B Winblad

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi Mild cognitive impairment in the general population: occurrence and progression to Alzheimer disease
    Katie Palmer
    Aging Research Center, Karolinska Institutet, and Stockholm Gerontology Research Center, Stockholm, Sweden
    Am J Geriatr Psychiatry 16:603-11. 2008
  2. pmc Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment
    Chaorui Huang
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Divison of Geriatric Medicine, Huddinge University Hospital, Sweden
    BMC Neurol 2:9. 2002
  3. ncbi Outcome measures in Alzheimer's disease: do they go far enough?
    B Winblad
    Karolinska Institutet, Alzheimer Research Center, Department of Clinical Neuroscience, Huddinge University Hospital, Sweden
    Dement Geriatr Cogn Disord 11:3-10. 2000
  4. ncbi Piracetam: a review of pharmacological properties and clinical uses
    Bengt Winblad
    Karolinska Institutet, Neurotec, Huddinge, University Hospital B 84, S 14186 Stockholm, Sweden
    CNS Drug Rev 11:169-82. 2005
  5. ncbi Long-term treatment of Alzheimer disease: efficacy and safety of acetylcholinesterase inhibitors
    Bengt Winblad
    Karolinska Institutet, Alzheimer s Disease Research Center, Neurotec Department, Division of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Alzheimer Dis Assoc Disord 18:S2-8. 2004
  6. ncbi Treating the full spectrum of dementia with memantine
    Bengt Winblad
    Karolinska Institutet, Division of Geriatric Medicine, Huddinge University Hospital, Huddinge, Sweden
    Int J Geriatr Psychiatry 18:S41-6. 2003
  7. ncbi Memantine offers new possibilities for the treatment of VaD
    Bengt Winblad
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine and Geriatric Epidemiology, Huddinge University Hospital, 141 86 Stockholm, Sweden
    Lancet Neurol 1:469. 2002
  8. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
  9. ncbi Pharmacotherapy of Alzheimer's disease: is there a need to redefine treatment success?
    B Winblad
    Karolinska Institutet, Alzheimer Research Center, Huddinge University Hospital, Stockholm, Sweden
    Int J Geriatr Psychiatry 16:653-66. 2001
  10. ncbi Maintaining functional and behavioral abilities in Alzheimer disease
    B Winblad
    Karolinska Institutet, Alzheimer Disease Research Center, Huddinge Hospital, Sweden
    Alzheimer Dis Assoc Disord 15:S34-40. 2001

Collaborators

Detail Information

Publications157 found, 100 shown here

  1. doi Mild cognitive impairment in the general population: occurrence and progression to Alzheimer disease
    Katie Palmer
    Aging Research Center, Karolinska Institutet, and Stockholm Gerontology Research Center, Stockholm, Sweden
    Am J Geriatr Psychiatry 16:603-11. 2008
    ....
  2. pmc Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment
    Chaorui Huang
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Divison of Geriatric Medicine, Huddinge University Hospital, Sweden
    BMC Neurol 2:9. 2002
    ..Regional cerebral blood flow (rCBF) as measured by single photon emission computed tomography (SPECT) was used to study the heterogeneity of MCI and to look for predictors of future development of AD...
  3. ncbi Outcome measures in Alzheimer's disease: do they go far enough?
    B Winblad
    Karolinska Institutet, Alzheimer Research Center, Department of Clinical Neuroscience, Huddinge University Hospital, Sweden
    Dement Geriatr Cogn Disord 11:3-10. 2000
    ....
  4. ncbi Piracetam: a review of pharmacological properties and clinical uses
    Bengt Winblad
    Karolinska Institutet, Neurotec, Huddinge, University Hospital B 84, S 14186 Stockholm, Sweden
    CNS Drug Rev 11:169-82. 2005
    ..Its efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia. While high doses are sometimes necessary, piracetam is well tolerated...
  5. ncbi Long-term treatment of Alzheimer disease: efficacy and safety of acetylcholinesterase inhibitors
    Bengt Winblad
    Karolinska Institutet, Alzheimer s Disease Research Center, Neurotec Department, Division of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Alzheimer Dis Assoc Disord 18:S2-8. 2004
    ..Patients who received continuous pharmacologic treatment from the outset generally had better long-term outcomes than those who received placebo in the double-blind phase of these trials...
  6. ncbi Treating the full spectrum of dementia with memantine
    Bengt Winblad
    Karolinska Institutet, Division of Geriatric Medicine, Huddinge University Hospital, Huddinge, Sweden
    Int J Geriatr Psychiatry 18:S41-6. 2003
    ..The later findings are results from the M-BEST study, which is briefly rewieved here with some of the epidemiological, socioeconomical and clinical implications of such therapy...
  7. ncbi Memantine offers new possibilities for the treatment of VaD
    Bengt Winblad
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine and Geriatric Epidemiology, Huddinge University Hospital, 141 86 Stockholm, Sweden
    Lancet Neurol 1:469. 2002
  8. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
    ....
  9. ncbi Pharmacotherapy of Alzheimer's disease: is there a need to redefine treatment success?
    B Winblad
    Karolinska Institutet, Alzheimer Research Center, Huddinge University Hospital, Stockholm, Sweden
    Int J Geriatr Psychiatry 16:653-66. 2001
    ....
  10. ncbi Maintaining functional and behavioral abilities in Alzheimer disease
    B Winblad
    Karolinska Institutet, Alzheimer Disease Research Center, Huddinge Hospital, Sweden
    Alzheimer Dis Assoc Disord 15:S34-40. 2001
    ..These behavioral benefits were associated with reduced caregiver distress and translated into reduced caregiver time. These benefits would be expected to make an important difference to the quality of life of patients and caregivers...
  11. ncbi A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD
    B Winblad
    Karolinska Institutet, Alzheimer s Disease Research Center, Division of Geriatric Medicine, Huddinge Hospital B, Stockholm, Sweden
    Neurology 57:489-95. 2001
    ..To evaluate the long-term clinical efficacy and safety of donepezil versus placebo over 1 year in patients with mild to moderate AD...
  12. ncbi Assessing the societal impact of acetylcholinesterase inhibitor therapies
    B Winblad
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care, Karolinska Institute, Stockholm, Sweden
    Alzheimer Dis Assoc Disord 13:S9-19. 1999
    ..Thus, the health economics of dementia is an extremely complex area of study that is rapidly growing, due to the likelihood that cost-effectiveness will form the basis for future reimbursement decisions...
  13. ncbi CD28-B7 costimulation: a critical role for initiation and development of experimental autoimmune neuritis in C57BL/6 mice
    Y Zhu
    Division of Geriatric Medicine B84, Department of Clinical Neuroscience, Karolinska Institutet, Huddinge University Hospital, S 141 86 Huddinge, Stockholm, Sweden
    J Neuroimmunol 114:114-21. 2001
    ..Evidently, CD28 is required for interaction with B7 to regulate the activation of T and B cells that initiates development of EAN...
  14. ncbi 3-year study of donepezil therapy in Alzheimer's disease: effects of early and continuous therapy
    B Winblad
    Karolinska University Hospital Huddinge, Stockholm, Sweden
    Dement Geriatr Cogn Disord 21:353-63. 2006
    ..These data support the long-term efficacy and safety of donepezil...
  15. doi Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study
    B Hooshmand
    Aging Research Center, KarolinskaInstitutet, Stockholm, Sweden
    J Intern Med 271:204-12. 2012
    ....
  16. ncbi Institutionalization in the elderly: the role of chronic diseases and dementia. Cross-sectional and longitudinal data from a population-based study
    H Aguero-Torres
    Stockholm Gerontology Research Center, Neurotec, Karolinska Institutet, Stockholm, Sweden
    J Clin Epidemiol 54:795-801. 2001
    ..This study confirms that dementia and cognitive impairment are the main contributors to institutionalization in the elderly, independently of their sociodemographic status, social network, or functional status...
  17. doi Occurrence of cognitive impairment and dementia in the community: a 9-year-long prospective study
    B Caracciolo
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurology 70:1778-85. 2008
    ....
  18. doi Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study
    B Hooshmand
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet, Gavlegatan 16, S 113 30, Stockholm, Sweden
    Neurology 75:1408-14. 2010
    ..To examine the relation between serum levels of homocysteine (tHcy) and holotranscobalamin (holoTC), the active fraction of vitamin B12, and risk of incident Alzheimer disease (AD) in a sample of Finnish community-dwelling elderly...
  19. ncbi Caspase cleaved presenilin-1 is part of active gamma-secretase complexes
    Camilla A Hansson
    Karolinska Institutet, Neurotec, Section for Experimental Geriatrics, Huddinge, Sweden
    J Neurochem 97:356-64. 2006
    ..Together, the data show that gamma-secretase complexes containing PS1-caspCTF are active, and suggest that this proteolytic activity is also important in dying cells and may affect the progression of AD...
  20. ncbi Lead concentrations in elderly urban people related to blood pressure and mental performance: results from a population-based study
    M Nordberg
    Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Am J Ind Med 38:290-4. 2000
    ..The Kungsholmen project is a longitudinal study of ageing and dementia conducted in Stockholm in 1987. In a 1994-96 follow-up, 804 subjects had their blood samples analyzed for lead...
  21. ncbi Association of stroke with dementia, cognitive impairment, and functional disability in the very old: a population-based study
    L Zhu
    Stockholm Gerontology Research Center and Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Stroke 29:2094-9. 1998
    ..BACKGROUND and..
  22. ncbi Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade enhances incidence and severity of experimental autoimmune neuritis in resistant mice
    J Zhu
    Division of Geriatric Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 115:111-7. 2001
    ..Thus, manipulation of CTLA-4/B7 costimulatory pathway by CTLA-4 blockade can promote autoreactivity and break the relative tolerance to peripheral autoantigen P0 in resistant B6 mice...
  23. pmc Clinical trials in mild cognitive impairment: lessons for the future
    V Jelic
    Karolinska Institutet, Neurotec Department, Division of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 77:429-38. 2006
    ....
  24. doi The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population
    B Caracciolo
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, Stockholm 113 30, Sweden
    J Neurol Neurosurg Psychiatry 82:788-93. 2011
    ..To investigate the symptom of low mood as a predictor of mild cognitive impairment (MCI) and its progression to dementia, taking into account: (i) MCI severity, (ii) time of assessment and (iii) interaction with other factors...
  25. ncbi IL-1beta and ICE mRNA are not altered upon beta-amyloid(25-35) induced neurotoxicity in human neuroblastoma cells
    A Diana
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Geriatric Medicine, Karolinska Institute, Novum, KFC, S 141 86, Huddinge, Sweden
    Int J Dev Neurosci 18:237-46. 2000
    ..It is conceivable that in the absence of glial elements, such as in the present neuroblastoma cell line, beta-amyloid triggers the toxicity through a direct action and/or through the production of other harmful molecules...
  26. ncbi Increased expression of mRNA encoding interleukin-1beta and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration
    C Eriksson
    Division of Geriatric Medicine, Neurotec, Karolinska Institute, Huddinge Hospital, Novum, Huddinge, Sweden
    J Neurosci Res 60:266-79. 2000
    ....
  27. ncbi Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice
    Rui Sheng Duan
    Division of Experimental Geriatrics Novum, plan 5, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Exp Neurol 202:373-80. 2006
    ..05). Taken together, these findings imply that apoE modulates hippocampal damage induced by KA and found early in the sequence of human Alzheimer's brain changes, by modulating microglial activation...
  28. doi Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen Project
    Anita Karp
    Aging Research Center, Karolinska Institutet, and the Stockholm Gerontology Research Center, Gavlegatan 16, Stockholm, Sweden
    Am J Geriatr Psychiatry 17:227-36. 2009
    ..This study aimed to explore the association between work complexity factors at midlife and dementia risk in late life under the hypothesis that high work complexity may modulate the increased dementia risk due to low education...
  29. ncbi Nicergoline stimulates protein kinase C mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells
    A Cedazo-Minguez
    Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
    Neurochem Int 35:307-15. 1999
    ..These results indicate that nicergoline can modulate alpha-secretase APP processing by a PKC dependent mechanism that is likely to involve the gamma and epsilon isoforms of this enzyme...
  30. ncbi Longitudinal changes in quantitative EEG during long-term tacrine treatment of patients with Alzheimer's disease
    V Jelic
    Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, Huddinge University Hospital, Sweden
    Neurosci Lett 254:85-8. 1998
    ..These findings suggest that slowing in fast EEG frequencies during chronic treatment with AChE inhibitors may provide an early indicator of declining treatment efficiency...
  31. ncbi Quantitative autoradiography of [3H]forskolin binding sites in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits
    A Garcia-Jimenez
    Karolinska Institutet, Neurotec, Huddinge, Sweden
    Brain Res 850:104-17. 1999
    ..The specific change in the effect of a low concentration of Gpp[NH]p on the binding could indicate the loss of Ca2+/calmodulin-sensitive AC isoforms in AD...
  32. ncbi Preclinical symptoms of major depression in very old age: a prospective longitudinal study
    A K Berger
    Stockholm Gerontology Research Center and the Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Stockholm, Sweden
    Am J Psychiatry 155:1039-43. 1998
    ..The authors' goal was to examine whether individuals diagnosed as having major depression experienced greater levels of depressive symptoms and cognitive dysfunction up to 3 years before the clinical diagnosis was rendered...
  33. ncbi PTEN, Akt, and GSK3beta signalling in rat primary cortical neuronal cultures following tumor necrosis factor-alpha and trans-4-hydroxy-2-nonenal treatments
    A Rickle
    Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Center KASPAC, NVS, Novum, Huddinge, Sweden
    J Neurosci Res 84:596-605. 2006
    ..In conclusion, PTEN inhibition gives a mild reversal of TNFalpha- but not HNE-induced cell death via the PI3K pathway...
  34. ncbi Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Huddinge, Sweden
    J Neurochem 92:1104-15. 2005
    ..Thus, 100 microM zinc might activate PKB, GSK-3beta, ERK1/2, JNK, p38 and p70S6K, that are consequently involved in tau changes in SH-SY5Y cells...
  35. ncbi Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2
    Wen Lin An
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
    Brain Res Mol Brain Res 135:40-7. 2005
    ..These results indicate that a zinc-induced anti-apoptotic response in SH-SY5Y cells likely occurs through ERK1/2...
  36. ncbi APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations
    Anna Bergman
    Karolinska Institutet, Neurotec, Section for Experimental Geriatrics, Novum, SE 141 86, Huddinge, Sweden
    Exp Cell Res 287:1-9. 2003
    ..These findings indicate that there are very similar routes for Abeta and AICD formation but that FAD-linked mutations in APP primarily affect gamma-secretase-mediated Abeta42 formation, and not AICD signaling...
  37. doi Gender differences in susceptibility to kainic acid-induced neurodegeneration in aged C57BL/6 mice
    Xing Mei Zhang
    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
    Neurotoxicology 29:406-12. 2008
    ..These results denote the disparity of aging and gender in KA-induced hippocampal neurodegeneration and aged female mice are more sensitive to the excitotoxicity...
  38. doi Low diastolic pressure and risk of dementia in very old people: a longitudinal study
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet Stockholm University, Stockholm, Sweden
    Dement Geriatr Cogn Disord 28:213-9. 2009
    ..Midlife high blood pressure is linked to late-life dementia. We sought to investigate the temporal relation of blood pressure to the risk of dementia and Alzhei-mer's disease (AD) among older adults...
  39. pmc Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex
    C Qiu
    Ageing Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and the Stockholm Gerontology Research Centre, Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 75:828-33. 2004
    ..The risk effect of APOE epsilon 4 allele for Alzheimer's disease is acknowledged, whereas the putative protective effect of epsilon 2 allele remains in debate...
  40. ncbi Expression of neurotrophin-3 mRNA in the rat visual cortex and hippocampus is influenced by environmental conditions
    M Torasdotter
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge University Hospital, Sweden
    Neurosci Lett 218:107-10. 1996
    ..These results indicate a possible role for NT-3 in synaptic plasticity...
  41. doi Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study
    W L Xu
    Department of Neurobiology, Aging Research Center, Care Sciences and Society, Stockholm Gerontology Research Center, Karolinska Institutet, Stockholm, Sweden
    Diabetologia 52:1031-9. 2009
    ..We aimed to clarify the association of diabetes with different dementing disorders taking into account glycaemic control, and to explore the link between glucose dysregulation and neurodegeneration...
  42. ncbi Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
    E Arnaiz
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy, and Elderly Care Research NEUROTEC, Huddinge University Hospital, Sweden
    Neuroreport 12:851-5. 2001
    ..Measures of temporoparietal cerebral metabolism and visuospatial function may aid in predicting the evolution to AD for patients with MCI...
  43. ncbi Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer's disease
    V Jelic
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine, B 84, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    Neurobiol Aging 21:533-40. 2000
    ....
  44. ncbi Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
    A Cedazo-Minguez
    Karolinska Institutet, Neurotec, Section for Geriatric Medicine, Novum, KFC, Plan 4, S 141 86 Huddinge, Sweden
    Neurochem Int 38:615-25. 2001
    ..These effects could contribute to the reported PKC alterations seen in AD. However, it is unlikely that the contribution of different apoE isoforms to AD pathology occurs via effects on APP processing...
  45. ncbi Incidence of dementia in relation to stroke and the apolipoprotein E epsilon4 allele in the very old. Findings from a population-based longitudinal study
    L Zhu
    Stockholm Gerontology Research Center, Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Stroke 31:53-60. 2000
    ..Both stroke and the apolipoprotein E (APOE) epsilon4 allele increase the risk of dementia. However, the interaction between stroke and APOE on dementia is still unclear. We addressed this topic by using a longitudinal design...
  46. ncbi Influence of differential housing on emotional behaviour and neurotrophin levels in mice
    Shun Wei Zhu
    Division of Experimental Geriatric Medicine, Neurotec, Karolinska University Hospital, Huddinge, Novum, 141 86 Stockholm, Sweden
    Behav Brain Res 169:10-20. 2006
    ....
  47. ncbi Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
    Camilla A Hansson
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Novum, SE 141 57 Huddinge, Sweden
    J Biol Chem 279:51654-60. 2004
    ..This novel localization of NCT, PS1, APH-1, and PEN-2 expands the role and importance of gamma-secretase activity to mitochondria...
  48. doi Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer's disease
    Ewa Kloskowska
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    J Cell Mol Med 14:1816-23. 2010
    ..The Tg6590 transgenic rat line should prove a suitable model of early AD for advanced studies including serial cerebrospinal fluid sampling, electrophysiology, neuroimaging or complex behavioural testing...
  49. pmc Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
    Am J Pathol 163:591-607. 2003
    ..A p70 S6 kinase modulated up-regulation of tau translation might contribute to PHF-tau accumulation in neurons with neurofibrillary changes...
  50. ncbi Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's disease
    S Akterin
    Section of Experimental Geriatrics, Neurotec Department, Karolinska Institutet, Kliniskt Forskningscentrum KFC, Novum, Huddinge, Sweden
    Cell Death Differ 13:1454-65. 2006
    ..Thus, Abeta neurotoxicity might be mediated by oxidation of GRX1 or TRX1 and subsequent activation of the ASK1 cascade. Deregulation of GRX1 and TRX1 antioxidant systems could be important events in AD pathogenesis...
  51. ncbi Calcium ionophore A23187 specifically decreases the secretion of beta-secretase cleaved amyloid precursor protein during apoptosis in primary rat cortical cultures
    K Sennvik
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine, KFC Novum, Huddinge, Sweden
    J Neurosci Res 63:429-37. 2001
    ..We conclude that calcium homeostasis is an important apoptotic effector specifically affecting the beta-secretase cleavage of APP...
  52. ncbi Interaction between estrogen receptor 1 and the epsilon4 allele of apolipoprotein E increases the risk of familial Alzheimer's disease in women
    K M Mattila
    Alzheimer s Disease Research Centre, KFC, Novum, Karolinska Institutet, S 14186, Huddinge, Sweden
    Neurosci Lett 282:45-8. 2000
    ..Furthermore, the Pp genotype frequency was found to be significantly increased in Finnish women with sporadic AD. We, thus, conclude that the ESR1 gene may have a role in the development of AD in females...
  53. ncbi Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population
    C Cornelius
    Aging Research Centre, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm Gerontology Research Centre, Stockholm, Sweden
    Neuroepidemiology 23:135-43. 2004
    ..23; 95% CI 0.03-1.68). This could be due to the small samples in our study, or to comorbidity contributing to the development of dementia in this elderly population...
  54. ncbi Economic aspects on drug therapy of dementia
    A Wimo
    Department of Neurotec, Aging Research Center, Karolinska Institute, Stockholm, Sweden
    Curr Pharm Des 10:295-301. 2004
    ..Available data show that there is support for a view that treatment is cost-neutral or perhaps cost saving which in combination with positive effects in terms of efficacy may indicate cost-effectiveness...
  55. ncbi Psychotropic drug use in elderly people with and without dementia
    M S Giron
    Division of Geriatric Medicine, Neurotec, Karolinska Institute, Stockholm, Sweden
    Int J Geriatr Psychiatry 16:900-6. 2001
    ..To determine the prevalence of psychotropic drug use in very old persons with and without dementia in two time periods, and describe the patterns of psychotropic drug use between institutions and non-institutions...
  56. ncbi Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells
    B O Popescu
    Karolinska Institute, Neurotec, Division of Geriatric Medicine, KFC, Novum, Huddinge, Sweden
    J Neurosci Res 66:122-34. 2001
    ..e., PARP and gelsolin), simultaneous with minimum detectable caspase-3 activation. Therefore, alternative cleavage of PS1 may play an important role for the regulation of the proteolytic cascade activated during apoptosis...
  57. ncbi Aging and the occurrence of dementia: findings from a population-based cohort with a large sample of nonagenarians
    E von Strauss
    Stockholm Gerontology Research Center, Division of Geriatric Medicine, Neurotec, Karolinska Institute, Stockholm, Sweden
    Arch Neurol 56:587-92. 1999
    ..This question is relevant both for understanding the pathogenetic mechanism of the dementias and for the public health prospective because of the increasing number of 85-year-old or older persons in our population...
  58. ncbi Early diagnosis of Alzheimer dementia based on clinical and biological factors
    O Almkvist
    Division of Geriatric Medicine, Huddinge University Hospital, Sweden
    Eur Arch Psychiatry Clin Neurosci 249:3-9. 1999
    ..It is concluded that still no single marker of AD exists, which makes it necessary to rely on data from multiple sources in order to arrive at the best possible diagnosis of AD...
  59. ncbi Vitamin B(12) and folate in relation to the development of Alzheimer's disease
    H X Wang
    Stockholm Gerontology Research Center and Division of Geriatric Medicine, Neurotec, Karolinska Institutet, Stockholm
    Neurology 56:1188-94. 2001
    ..To explore the associations of low serum levels of vitamin B(12) and folate with AD occurrence...
  60. ncbi Incidence of stroke in relation to cognitive function and dementia in the Kungsholmen Project
    L Zhu
    Stockholm Gerontology Research Center and Department of Geriatric Medicine, Neurotec, Karolinska Institute, Stockholm, Sweden
    Neurology 54:2103-7. 2000
    ..To investigate whether cognitive function is related to incidence of stroke...
  61. ncbi Growth-associated protein GAP-43 in the frontal cortex and in the hippocampus in Alzheimer's disease: an immunohistochemical and quantitative study
    N Bogdanovic
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge Hospital, Sweden
    J Neural Transm 107:463-78. 2000
    ..Our findings may suggest that in the frontal cortex, GAP-43 levels decline as a consequence of the synaptic degeneration, while in the hippocampus, sprouting processes, involving GAP-43, are active...
  62. ncbi Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication?
    Z Guo
    Stockholm Gerontology Research Center and Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Am J Epidemiol 153:225-31. 2001
    ..Further studies are needed to clarify whether use of antihypertensive medication, especially diuretics, modifies the effect of the allele...
  63. ncbi Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
    Xin Wen Zhou
    Karolinska Institutet, Department of Neurotec, Geriatric lab, Novum Plan 5, S 14157, Huddinge, Sweden
    Neurobiol Dis 22:657-68. 2006
    ..Assessments of levels of these abnormal proteins by dot blots may serve as a useful complement to the morphological evaluations in diagnosis of AD...
  64. ncbi Small heat shock proteins Hsp27 or alphaB-crystallin and the protein components of neurofibrillary tangles: tau and neurofilaments
    Cecilia Bjorkdahl
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI Alzheimer s Disease Research Center, Novum, Huddinge, Sweden
    J Neurosci Res 86:1343-52. 2008
    ..Furthermore, Hsp27 might also be involved in AD pathology by aggravating MT disruption by tau phosphorylation...
  65. ncbi Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice
    Zhiguo Chen
    Neurotec, Division of Experimental Geriatrics, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Brain Res 931:135-45. 2002
    ..This animal model could provide a valuable tool for exploring the role of excitotoxicity in neuropathological conditions and should be further evaluated in gene-targeting studies of neurodegenerative diseases...
  66. ncbi Alpha-MSH rescues neurons from excitotoxic cell death
    Asa Forslin Aronsson
    Division of Neurodegeneration and Neuroinflammation, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    J Mol Neurosci 33:239-51. 2007
    ..Furthermore, the administration of alpha-MSH resulted in a similar increase in cell viability, supporting the hypothesis that administration of alpha-MSH has rescuing effects on neurons subjected to excitotoxic insults...
  67. ncbi Cerebrovascular diseases and depression: epidemiology, mechanisms and treatment
    F Göthe
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Panminerva Med 54:161-70. 2012
    ..There is emerging evidence that treatment of cardiovascular disease and risk-factors can reduce the risk for late-life depression, but more studies are needed to test this hypothesis...
  68. doi Personality and lifestyle in relation to dementia incidence
    H X Wang
    Aging Research Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet, Gavlegatan 16, 113 30 Stockholm, Sweden
    Neurology 72:253-9. 2009
    ..The aim of the current study was to explore the separate and combined effects of neuroticism and extraversion on the risk of dementia, and to examine whether lifestyle factors may modify this association...
  69. ncbi Protective effect of Rolipram in experimental autoimmune neuritis: protection is associated with down-regulation of IFN-gamma and inflammatory chemokines as well as up-regulation of IL-4 in peripheral nervous system
    N Abbas
    Dept of Clinical Neuroscience, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
    Autoimmunity 32:93-9. 2000
    ..These observations call for further studies on the potential role of Rolipram in the treatment of autoimmune diseases...
  70. ncbi Elevated cortical zinc in Alzheimer disease
    D Religa
    Neurotec, Experimental Geriatrics, Karolinska Institutet, Stockholm, Sweden
    Neurology 67:69-75. 2006
    ..To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta) burden and dementia severity...
  71. ncbi Neuroglia in the inferior olivary nucleus during normal aging and Alzheimer's disease
    H Lasn
    Section for Clinical Geriatric, NEUROTEC Institutionen, Karolinska Institutet, Stockholm, Sweden
    J Cell Mol Med 10:145-56. 2006
    ..Using a novel unbiased quantitative method, we were able to describe significant oligodendroglial loss in the PO but the pathogenic mechanism behind remains unknown...
  72. ncbi White matter lesions impair initiation of FAS flow
    S E Fernaeus
    Department of Clinical Neuroscience and Family Medicine, Division of Geriatric Medicine, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 12:52-6. 2001
    ..The initial FAS performance was related to anterior WMH, in particular left frontal or lateral periventricular hyperintensities, whereas the late FAS performance was not related to any index of WMH...
  73. ncbi Predictors of progression from mild cognitive impairment to Alzheimer disease
    K Palmer
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Neurology 68:1596-602. 2007
    ..To determine the occurrence of neuropsychiatric symptomatology and the relation to future development of Alzheimer disease (AD) in persons with and without mild cognitive impairment (MCI)...
  74. ncbi Work-related physical activity and the risk of dementia and Alzheimer's disease
    Suvi Rovio
    Aging Research Center, NVS, Karolinska Institutet, Stockholm, Sweden
    Int J Geriatr Psychiatry 22:874-82. 2007
    ..This study aimed to clarify the association between work-related physical activity and dementia/AD...
  75. ncbi IL-18 deficiency aggravates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice due to an overcompensation by IL-12
    Xing Mei Zhang
    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital in Huddinge, Stockholm, Sweden
    Exp Neurol 205:64-73. 2007
    ..These results suggest that the role of IL-18 in excitotoxic injury in IL-18 deficient mice may be overcompensated by increased IL-12 secretion...
  76. ncbi Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
    Suvi Rovio
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 4:705-11. 2005
    ..The aim of our study was to investigate the association between leisure-time physical activity at midlife and the subsequent development of dementia and Alzheimer's disease (AD)...
  77. ncbi Pharmacoeconomics of mild cognitive impairment
    Anders Wimo
    Division of Geriatric Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Acta Neurol Scand Suppl 179:94-9. 2003
    ..From the Kungsholmen project in Sweden, there are indications that the postponement between MCI and manifest dementia may result in short-term benefits (a few years) of about SEK50,000 (5300 US dollars)...
  78. ncbi Prevention of Alzheimer's disease and dementia. Major findings from the Kungsholmen Project
    Laura Fratiglioni
    Karolinska Institutet, Aging Research Center, Division of Geriatric Epidemiology, NVS, and Stockholm Gerontology Research Center, Gavlegatan 16, S 113 30 Stockholm, Sweden
    Physiol Behav 92:98-104. 2007
    ..At the moment it is also possible to delineate some preventative strategies for dementia...
  79. doi Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology
    R Liu
    Karolinska Institutet, KI Alzheimer Disease Research Center KI ADRC, Novum, Huddinge, Sweden
    J Cell Mol Med 12:241-57. 2008
    ....
  80. ncbi Mild cognitive impairment in the population and physical health: data on 1,435 individuals aged 75 to 95
    G B Frisoni
    Stockholm Gerontology Research Center, Division of Geriatric Medicine, Neurotec, Karolinska Institute, Sweden
    J Gerontol A Biol Sci Med Sci 55:M322-8. 2000
    ..The physical health correlates of mild cognitive impairment (MCI) in the older individual are poorly known. The aim of this study was to investigate the relationship between physical health and MCI with population data...
  81. ncbi IPECAD5--Fifth International Pharmaco-Economic Conference on Alzheimer's Disease
    A Gustavsson
    KI Alzheimer s Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum Plan 5, 141 86 Stockholm, Sweden
    J Nutr Health Aging 14:358-60. 2010
    ....
  82. ncbi The interplay of institution and family caregiving: relations between patient hassles, nursing home hassles and caregivers' burnout
    B Almberg
    Stockholm Gerontology Research Center and Department of Clinical Neuroscience and Family Medicine Division of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Int J Geriatr Psychiatry 15:931-9. 2000
    ..All subscales except basic ADL were correlated to burnout. However, regression analysis showed the nursing home hassles to be the most important stresses explaining variance in burnout among family caregivers...
  83. doi The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study
    A Marengoni
    NVS Department, Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 265:288-95. 2009
    ..We aimed to disentangle the effect of chronic multimorbidity and disability on 3-year functional decline and survival in the elderly...
  84. ncbi High suicidal ideation in persons testing for Huntington's disease
    T B Robins Wahlin
    Stockholm Gerontology Research Center, Department of Clinical Neuroscience and Occupational Therapy and Elderly Care Research, Karolinska Institute, Sweden
    Acta Neurol Scand 102:150-61. 2000
    ..The need for counseling, using a well designed protocol, and the importance of focusing on suicide risk of participants in predictive testing programs is emphasized...
  85. ncbi Flow cytometry as a method for studying effects of stressors on primary rat neurons
    H Behbahani
    Neurotec Department, Division of Experimental Geriatrics, Novum, KASPAC, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Neurosci Res 82:432-41. 2005
    ..This technique could be useful for screening and testing of pharmacological compounds relevant to neurodegenerative disorders...
  86. ncbi P0 glycoprotein peptides 56-71 and 180-199 dose-dependently induce acute and chronic experimental autoimmune neuritis in Lewis rats associated with epitope spreading
    J Zhu
    Division of Geriatric Medicine, Huddinge University Hospital, S 141 86 Huddinge, Stockholm, Sweden
    J Neuroimmunol 114:99-106. 2001
    ..The results support the hypothesis that high dose autoantigen immunization induces extensive determinant spreading and chronic course of autoimmune diseases...
  87. ncbi IDEAL: a 6-month, double-blind, placebo-controlled study of the first skin patch for Alzheimer disease
    B Winblad
    Karolinska Institutet Alzheimer Research Center, Stockholm, Sweden
    Neurology 69:S14-22. 2007
    ..Local skin tolerability was good. The transdermal patch with rivastigmine may offer additional therapeutic benefits and may prove to be the best delivery system for this drug to treat AD...
  88. ncbi Education and dementia: what lies behind the association?
    T Ngandu
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, 11330 Stockholm, Sweden
    Neurology 69:1442-50. 2007
    ..People with low education have unhealthier lifestyles and more cardiovascular risk factors, but it is unclear how this affects the association between education and dementia...
  89. ncbi Late-life body mass index and dementia incidence: nine-year follow-up data from the Kungsholmen Project
    Anna Rita Atti
    Aging Research Center, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    J Am Geriatr Soc 56:111-6. 2008
    ..To describe the association between late-life body mass index (BMI) and dementia development with a time perspective and to investigate the effect of weight changes on dementia incidence...
  90. doi Donepezil treatment of severe Alzheimer's disease in nursing home settings. A responder analysis
    Vesna Jelic
    Division of Geriatric Medicine, Department of NVS, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Dement Geriatr Cogn Disord 26:458-66. 2008
    ..Our objective was to define clinically meaningful outcomes in donepezil versus placebo treatment in severe Alzheimer's disease (AD) and to describe characteristics of responders...
  91. doi Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
    Xin Wen Zhou
    Karolinska Institutet, KI Alzheimer Disease Research Center KI ADRC, Novum, Huddinge, Sweden
    Neurobiol Dis 31:386-94. 2008
    ....
  92. pmc Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden
    Alessandra Marengoni
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Am J Public Health 98:1198-200. 2008
    ..Multimorbidity is the most common clinical picture of the elderly and may be increased by unhealthy behaviors linked to education...
  93. ncbi Cerebrovascular disease, APOE epsilon4 allele and cognitive decline in a cognitively normal population
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurol Res 28:650-6. 2006
    ..To investigate whether cerebrovascular disease (CVD) and apolipoprotein E (APOE) epsilon4 allele were associated with cognitive decline and whether the relationship between CVD and cognitive decline varied by APOE epsilon4 status...
  94. doi Genetic association to the amyloid plaque associated protein gene COL25A1 in Alzheimer's disease
    Charlotte Forsell
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KASPAC, Novum, S 141 57 Huddinge, Sweden
    Neurobiol Aging 31:409-15. 2010
    ..Thus, in addition to the biochemical data, there is now genetic evidence of association between COL25A1 and risk for Alzheimer's disease...
  95. ncbi Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study
    Bengt Winblad
    Karolinska Institutet, Alzheimer s Disease Research Center, Department of Neurotec, Division of Geriatric Medicine, Karolinska University Hospital, Huddinge, 14186 Stockholm, Sweden
    Lancet 367:1057-65. 2006
    ..Our aim was to ascertain the effectiveness of donepezil in patients with severe Alzheimer's disease, by focusing primarily on cognition and activities of daily living...
  96. doi Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice
    Shun Wei Zhu
    Alzheimer s Disease Research Center, NVS Department, Karolinska Institutet, Stockholm 141 86, Sweden
    Behav Brain Res 197:339-46. 2009
    ..Here we provide additional evidence that exploratory activity is influenced by BDNF...
  97. ncbi Cytokine production by a human microglial cell line: effects of beta-amyloid and alpha-melanocyte-stimulating hormone
    Catharina Lindberg
    Karolinska Institutet, Neurotec Department, Division of Experimental Geriatrics, Karolinska University Hospital Huddinge, Novum, SE 141 86 Stockholm, Sweden
    Neurotox Res 8:267-76. 2005
    ..RT-PCR showed the expression of MCR1, MCR3, MCR4 and MCR5 mRNA. The combined data suggest that the effect of alpha-MSH in increasing IL-6 release from the human microglial cell line is mediated by MCR3 or MCR5...
  98. pmc Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice
    Xing Mei Zhang
    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
    J Neuroinflammation 7:26. 2010
    ..Additionally, IL-18 participates in fundamental inflammatory processes that increase during aging. In the present study, we were interested in the role of IL-18 in KA-induced neurodegeneration in aged female C57BL/6 mice...
  99. doi High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age
    Francesca Mangialasche
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 20:1029-37. 2010
    ..The neuroprotective effect of vitamin E seems to be related to the combination of different forms, rather than to alpha-tocopherol alone, whose efficacy in interventions against AD is currently debated...
  100. doi Interactions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cells
    Xin Wen Zhou
    Karolinska Institutet, KI Alzheimer Disease Research Center KI ADRC, Novum, Huddinge, Sweden
    J Alzheimers Dis 17:929-37. 2009
    ..The final phosphorylation state of tau is possibly caused by the synergic action of the three enzymes...
  101. pmc Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease
    Jin Jing Pei
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Huddinge, Sweden
    Am J Pathol 163:845-58. 2003
    ....