Torbjorn Tomson

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..The authors therefore set out to analyse previous diagnosis of epilepsy as a risk factor for certain cancer forms in a case control study...

..We have now examined the effect of surgery on cardiac autonomic control in the same patients...

..Valproate can be proposed safely to patients with comorbid psychiatric disease or underlying psychiatric vulnerability...

..Little information is, however, available on HRV in untreated patients with newly diagnosed epilepsy...

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..Information on pregnancy outcomes with newer generation AEDs other than lamotrigine are still insufficient...

..To study pharmacokinetics of levetiracetam (LEV) during pregnancy, delivery, lactation, and in the neonatal period...

..This reviews addresses recent reports on the risk for birth defects and impaired postnatal development attributable to prenatal exposure to AEDs...

..Systematic studies of the effects of pregnancy on the pharmacokinetics of the other newer-generation AEDs are urgently needed...

..Further large-scale case-control studies are needed to assess the role of AEDs in order to form a basis for treatment strategies aiming at seizure control and prevention of SUDEP...

..For most of the new-generation AEDs, there is an urgent need for further kinetic data from pregnancy and breast-feeding...

..This review provides a critical discussion and comparison of important methodological aspects of AED and pregnancy registries along with a summary of results published so far...

..Retrospective and a few small prospective studies suggest that exposure to valproate also might be associated with a lower verbal IQ at school age, but further prospective studies are needed to draw firm conclusions...

..Here, we review SUDEP rates, risk factors, triggers, and proposed mechanisms, and critically assess potential preventive strategies. Gaps in knowledge are discussed and ways forward are suggested...

..05). Our data suggest that there may be a transient decline in clearance of LTG in conjunction with presumed menopause...

..Valproate seems to reduce the induction of lamotrigine metabolism associated with pregnancy or use of contraceptives...

..Their objectives were to exchange information on their methodologies and to discuss areas where harmonization might be possible. This report summarizes these discussions...

..These conclusions are largely in line with the recently published report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurology and the American Epilepsy Society...

..In summary, pregabalin provided a consistent improvement in seizure reduction and comparable tolerability in patients with partial-onset epilepsy regardless of the number of concomitant AEDs...

..Withdrawing or changing an AED should generally be avoided during pregnancy. Women with epilepsy on AED treatment should be encouraged to breast-feed...

..To study the pharmacokinetics of gabapentin (GBP) during delivery, lactation, and in the neonatal period...

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..We aimed to establish the risks of major congenital malformations after monotherapy exposure to four major antiepileptic drugs at different doses...

..We examined night versus daytime HRV in patients with newly diagnosed and refractory localization-related epilepsy, assessing the effects of drug treatment and epilepsy surgery on the night/daytime HRV ratio...

..To study diabetes, acute myocardial infarction, and stroke as risk factors for unprovoked seizures in a population-based cohort with incident cases of epilepsy...

..The most common direct seizure-related cause of death in adolescents and young adults is sudden unexpected death, which is 24 times more common than in the general population...

..To study hospitalization for psychiatric disorders before and after onset of unprovoked epileptic seizures/epilepsy...

..Physicians should be aware of the potential cardiovascular implications of epilepsy...

..To further characterize pregnancy-induced alterations in the pharmacokinetics of lamotrigine (LTG)...

..The odds ratio with 95% confidence interval was 3.7 (CI 1.2-11.0) for MS and 8.0 (2.2-30.0) for SLE, suggesting an increased risk of unprovoked seizures in patients with both these diagnoses...

..To study the effects of pregnancy on plasma concentrations of topiramate (TPM)...

..Using 120-124 mM as reference, odds ratios (95% confidence interval) for having seizures at serum sodium levels of 115-119 mM was 3.85 (0.40-37.53), 8.43 (0.859-82.85) at 110-114 mM, and 18.06 (1.96-166.86) at <110 mM...

..To investigate possible underlying mechanisms for alterations in lamotrigine (LTG) kinetics by gestation and use of contraceptives...

..In addition, subcutaneous microdialysate VPA levels were consistently lower than unbound plasma levels in steady state but not after single dose. The mechanisms underlying this observation need to be studied further...

..Moreover, the preventive measures in legislation may be ignored by many people with epilepsy...

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..This risk seems to be reduced after successful surgery but whether this is an effect of surgery or reflects pre-existing differences between good and poor responders is under debate...

..Hence, with the present study design we were unable to identify specific target ranges of GBP and VGB serum concentrations...

..To investigate the pharmacokinetics of lamotrigine (LTG) during delivery, during the neonatal period, and lactation...

..Our observations demonstrate that CBZ may suppress both parasympathetic and sympathetic functions in newly diagnosed patients with epilepsy. The possible implications of our results for sudden unexpected death in epilepsy are discussed...

..If disagreement exists about which category fits a particular case, we suggest the use of consensus decision by a panel of informed reviewers to adjudicate the classification of the case...

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..The finding underlines the need for repeated information when effects on prescription habits are wanted...

..Reliable estimation of unbound phenytoin is not possible at present...

..To discuss the potential value of therapeutic drug monitoring (TDM) of the new antiepileptic drugs gabapentin, lamotrigine, oxcarbazepine, tiagabine, topiramate, vigabatrin and zonisamide...

..To study the incidence of extremity fractures in a group of adult patients with epilepsy attending an outpatient clinic compared with the incidence of fractures in the general population in the same geographic area...

..Our objective was to compare the efficacy and safety of gabapentin and vigabatrin as first-line add-on treatment in patients with partial epilepsy...

..5-5 y of age in children exposed to phenytoin may indicate a subtle influence on psychomotor development, which may be more obvious at school age: thus, larger studies and further follow-up are warranted...

..It appears, however, that the risk of SUD is closely related to seizure frequency, being 40 times higher in patients who continue to have seizures than in those who are seizure-free...