Genomes and Genes
Keng Ling Wallin
Affiliation: Karolinska Institutet
- A population-based prospective study of Chlamydia trachomatis infection and cervical carcinomaKeng Ling Wallin
Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
Int J Cancer 101:371-4. 2002..trachomatis in both the prediagnostic smear and in the subsequent cervical cancer. In conclusion, a prior cervical C. trachomatis infection was associated with an increased risk for development of invasive cervical cancer...
- Genetic alterations in cervical carcinomas: frequent low-level amplifications of oncogenes are associated with human papillomavirus infectionAnju Zhang
Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden
Int J Cancer 101:427-33. 2002..These findings indicate that HPV-associated cervical carcinomas bear frequent alterations of these genes, which may have critical biologic impact on the development and progression of carcinoma of the uterine cervix...
- Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancerJian Liu Wang
Department of Molecular Medicine, Center for Molecular Medicine, Karolinska Institute, Cancer Center Karolinska, Karolinska University Hospital, Stockholm, Sweden
Clin Cancer Res 10:2407-14. 2004..The purpose of this research was to evaluate the clinical significance of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen (PCNA) expression in tumor progression of cervical cancer...
- Risk of invasive cervical cancer associated with polymorphic HLA DR/DQ haplotypesMehran Ghaderi
Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
Int J Cancer 100:698-701. 2002..4] and 4.33 (CI: 2.1-8.5), corresponding to population attributable proportions of 27.9% and 30.8%, respectively. A susceptibility locus in the HLA class II region is involved in a substantial fraction of the etiology of cervical cancer...
- Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervixAnju Zhang
Department of Molecular Medicine, Karolinska Institute, Karolinska University Hospital, CMM, SE 171 76, Stockholm, Sweden
Oncogene 23:7441-7. 2004..Widespread over-erosion of telomeres or telomere dysfunction in very early stages of cervical tumorigenesis might fuel transformation processes by driving chromosomal instability...
- Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smearsSonia Andersson
Department for Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Am J Pathol 175:1831-47. 2009..Among the markers tested, detection of TERC amplification in cytological samples has the highest combined sensitivity and specificity for discernment of low-grade from high-grade dysplasia and cancer...
- Genetic polymorphism of chemokine receptors CCR2 and CCR5 in Swedish cervical cancer patientsBiying Zheng
Department of Molecular Medicine and Surgery, Karolinska Institute, Center for Molecular Medicine and Karolinska University Hospital Solna, Stockholm, Sweden
Anticancer Res 26:3669-74. 2006..045) compare to HPV negative group. The delta-32 mutation on the CCR locus is imperceptibly associated with increased risk of HPV infection. In total, cervical neoplasia was not associated with genetic polymorphism of CCR2 and CCR5...
- Tag-array based HPV genotyping by competitive hybridization and extensionMax Käller
Department of Biotechnology, Royal Institute of Technology KTH, AlbaNova University Center, Stockholm, Sweden
J Virol Methods 129:102-12. 2005..We can thus conclude that the developed assay is highly sensitive, with improved throughput and with excellent possibility to detect multiple infections...
- Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomasAnju Zhang
Department of Oncology and Pathology, Karolinska Hospital, Stockholm, Sweden
Genes Chromosomes Cancer 34:269-75. 2002..Taken together, the hTERT gene amplification, directly or indirectly targeted by human papillomavirus, may be one of the driving forces responsible for upregulation of hTERT expression and activation of telomerase in cervical cancers...
- p16INK4A and p14ARF expression pattern by immunohistochemistry in human papillomavirus-related cervical neoplasiaJian Liu Wang
Department of Molecular Medicine, Karolinska Institute, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
Mod Pathol 18:629-37. 2005..In conclusion, overexpression of p16INK4A and p14ARF act as potential biomarkers for cervical cancer progression from premalignant lesions...
- Mutation of PIK3CA: possible risk factor for cervical carcinogenesis in older womenBaoxia Cui
Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
Int J Oncol 34:409-16. 2009..The results suggest that PIK3CA mutations are a late event and uncommon in the progression of malignant tumors, but it appears that they facilitate carcinogenesis in older women...
- Sentinel-base DNA genotyping using multiple sequencing primers for high-risk human papillomavirusesBaback Gharizadeh
Stanford Genome Technology Center, Stanford University, 855 California Avenue, Palo Alto, CA 94304, USA
Mol Cell Probes 20:230-8. 2006..These proof-of-concept studies establish the assay to be accurate, reliable, rapid, flexible, and cost-effective, providing evidence of the feasibility this technique for use in clinical settings...
- p16INK4a and laminin-5gamma2 chain expression during the progression of cervical neoplasiaJian Liu Wang
Department of Molecular Medicine and Surgery, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden
Acta Oncol 45:676-84. 2006..2+/-52.7 months) (p < 0.05). Thus co-expression of p16INK4a, laminin-5gamma2 chain and PCNA may be valuable for the prediction progression of cervical neoplasia...
- Multiple-primer DNA sequencing methodBaback Gharizadeh
Department of Biotechnology, Stockholm Center for Physics, Astronomy and Biotechnology, Royal Institute of Technology, Sweden
Electrophoresis 24:1145-51. 2003..The new strategy is highly suitable for diagnostic typing of relevant species/genotypes of microorganisms...
- Does HPV-status 6-12 months after treatment of high grade dysplasia in the uterine cervix predict long term recurrence?Bjorn Strander
Department of Obstetrics and Gynaecology, Sahlgrenska Academy, University of Goteborg, SE 413 45 Goteborg, Sweden
Eur J Cancer 43:1849-55. 2007..Women once treated for high grade cervical dysplasia have a high long term risk for developing new dysplasia or cancer...
- Expression of p16INK4a and MIB-1 in relation to histopathology and HPV types in cervical adenocarcinomaSusanne Muller
Department for Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska University Hospital at Huddinge, Karolinska Institutet, S 141 86 Stockholm, Sweden
Int J Oncol 32:333-40. 2008..Thus, immunostaining for p16INK4a appears to be a useful diagnostic tool for cervical adenocarcinoma...
- Type-specific multiple sequencing primers: a novel strategy for reliable and rapid genotyping of human papillomaviruses by pyrosequencing technologyBaback Gharizadeh
Stanford Genome Technology Center, Stanford University, Palo Alto, California, USA
J Mol Diagn 7:198-205. 2005..The multiple sequencing primer method has proved to be a multifaceted approach for typing of human papillomaviruses by DNA sequencing technologies...