Eddie Weitzberg

Summary

Affiliation: Karolinska Hospital
Country: Sweden

Publications

  1. ncbi request reprint Paranasal sinus ventilation by humming
    Svante Granqvist
    Department of Speech Music Hearing, KTH, Stockholm, Sweden
    J Acoust Soc Am 119:2611-7. 2006
  2. ncbi request reprint Humming greatly increases nasal nitric oxide
    Eddie Weitzberg
    Department of Anesthesiology and Intensive Care, Karolinska Hospital, Stockholm, Sweden
    Am J Respir Crit Care Med 166:144-5. 2002
  3. doi request reprint Multivariate outcome prediction in traumatic brain injury with focus on laboratory values
    David W Nelson
    Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care, Karolinska Institutet, Stockholm, Sweden
    J Neurotrauma 29:2613-24. 2012
  4. pmc Analyses of cerebral microdialysis in patients with traumatic brain injury: relations to intracranial pressure, cerebral perfusion pressure and catheter placement
    David W Nelson
    Neurointensive Care Unit, Karolinska University Hospital, Stockholm, Sweden
    BMC Med 9:21. 2011
  5. doi request reprint Inhibition of cancer cell replication by inorganic nitrite
    Edward Morcos
    Karolinska University Hospital, Stockholm, Sweden
    Nutr Cancer 62:501-4. 2010
  6. ncbi request reprint Comparison of a single indicator and gravimetric technique for estimation of extravascular lung water in endotoxemic pigs
    Patrik Rossi
    Department of Physiology and Pharmacology, Section of Anaesthesiology and Intensive Care Medicine, Karolinska Institute, Stockholm, Sweden
    Crit Care Med 34:1437-43. 2006
  7. doi request reprint Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care
    Eddie Weitzberg
    Section of Anesthesiology and Intensive Care, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1460-75. 2010
  8. ncbi request reprint Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans
    Filip J Larsen
    Departments of Physiology and Pharmacology FJL, TAS, MPM, JOL, and EW, Medical Biochemistry and Biophysics, Division of Physiological Chemistry II AC and CEW, and Clinical Science and Education, Södersjukhuset TN, Karolinska Institutet, Stockholm, Sweden, and the Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden BE
    Am J Clin Nutr 99:843-50. 2014
  9. ncbi request reprint Rectal mucosal nitric oxide in differentiation of inflammatory bowel disease and irritable bowel syndrome
    Claudia I Reinders
    Division of Pharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Clin Gastroenterol Hepatol 3:777-83. 2005
  10. ncbi request reprint Intragastric nitric oxide is abolished in intubated patients and restored by nitrite
    Håkan Björne
    Department of Anesthesiology and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
    Crit Care Med 33:1722-7. 2005

Detail Information

Publications40

  1. ncbi request reprint Paranasal sinus ventilation by humming
    Svante Granqvist
    Department of Speech Music Hearing, KTH, Stockholm, Sweden
    J Acoust Soc Am 119:2611-7. 2006
    ....
  2. ncbi request reprint Humming greatly increases nasal nitric oxide
    Eddie Weitzberg
    Department of Anesthesiology and Intensive Care, Karolinska Hospital, Stockholm, Sweden
    Am J Respir Crit Care Med 166:144-5. 2002
    ..Nasal NO measurements during humming may be a useful noninvasive test of sinus NO production and ostial patency. In addition, any therapeutic effects of the improved sinus ventilation caused by humming should be investigated...
  3. doi request reprint Multivariate outcome prediction in traumatic brain injury with focus on laboratory values
    David W Nelson
    Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care, Karolinska Institutet, Stockholm, Sweden
    J Neurotrauma 29:2613-24. 2012
    ..In total, laboratory variables added an additional 1.3-4.4% to pseudo R²...
  4. pmc Analyses of cerebral microdialysis in patients with traumatic brain injury: relations to intracranial pressure, cerebral perfusion pressure and catheter placement
    David W Nelson
    Neurointensive Care Unit, Karolinska University Hospital, Stockholm, Sweden
    BMC Med 9:21. 2011
    ..They are used as surrogate monitors of cerebral blood flow and have an established relation to outcome. The purpose of this study was to investigate the relations between MD parameters and ICP and/or CPP in patients with TBI...
  5. doi request reprint Inhibition of cancer cell replication by inorganic nitrite
    Edward Morcos
    Karolinska University Hospital, Stockholm, Sweden
    Nutr Cancer 62:501-4. 2010
    ..The inhibitory effect is likely caused by nitric oxide and possibly other reactive nitrogen oxides formed from acidified nitrite...
  6. ncbi request reprint Comparison of a single indicator and gravimetric technique for estimation of extravascular lung water in endotoxemic pigs
    Patrik Rossi
    Department of Physiology and Pharmacology, Section of Anaesthesiology and Intensive Care Medicine, Karolinska Institute, Stockholm, Sweden
    Crit Care Med 34:1437-43. 2006
    ..To compare the single thermal indicator dilution (STID) technique for measurement of extravascular lung water (EVLW(STID)) with gravimetrically determined EVLW (EVLW(GRAV)) in anesthetized pigs under sham and endotoxemic conditions...
  7. doi request reprint Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care
    Eddie Weitzberg
    Section of Anesthesiology and Intensive Care, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1460-75. 2010
    ..In this article, we present an overview of this field of research with emphasis on relevance in anesthesiology and intensive care...
  8. ncbi request reprint Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans
    Filip J Larsen
    Departments of Physiology and Pharmacology FJL, TAS, MPM, JOL, and EW, Medical Biochemistry and Biophysics, Division of Physiological Chemistry II AC and CEW, and Clinical Science and Education, Södersjukhuset TN, Karolinska Institutet, Stockholm, Sweden, and the Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden BE
    Am J Clin Nutr 99:843-50. 2014
    ..The bioactivation of nitrate involves its active accumulation in saliva followed by a sequential reduction to nitrite, nitric oxide, and other reactive nitrogen species...
  9. ncbi request reprint Rectal mucosal nitric oxide in differentiation of inflammatory bowel disease and irritable bowel syndrome
    Claudia I Reinders
    Division of Pharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Clin Gastroenterol Hepatol 3:777-83. 2005
    ..To further evaluate this disease marker, we compared NO in patients with irritable bowel syndrome (IBS) with those found in patients with active IBD and in healthy control subjects...
  10. ncbi request reprint Intragastric nitric oxide is abolished in intubated patients and restored by nitrite
    Håkan Björne
    Department of Anesthesiology and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
    Crit Care Med 33:1722-7. 2005
    ..We studied intragastric NO levels in healthy controls and in intubated intensive care unit patients before and after supplementation with nitrite...
  11. ncbi request reprint Technology insight: calprotectin, lactoferrin and nitric oxide as novel markers of inflammatory bowel disease
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Nat Clin Pract Gastroenterol Hepatol 2:96-102. 2005
    ..Here, we discuss what is known about these markers, how they could be used in clinical practice and how they can complement existing techniques used for the diagnosis and monitoring of inflammatory bowel disease...
  12. doi request reprint Inhaled tezosentan reduces pulmonary hypertension in endotoxin-induced lung injury
    Björn P Persson
    Section of Anaesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Shock 32:427-34. 2009
    ..These effects were obtained with only minor systemic uptake of tezosentan and without affecting circulating levels of plasma ET-1 as compared with intravenous administration...
  13. doi request reprint Novel aspects of dietary nitrate and human health
    Eddie Weitzberg
    Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Annu Rev Nutr 33:129-59. 2013
    ..In our diet, vegetables are the major source of nitrate that can fuel a nitrate-nitrite-NO pathway. Herein we discuss the nutritional aspects of this pathway and what is presently known about the implications for human health. ..
  14. doi request reprint Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans
    Tomas A Schiffer
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Respir Physiol Neurobiol 185:339-48. 2013
    ..During cycle ergometry nitrate had no effect on SaO(2), FETO(2) or maximum apnea duration. The negative effects of inorganic nitrate during static apnea may be explained by an attenuated diving response...
  15. doi request reprint NO generation from inorganic nitrate and nitrite: Role in physiology, nutrition and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Division of Pharmacology Karolinska Institutet, Stockholm, Sweden
    Arch Pharm Res 32:1119-26. 2009
    ..Finally, there is an intriguing nutritional aspect to this, since the major supply of nitrate and nitrite in our bodies comes from our everyday diet. Here we review recent advances in this exciting area of research...
  16. ncbi request reprint Cardioprotective effects of vegetables: is nitrate the answer?
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet 171 77, Stockholm, Sweden
    Nitric Oxide 15:359-62. 2006
    ....
  17. ncbi request reprint NO generation from nitrite and its role in vascular control
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 25:915-22. 2005
    ..With this new knowledge, nitrate and nitrite should probably be viewed as storage pools for NO rather than inert waste products. Here we discuss novel aspects of nitrite-dependent NO generation in vivo and its role in vascular control...
  18. pmc Nitrate and nitrite in biology, nutrition and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Nat Chem Biol 5:865-9. 2009
    ..The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm...
  19. ncbi request reprint Outcome of traumatic brain injuries in 1,508 patients: impact of prehospital care
    Anders Rudehill
    Department of Anesthesiology and Intensive Care, Karolinska Hospital and Institute, Stockholm, Sweden
    J Neurotrauma 19:855-68. 2002
    ..We posit that the introduction of effective prehospital care most likely contributed to the improved postresuscitation neurological status and consequently to the better outcome observed after January 1993...
  20. ncbi request reprint Totally implantable subcutaneous port system versus central venous catheter placed before induction chemotherapy in patients with acute leukaemia-a randomized study
    Eva Johansson
    Division of Hematology, Department of Medicine, Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Support Care Cancer 12:99-105. 2004
    ..02). Despite fewer infectious complications in the PORT group the use of a double-lumen CVC is advocated in patients with AL undergoing induction treatment due to the risk of extensive local bleeding after placement of the PORT...
  21. ncbi request reprint Multiple single-breath measurements of nitric oxide in the intubated patient
    Daniel C Törnberg
    Department of Anesthesiology and Intensive Care, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 168:1210-5. 2003
    ..Further studies will reveal whether this methodology will improve the value of exhaled NO analysis in intubated, mechanically ventilated patients with pulmonary disease...
  22. pmc Endothelin receptor A antagonism attenuates renal medullary blood flow impairment in endotoxemic pigs
    Johan Fenhammar
    Department of Anaesthesiology and Intensive Care, Karolinska University Hospital Huddinge, Huddinge, Stockholm, Sweden
    PLoS ONE 6:e21534. 2011
    ..Here we investigated if the renal circulatory and metabolic effects of endothelin during endotoxemia are mediated through activation of endothelin-A receptors...
  23. ncbi request reprint Intestinal nitric oxide in the normal and endotoxemic pig
    Rickard E Malmström
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Shock 18:456-60. 2002
    ..We conclude that intestinal NO is a product of mucosal NO synthase activity, and is profoundly decreased during endotoxemia in the pig...
  24. pmc Intravesical nitric oxide delivery for prevention of catheter-associated urinary tract infections
    Stefan Carlsson
    Department of Surgery, Section of Urology, Karolinska Hospital, and Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Stockholm, Sweden
    Antimicrob Agents Chemother 49:2352-5. 2005
    ..Future clinical trials will reveal whether this novel approach for the intravesical delivery of an antibacterial gas could be used to prevent catheter-associated infections...
  25. doi request reprint Extended analysis of early computed tomography scans of traumatic brain injured patients and relations to outcome
    David W Nelson
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    J Neurotrauma 27:51-64. 2010
    ..Finally we present a practical clinical "rule of thumb" to help predict the probability of unfavorable outcome using clinical and CT variables...
  26. ncbi request reprint Increased rectal nitric oxide in children with active inflammatory bowel disease
    Tryggve Ljung
    Departments of Gastroenterology and Hepatology, Karolinska Hospital, Stockholm, Sweden
    J Pediatr Gastroenterol Nutr 34:302-6. 2002
    ..The aim of the current study was to determine whether this method could be applied to identify inflammatory activity in ulcerative colitis and Crohn disease in children...
  27. pmc Nitrite in saliva increases gastric mucosal blood flow and mucus thickness
    HåKan Björne H
    Department of Anesthesiology and Intensive Care, Karolinska Hospital, Stockholm, Sweden
    J Clin Invest 113:106-14. 2004
    ..These effects are likely mediated through nonenzymatic generation of NO via activation of guanylyl cyclase. This supports a gastroprotective role of salivary nitrate/nitrite...
  28. ncbi request reprint Wedging the pulmonary artery catheter: changes in left atrial and pulmonary artery pressures and risk for perforation
    Göran Settergren
    Department of Surgical Sciences, Karolinska University Hospital, Stockholm, Sweden
    J Cardiothorac Vasc Anesth 20:311-4. 2006
    ..The authors studied whether wedging would alter mean left atrial pressure (LAP), and report perforations with PACs in their unit since 1975...
  29. ncbi request reprint Differentiated and dose-related cardiovascular effects of a dual endothelin receptor antagonist in endotoxin shock
    David Konrad
    Department of Surgical Sciences, Section for Anaesthesiology and Intensive Care, Karolinska Institute, Stockholm, Sweden
    Crit Care Med 32:1192-9. 2004
    ..To evaluate the effects of endothelin receptor antagonism on cardiac performance in endotoxin shock...
  30. ncbi request reprint Endogenous nitric oxide release by vasoactive drugs monitored in exhaled air
    Rickard E Malmström
    Department of Surgical Sciences, Karolinska Institute, S 17176 Stockholm, Sweden
    Am J Respir Crit Care Med 168:114-20. 2003
    ..Moreover, the possibility of using exhaled NO as an indicator of pulmonary endothelial dysfunction merits further studies...
  31. ncbi request reprint Humming, nitric oxide, and paranasal sinus obstruction
    Jon O Lundberg
    JAMA 289:302-3. 2003
  32. pmc Rectal nitric oxide gas and stool cytokine levels during the course of infectious gastroenteritis
    Anders Enocksson
    Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Clin Diagn Lab Immunol 11:250-4. 2004
    ..Our data point to the possibility of using this easy, minimally invasive method for luminal NO measurement as a diagnostic tool, among others, to evaluate the degree of intestinal inflammation in patients with infectious gastroenteritis...
  33. doi request reprint Nitrite reduction to nitric oxide in the vasculature
    Jon O Lundberg
    Am J Physiol Heart Circ Physiol 295:H477-8. 2008
  34. ncbi request reprint A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
    Emmelie A Jansson
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, SE 171 77 Stockholm, Sweden
    Nat Chem Biol 4:411-7. 2008
    ..Our findings suggest a role for mammalian nitrate reduction in regulation of nitrite and NO homeostasis...
  35. pmc Extrapulmonary effects of nitric oxide inhalation therapy: time to consider new dosing regimes?
    Jon O Lundberg
    Crit Care 12:406. 2008
  36. doi request reprint The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Nat Rev Drug Discov 7:156-67. 2008
    ....
  37. ncbi request reprint Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate
    Emmelie A Jansson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 77, Sweden
    Free Radic Biol Med 42:510-8. 2007
    ..Future studies will reveal if a diet rich in nitrate can offer an additional nutritional approach to preventing and treating peptic ulcer disease...
  38. ncbi request reprint Endothelin and nitric oxide in inflammation: could there be a need for endothelin blocking anti-inflammatory drugs?
    Rickard E Malmström
    J Hypertens 22:27-9. 2004
  39. ncbi request reprint Cerebral microdialysis of patients with severe traumatic brain injury exhibits highly individualistic patterns as visualized by cluster analysis with self-organizing maps
    David W Nelson
    Department of Anaesthesiology and Intensive Care, Karolinska University Hospital, Stockholm Sweden
    Crit Care Med 32:2428-36. 2004
    ..To analyze patterns of cerebral microdialysis in patients with traumatic brain injury and, with a neural network methodology, investigate pattern relationships to intracranial pressure and cerebral perfusion pressure...
  40. ncbi request reprint Letter regarding the article by Katz et al, "Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure"
    Jon Lundberg
    Circulation 112:e84; author reply e84. 2005