Affiliation: Karolinska Institutet
- The focal adhesion protein vinexin alpha regulates the phosphorylation and activity of estrogen receptor alphaMichel Tujague
Department of Biosciences, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
J Biol Chem 279:9255-63. 2004..These results establish a new model of transcriptional regulation where components of the cell-cell and cell-substrate adhesion complexes can regulate the phosphorylation and activity of steroid receptors...
- Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cellsChunyan Zhao
Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
Cancer Res 67:3955-62. 2007..Our data suggest that ERbeta2 could influence ERalpha-mediated effects relevant for breast cancer development, including hormone responsiveness...
- Estrogen receptors: how do they signal and what are their targetsNina Heldring
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
Physiol Rev 87:905-31. 2007..In this review we focus on several of the interesting recent discoveries concerning estrogen receptors, on estrogen as a morphogen, and on the molecular mechanisms of anti-estrogen signaling...
- Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promotersJason Matthews
Department of Biosciences at Novum, Karolinska Institutet, Huddinge 14157, Sweden
Mol Endocrinol 20:534-43. 2006..The altered recruitment of the activating protein-1 complex, combined with the reduction in ERalpha protein levels, may partly explain the antagonistic effect of ERbeta on ERalpha-mediated transcription...