Affiliation: Karolinska Institutet
- Increased levels of proinflammatory cytokines and nitric oxide metabolites in neuropsychiatric lupus erythematosusE Svenungsson
Department of Medicine, Rheumatology Unit, Karolinska Hospital, S 171 76 Stockholm, Sweden
Ann Rheum Dis 60:372-9. 2001..To investigate systemic and intrathecal production of proinflammatory cytokines in relation to cerebrospinal fluid (CSF) nitric oxide (NO) release in patients with neuropsychiatric lupus erythematosus (NPLE)...
- Risk factors for cardiovascular disease in systemic lupus erythematosusE Svenungsson
Department of Rheumatology and Centre for Molecular Medicine, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
Circulation 104:1887-93. 2001..We determined the prevalence of traditional and nontraditional risk factors for CVD in SLE patients with and without CVD compared with controls...
- TNF-alpha: a link between hypertriglyceridaemia and inflammation in SLE patients with cardiovascular diseaseE Svenungsson
Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Lupus 12:454-61. 2003..sTNFR1 and sTNFR2 are strongly associated with CVD in SLE but their exact roles in disease development remain to be elucidated...
- Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor alpha/tumor necrosis factor receptor system in systemic lupus erythematosusElisabet Svenungsson
Department of Medicine, Karolinska Institute, Stockholm, Sweden
Arthritis Rheum 48:2533-40. 2003....
- Cardiac valvular abnormalities are frequent in systemic lupus erythematosus patients with manifest arterial diseaseK Jensen-Urstad
Cardiovascular Laboratory, Department of Medicine, Karolinska Institute at Karolinska Hospital, Stockholm, Sweden
Lupus 11:744-52. 2002..In conclusion, valvular abnormalities are strongly associated with CVD in SLE. Raised levels of homocysteine and triglycerides characterize patients with cardiac valve abnormalities...
- No signs of immunoactivation in the cerebrospinal fluid during treatment with infliximabM Andersson
Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Ann Rheum Dis 65:1237-40. 2006..Induction of systemic IFNgamma production may still be relevant in neuroinflammation associated with treatment with anti-TNFalpha...
- Natural antibodies against phosphorylcholine as potential protective factors in SLEJ Su
Rheumatology Unit, Karolinska University Hospital, Huddinge, Karolinska Institutet corrected Stockholm, Sweden
Rheumatology (Oxford) 47:1144-50. 2008..We have recently reported that natural antibodies against phosphorylcholine (anti-PC) have atheroprotective properties. Here we compare anti-PC with other autoantibodies in SLE patients with and without cardiovascular disease (CVD)...
- Dyslipidaemia and lipoprotein pattern in systemic lupus erythematosus (SLE) and SLE-related cardiovascular diseaseX Hua
Department of Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
Scand J Rheumatol 38:184-9. 2009..This study focused on lipoprotein composition and properties in systemic lupus erythematosus (SLE)...
- Cerebrospinal fluid levels of a proliferation-inducing ligand (APRIL) are increased in patients with neuropsychiatric systemic lupus erythematosusL Hopia
Division of Neurology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
Scand J Rheumatol 40:363-72. 2011..In particular, the association between fatigue and APRIL/BAFF activity was investigated...
- Analysis of JC virus DNA in NPSLE patients treated with different immunomodulatory agentsE Iacobaeus
Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institute, Sweden
Lupus 22:307-11. 2013....
- An exploration of patient-reported symptoms in systemic lupus erythematosus and the relationship to health-related quality of lifeS Pettersson
Rheumatology Clinic, Karolinska University Hospital, Solna, Stockholm, Sweden
Scand J Rheumatol 41:383-90. 2012....
- Cutaneous manifestations and serological findings in 260 patients with systemic lupus erythematosusC M Grönhagen
Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Division of Dermatology, Danderyd, Sweden
Lupus 19:1187-94. 2010..Regular examination by a dermatologist is called for in SLE patients...
- Autoantibodies to the functionally active RING-domain of Ro52/SSA are associated with disease activity in patients with lupusM Kvarnstrom
Department of Medicine, Karolinska Institutet, Sweden
Lupus 22:477-85. 2013....
- Decreased binding of annexin v to endothelial cells: a potential mechanism in atherothrombosis of patients with systemic lupus erythematosusAnna Cederholm
Department of Medicine, Center for Infectious Medicine, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
Arterioscler Thromb Vasc Biol 25:198-203. 2005..The cause of the exceedingly high risk of atherothrombosis in systemic lupus erythematosus (SLE) is not clear but antiphospholipid antibodies (aPL) and potentially antithrombotic annexin V have been implicated...
- Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestationsJohan Frostegard
Center for Infectious Medicine and Center for Metabolism and Endocrinology, Department of Medicine, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
Arthritis Rheum 52:192-200. 2005..Autoantibodies to OxLDL are common in SLE and cross-react with anticardiolipin antibodies (aCL). We therefore hypothesized that lipid peroxidation is enhanced in patients with SLE in general...
- The A-1087IL-10 allele is associated with cardiovascular disease in SLEGuo Zhong Fei
Rheumatology Unit, Department of Medicine at Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
Atherosclerosis 177:409-14. 2004..Furthermore, the IL-10 AA genotype is associated with reduced ratio of atheroprotective to atherogenic cytokines in SLE patients with CVD...
- A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humansLudmila Prokunina
Institute of Genetics and Pathology, Section for Medical Genetics, Rudbeck Laboratories, University of Uppsala, Dag Hammarsjölds väg 20, 751 85, Uppsala, Sweden
Nat Genet 32:666-9. 2002....
- Decreased levels of soluble amyloid beta-protein precursor and beta-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosusEstelle Trysberg
Department of Rheumatology and Inflammation Research, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
Arthritis Res Ther 6:R129-36. 2004..Finally, the increased TGF-beta levels observed may support a notion of an ongoing anti-inflammatory response counteracting tissue injury caused by CNS lupus...
- Platelet-activating factor-acetylhydrolase and other novel risk and protective factors for cardiovascular disease in systemic lupus erythematosusAnna Cederholm
Karolinska University Hospital, Huddinge, Sweden
Arthritis Rheum 50:2869-76. 2004..It is therefore interesting that the risk of CVD is high in inflammatory diseases such as systemic lupus erythematosus (SLE). In this study, we investigated nontraditional risk factors for the development of CVD in patients with SLE...
- Association of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosusElena Sanchez
Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
Arthritis Rheum 56:3080-6. 2007..To determine the potential role of the CD24 A57V gene polymorphism in systemic lupus erythematosus (SLE)...
- A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5Snaevar Sigurdsson
Molecular Medicine, Department of Medical Sciences, Uppsala University, SE 75185 Uppsala, Sweden
Hum Mol Genet 17:2868-76. 2008..82-fold risk of SLE with two independent risk alleles of the IRF5 (interferon regulatory factor 5) gene...
- Corrigendum: Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosusSergey V Kozyrev
Nat Genet 40:484. 2008
- Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosusSergey V Kozyrev
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden
Nat Genet 40:211-6. 2008..The disease-associated variants could contribute to sustained B cell-receptor signaling and B-cell hyperactivity characteristic of this disease...
- Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosusSnaevar Sigurdsson
Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Hum Mol Genet 17:872-81. 2008..We have found that the same IRF5 allele also confers risk for inflammatory bowel diseases and multiple sclerosis, suggesting a general role for IRF5 in autoimmune diseases...
- Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupusRobert R Graham
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 104:6758-63. 2007....