diabetes mellitus and risk of dementia, Alzheimer disease (AD), and vascular dementia (VaD)...
  93. doi request reprint Safety and efficacy of galantamine in subjects with mild cognitive impairment
    B Winblad
    Karolinska Institutet, Alzheimer s Disease Research Center, Division of Geriatric Medicine, Stockholm, Sweden
    Neurology 70:2024-35. 2008
    ....
  94. ncbi request reprint Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains
    J A Johnston
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Novum KFC, Huddinge, Sweden
    Brain Res Mol Brain Res 43:85-95. 1996
    ....
  95. ncbi request reprint The appropriateness of drug use in an older nondemented and demented population
    M S Giron
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Karolinska Institute, Stockholm, Sweden
    J Am Geriatr Soc 49:277-83. 2001
    ..The exposure of demented subjects to psychotropic drugs and nondemented subjects to cardiovascular drugs reflect the high frequency of prescribing these drugs in this population...
  96. ncbi request reprint P0 glycoprotein peptides 56-71 and 180-199 dose-dependently induce acute and chronic experimental autoimmune neuritis in Lewis rats associated with epitope spreading
    J Zhu
    Division of Geriatric Medicine, Huddinge University Hospital, S 141 86 Huddinge, Stockholm, Sweden
    J Neuroimmunol 114:99-106. 2001
    ..The results support the hypothesis that high dose autoantigen immunization induces extensive determinant spreading and chronic course of autoimmune diseases...
  97. ncbi request reprint Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication?
    Z Guo
    Stockholm Gerontology Research Center and Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Am J Epidemiol 153:225-31. 2001
    ..Further studies are needed to clarify whether use of antihypertensive medication, especially diuretics, modifies the effect of the allele...
  98. ncbi request reprint Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: a longitudinal study from the Kungsholmen project
    Hui Xin Wang
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec, Karolinska Institutet, and Stockholm Gerontology Research Center, Stockholm, Sweden
    Am J Epidemiol 155:1081-7. 2002
    ....
  99. ncbi request reprint Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse
    Mircea Oprica
    Neurotec Department, Division of Experimental Geriatrics, Karolinska Institutet, Novum, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden
    Acta Neuropathol 108:69-80. 2004
    ....
  100. ncbi request reprint Small heat shock proteins Hsp27 or alphaB-crystallin and the protein components of neurofibrillary tangles: tau and neurofilaments
    Cecilia Bjorkdahl
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI Alzheimer s Disease Research Center, Novum, Huddinge, Sweden
    J Neurosci Res 86:1343-52. 2008
    ..Furthermore, Hsp27 might also be involved in AD pathology by aggravating MT disruption by tau phosphorylation...
  101. ncbi request reprint Pharmacoeconomics of mild cognitive impairment
    Anders Wimo
    Division of Geriatric Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Acta Neurol Scand Suppl 179:94-9. 2003
    ..From the Kungsholmen project in Sweden, there are indications that the postponement between MCI and manifest dementia may result in short-term benefits (a few years) of about SEK50,000 (5300 US dollars)...