Peter Stenvinkel

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Chronic kidney disease: a public health priority and harbinger of premature cardiovascular disease
    P Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 268:456-67. 2010
  2. pmc Elevated circulating levels and tissue expression of pentraxin 3 in uremia: a reflection of endothelial dysfunction
    Anna Witasp
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e63493. 2013
  3. pmc Inflammation as a target for improving health in chronic kidney disease
    Peter Stenvinkel
    Division of Renal Medicine, K56, Karolinska University Hospital at Huddinge 141 86 Stockholm Sweden
    F1000 Med Rep 2:88. 2010
  4. pmc Metabolic changes in summer active and anuric hibernating free-ranging brown bears (Ursus arctos)
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e72934. 2013
  5. doi request reprint Kidney biomimicry--a rediscovered scientific field that could provide hope to patients with kidney disease
    Peter Stenvinkel
    Division of Renal Medicine, Karolinska University Hospital at Huddinge, Karolinska Institutet, Stockholm, Sweden Electronic address
    Arch Med Res 44:584-90. 2013
  6. doi request reprint Chronic kidney disease: a clinical model of premature aging
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Am J Kidney Dis 62:339-51. 2013
  7. doi request reprint Hibernating bears (Ursidae): metabolic magicians of definite interest for the nephrologist
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science Intervention and Technology, Karolinska University Hospital, Stockholm, Sweden
    Kidney Int 83:207-12. 2013
  8. doi request reprint The vulnerable man: impact of testosterone deficiency on the uraemic phenotype
    Juan Jesus Carrero
    Correspondence and offprint requests to Peter Stenvinkel E mail
    Nephrol Dial Transplant 27:4030-41. 2012
  9. doi request reprint Hypogonadism in males with chronic kidney disease: another cause of resistance to erythropoiesis-stimulating agents?
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Contrib Nephrol 178:35-9. 2012
  10. doi request reprint Dialysis in 2011: Can cardiovascular risk in dialysis patients be decreased?
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital at Huddinge, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Nat Rev Nephrol 8:72-4. 2012

Collaborators

Detail Information

Publications137 found, 100 shown here

  1. doi request reprint Chronic kidney disease: a public health priority and harbinger of premature cardiovascular disease
    P Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 268:456-67. 2010
    ..Thus, novel treatment strategies are needed in this high-risk patient group...
  2. pmc Elevated circulating levels and tissue expression of pentraxin 3 in uremia: a reflection of endothelial dysfunction
    Anna Witasp
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e63493. 2013
    ..PTX3 may be involved in adipose tissue-orchestrated mechanisms that are restricted to the uremic milieu and modify inflammation and vascular complications in CKD patients...
  3. pmc Inflammation as a target for improving health in chronic kidney disease
    Peter Stenvinkel
    Division of Renal Medicine, K56, Karolinska University Hospital at Huddinge 141 86 Stockholm Sweden
    F1000 Med Rep 2:88. 2010
    ..However, no randomized controlled trials on anti-inflammatory treatment have yet been performed to test the hypothesis that persistent low-grade inflammation contributes to uremic morbidity and mortality...
  4. pmc Metabolic changes in summer active and anuric hibernating free-ranging brown bears (Ursus arctos)
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e72934. 2013
    ..Further studies to understand how bears can prevent the development of uremia despite minimal renal function during hibernation could provide new therapeutic avenues for the treatment of human kidney disease. ..
  5. doi request reprint Kidney biomimicry--a rediscovered scientific field that could provide hope to patients with kidney disease
    Peter Stenvinkel
    Division of Renal Medicine, Karolinska University Hospital at Huddinge, Karolinska Institutet, Stockholm, Sweden Electronic address
    Arch Med Res 44:584-90. 2013
    ..We suggest that investigation of evolutionary biology and comparative physiology might provide new insights for the prevention and treatment of kidney disease. ..
  6. doi request reprint Chronic kidney disease: a clinical model of premature aging
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Am J Kidney Dis 62:339-51. 2013
    ....
  7. doi request reprint Hibernating bears (Ursidae): metabolic magicians of definite interest for the nephrologist
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science Intervention and Technology, Karolinska University Hospital, Stockholm, Sweden
    Kidney Int 83:207-12. 2013
    ....
  8. doi request reprint The vulnerable man: impact of testosterone deficiency on the uraemic phenotype
    Juan Jesus Carrero
    Correspondence and offprint requests to Peter Stenvinkel E mail
    Nephrol Dial Transplant 27:4030-41. 2012
    ..This review makes a case for consideration of screening and better management of hypogonadism in men undergoing dialysis...
  9. doi request reprint Hypogonadism in males with chronic kidney disease: another cause of resistance to erythropoiesis-stimulating agents?
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Contrib Nephrol 178:35-9. 2012
    ..Thus, a randomized controlled trial is needed to test the possibility that restoration of testosterone levels in hypogonadal CKD males may translate into lower prevalence of anemia, better ESA responsiveness and better quality of life...
  10. doi request reprint Dialysis in 2011: Can cardiovascular risk in dialysis patients be decreased?
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital at Huddinge, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Nat Rev Nephrol 8:72-4. 2012
    ..Several publications in 2011 addressed how interventions can modify cardiovascular risk factors and improve outcomes...
  11. ncbi request reprint Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease?
    P Stenvinkel
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 261:488-99. 2007
    ..DNA methylation is an important cellular mechanism modulating gene expression associated with ageing, inflammation and atherosclerotic processes...
  12. doi request reprint Adiponectin in chronic kidney disease: a complex and context sensitive clinical situation
    Peter Stenvinkel
    Divisions of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Ren Nutr 21:82-6. 2011
    ..Until nutritional and pharmacological treatment strategies that increase adiponectin in uremic patients can be advocated nephrologists have an important task to unravel the observed paradoxes...
  13. ncbi request reprint Resolved: being fat is good for dialysis patients: the Godzilla effect: con
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Am Soc Nephrol 19:1062-4. 2008
  14. ncbi request reprint New insights on inflammation in chronic kidney disease-genetic and non-genetic factors
    Peter Stenvinkel
    Division of Renal Medicine K56, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital at Huddinge, 14186 Stockholm, Suède
    Nephrol Ther 2:111-9. 2006
    ..Indeed, multiple cytokine DNA polymorphisms may affect the inflammatory state, the clinical phenotype as well as outcome in this patient population...
  15. ncbi request reprint C-reactive protein--does it promote vascular disease?
    Peter Stenvinkel
    Department of Renal Medicine K56, Karolinska Institutet, Karolinska University Hospital at Huddinge
    Nephrol Dial Transplant 21:2718-20. 2006
  16. ncbi request reprint Inflammation in end-stage renal disease: the hidden enemy
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Nephrology (Carlton) 11:36-41. 2006
    ..Elevated CRP in dialysis patients could be evaluated at three different levels: (i) national/regional level; (ii) dialysis unit level; and (iii) individual patient level...
  17. ncbi request reprint Statin treatment and diabetes affect myeloperoxidase activity in maintenance hemodialysis patients
    Peter Stenvinkel
    Division of Renal Medicine K56, Karolinska University Hospital at Huddinge, 14186 Stockholm, Sweden
    Clin J Am Soc Nephrol 1:281-7. 2006
    ..2 deltaOD630/min per mg protein) MPO activity compared with 18 who had diabetes and were not taking statins. This cross-sectional study suggests that both diabetes and statin treatment affect MPO activity in prevalent HD patients...
  18. doi request reprint Epigenetics and the uremic phenotype: a matter of balance
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Contrib Nephrol 161:55-62. 2008
    ....
  19. ncbi request reprint [Cardiovascular disease increases the risk of renal failure]
    Peter Stenvinkel
    Karolinska Universitetssjukhuset Huddinge, Stockholm
    Lakartidningen 104:2495. 2007
  20. doi request reprint Does the uremic milieu affect the epigenotype?
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden
    J Ren Nutr 19:82-5. 2009
    ....
  21. doi request reprint Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?
    Peter Stenvinkel
    Department of Renal Medicine, K56, Karolinska University Hospital at Huddinge, 141 86 Stockholm, Sweden
    Clin J Am Soc Nephrol 3:505-21. 2008
    ..Finally, two novel disciplines, proteomics and epigenetics, will be discussed, because these tools may be helpful in the understanding of the discussed vascular risk factors...
  22. ncbi request reprint Inflammation modifies the association of osteoprotegerin with mortality in chronic kidney disease
    Keisuke Matsubara
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Nephrol 22:774-82. 2009
    ..The production and expression of osteoprotegerin (OPG), a bone regulating protein, is regulated by inflammatory cytokines...
  23. pmc Novel links between the long pentraxin 3, endothelial dysfunction, and albuminuria in early and advanced chronic kidney disease
    Mohamed E Suliman
    Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Divisions of Renal Medicine and Baxter Novum, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin J Am Soc Nephrol 3:976-85. 2008
    ..Albuminuria and inflammation predict cardiovascular events. Pentraxin 3, an inflammatory mediator produced by, among others, endothelial cells, may have a role in atherogenesis...
  24. pmc Serum albumin as predictor of nutritional status in patients with ESRD
    Thiane Gama-Axelsson
    Divisions of Baxter Novum and Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Clin J Am Soc Nephrol 7:1446-53. 2012
    ..This study investigated serum albumin and its correlation with several markers of nutritional status in incident and prevalent dialysis patients...
  25. doi request reprint Testosterone deficiency is a cause of anaemia and reduced responsiveness to erythropoiesis-stimulating agents in men with chronic kidney disease
    Juan Jesus Carrero
    Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 27:709-15. 2012
    ..Additionally, we studied associations between endogenous testosterone levels and ESA dose (U/kg/week) in 126 ESA-treated men undergoing haemodialysis (HD)...
  26. ncbi request reprint Serum albumin, C-reactive protein, interleukin 6, and fetuin a as predictors of malnutrition, cardiovascular disease, and mortality in patients with ESRD
    Hirokazu Honda
    Division of Renal Medicine, Department of Clinical Science, Interventions and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Kidney Dis 47:139-48. 2006
    ..In this study, multivariate analyses were performed to assess these 4 biomarkers as predictors of malnutrition, CVD, and mortality in patients with ESRD...
  27. doi request reprint Bone mineral density in end-stage renal disease patients: association with wasting, cardiovascular disease and mortality
    Keisuke Matsubara
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Blood Purif 26:284-90. 2008
    ..We have investigated the relationship between bone mineral density (BMD) and inflammation, wasting, CVD and mortality in ESRD patients...
  28. doi request reprint Muscle atrophy, inflammation and clinical outcome in incident and prevalent dialysis patients
    Juan Jesus Carrero
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Clin Nutr 27:557-64. 2008
    ..We tested the usefulness of a simple observer subjective muscle atrophy (MA) grading in relation to morbidity and mortality in ESRD patients...
  29. ncbi request reprint Self-rated appetite as a predictor of mortality in patients with stage 5 chronic kidney disease
    Thiane Gama-Axelsson
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Ren Nutr 23:106-13. 2013
    ..To investigate the level of anorexia and its correlation with mortality in chronic kidney disease stage 5 patients not yet on dialysis (CKD5-ND) and in those with stage 5 chronic kidney disease undergoing dialysis (CKD5-D)...
  30. doi request reprint Visfatin is increased in chronic kidney disease patients with poor appetite and correlates negatively with fasting serum amino acids and triglyceride levels
    Juan J Carrero
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 25:901-6. 2010
    ..We hypothesized that increased visfatin levels in CKD patients may be involved in the regulation of appetite and nutrient homeostasis...
  31. ncbi request reprint Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease?
    Jonas Axelsson
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Am J Nephrol 28:669-76. 2008
    ..We studied circulating AHSG (ELISA) and two common functional AHSG gene polymorphisms (at amino acids Thr248Met (C-T) and Thr256Ser (C-G) using Pyrosequencing) and related these to multiple components of the metabolic syndrome...
  32. ncbi request reprint Hyperhomocysteinemia in relation to plasma free amino acids, biomarkers of inflammation and mortality in patients with chronic kidney disease starting dialysis therapy
    Mohamed E Suliman
    Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Kidney Dis 44:455-65. 2004
    ..Plasma levels of total homocysteine (tHcy) and free amino acids (AAs) are influenced by nutritional status in patients with chronic kidney disease (CKD), whereas the role of chronic inflammation is not clear...
  33. ncbi request reprint Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality
    Hirokazu Honda
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Clin Nutr 86:633-8. 2007
    ..Overweight in ESRD patients, however, is reported to be associated with better survival...
  34. ncbi request reprint Body fat mass and serum leptin levels influence epoetin sensitivity in patients with ESRD
    Jonas Axelsson
    Division of Renal Medicine, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Am J Kidney Dis 46:628-34. 2005
    ..Furthermore, the adipokine leptin stimulates human erythroid development in vitro. In the present study, we investigate the impact of fat mass and leptin level on epoetin sensitivity in patients with ESRD...
  35. pmc Additive effects of soluble TWEAK and inflammation on mortality in hemodialysis patients
    Juan J Carrero
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Clin J Am Soc Nephrol 4:110-8. 2009
    ..Reduced soluble TNF-like weak inducer of apoptosis (sTWEAK) plasma levels have been reported both in patients with subclinical atherosclerosis and CKD...
  36. ncbi request reprint Consequences of low plasma histidine in chronic kidney disease patients: associations with inflammation, oxidative stress, and mortality
    Makoto Watanabe
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Am J Clin Nutr 87:1860-6. 2008
    ..Histidine is considered as an antiinflammatory and antioxidant factor. Histidine deficiency may contribute to an impaired nutritional state in patients with chronic kidney disease (CKD)...
  37. ncbi request reprint Comparison of nutritional and inflammatory markers in dialysis patients with reduced appetite
    Juan Jesus Carrero
    Division of Renal, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    Am J Clin Nutr 85:695-701. 2007
    ..Anorexia is common in chronic kidney disease and worsens as the disease progresses. Sex hormones and inflammatory cytokines may be related to feeding behavior...
  38. ncbi request reprint Plasma sulfur amino acids in relation to cardiovascular disease, nutritional status, and diabetes mellitus in patients with chronic renal failure at start of dialysis therapy
    Mohamed E Suliman
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Am J Kidney Dis 40:480-8. 2002
    ..Malnutrition, hypoalbuminemia, and DM in patients with CRF influence sAA levels, mainly plasma tHcy, which should be considered when evaluating hyperhomocysteinemia as a cardiovascular risk factor...
  39. doi request reprint Comorbidity and acute clinical events as determinants of C-reactive protein variation in hemodialysis patients: implications for patient survival
    Sunna Snaedal
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Am J Kidney Dis 53:1024-33. 2009
    ..Patients with chronic kidney disease stage 5 have high comorbidity and are prone to inflammation that may contribute to the high cardiovascular mortality risk...
  40. ncbi request reprint Associations between circulating inflammatory markers and residual renal function in CRF patients
    Roberto Pecoits-Filho
    Division of Renal Medicine, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Am J Kidney Dis 41:1212-8. 2003
    ..The aim of the present study is to analyze the relationship between inflammation and glomerular filtration rate (GFR) in 176 patients (age, 52 +/- 1 years; GFR, 6.5 +/- 0.1 mL/min) close to the initiation of renal replacement therapy...
  41. ncbi request reprint Changes in fat mass correlate with changes in soluble sCD163, a marker of mature macrophages, in patients with CKD
    Jonas Axelsson
    Division of Renal Medicine, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Kidney Dis 48:916-25. 2006
    ..Here, we investigate this putative relationship in patients with chronic kidney disease (CKD) by using the novel macrophage marker soluble (s)CD163...
  42. ncbi request reprint Plasma pentosidine is associated with inflammation and malnutrition in end-stage renal disease patients starting on dialysis therapy
    Mohammed E Suliman
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Am Soc Nephrol 14:1614-22. 2003
    ..However, in this small cohort, the plasma pentosidine content did not predict outcome. Thus, accumulation of plasma pentosidine is unlikely to be an appropriate clinically useful marker to predict mortality in ESRD patients...
  43. doi request reprint Elevated serum levels of S-adenosylhomocysteine, but not homocysteine, are associated with cardiovascular disease in stage 5 chronic kidney disease patients
    Alessandro Valli
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin Chim Acta 395:106-10. 2008
    ..Although, S-adenosylhomocysteine (SAH) levels have been linked to CVD in non-renal populations, such relationship has not been evaluated in CKD...
  44. ncbi request reprint Adipose tissue and its relation to inflammation: the role of adipokines
    Jonas Axelsson
    Division of Renal Medicine, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Ren Nutr 15:131-6. 2005
    ..Such an imbalance may, via effects on the central nervous system and the vasculature, contribute to wasting, atherosclerosis, and insulin resistance--all common features of ESRD...
  45. doi request reprint Lipoprotein lipase 1595 c/g and hepatic lipase -480 c/t polymorphisms--impact on lipid profile in incident dialysis patients
    Michal Chmielewski
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Technology and Intervention, Karolinska Institutet, Stockholm, Sweden
    Blood Purif 26:555-60. 2008
    ..The present study was undertaken to clarify the impact of the two polymorphisms on lipid parameters and cardiovascular risk in incident dialysis patients...
  46. ncbi request reprint Plasma pentraxin 3 in patients with chronic kidney disease: associations with renal function, protein-energy wasting, cardiovascular disease, and mortality
    Mengli Tong
    Division of Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin J Am Soc Nephrol 2:889-97. 2007
    ..Plasma protein pentraxin 3 concentrations are elevated in a wide range of diseased states. However, no study has evaluated protein pentraxin 3 in patients with chronic kidney disease...
  47. ncbi request reprint Interleukin-1 gene cluster polymorphisms are associated with nutritional status and inflammation in patients with end-stage renal disease
    Yukio Maruyama
    Department of Clinical Science, Divisions of Renal Medicine and Baxter Novum, Karolinska Institutet, Stockholm, Sweden
    Blood Purif 23:384-93. 2005
    ..Interleukin-1beta (IL-1beta) and its receptor antagonist (IL-1Ra) may play a pivotal role in the pathogenesis of wasting and inflammation...
  48. ncbi request reprint J-shaped mortality relationship for uric acid in CKD
    Mohamed E Suliman
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Kidney Dis 48:761-71. 2006
    ..Hyperuricemia has been associated with increased cardiovascular mortality in the general population, but less is known about this association in patients with CKD...
  49. doi request reprint Protein-energy wasting modifies the association of ghrelin with inflammation, leptin, and mortality in hemodialysis patients
    Juan J Carrero
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 79:749-56. 2011
    ..Thus, since these patients were more anorectic, our results provide a clinical scenario where ghrelin therapies may be particularly useful...
  50. doi request reprint Circulating vascular endothelial growth factor (VEGF) and its soluble receptor 1 (sVEGFR-1) are associated with inflammation and mortality in incident dialysis patients
    Jiangzi Yuan
    Renal Medicine and Baxter Novum, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 28:2356-63. 2013
    ..We investigated determinants of VEGF and sVEGFR-1 as well as their relationship with all-cause mortality in incident dialysis patients...
  51. doi request reprint Relation between serum fibroblast growth factor-23 level and mortality in incident dialysis patients: are gender and cardiovascular disease confounding the relationship?
    Hannes Olauson
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 25:3033-8. 2010
    ..Herein, our aim was to evaluate the relation between FGF23 and mortality, including the impact of gender and cardiovascular disease (CVD), in a Swedish cohort of 'incident' dialysis patients...
  52. ncbi request reprint Circulating levels of visfatin/pre-B-cell colony-enhancing factor 1 in relation to genotype, GFR, body composition, and survival in patients with CKD
    Jonas Axelsson
    Division of Renal Medicine, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden
    Am J Kidney Dis 49:237-44. 2007
    ....
  53. doi request reprint Clinical importance of an elevated circulating chemerin level in incident dialysis patients
    Tae Yamamoto
    Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden
    Nephrol Dial Transplant 25:4017-23. 2010
    ..We explored possible links between chemerin and various clinical, nutritional and biochemical markers as well as its association with 5-year all-cause mortality...
  54. ncbi request reprint Elevated serum 8-oxo-dG in hemodialysis patients: a marker of systemic inflammation?
    Siamak Haghdoost
    Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
    Antioxid Redox Signal 8:2169-73. 2006
    ..Serum levels of 8-oxo-dG, in combination with other inflammatory markers, serve as useful diagnostic tools for identification of patients in risk for inflammatory complications...
  55. ncbi request reprint Inflammation contributes to low plasma amino acid concentrations in patients with chronic kidney disease
    Mohammed E Suliman
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Clin Nutr 82:342-9. 2005
    ..Inflammation and malnutrition are common in chronic kidney disease (CKD) patients, and plasma concentrations of free amino acids (AAs) in these patients are often abnormal. Malnutrition contributes to alterations in AA concentrations...
  56. ncbi request reprint Associations between plasma ghrelin levels and body composition in end-stage renal disease: a longitudinal study
    Ernesto Rodriguez Ayala
    Division of Renal Medicine, Department of Clinical Science, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 19:421-6. 2004
    ..However, no data are available on the relationship between body composition and plasma ghrelin levels in this patient group...
  57. ncbi request reprint Enhanced RAGE-mediated NFkappaB stimulation in inflamed hemodialysis patients
    Ernesto Rodríguez-Ayala
    Division of Renal Medicine, Department of Clinical Science, Karolinska Institutet, K56, Karolinska University Hospital at Huddinge, 141 86 Stockholm, Sweden
    Atherosclerosis 180:333-40. 2005
    ..Inflammation and oxidative stress biomarkers are interrelated in ESRD. Inflammatory cell signal pathways, such as NFkappaB, are activated by CML-modification of proteins via RAGE...
  58. ncbi request reprint Gene polymorphism association studies in dialysis: the nutrition-inflammation axis
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    Semin Dial 18:322-30. 2005
    ....
  59. doi request reprint Abdominal fat deposition is associated with increased inflammation, protein-energy wasting and worse outcome in patients undergoing haemodialysis
    Antonio Carlos Cordeiro
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 25:562-8. 2010
    ..We tested the hypothesis that abdominal fat deposition in HD patients is a risk factor associated with both increased inflammation and protein-energy wasting (PEW), as well as elevated mortality risk...
  60. ncbi request reprint Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism
    Xin Wang
    Divisions of Renal Medicine and Baxter Novum, Karolinska Institutet, K 56 Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    Nephrol Dial Transplant 22:196-202. 2007
    ..In this longitudinal cohort study, we investigated the impact of the UCP2 insertion/deletion (ins/del) polymorphism on body composition changes in ESRD patients starting dialysis...
  61. ncbi request reprint Truncal fat mass as a contributor to inflammation in end-stage renal disease
    Jonas Axelsson
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm
    Am J Clin Nutr 80:1222-9. 2004
    ..Adipose tissue is an endocrine organ that may contribute to an inflammatory burden by secreting adipocytokines such as interleukin 6 (IL-6)...
  62. doi request reprint Prevalence and clinical implications of testosterone deficiency in men with end-stage renal disease
    Juan Jesus Carrero
    Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 26:184-90. 2011
    ..However, the prevalence of testosterone deficiency in end-stage renal disease (ESRD) is not well defined. We hereby explore the prevalence and correlates of clinical testosterone deficiency in a large cohort of ESRD male patients...
  63. pmc Prolactin levels, endothelial dysfunction, and the risk of cardiovascular events and mortality in patients with CKD
    Juan Jesus Carrero
    Divison of Renal Medicine, Karolinska Institutet, Sweden
    Clin J Am Soc Nephrol 7:207-15. 2012
    ..Given the elevated cardiovascular risk of CKD, this study examined links between prolactinemia, vascular derangements, and outcomes...
  64. ncbi request reprint Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin
    Peter Stenvinkel
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska University Hospital, Stockholm, Sweden
    Kidney Int 67:2383-92. 2005
    ..In the present study, we evaluated the association between fetuin-A, clinical phenotype, and outcome, as well as the impact of fetuin gene (AHSG) polymorphisms on the protein product and outcome...
  65. doi request reprint Postprandial metabolic response to a fat- and carbohydrate-rich meal in patients with chronic kidney disease
    Tetsu Miyamoto
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 26:2231-7. 2011
    ..While chronic kidney disease (CKD) is associated with dysmetabolism including a marked insulin resistance, the postprandial response has not comprehensively been studied in CKD patients...
  66. doi request reprint Serum retinol-binding protein concentration and its association with components of the uremic metabolic syndrome in nondiabetic patients with chronic kidney disease stage 5
    Jonas Axelsson
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Nephrol 29:447-53. 2009
    ..Although RBP is elevated in type 2 diabetics with mild CKD, its role in advanced CKD is not well studied. We hypothesized that altered RBP levels in CKD could be one factor contributing to the uremic insulin resistance...
  67. doi request reprint N-terminal pro-brain natriuretic peptide independently predicts protein energy wasting and is associated with all-cause mortality in prevalent HD patients
    Qunying Guo
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden
    Am J Nephrol 29:516-23. 2009
    ..We hypothesized that common confounders, such as protein-energy wasting (PEW) and inflammation could modulate this relationship...
  68. ncbi request reprint Associations of VEGF and its receptors sVEGFR-1 and -2 with cardiovascular disease and survival in prevalent haemodialysis patients
    Qunying Guo
    1Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 24:3468-73. 2009
    ..Soluble VEGF receptors (sVEGFR)-1 and -2 are circulating endogenous modulators of VEGF activity. We thus studied the relationship between sVEGFR-1 and -2 and survival in a cohort of prevalent haemodialysis (HD) patients...
  69. ncbi request reprint Use of single-nucleotide polymorphisms in the search for genetic modifiers of the uremic phenotype
    Anna Witasp
    Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden
    J Ren Nutr 17:17-22. 2007
    ....
  70. ncbi request reprint Overestimation of advanced oxidation protein products in uremic plasma due to presence of triglycerides and other endogenous factors
    Alessandro Valli
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Stockholm, Sweden
    Clin Chim Acta 379:87-94. 2007
    ..Advanced oxidation protein products (AOPP), a suggested protein biomarker of oxidative stress, are elevated in patients with chronic kidney disease (CKD), who also often suffer from hypertriglyceridemia...
  71. pmc Circulating follistatin in patients with chronic kidney disease: implications for muscle strength, bone mineral density, inflammation, and survival
    Tetsu Miyamoto
    Division of Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden
    Clin J Am Soc Nephrol 6:1001-8. 2011
    ..Follistatin mediates muscle growth and bone mineralization. At present, it is unknown whether circulating follistatin levels are altered in chronic kidney disease (CKD) or links to CKD risk factors and outcomes...
  72. ncbi request reprint Vascular calcification inhibitors in relation to cardiovascular disease with special emphasis on fetuin-A in chronic kidney disease
    Mohamed E Suliman
    Department of Clinical Science, Intervention and Technology, Divisions of Renal Medicine and Baxter Novum, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    Adv Clin Chem 46:217-62. 2008
    ..Recent experimental and clinical studies also suggest an intriguing link between fetuin-A, insulin resistance, and the metabolic syndrome...
  73. ncbi request reprint Association between oestrogen receptor alpha gene polymorphism and mortality in female end-stage renal disease patients
    Sawako Kato
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, K 56, 141 86, Stockholm, Sweden
    Nephrol Dial Transplant 22:2571-7. 2007
    ....
  74. ncbi request reprint Identifying and managing malnutrition stemming from different causes
    Sung Hee Chung
    Division of Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Perit Dial Int 27:S239-44. 2007
    ..The present review briefly discusses the causes of PEM/W, the methods most commonly used to identify the condition, and the new management strategies available...
  75. doi request reprint Influence of erythropoiesis-stimulating agents on glycated hemoglobin in nondiabetic kidney diseases at the start of dialysis
    Antonio Carlos Cordeiro
    Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden
    Am J Nephrol 33:17-24. 2011
    ..We evaluated the association of HbA₁(C) with other parameters of glucose homeostasis and tested its association with ESA use and mortality in nondiabetic incident dialysis patients...
  76. pmc Effect of circulating soluble receptor for advanced glycation end products (sRAGE) and the proinflammatory RAGE ligand (EN-RAGE, S100A12) on mortality in hemodialysis patients
    Ayumu Nakashima
    Division of Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Clin J Am Soc Nephrol 5:2213-9. 2010
    ..Whether alterations at this level contribute to the increased mortality observed in patients on dialysis is currently unknown...
  77. ncbi request reprint Reduced gene expression of adiponectin in fat tissue from patients with end-stage renal disease
    Alicia Marchlewska
    Department of Molecular Medicine, Divisions of Renal Medicine and Baxter Novum, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 66:46-50. 2004
    ..Although plasma levels of adiponectin, a recently discovered anti-inflammatory and antiatherogenic adipocytokine, are markedly elevated in ESRD, gene expression of adiponectin (ApM1) has not been analyzed in ESRD patients...
  78. ncbi request reprint Soluble adhesion molecules in end-stage renal disease: a predictor of outcome
    Mohamed E Suliman
    Department of Renal Medicine and Baxter Novum, K56, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    Nephrol Dial Transplant 21:1603-10. 2006
    ....
  79. doi request reprint The role of the TGF/Smad signaling pathway in peritoneal fibrosis induced by peritoneal dialysis solutions
    Qiang Yao
    Divisions of Baxter Novum and Renal Medicine, Department of Clinical Science, Karolinska Institutet, Stockholm, Sweden
    Nephron Exp Nephrol 109:e71-8. 2008
    ....
  80. ncbi request reprint The prognostic impact of fluctuating levels of C-reactive protein in Brazilian haemodialysis patients: a prospective study
    Marcelo M Nascimento
    Division of Renal Medicine, Department of Clinical Science, Karolinska Institutet, Karolinka University Hospital Huddinge, Stockholm, Sweden
    Nephrol Dial Transplant 19:2803-9. 2004
    ..A single elevated C-reactive protein (CRP) value predicts mortality in haemodialysis (HD) patients, but the relative importance of repeated vs occasional positive systemic inflammatory response findings is not known...
  81. doi request reprint Persistent inflammation as a catalyst for other risk factors in chronic kidney disease: a hypothesis proposal
    Juan Jesus Carrero
    Department of Clinical Science, Karolinska Institutet, Stockholm, Sweden
    Clin J Am Soc Nephrol 4:S49-55. 2009
    ....
  82. doi request reprint Cytokine dysregulation in chronic kidney disease: how can we treat it?
    Juan Jesus Carrero
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Blood Purif 26:291-9. 2008
    ....
  83. ncbi request reprint Risk factors for cardiovascular disease in patients undergoing peritoneal dialysis
    Elvia Garcia-Lopez
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Perit Dial Int 27:S205-9. 2007
    ....
  84. ncbi request reprint Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin
    Peter Stenvinkel
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science and Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 65:274-81. 2004
    ..Adiponectin is an adipocytokine that may have significant anti-inflammatory and anti-atherosclerotic effects. Low adiponectin levels have previously been found in patients with high risk for CVD...
  85. doi request reprint Systemic and local inflammation in peritoneal dialysis: mechanisms, biomarkers and effects on outcome
    Antonio Carlos Cordeiro
    Department of Clinical Science, Intervention and Technology Karolinska Institutet, Stockholm, Sweden
    Contrib Nephrol 163:132-9. 2009
    ..Understanding the pathophysiology of inflammation in PD is essential for the adoption of adequate strategies to improve both membrane and patient survival...
  86. ncbi request reprint Inflammation and outcome in end-stage renal failure: does female gender constitute a survival advantage?
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Kidney Int 62:1791-8. 2002
    ..However, although sex hormones may influence serum levels of inflammatory proteins, gender has not been taken into consideration in previous studies of inflammation and outcome in ESRD patients...
  87. ncbi request reprint Inflammation and oxidative stress in ESRD--the role of myeloperoxidase
    Yukio Maruyama
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska University Hospital at Huddinge, Karolinska Institutet, Stockholm, Sweden
    J Nephrol 17:S72-6. 2004
    ..Nutritional and pharmacological antioxidant strategies that interfere with chlorinated MPO-associated oxidative stress pathways need to be investigated in the ESRD patient population...
  88. ncbi request reprint A comparative analysis of nutritional parameters as predictors of outcome in male and female ESRD patients
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Nephrol Dial Transplant 17:1266-74. 2002
    ..Consequently, we need other nutritional markers that can predict outcome. However, males and females differ as regards body composition and it is not known how this may influence the predictive power of different nutritional markers...
  89. ncbi request reprint C-reactive protein in end-stage renal disease: are there reasons to measure it?
    Peter Stenvinkel
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Blood Purif 23:72-8. 2005
    ....
  90. ncbi request reprint Inflammation in end-stage renal disease: sources, consequences, and therapy
    Peter Stenvinkel
    Department of Renal Medicine K56, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    Semin Dial 15:329-37. 2002
    ....
  91. ncbi request reprint Coronary artery disease in end-stage renal disease: no longer a simple plumbing problem
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Karolinska Institutet, K56 Huddinge University Hospital, 141 86 Huddinge, Sweden
    J Am Soc Nephrol 14:1927-39. 2003
  92. ncbi request reprint Chronic systemic inflammation in dialysis patients: an update on causes and consequences
    Qiang Yao
    Divisions of Baxter Novum and Renal Medicine, Department of Clinical Science, Karolinska Institutet, Stockholm, Sweden
    ASAIO J 50:lii-lvii. 2004
    ....
  93. ncbi request reprint Interleukin-6 is an independent predictor of mortality in patients starting dialysis treatment
    Roberto Pecoits-Filho
    Division of Renal Medicine, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Nephrol Dial Transplant 17:1684-8. 2002
    ..The predictive power of sIL-6R levels on outcome is also unknown in this patient population...
  94. doi request reprint Endothelial dysfunction in type-2 diabetics with early diabetic nephropathy is associated with low circulating adiponectin
    Mahmut Ilker Yilmaz
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, K56 Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    Nephrol Dial Transplant 23:1621-7. 2008
    ..We hypothesized that altered kidney clearance and/or metabolism of vasoactive peptides occurring during proteinuria could link early diabetic nephropathy to cardio vascular disease (CVD)...
  95. pmc Low serum testosterone increases mortality risk among male dialysis patients
    Juan Jesus Carrero
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Am Soc Nephrol 20:613-20. 2009
    ..Hypogonadism may be an additional treatable risk factor for patients with chronic kidney disease...
  96. doi request reprint Influence of the CYP2D6 polymorphism and hemodialysis on codeine disposition in patients with end-stage renal disease
    Hadi Molanaei
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Eur J Clin Pharmacol 66:269-73. 2010
    ..We studied the influence of three factors on drug disposition: genetic polymorphism, impaired renal excretion of drug metabolites, and the possible elimination by hemodialysis (HD), using codeine as a model drug...
  97. ncbi request reprint Being an inflamed peritoneal dialysis patient - a Dante's journey
    Juan Jesus Carrero
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Contrib Nephrol 150:144-51. 2006
    ..Finally, we briefly explore potential strategies specifically aiming at reducing intraperitoneal and systemic inflammation in PD patients...
  98. ncbi request reprint Statins to treat chronic inflammation in dialysis patients--is this feasible?
    Olof Heimburger
    Department of Renal Medicine, Karolinska University Hospital, Karolinska Institutet Stockholm, Sweden
    Perit Dial Int 27:254-7. 2007
  99. ncbi request reprint Leptin, ghrelin, and proinflammatory cytokines: compounds with nutritional impact in chronic kidney disease?
    Peter Stenvinkel
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Huddinge University Hospital, Sweden
    Adv Ren Replace Ther 10:332-45. 2003
    ....
  100. ncbi request reprint Appetite disorders in uremia
    Juan Jesus Carrero
    Division of Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Sweden
    J Ren Nutr 18:107-13. 2008
    ..Based on megestrol acetate interventions and the recent observation that sex may modulate uremic appetite behavior, the potential role of sex hormones in treating chronic kidney disease anorexia needs to be further explored...
  101. ncbi request reprint Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure
    P Stenvinkel
    Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Sweden
    Kidney Int 55:1899-911. 1999
    ..In chronic renal failure (CRF), the prevalence of an acute-phase response has been associated with an increased mortality...