Katarina Varnas

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
    Aurelija Jucaite
    AstraZeneca Global Clinical Development, Södertälje 151 85, Sweden
    EJNMMI Res 2:15. 2012
  2. doi request reprint A PET study with [11C]AZ10419369 to determine brain 5-HT1B receptor occupancy of zolmitriptan in healthy male volunteers
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, SE 17176 Stockholm, Sweden
    Cephalalgia 33:853-60. 2013
  3. doi request reprint Modeling of PET data in CNS drug discovery and development
    Katarina Varnas
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Pharmacokinet Pharmacodyn 40:267-79. 2013
  4. doi request reprint Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden
    Psychopharmacology (Berl) 213:533-45. 2011
  5. pmc Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain
    Katarina Varnas
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Cereb Blood Flow Metab 31:113-23. 2011
  6. doi request reprint Brain-derived neurotrophic factor polymorphisms and frontal cortex morphology in schizophrenia
    Katarina Varnas
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Psychiatr Genet 18:177-83. 2008
  7. ncbi request reprint Cerebellar volumes in men with schizophrenia and alcohol dependence
    Katarina Varnas
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Psychiatry Clin Neurosci 61:326-9. 2007
  8. doi request reprint Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate
    Magnus Schou
    AstraZeneca Translational Sciences Centre, PET CoE, Dept of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, SE 17176 Stockholm, Sweden
    Nucl Med Biol 40:410-4. 2013
  9. pmc Arterial input function derived from pairwise correlations between PET-image voxels
    Martin Schain
    Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
    J Cereb Blood Flow Metab 33:1058-65. 2013
  10. pmc Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients
    Anton Forsberg
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:580-93. 2013

Detail Information

Publications22

  1. pmc Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
    Aurelija Jucaite
    AstraZeneca Global Clinical Development, Södertälje 151 85, Sweden
    EJNMMI Res 2:15. 2012
    ..abstract:..
  2. doi request reprint A PET study with [11C]AZ10419369 to determine brain 5-HT1B receptor occupancy of zolmitriptan in healthy male volunteers
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, SE 17176 Stockholm, Sweden
    Cephalalgia 33:853-60. 2013
    ..To investigate the occupancy at brain 5-hydroxytryptamine (5-HT) 1B receptors in human subjects after administration of the antimigraine drug zolmitriptan...
  3. doi request reprint Modeling of PET data in CNS drug discovery and development
    Katarina Varnas
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Pharmacokinet Pharmacodyn 40:267-79. 2013
    ..The utility of PET kinetic modeling in the development of novel CNS drugs is illustrated by examples from studies of the brain kinetic properties of radiolabeled drug molecules...
  4. doi request reprint Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden
    Psychopharmacology (Berl) 213:533-45. 2011
    ..AZD3783 is a recently developed, orally bioavailable 5-HT(1B) receptor antagonist with potential antidepressant properties...
  5. pmc Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain
    Katarina Varnas
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Cereb Blood Flow Metab 31:113-23. 2011
    ..The findings support the use of reference tissue models in applied clinical studies with [(11)C]AZ10419369...
  6. doi request reprint Brain-derived neurotrophic factor polymorphisms and frontal cortex morphology in schizophrenia
    Katarina Varnas
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Psychiatr Genet 18:177-83. 2008
    ..To investigate associations between brain-derived neurotrophic factor (BDNF) gene polymorphisms and regional frontal cortical thickness and volume in patients with schizophrenia and healthy control participants...
  7. ncbi request reprint Cerebellar volumes in men with schizophrenia and alcohol dependence
    Katarina Varnas
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Psychiatry Clin Neurosci 61:326-9. 2007
    ..The results provide indications for differential morphological abnormalities of the cerebellar vermis in patients with schizophrenia and alcohol dependence...
  8. doi request reprint Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate
    Magnus Schou
    AstraZeneca Translational Sciences Centre, PET CoE, Dept of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, SE 17176 Stockholm, Sweden
    Nucl Med Biol 40:410-4. 2013
    ..As part of the preclinical evaluation of AZD1940, a microdosing study with positron emission tomography (PET) was conducted to assess brain exposure...
  9. pmc Arterial input function derived from pairwise correlations between PET-image voxels
    Martin Schain
    Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
    J Cereb Blood Flow Metab 33:1058-65. 2013
    ..This approach performed similarly or even better than the other methods, and could be considered in applied clinical studies. Applications to other radioligands are needed for further verification. ..
  10. pmc Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients
    Anton Forsberg
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:580-93. 2013
    ..The aim of this study was to evaluate AZD2995 side by side with AZD2184 as novel PET radioligands for imaging of amyloid-β in Alzheimer's disease (AD)...
  11. doi request reprint Grey and white matter proportional relationships in the cerebellar vermis altered in schizophrenia
    Glenn Lawyer
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Cerebellum 8:52-60. 2009
    ..Tissue class volumes in the cerebellar vermis were strongly interrelated in controls. These relationships were disturbed in patients with schizophrenia...
  12. doi request reprint Investigating possible subtypes of schizophrenia patients and controls based on brain cortical thickness
    Glenn Lawyer
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Psychiatry Res 164:254-64. 2008
    ..The study found no subtypes specific to patients. It suggested, however, that associations between abnormally thin cortex and schizophrenia are more widespread than shown by previously published results based on significance testing...
  13. ncbi request reprint Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, Sweden
    Hum Brain Mapp 22:246-60. 2004
    ..The qualitative and quantitative information reported in this study might provide important complements to in vivo neuroimaging studies of the 5-HT system...
  14. ncbi request reprint Regional thinning of the cerebral cortex in schizophrenia: effects of diagnosis, age and antipsychotic medication
    Ragnar Nesvåg
    Department of Psychiatric Research, Diakonhjemmet Hospital, and Institute of Psychiatry, University of Oslo, Norway
    Schizophr Res 98:16-28. 2008
    ..The lack of significant influence from antipsychotic medication supports that regional cortical thinning is an inherent feature of the neurobiological disease process in schizophrenia...
  15. doi request reprint Local and covariate-modulated false discovery rates applied in neuroimaging
    Glenn Lawyer
    Department of Psychiatry, University of Oslo, Oslo, Norway
    Neuroimage 47:213-9. 2009
    ..The increased statistical precision from more accurate models of the distribution of the test statistic demonstrates the potential of these methods for neuroimaging and suggests the possibility to test novel hypothesis...
  16. doi request reprint Radiosynthesis of the candidate beta-amyloid radioligand [(11)C]AZD2184: Positron emission tomography examination and metabolite analysis in cynomolgus monkeys
    Jan D Andersson
    Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
    Synapse 64:733-41. 2010
    ..On the basis of the labeling chemistry and the results of the biological evaluation, we conclude that [(11)C]5 should be useful for routine clinical studies...
  17. ncbi request reprint Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [3H]SB-269970
    Katarina Varnas
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176 Stockholm, Sweden
    Neurosci Lett 367:313-6. 2004
    ..The distribution pattern obtained in this study supports the involvement of this receptor subtype in affective behavior and cognition...
  18. doi request reprint Positron emission tomography imaging of 5-hydroxytryptamine1B receptors in Parkinson's disease
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden Stockholm Brain Institute, Stockholm, Sweden Electronic address
    Neurobiol Aging 35:867-75. 2014
    ..The demonstrated age effect on 5-HT(1B) receptors suggest a physiologic and PD-related decline of serotonin function, indicating the importance of controlling for age in clinical studies...
  19. doi request reprint Radiosynthesis and evaluation of new α1-adrenoceptor antagonists as PET radioligands for brain imaging
    Anu J Airaksinen
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176 Stockholm, Sweden
    Nucl Med Biol 40:747-54. 2013
    ..Our aim was to develop an α1-adrenoceptor specific PET radioligand for brain imaging...
  20. doi request reprint Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: A PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Karolinska Institutet, Center for Psychiatric Research and Education, Stockholm, Sweden
    Synapse 68:89-97. 2014
    ..Further clinical development of TM38837 is warranted. Synapse 68:89-97, 2014. © 2013 Wiley Periodicals, Inc. ..
  21. ncbi request reprint Distribution of 5-HT4 receptors in the postmortem human brain--an autoradiographic study using [125I]SB 207710
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 17176 Stockholm, Sweden
    Eur Neuropsychopharmacol 13:228-34. 2003
    ....
  22. doi request reprint Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model
    Stal Saurav Shrestha
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA Electronic address
    Neurosci Lett 559:163-8. 2014
    ..Taken together, our findings demonstrate that antidepressant effects on the serotonergic system are shaped by a GxE interaction that depends on antidepressant class and brain region. ..