Eric Westman

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Regional magnetic resonance imaging measures for multivariate analysis in Alzheimer's disease and mild cognitive impairment
    Eric Westman
    Department of Neuroimaging, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Brain Topogr 26:9-23. 2013
  2. doi request reprint Combining MRI and CSF measures for classification of Alzheimer's disease and prediction of mild cognitive impairment conversion
    Eric Westman
    Department of Neuroimaging, Institute of Psychiatry, King s College London, London, UK
    Neuroimage 62:229-38. 2012
  3. doi request reprint Magnetic resonance imaging and magnetic resonance spectroscopy for detection of early Alzheimer's disease
    Eric Westman
    NIHR Specialist Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust, Kings College London, Institute of Psychiatry, London, UK
    J Alzheimers Dis 26:307-19. 2011
  4. doi request reprint AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America
    Eric Westman
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neuroimage 58:818-28. 2011
  5. doi request reprint Combining MRI and MRS to distinguish between Alzheimer's disease and healthy controls
    Eric Westman
    Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Alzheimers Dis 22:171-81. 2010
  6. doi request reprint Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls
    Eric Westman
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neuroimage 54:1178-87. 2011
  7. pmc Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's disease
    Eric Westman
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e22506. 2011
  8. pmc In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment
    Eric Westman
    Department of Neurobiology, Health Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    BMC Neurosci 10:33. 2009
  9. doi request reprint Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease
    Latha Velayudhan
    King s College London, Institute of Psychiatry, London and NIHR Biomedical Research Centre for Mental Health, London, UK
    J Alzheimers Dis 33:755-66. 2013
  10. doi request reprint The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months
    Andrew Simmons
    NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King s College London, London, UK
    Int J Geriatr Psychiatry 26:75-82. 2011

Collaborators

Detail Information

Publications29

  1. pmc Regional magnetic resonance imaging measures for multivariate analysis in Alzheimer's disease and mild cognitive impairment
    Eric Westman
    Department of Neuroimaging, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Brain Topogr 26:9-23. 2013
    ..The appropriate choice of input for multivariate analysis in AD and MCI is of great importance. The results support the use of un-normalised cortical thickness measures and volumes normalised by ICV...
  2. doi request reprint Combining MRI and CSF measures for classification of Alzheimer's disease and prediction of mild cognitive impairment conversion
    Eric Westman
    Department of Neuroimaging, Institute of Psychiatry, King s College London, London, UK
    Neuroimage 62:229-38. 2012
    ....
  3. doi request reprint Magnetic resonance imaging and magnetic resonance spectroscopy for detection of early Alzheimer's disease
    Eric Westman
    NIHR Specialist Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust, Kings College London, Institute of Psychiatry, London, UK
    J Alzheimers Dis 26:307-19. 2011
    ..Adding MRS measures to a multivariate analysis of MRI measures resulted in significantly better classification than using MRI measures alone. The method shows strong potential for discriminating between Alzheimer's disease and controls...
  4. doi request reprint AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America
    Eric Westman
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neuroimage 58:818-28. 2011
    ..This demonstrates that the methods used are robust and that large data sets can be combined if MRI imaging protocols are carefully aligned...
  5. doi request reprint Combining MRI and MRS to distinguish between Alzheimer's disease and healthy controls
    Eric Westman
    Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Alzheimers Dis 22:171-81. 2010
    ..The OPLS method shows strong potential for discriminating between Alzheimer's disease and controls...
  6. doi request reprint Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls
    Eric Westman
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neuroimage 54:1178-87. 2011
    ..Combining the different MRI measures together resulted in a significantly better classification than using them separately. OPLS also shows potential for predicting conversion from MCI to AD...
  7. pmc Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's disease
    Eric Westman
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e22506. 2011
    ..2) To assess how well the three techniques perform when predicting future conversion from mild cognitive impairment (MCI) to AD...
  8. pmc In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment
    Eric Westman
    Department of Neurobiology, Health Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    BMC Neurosci 10:33. 2009
    ..The aim of this study was to investigate if multivariate data analysis could detect changes in the pattern of the metabolic profile after donepezil treatment...
  9. doi request reprint Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease
    Latha Velayudhan
    King s College London, Institute of Psychiatry, London and NIHR Biomedical Research Centre for Mental Health, London, UK
    J Alzheimers Dis 33:755-66. 2013
    ..Focusing on structural analyses that predict decline can identify those individuals at greatest risk for future cognitive loss. This may have potential for increasing the efficacy of early intervention...
  10. doi request reprint The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months
    Andrew Simmons
    NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King s College London, London, UK
    Int J Geriatr Psychiatry 26:75-82. 2011
    ..To describe the AddNeuroMed imaging framework for multi-centre magnetic resonance imaging (MRI) assessment of longitudinal changes in Alzheimer's disease and report on early results from the first 24 months of the project...
  11. ncbi request reprint Different multivariate techniques for automated classification of MRI data in Alzheimer's disease and mild cognitive impairment
    Carlos Aguilar
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Psychiatry Res 212:89-98. 2013
    ..The value of the multivariate models derived from the classification of AD vs. CTL was shown to be robust and efficient in the identification of MCI converters...
  12. doi request reprint MRI measures of Alzheimer's disease and the AddNeuroMed study
    Andrew Simmons
    NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King s College London and the MRC Centre for Neurodegeneration, King s College London, Institute of Psychiatry, London SE5 8AF, United Kingdom
    Ann N Y Acad Sci 1180:47-55. 2009
    ..Measurements of normalized whole brain volume, whole brain cortical thickness, and point-by-point group-based cortical thickness measurements, demonstrating the power of the automated image analysis techniques employed, are reported...
  13. pmc Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
    Madhav Thambisetty
    King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 67:739-48. 2010
    ..Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD)...
  14. ncbi request reprint Age related changes in brain metabolites observed by 1H MRS in APP/PS1 mice
    Johanna Oberg
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 14186 Stockholm, Sweden
    Neurobiol Aging 29:1423-33. 2008
    ..First differences in metabolite content were readily seen at 2.5 months, when volume defects in tg mice were present, but no amyloid plaques...
  15. ncbi request reprint Reorganization of sensory processing below the level of spinal cord injury as revealed by fMRI
    Toshiki Endo
    Department of Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
    Exp Neurol 209:155-60. 2008
    ..Combining brain and spinal cord fMRI allows the visualization of neuronal activities along the entire neuroaxis and thereby an evaluation of the different plastic responses to CNS injuries that occur in the brain and the spinal cord...
  16. ncbi request reprint Carbamazepine treatment recovered low N-acetylaspartate+N-acetylaspartylglutamate (tNAA) levels in the megencephaly mouse BALB/cByJ-Kv1.1(mceph/mceph)
    Eric Westman
    Department of Neurobiology, Health Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Dis 26:221-8. 2007
    ..Furthermore, CBZ treatment recovered tCho and tNAA levels in mceph/mceph. Thus, distinct differences in MRS spectra between mceph/mceph and wt mice were depicted and treatment effects of CBZ were monitored using MRS...
  17. pmc 1H-MRS in spinal cord injury: acute and chronic metabolite alterations in rat brain and lumbar spinal cord
    Matthias Erschbamer
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, SE 171 77 Stockholm, Sweden
    Eur J Neurosci 33:678-88. 2011
    ..We provide evidence for dynamic temporal changes at both ends of the neuraxis, cortex cerebri and distal spinal cord, while deep brain areas appear less affected...
  18. pmc Ratio of Aβ42/P-tau181p in CSF is associated with aberrant default mode network in AD
    Xiaozhen Li
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Sci Rep 3:1339. 2013
    ..This finding implicates that the brain functional connectivity within DMN is affected by pathological changes at early stage in AD. This may provide a better understanding of AD pathology progression and improve AD diagnosis...
  19. ncbi request reprint Structural brain changes associated with depressive symptoms in the elderly with Alzheimer's disease
    Aleksandra Lebedeva
    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 85:930-5. 2014
    ..To examine neuroanatomical changes associated with depressive symptoms in Alzheimer's disease (AD) and the relationship between brain structure and cerebrospinal fluid (CSF) AD biomarkers in depressed and non-depressed patients...
  20. ncbi request reprint Initial cognitive decline is associated with cortical thinning in early Parkinson disease
    Joana B Pereira
    From the Department of Neurobiology, Care Sciences and Society J B P, E W, and Centre for Alzheimer s Disease Research, Department of Neurobiology, Care Sciences and Society D A, Karolinska Institutet, Stockholm Centre for Molecular Medicine P S, Department of Neurology and Clinical Neuroscience, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden Department of Psychiatry and Neurology D W, Perelman School of Medicine at the University of Pennsylvania, Philadelphia VA Medical Center and The Norwegian Center for Movement Disorders K B, and Centre for Age Related Medicine, Department of Psychiatry A L, D A, Stavanger University Hospital, Stavanger, Norway
    Neurology 82:2017-25. 2014
    ....
  21. pmc Kv1.1 null mice have enlarged hippocampus and ventral cortex
    Ann Sophie Persson
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    BMC Neurosci 8:10. 2007
    ..1 are known to cause episodic ataxia type 1 and temporal lobe epilepsy. Mice that express a malfunctional, truncated Kv1.1 (BALB/cByJ-Kv1.1mceph/mceph) show a markedly enlarged hippocampus and ventral cortex in adulthood...
  22. doi request reprint Regional vulnerability of hippocampal subfields to aging measured by structural and diffusion MRI
    Joana B Pereira
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain Institute of Biomedical Research August Pi i Sunyer IDIBAPS, Barcelona, Spain Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Hippocampus 24:403-14. 2014
    ..These results indicate that age has an effect both on volume and diffusion tensor imaging measures in different subfields, suggesting they provide complementary information on age-related processes in the hippocampus...
  23. ncbi request reprint Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study
    Steven J Kiddle
    King s College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK
    J Alzheimers Dis 38:515-31. 2014
    ..This suggests that AD pathology does affect the blood proteome with some consistency...
  24. doi request reprint Multispectral MRI segmentation of age related white matter changes using a cascade of support vector machines
    Soheil Damangir
    Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden
    J Neurol Sci 322:211-6. 2012
    ..This is a completely competitive and fast automatic segmentation framework, capable of using different input sequences, without changes or restrictions of the image analysis algorithm...
  25. doi request reprint Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment
    Per Svenningsson
    Centre for Molecular Medicine, Department of Neurology and Clinical Neuroscience, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Lancet Neurol 11:697-707. 2012
    ..Whether these or other treatments can delay the progression from mild cognitive impairment to dementia in Parkinson's disease is a key research question...
  26. pmc Is the subcallosal medial prefrontal cortex a common site of atrophy in Alzheimer's disease and frontotemporal lobar degeneration?
    Olof Lindberg
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet Stockholm, Sweden
    Front Aging Neurosci 4:32. 2012
    ..Atrophy of the SMPC may thus be affected by either initial temporal or initial frontal atrophy, making it a common site of frontal atrophy in the dementia subtypes investigated...
  27. doi request reprint Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation
    Michael Scholl
    Division of Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 32:1388-99. 2011
    ..Global cortical CMRglc and cognition were distinctly decreased. PIB binding was comparable with sporadic AD patterns but showing slightly higher striatal levels...
  28. ncbi request reprint Cognitive decline is mediated by gray matter changes during middle age
    Daniel Ferreira
    Faculty of Psychology, University of La Laguna, La Laguna, Tenerife, Spain Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 35:1086-94. 2014
    ..To define the early stages of the aging process may allow early detection of pathologic changes and therapeutic interventions. ..
  29. ncbi request reprint Blood oxygenation level-dependent visualization of synaptic relay stations of sensory pathways along the neuroaxis in response to graded sensory stimulation of a limb
    Johan Lilja
    Department of Neuroscience, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Neurosci 26:6330-6. 2006
    ..Rat spinal cord fMRI should become a useful tool in experimental spinal cord injury and pain research...