Maria Sunnerhagen

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi The new MATH: homology suggests shared binding surfaces in meprin tetramers and TRAF trimers
    Maria Sunnerhagen
    Molecular Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
    FEBS Lett 530:1-3. 2002
  2. ncbi Molecular mapping of functionalities in the solution structure of reduced Grx4, a monothiol glutaredoxin from Escherichia coli
    Malin Fladvad
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 280:24553-61. 2005
  3. ncbi Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface
    Alexander Espinosa
    Rheumatology Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    J Biol Chem 286:36478-91. 2011
  4. ncbi A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin reductase
    Aristi Potamitou Fernandes
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 280:24544-52. 2005
  5. ncbi Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjögren's syndrome
    Lars Ottosson
    Rheumatology Unit, Department of Medicine, CMM L8 04, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Mol Immunol 43:588-98. 2006
  6. ncbi N and C-terminal sub-regions in the c-Myc transactivation region and their joint role in creating versatility in folding and binding
    Malin Fladvad
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Mol Biol 346:175-89. 2005
  7. ncbi Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block
    Linn S Strandberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Immunol 185:3574-82. 2010
  8. ncbi Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52
    Janosch Hennig
    Molecular Biotechnology, IFM, Campus Valla, Linkoping University, S 581 83 Linkoping, Sweden
    J Biol Chem 280:33250-61. 2005

Collaborators

Detail Information

Publications8

  1. ncbi The new MATH: homology suggests shared binding surfaces in meprin tetramers and TRAF trimers
    Maria Sunnerhagen
    Molecular Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
    FEBS Lett 530:1-3. 2002
    ..Our analysis suggests it is highly likely that the same oligomerization surface is used. The analysis has implications for the widely distributed group of proteins containing MATH domains...
  2. ncbi Molecular mapping of functionalities in the solution structure of reduced Grx4, a monothiol glutaredoxin from Escherichia coli
    Malin Fladvad
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 280:24553-61. 2005
    ..Structural and functional implications are discussed with particular emphasis on identifying common monothiol glutaredoxin properties in substrate specificity and ligand binding events, linking the thioredoxin and glutaredoxin systems...
  3. ncbi Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface
    Alexander Espinosa
    Rheumatology Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    J Biol Chem 286:36478-91. 2011
    ..Our data suggest that anti-Ro52 autoantibodies binding the RING domain of Ro52 may be actively involved in the pathogenesis of rheumatic autoimmune disease by inhibiting Ro52-mediated ubiquitination...
  4. ncbi A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin reductase
    Aristi Potamitou Fernandes
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 280:24544-52. 2005
    ..Grx4 was highly elevated upon iron depletion, suggesting an iron-related function for the protein...
  5. ncbi Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjögren's syndrome
    Lars Ottosson
    Rheumatology Unit, Department of Medicine, CMM L8 04, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Mol Immunol 43:588-98. 2006
    ..The results form a basis for further Ro52 functional studies on the proteome level...
  6. ncbi N and C-terminal sub-regions in the c-Myc transactivation region and their joint role in creating versatility in folding and binding
    Malin Fladvad
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Mol Biol 346:175-89. 2005
    ..This hints towards understanding how binding of a range of targets can be accomplished to a single transactivation domain...
  7. ncbi Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block
    Linn S Strandberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Immunol 185:3574-82. 2010
    ..Our findings show that generation of pathogenic Ro52 Abs is restricted by maternal MHC, whereas the fetal MHC locus regulates susceptibility and determines the fetal disease outcome in anti-Ro52-positive pregnancies...
  8. ncbi Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52
    Janosch Hennig
    Molecular Biotechnology, IFM, Campus Valla, Linkoping University, S 581 83 Linkoping, Sweden
    J Biol Chem 280:33250-61. 2005
    ..Taken together with our previous analysis of autoantigenic epitopes in the coiled-coil region, localization of autoantigenic epitopes in Ro52 appears closely related to molecular functionalities...