Nils Wahlgren

Summary

Affiliation: Karolinska University Hospital
Country: Sweden

Publications

  1. doi request reprint Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study
    Nils Wahlgren
    Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Lancet 372:1303-9. 2008
  2. doi request reprint Disappearing hyperdense middle cerebral artery sign in ischaemic stroke patients treated with intravenous thrombolysis: clinical course and prognostic significance
    T Kharitonova
    Department of Neurology, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 80:273-8. 2009
  3. doi request reprint Mechanical thrombectomy in acute ischemic stroke: Consensus statement by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN
    Nils Wahlgren
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
    Int J Stroke 11:134-47. 2016
  4. ncbi request reprint Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study
    Nils Wahlgren
    Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Lancet 369:275-82. 2007
  5. doi request reprint Systemic thrombolysis in clinical practice: what have we learned after the Safe Implementation of Thrombolysis in Stroke Monitoring Study?
    Nils Wahlgren
    Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Cerebrovasc Dis 27:168-76. 2009
  6. doi request reprint Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST)
    Nils Wahlgren
    Department of Neurology, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Stroke 39:3316-22. 2008
  7. doi request reprint Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score
    Michael Mazya
    Department of Neurology, Karolinska University Hospital Solna, Karolinska Stroke Research, Stockholm, Sweden
    Stroke 43:1524-31. 2012
  8. doi request reprint Association of admission blood glucose and outcome in patients treated with intravenous thrombolysis: results from the Safe Implementation of Treatments in Stroke International Stroke Thrombolysis Register (SITS-ISTR)
    Niaz Ahmed
    Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden
    Arch Neurol 67:1123-30. 2010
  9. doi request reprint Within-day and weekly variations of thrombolysis in acute ischemic stroke: results from safe implementation of treatments in stroke-international stroke thrombolysis register
    Svetlana Lorenzano
    From the Emergency Department Stroke Unit, Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L, D T Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden N A, N W Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland T T Acute Stroke Unit, Department of Neuroscience, Hospital Universitari Germas Trias i Pujol, Universidad Autonoma de Barcelona, Barcelona, Spain M G, A D International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M Department of Neurology, University Hospital, Plzen, Czech Republic P S and Department of Neurology and Rehabilitation, Tampere University Hospital, Tampere, Finland J O
    Stroke 45:176-84. 2014
  10. doi request reprint Importance of cerebral artery recanalization in patients with stroke with and without neurological improvement after intravenous thrombolysis
    Tatiana V Kharitonova
    Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
    Stroke 44:2513-8. 2013

Collaborators

Detail Information

Publications28

  1. doi request reprint Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study
    Nils Wahlgren
    Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Lancet 372:1303-9. 2008
    ..5 h versus those treated within 3 h, who were recorded in the in the Safe Implementation of Treatments in Stroke (SITS), a prospective internet-based audit of the International Stroke Thrombolysis Registry (ISTR)...
  2. doi request reprint Disappearing hyperdense middle cerebral artery sign in ischaemic stroke patients treated with intravenous thrombolysis: clinical course and prognostic significance
    T Kharitonova
    Department of Neurology, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 80:273-8. 2009
    ..Its disappearance after thrombolytic therapy is poorly described. Taking the rate of HMCAS disappearance as a surrogate for MCA recanalisation, its prognostic value after intravenous thrombolysis was examined...
  3. doi request reprint Mechanical thrombectomy in acute ischemic stroke: Consensus statement by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN
    Nils Wahlgren
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
    Int J Stroke 11:134-47. 2016
    ..The statement is supported by ESO, European Society of Minimally Invasive Neurological Therapy (ESMINT), European Society of Neuroradiology (ESNR), and European Academy of Neurology (EAN). ..
  4. ncbi request reprint Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study
    Nils Wahlgren
    Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Lancet 369:275-82. 2007
    ..Under European Union regulations, SITS-MOST was required to assess the safety profile of alteplase in clinical practice by comparison with results in randomised controlled trials...
  5. doi request reprint Systemic thrombolysis in clinical practice: what have we learned after the Safe Implementation of Thrombolysis in Stroke Monitoring Study?
    Nils Wahlgren
    Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Cerebrovasc Dis 27:168-76. 2009
    ..Important information is currently collected on the effect on door-to-needle time and safety of a broad implementation of thrombolysis in a later time window...
  6. doi request reprint Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST)
    Nils Wahlgren
    Department of Neurology, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Stroke 39:3316-22. 2008
    ..We aimed to identify outcome predictors and adjust the outcomes of the SITS-MOST to the baseline characteristics of RCTs...
  7. doi request reprint Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score
    Michael Mazya
    Department of Neurology, Karolinska University Hospital Solna, Karolinska Stroke Research, Stockholm, Sweden
    Stroke 43:1524-31. 2012
    ..Symptomatic intracerebral hemorrhage (SICH) is a serious complication in patients with acute ischemic stroke treated with intravenous thrombolysis. We aimed to develop a clinical score that can easily be applied to predict the risk of SICH...
  8. doi request reprint Association of admission blood glucose and outcome in patients treated with intravenous thrombolysis: results from the Safe Implementation of Treatments in Stroke International Stroke Thrombolysis Register (SITS-ISTR)
    Niaz Ahmed
    Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden
    Arch Neurol 67:1123-30. 2010
    ..To determine the association between admission blood glucose and outcome in ischemic stroke patients treated with thrombolysis...
  9. doi request reprint Within-day and weekly variations of thrombolysis in acute ischemic stroke: results from safe implementation of treatments in stroke-international stroke thrombolysis register
    Svetlana Lorenzano
    From the Emergency Department Stroke Unit, Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L, D T Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden N A, N W Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland T T Acute Stroke Unit, Department of Neuroscience, Hospital Universitari Germas Trias i Pujol, Universidad Autonoma de Barcelona, Barcelona, Spain M G, A D International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M Department of Neurology, University Hospital, Plzen, Czech Republic P S and Department of Neurology and Rehabilitation, Tampere University Hospital, Tampere, Finland J O
    Stroke 45:176-84. 2014
    ..In this large cohort study, we evaluated whether thrombolytic treatment has a within-day and weekly variability corresponding to circadian and weekly patterns of ischemic stroke onset, and whether these have impact on clinical outcome...
  10. doi request reprint Importance of cerebral artery recanalization in patients with stroke with and without neurological improvement after intravenous thrombolysis
    Tatiana V Kharitonova
    Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
    Stroke 44:2513-8. 2013
    ..We aimed to evaluate the importance of restoration of blood flow at the arterial occlusion site in subgroups of patients with stroke stratified by early NI after IVT...
  11. doi request reprint Does sex influence the response to intravenous thrombolysis in ischemic stroke?: answers from safe implementation of treatments in Stroke-International Stroke Thrombolysis Register
    Svetlana Lorenzano
    From the Emergency Department Stroke Unit, Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L, A F, D T Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden N A, N W International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland T T and Stroke Research Offices, Royal Infirmary, Keele University, North Staffordshire, United Kingdom C R
    Stroke 44:3401-6. 2013
    ..We aimed to evaluate differences in 3-month outcome between sexes in intravenous tissue-type plasminogen activator-treated patients registered in the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register...
  12. doi request reprint Remote or extraischemic intracerebral hemorrhage--an uncommon complication of stroke thrombolysis: results from the safe implementation of treatments in stroke-international stroke thrombolysis register
    Michael V Mazya
    From the Department of Neurology, Karolinska University Hospital M V M, N A, N W and Department of Clinical Neuroscience M V M, N A, N W, Karolinska Institutet, Stockholm, Sweden Stroke Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom G A F Department of Neurology, University of Leipzig, Leipzig, Germany C H International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M and Stroke Unit, Centro Hospitalar Lisboa Central, Lisbon, Portugal A P N
    Stroke 45:1657-63. 2014
    ..We aimed to describe risk factors, 3-month mortality, and functional outcome in patients with the poorly understood complication of remote intracerebral hemorrhage, as well as local intracerebral hemorrhage...
  13. doi request reprint Safety of intravenous thrombolysis for ischemic stroke in patients treated with warfarin
    Michael V Mazya
    Department of Neurology, Karolinska University Hospital and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Ann Neurol 74:266-74. 2013
    ..7. The influence of warfarin on symptomatic intracerebral hemorrhage (SICH), arterial recanalization, and long-term functional outcome in stroke thrombolysis remains unclear...
  14. doi request reprint Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR
    Niaz Ahmed
    Department of Neurology, Karolinska University Hospital, and Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 9:866-74. 2010
    ..5 h after stroke onset. We aimed to assess the implementation of the wider time window, its effect on the admission-to-treatment time, and safety and functional outcome in patients recorded in SITS-ISTR...
  15. doi request reprint Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR
    Niaz Ahmed
    SITS International Coordination Office, Karolinska Stroke Research, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden
    Stroke 40:2442-9. 2009
    ..We determined retrospectively the association of BP and antihypertensive therapy with clinical outcomes after stroke thrombolysis...
  16. doi request reprint External validation of the SEDAN score for prediction of intracerebral hemorrhage in stroke thrombolysis
    Michael V Mazya
    Department of Neurology, SITS International Coordination Office, Karolinska Stroke Research, Karolinska University Hospital, Solna, Stockholm 17176, Sweden
    Stroke 44:1595-600. 2013
    ..We assessed the performance of the score in predicting SICH per the ECASS II and Safe Implementation of Treatments in Stroke Monitoring Study (SITS-MOST) definitions in the SITS-International Stroke Thrombolysis Register (SITS-ISTR)...
  17. doi request reprint Association of early National Institutes of Health Stroke Scale improvement with vessel recanalization and functional outcome after intravenous thrombolysis in ischemic stroke
    Tatiana Kharitonova
    Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Sweden
    Stroke 42:1638-43. 2011
    ....
  18. doi request reprint IV thrombolysis in very severe and severe ischemic stroke: Results from the SITS-ISTR Registry
    Michael V Mazya
    From the Department of Neurology M V M, N W, N A, Karolinska University Hospital, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Acute Stroke Unit and Cerebrovascular Clinic K R L, Institute of Cardiovascular and Medical Sciences, University of Glasgow Stroke Unit D C, Watford General Hospital, UK Department of Neurology V M R, North Estonia Medical Centre, Tallinn, Estonia International Clinical Research Center and Department of Neurology R M, St Anne s University Hospital, Brno, Czech Republic and Department of Neurology and Psychiatry D T, Sapienza University of Rome, Italy
    Neurology 85:2098-106. 2015
    ..To study the safety of off-label IV thrombolysis in patients with very severe stroke (NIH Stroke Scale [NIHSS] scores >25) compared with severe stroke (NIHSS scores 15-25), where treatment is within European regulations...
  19. pmc Mechanical thrombectomy in acute ischemic stroke-experience from 6 years of practice
    Asa Kuntze Söderqvist
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroradiology 56:477-86. 2014
    ..We present our results from the first 6 years with mechanical thrombectomy in the treatment of ischemic stroke...
  20. doi request reprint Trends in Door-to-Thrombolysis Time in the Safe Implementation of Stroke Thrombolysis Registry: Effect of Center Volume and Duration of Registry Membership
    Daniel Strbian
    From the Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland D S, T T Department of Neurology, Karolinska University Hospital, Stockholm, Sweden N A, N W Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom K R L Emergency Department Stroke Unit, Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy D T University Hospital of North Staffordshire, Stoke on Trent, United Kingdom C R and Institute for Molecular Medicine Finland, University of Helsinki, Finland I L S
    Stroke 46:1275-80. 2015
    ..There are considerable intercenter variations in treatment delivery. We analyzed the trends of door-to-needle times (DNTs) in the Safe Implementation of Thrombolysis in Stroke registry between 2003 and 2011...
  21. doi request reprint Hyperdense middle cerebral artery sign on admission CT scan--prognostic significance for ischaemic stroke patients treated with intravenous thrombolysis in the safe implementation of thrombolysis in Stroke International Stroke Thrombolysis Register
    Tatiana Kharitonova
    Department of Neurology, Karolinska Stroke Research Unit, SITS International Coordination Office, Karolinska University Hospital Solna, Stockholm, Sweden
    Cerebrovasc Dis 27:51-9. 2009
    ..Hyperdense middle cerebral artery sign (HMCAS) on CT scan before stroke thrombolysis is associated with increased risk for haemorrhage and unfavourable outcome in several small studies...
  22. doi request reprint Threshold for NIH stroke scale in predicting vessel occlusion and functional outcome after stroke thrombolysis
    Charith Cooray
    Department of Clinical Neurosciences, Karolinska Institutet, Solna, Sweden
    Int J Stroke 10:822-9. 2015
    ..Data are limited on optimal threshold for baseline National Institutes of Health Stroke Scale in predicting outcome after stroke thrombolysis (intravenous thrombolysis)...
  23. doi request reprint Face Arm Speech Time Test use in the prehospital setting, better in the ambulance than in the emergency medical communication center
    Annika Berglund
    Karolinska Institutet Stroke Research Network at Södersjukhuset, Sodersjukhuset, Stockholm, Sweden
    Cerebrovasc Dis 37:212-6. 2014
    ..This substudy aims to evaluate the implementation of the FAST test in the EMCC and the ambulance service...
  24. doi request reprint Mobile Phone-Based Questionnaire for Assessing 3 Months Modified Rankin Score After Acute Stroke: A Pilot Study
    Charith Cooray
    From the Department of Clinical Neurosciences, Karolinska Institutet and Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
    Circ Cardiovasc Qual Outcomes 8:S125-30. 2015
    ..We investigated whether automatic assessment of the modified Rankin Scale (mRS) based on a mobile phone questionnaire may serve as an alternative to mRS assessments at clinical visits after stroke...
  25. doi request reprint Changes in European Label and Guideline Adherence After Updated Recommendations for Stroke Thrombolysis: Results From the Safe Implementation of Treatments in Stroke Registry
    Nadim Anani
    From the Health Informatics Centre, Department of Learning, Informatics, Management and Ethics N Anani, R C, S K and Stroke Research Unit, Department of Clinical Neuroscience M V M, O B, N Ahmed, N W, T P M, Karolinska Institutet, Stockholm, Sweden Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden M V M, N Ahmed, N W, T P M Department of Neurology, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland O B and Cambio Healthcare Systems, Stockholm, Sweden R C
    Circ Cardiovasc Qual Outcomes 8:S155-62. 2015
    ..5 hours, which the label still prohibited. Our aim was to compare contraindication nonadherence before and after the guideline update...
  26. ncbi request reprint Higher prehospital priority level of stroke improves thrombolysis frequency and time to stroke unit: the Hyper Acute STroke Alarm (HASTA) study
    Annika Berglund
    Karolinska Institutet, Department of Clinical Science and Education, Sodersjukhuset, 118 83 Stockholm, Sweden
    Stroke 43:2666-70. 2012
    ....
  27. doi request reprint Mechanical thrombectomy as the primary treatment for acute basilar artery occlusion: experience from 5 years of practice
    Tommy Andersson
    Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    J Neurointerv Surg 5:221-5. 2013
    ..In this study, data are presented on 28 patients treated with mechanical thrombectomy as the preferred treatment for basilar artery occlusion...
  28. doi request reprint How common is isolated dysphasia among patients with stroke treated with intravenous thrombolysis, and what is their outcome? Results from the SITS-ISTR
    Erik Lundström
    Department of Neurology, Karolinska University Hospital and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    BMJ Open 5:e009109. 2015
    ..To describe the frequency and outcome of isolated dysphasia among patients treated with intravenous thrombolysis (IVT)...