Mita M Thapar
Affiliation: Karolinska Institutet
- In vitro recrudescence of Plasmodium falciparum parasites suppressed to dormant state by atovaquone alone and in combination with proguanilMita M Thapar
Department of Medicine, Infectious Diseases Unit, Malaria Research Laboratory, M9 02, Karolinska University Hospital, Karolinska Institute, SE 171 76 Stockholm, Sweden
Trans R Soc Trop Med Hyg 99:62-70. 2005..The baseline susceptibilities of the parasites to individual drugs were similar before and after recrudescence in all experiments...
- Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil against Plasmodium falciparum in vitroMita M Thapar
Unit of Infectious Diseases, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
Trans R Soc Trop Med Hyg 97:331-7. 2003..We conclude that the effectiveness of Malarone is due to the synergism between atovaquone and proguanil and may not require the presence of cycloguanil...
- Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reportsAnna Farnert
Department of Medicine, Division of Infectious Diseases, Karolinska Institute, Karolinska Hospital, S 171 76 Stockholm, Sweden
BMJ 326:628-9. 2003
- Time-dependent pharmacokinetics and drug metabolism of atovaquone plus proguanil (Malarone) when taken as chemoprophylaxisMita M Thapar
Department of Infectious Diseases, Malaria Research Laboratory, L7 03, Karolinska Hospital, Stockholm 17176, Sweden
Eur J Clin Pharmacol 58:19-27. 2002..To determine the pharmacokinetic profiles of atovaquone (ATO), proguanil (PROG) and its active metabolite cycloguanil (CYCLO) with respect to possible accumulation and kinetic interaction upon repeated dosing with Malarone...