Andrea Varrone

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease
    Andrea Varrone
    Biostructure and Bioimaging Institute, National Research Council Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
    Eur J Nucl Med Mol Imaging 34:1071-81. 2007
  2. ncbi request reprint Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2: an FP-CIT SPECT study
    Maria Teresa Pellecchia
    Department of Neurological Sciences, University Federico II, Napoli, Italy
    Mov Disord 22:559-63. 2007
  3. ncbi request reprint Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
    Hristina Jovanovic
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neuroimage 39:1408-19. 2008
  4. doi request reprint Positron emission tomography imaging of 5-hydroxytryptamine1B receptors in Parkinson's disease
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden Stockholm Brain Institute, Stockholm, Sweden Electronic address
    Neurobiol Aging 35:867-75. 2014
  5. pmc No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT
    Gerda Thomsen
    Neurobiology Research Unit 9201, Rigshospitalet and Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100, Denmark
    EJNMMI Res 3:39. 2013
  6. doi request reprint In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Hospital, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:921-31. 2013
  7. doi request reprint European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska University Hospital, R5 02, 17176 Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:213-27. 2013
  8. ncbi request reprint New developments of dopaminergic imaging in Parkinson's disease
    A Varrone
    Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
    Q J Nucl Med Mol Imaging 56:68-82. 2012
  9. doi request reprint Simplified quantification and whole-body distribution of [18F]FE-PE2I in nonhuman primates: prediction for human studies
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, SE 17176 Stockholm, Sweden
    Nucl Med Biol 39:295-303. 2012
  10. ncbi request reprint Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT
    Andrea Varrone
    Biostructure and Bioimaging Institute, National Research Council Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
    Eur J Nucl Med Mol Imaging 35:1343-9. 2008

Detail Information

Publications51

  1. ncbi request reprint Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease
    Andrea Varrone
    Biostructure and Bioimaging Institute, National Research Council Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
    Eur J Nucl Med Mol Imaging 34:1071-81. 2007
    ....
  2. ncbi request reprint Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2: an FP-CIT SPECT study
    Maria Teresa Pellecchia
    Department of Neurological Sciences, University Federico II, Napoli, Italy
    Mov Disord 22:559-63. 2007
    ..In 3 homozygotes and 1 heterozygote, a 2-year follow-up single photon emission computed tomography suggested no progression of nigrostriatal deficit...
  3. ncbi request reprint Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
    Hristina Jovanovic
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neuroimage 39:1408-19. 2008
    ..The result of the present study may help in understanding sex differences in drug treatment responses to drugs affecting the serotonin system...
  4. doi request reprint Positron emission tomography imaging of 5-hydroxytryptamine1B receptors in Parkinson's disease
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden Stockholm Brain Institute, Stockholm, Sweden Electronic address
    Neurobiol Aging 35:867-75. 2014
    ..The demonstrated age effect on 5-HT(1B) receptors suggest a physiologic and PD-related decline of serotonin function, indicating the importance of controlling for age in clinical studies...
  5. pmc No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT
    Gerda Thomsen
    Neurobiology Research Unit 9201, Rigshospitalet and Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100, Denmark
    EJNMMI Res 3:39. 2013
    ..We used the database to test the hypothesis that striatal DAT availability is changed in active smokers compared to non-smokers and ex-smokers...
  6. doi request reprint In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Hospital, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:921-31. 2013
    ..The aim of this study was to quantify in vivo binding of [(18)F]FEDAA1106 to TSPO in control subjects and AD patients...
  7. doi request reprint European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska University Hospital, R5 02, 17176 Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:213-27. 2013
    ..The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [(123)I]FP-CIT SPECT scans in healthy controls...
  8. ncbi request reprint New developments of dopaminergic imaging in Parkinson's disease
    A Varrone
    Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
    Q J Nucl Med Mol Imaging 56:68-82. 2012
    ....
  9. doi request reprint Simplified quantification and whole-body distribution of [18F]FE-PE2I in nonhuman primates: prediction for human studies
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, SE 17176 Stockholm, Sweden
    Nucl Med Biol 39:295-303. 2012
    ..18)F]FE-PE2I is a promising dopamine transporter (DAT) radioligand. In nonhuman primates, we examined the accuracy of simplified quantification methods and the estimates of radiation dose of [(18)F]FE-PE2I...
  10. ncbi request reprint Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT
    Andrea Varrone
    Biostructure and Bioimaging Institute, National Research Council Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
    Eur J Nucl Med Mol Imaging 35:1343-9. 2008
    ..There are limited data comparing the capability of the two types of system to measure dopamine transporter (DAT) loss in vivo...
  11. doi request reprint Imaging of the striatal and extrastriatal dopamine transporter with (18)F-LBT-999: quantification, biodistribution, and radiation dosimetry in nonhuman primates
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden
    J Nucl Med 52:1313-21. 2011
    ..2.1]octane-2-carboxylate ((18)F-LBT-999) in nonhuman primates...
  12. doi request reprint Molecular imaging of the dopamine transporter
    Andrea Varrone
    Centre for Psychiatry Research, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    J Nucl Med 51:1331-4. 2010
    ..Several radioligands are available for DAT imaging with SPECT and PET. This review summarizes the main SPECT and PET radioligands and the main applications of DAT imaging in neuropsychiatric disorders...
  13. doi request reprint Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section and Stockholm Brain Institute, R5 02, Karolinska Hospital, 17176, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:1639-50. 2009
    ..This study assessed the quantitative improvements provided by the implementation of the PSF modelling in the reconstruction of the PET data using the High Resolution Research Tomograph (HRRT)...
  14. doi request reprint In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Synapse 63:871-80. 2009
    ..The potential influence of the two radiometabolites on PET quantification requires further evaluation...
  15. doi request reprint Kinetic analysis and quantification of the dopamine transporter in the nonhuman primate brain with 11C-PE2I and 18F-FE-PE2I
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Hospital, Stockholm, Sweden
    J Nucl Med 52:132-9. 2011
    ....
  16. ncbi request reprint Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2: a human whole-body PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 35:630-6. 2008
    ..The aim of this study was to provide dosimetry estimates for (S,S)-[(18)F]FMeNER-D(2) based on human whole-body PET measurements...
  17. ncbi request reprint Reduced striatal [123 I]FP-CIT binding in SCA2 patients without parkinsonism
    Andrea Varrone
    Biostructure and Bioimaging Institute, National Research Council, Via S Pansini 5, 80131 Naples, Italy
    Ann Neurol 55:426-30. 2004
    ..Striatal DAT density of SCA2 patients correlated with the severity of cerebellar ataxia...
  18. doi request reprint Brain uptake and distribution of the dopamine D3 /D2 receptor partial agonist [11 C]cariprazine: an in vivo positron emission tomography study in nonhuman primates
    Miklos Toth
    Karolinska Institutet, Department of Clinical Neuroscience, Centrum for Psychiatry Research, S 171 76, Stockholm, Sweden
    Synapse 67:258-64. 2013
    ..Furthermore, in PET imaging [(11) C]cariprazine can effectively visualize dopamine D(3)/D(2) receptors in the nonhuman primate brain...
  19. doi request reprint PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans
    Simon Cervenka
    Department of Clinical Neuroscience, Stockholm Brain Institute Karolinska Institute, Stockholm, Sweden
    Synapse 64:478-85. 2010
    ..These preliminary results encourage approaches searching for individual patterns of receptor binding across the whole brain volume in clinical studies on the dopamine system...
  20. ncbi request reprint Imaging the norepinephrine transporter with positron emission tomography: initial human studies with (S,S)-[18F]FMeNER-D2
    Akihiro Takano
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 35:153-7. 2008
    ..A monkey occupancy study with the radioligand indicated that (S,S)-[(18)F]FMeNER-D(2) can be useful for quantitative PET analysis. In this preliminary study, regional distributions in the living human brain were evaluated...
  21. doi request reprint Improved mapping and quantification of serotonin transporter availability in the human brainstem with the HRRT
    Martin Schain
    Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Karolinska Hospital, R5 02, SE 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:228-37. 2013
    ..This study examined the potential to evaluate radioligand binding in brainstem nuclei, and assessed the effect of improved resolution on the outcome measures...
  22. doi request reprint Extrastriatal dopamine D(2) receptor binding in Huntington's disease
    Mouna Esmaeilzadeh
    PET Centre, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
    Hum Brain Mapp 32:1626-36. 2011
    ..Hence, the present study demonstrates that dopamine D(2) receptors extrinsic to the striatum are well preserved in early to mid stage patients with HD. This observation may have implication for the development of therapy for HD...
  23. doi request reprint Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [18F]FEDAA1106: a human whole-body PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 38:2058-65. 2011
    ..TSPO imaging is expected to be useful for the clinical evaluation of neuroinflammatory diseases. The aim of this study was to provide dosimetry estimates for [(18)F]FEDAA1106 based on human whole-body PET measurements...
  24. doi request reprint Mapping of the norepinephrine transporter in the human brain using PET with (S,S)-[18F]FMeNER-D2
    Akihiro Takano
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neuroimage 42:474-82. 2008
    ..This study indicated that (S,S)-[(18)F]FMeNER-D(2) combined with a template method provides detailed information on the distribution of NET in vivo and that functional ROIs on the template would be useful in further clinical studies...
  25. ncbi request reprint Nigrostriatal involvement in ataxia with oculomotor apraxia type 1
    Elena Salvatore
    Department of Neurological Sciences, University of Naples Federico II, Napoli, Italy
    J Neurol 255:45-8. 2008
    ..Nigrostriatal impairment occurred even in the absence of extrapyramidal features. Our data suggest subclinical involvement of basal ganglia in AOA1...
  26. ncbi request reprint Synthesis, radiolabeling and preliminary in vivo evaluation of [18F]FE-PE2I, a new probe for the dopamine transporter
    Magnus Schou
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    Bioorg Med Chem Lett 19:4843-5. 2009
    ..18)F]6 is a potential radioligand for imaging DATs in the human brain with PET...
  27. pmc Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain
    Katarina Varnas
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Cereb Blood Flow Metab 31:113-23. 2011
    ..The findings support the use of reference tissue models in applied clinical studies with [(11)C]AZ10419369...
  28. pmc Arterial input function derived from pairwise correlations between PET-image voxels
    Martin Schain
    Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
    J Cereb Blood Flow Metab 33:1058-65. 2013
    ..This approach performed similarly or even better than the other methods, and could be considered in applied clinical studies. Applications to other radioligands are needed for further verification. ..
  29. ncbi request reprint Comparative evaluations of norepinephrine transporter radioligands with reference tissue models in rhesus monkeys: (S,S)-[18F]FMeNER-D2 and (S,S)-[11C]MeNER
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, 171 76 Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:1885-91. 2009
    ..Although two norepinephrine transporter (NET) radioligands, (S,S)-[(18)F]FMeNER-D(2) and (S,S)-[(11)C]MeNER, have been reported to have different characteristics, there has not been a direct comparative study in vivo...
  30. doi request reprint Age and disease related changes in the translocator protein (TSPO) system in the human brain: positron emission tomography measurements with [11C]vinpocetine
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Centrum for Psychiatry Research, Stockholm, Sweden
    Neuroimage 56:1111-21. 2011
    ....
  31. doi request reprint Quantitative PET analyses of regional [11C]PE2I binding to the dopamine transporter--application to juvenile myoclonic epilepsy
    Ikuo Odano
    Psychiatric Section, Department of Clinical Neuroscience Karolinska Institutet, Stockholm, Sweden
    Neuroimage 59:3582-93. 2012
    ..The reference tissue models should be applied with better understanding of the biochemical nature of the radioligand and the reliability of these approaches...
  32. doi request reprint [18F]flumazenil binding to central benzodiazepine receptor studies by PET--quantitative analysis and comparisons with [11C]flumazenil
    Ikuo Odano
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuroimage 45:891-902. 2009
    ..The present analysis supports the use of pons as reference region in simplified protocols without arterial blood sampling. [(18)F]flumazenil should thus be an excellent choice for applied studies at centers not having a cyclotron...
  33. ncbi request reprint Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2
    Nicholas Seneca
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176, Stockholm, Sweden
    Psychopharmacology (Berl) 188:119-27. 2006
    ..Previous positron emission tomography (PET) studies had failed to demonstrate the feasibility of measuring a dose-dependent and saturable NET occupancy in human brain using [11C]MeNER...
  34. doi request reprint Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: a rhesus monkey study with (S,S)-[(18)F]FMeNER-D (2)
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, S 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:1308-14. 2009
    ..It may therefore be difficult to translate the results to the clinical situations. In the present study, the detailed change of NET occupancy was investigated among a wider range of doses in a more advanced manner...
  35. doi request reprint Quantification of serotonin transporter availability with [11C]MADAM--a comparison between the ECAT HRRT and HR systems
    Martin Schain
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden
    Neuroimage 60:800-7. 2012
    ..A secondary objective was to assess the effect of partial volume effect (PVE) correction on the cross-comparability between the two systems...
  36. doi request reprint Diffusion-weighted imaging in multiple system atrophy: a comparison between clinical subtypes
    Maria Teresa Pellecchia
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Mov Disord 24:689-96. 2009
    ..Based on our findings, Trace (D) measurements in the putamen and pons in MSA-P patients and in the cerebellum and MCP in MSA-C patients could serve as quantitative markers for microstructural damage in the course of disease...
  37. doi request reprint In vivo evaluation in cynomolgus monkey brain and metabolism of [¹⁸F]fluorodeprenyl: a new MAO-B pet radioligand
    Sangram Nag
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 17176 Stockholm, Sweden
    Synapse 66:323-30. 2012
    ..These results suggest that [¹⁸F]fluorodeprenyl is a potential PET radioligand for visualization of MAO-B activity...
  38. ncbi request reprint Reduced 5-HT1B receptor binding in the dorsal brain stem after cognitive behavioural therapy of major depressive disorder
    Mikael Tiger
    Department of Clinical Neuroscience, Karolinska Institutet, Centrum för psykiatriforskning, R5 0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden Electronic address
    Psychiatry Res 223:164-70. 2014
    ..The DBS contains the raphe nuclei, which regulate the serotonin system. This study gives support for the importance of serotonin and the 5-HT1B receptor in the biological response to psychological treatment of MDD. ..
  39. ncbi request reprint Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks
    Andrea Varrone
    Biostructure and Bioimaging Institute, National Research Council, Via S Pansini 5, 80131 Napoli, Italy
    Eur J Nucl Med Mol Imaging 29:1447-54. 2002
    ..Furthermore, they highlight the networks that are more specifically impaired in these disorders and that could be implicated in the emotional-behavioural and cognitive disturbances that characterise FTD and AD respectively...
  40. doi request reprint EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2
    Andrea Varrone
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital R5 02, 17176 Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:2103-10. 2009
    ..These guidelines are intended to present information specifically adapted for European practice. The information provided should be taken in the context of local conditions and regulations...
  41. doi request reprint Modeling of PET data in CNS drug discovery and development
    Katarina Varnas
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Pharmacokinet Pharmacodyn 40:267-79. 2013
    ..The utility of PET kinetic modeling in the development of novel CNS drugs is illustrated by examples from studies of the brain kinetic properties of radiolabeled drug molecules...
  42. doi request reprint Performance evaluation of the small-animal nanoScan PET/MRI system
    Kalman Nagy
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden and
    J Nucl Med 54:1825-32. 2013
    ..We evaluated the performance of the system, using the NEMA NU 4-2008 protocol for the PET component and the NEMA MS 1-2007, MS 2-2008, and MS 3-2007 standards for the MR imaging component...
  43. pmc In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106
    Akihiro Takano
    Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm SE 171 77, Sweden
    EJNMMI Res 3:30. 2013
    ..18F]FEDAA1106 is a recently developed PET radioligand for the in vivo quantification of TSPO. In the present study, we aimed at investigating the diagnostic usefulness of [18F]FEDAA1106 in patients with MS...
  44. doi request reprint Graphic plot analysis for estimating binding potential of translocator protein (TSPO) in positron emission tomography studies with [¹⁸F]FEDAA1106
    Yoko Ikoma
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, SE 171 76, Stockholm, Sweden
    Neuroimage 69:78-86. 2013
    ..In this paper, we evaluated two types of GA for reliable quantification of BP(ND) in PET study with [(18)F]FEDAA1106 using computer simulations and human data...
  45. pmc Confirmation of fenfluramine effect on 5-HT(1B) receptor binding of [(11)C]AZ10419369 using an equilibrium approach
    Sjoerd J Finnema
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Cereb Blood Flow Metab 32:685-95. 2012
    ..The more advanced methodology is suitable for exploring the sensitivity limit to serotonin release as measured using [(11)C]AZ10419369 and PET...
  46. doi request reprint Changes in cortical dopamine D1 receptor binding associated with cognitive training
    Fiona McNab
    Neuropediatric Unit, Department of Woman and Child Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
    Science 323:800-2. 2009
    ..This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo...
  47. doi request reprint Regional cerebral glucose metabolism after pridopidine (ACR16) treatment in patients with Huntington disease
    Mouna Esmaeilzadeh
    Department of Clinical Neuroscience, PET Centre, Karolinska University Hospital, Karolinska Institutet, Stockholm Brain Institute, Stockholm, Sweden
    Clin Neuropharmacol 34:95-100. 2011
    ..The objective of the study was to investigate the metabolic changes in patients with Huntington disease before and after pridopidine treatment...
  48. pmc Differences at brain SPECT between depressed females with and without adult ADHD and healthy controls: etiological considerations
    Ann Gardner
    Karolinska Institutet, Department of Clinical Neuroscience, Section of Psychiatry, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Behav Brain Funct 5:37. 2009
    ..abstract:..
  49. ncbi request reprint PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of parkinsonism
    Chiara Criscuolo
    Department of Neurological Sciences, Federico II University, Naples, Italy
    Mov Disord 21:1265-7. 2006
    ..The mother, heterozygote for W437X mutation, was affected by Parkinson's disease and 3 further relatives were reported affected, according to an autosomal dominant transmission...
  50. ncbi request reprint Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride SPET
    Masahiro Fujita
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT, USA
    Eur J Nucl Med Mol Imaging 31:644-54. 2004
    ..It is concluded that SC is required for accurate quantification of distribution volumes of receptor ligands in SPET studies...
  51. ncbi request reprint Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities
    Kyeong Min Kim
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita City, Osaka 565 8565, Japan
    J Nucl Med 44:512-9. 2003
    ..In this work, we evaluated the accuracy gained from a method of transmission-dependent convolution subtraction (TDCS) in the quantitation of activity that is highly concentrated in the striatum (STR)...