Thierry Soussi

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Shaping genetic alterations in human cancer: the p53 mutation paradigm
    Thierry Soussi
    Université P M Curie, 4 place Jussieu, 75005 Paris, France
    Cancer Cell 12:303-12. 2007
  2. ncbi request reprint p53 alterations in human cancer: more questions than answers
    T Soussi
    Department of Life Sciences, Université Pierre et Marie Curie Paris, Paris, France
    Oncogene 26:2145-56. 2007
  3. doi request reprint Advances in carcinogenesis: a historical perspective from observational studies to tumor genome sequencing and TP53 mutation spectrum analysis
    Thierry Soussi
    Karolinska Institute, Dept of Oncology Pathology Cancer Center Karolinska CCK, SE 171 76 Stockholm, Sweden
    Biochim Biophys Acta 1816:199-208. 2011
  4. doi request reprint MUT-TP53 2.0: a novel versatile matrix for statistical analysis of TP53 mutations in human cancer
    Thierry Soussi
    Karolinska Institute Department of Oncology Pathology Cancer Center Karolinska, Stockholm, Sweden
    Hum Mutat 31:1020-5. 2010
  5. doi request reprint When mutant p53 plays hide and seek: a new challenge for diagnosis and therapy?
    Thierry Soussi
    Department of Oncology Pathology, Cancer Centre Karolinska CCK, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Trends Mol Med 15:1-4. 2009
  6. ncbi request reprint Rapid and sensitive p53 alteration analysis in biopsies from lung cancer patients using a functional assay and a universal oligonucleotide array: a prospective study
    Coralie Fouquet
    EA3493, UPMC IC of corrected Laboratoire de génotoxicologie des tumeurs, Paris, France
    Clin Cancer Res 10:3479-89. 2004
  7. ncbi request reprint Analysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination
    Hanna Berglind
    Karolinska Institute, Department of Oncology Pathology, Cancer Center Karolinska CCK, Stockholm, Sweden
    Cancer Biol Ther 7:699-708. 2008
  8. ncbi request reprint Locus-specific mutation databases: pitfalls and good practice based on the p53 experience
    Thierry Soussi
    Université P M Curie, 4 place Jussieu, 75005 Paris, France
    Nat Rev Cancer 6:83-90. 2006
  9. ncbi request reprint Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations
    Thierry Soussi
    Laboratoire de Génotoxicologie des tumeurs, Departement de Pneumologie, Hopital Tenon, Paris, France
    Hum Mutat 25:6-17. 2005
  10. ncbi request reprint Meta-analysis of the p53 mutation database for mutant p53 biological activity reveals a methodologic bias in mutation detection
    Thierry Soussi
    Laboratoire de Génotoxicologie des tumeurs, UPMC, Dpt Pneumologie, Hopital Tenon, Paris, France
    Clin Cancer Res 12:62-9. 2006

Collaborators

  • Chikashi Ishioka
  • Christophe Beroud
  • Yudi Pawitan
  • Francis Barany
  • Bernard Milleron
  • Khuong Truong
  • Claudine Junien
  • Catherine Gallou
  • B J Iacopetta
  • Pascaline Tisserand
  • Coralie Fouquet
  • Bernard Leroy
  • Hanna Berglind
  • Zhi Ping Ren
  • Antonio Russo
  • Karim Bensaad
  • Jean Louis Fournier
  • Paola Monti
  • Alberto Inga
  • Gilberto Fronza
  • Shunsuke Kato
  • Monica Nister
  • Tommie Olofsson
  • Anja Smits
  • Hannu Kalimo
  • Mingqi Qu
  • Göran Hesselager
  • Viviana Bazan
  • David Kerr
  • Nicola Gebbia
  • Jacques Cadranel
  • Frederic Commo
  • Reyna Favis
  • Marie France Carette
  • Gerard Zalcman
  • Nathalie Rabbe
  • Marie Wislez
  • Martine Antoine
  • Xavier Sastre-Garau
  • Dominique Stoppa-Lyonnet
  • Giovanni Blandino
  • Remi Dendale
  • Osamu Tominaga
  • Véronique Marck
  • Sabrina Strano
  • Monique Fabre
  • Dany Rouillard
  • Keziban Unsal
  • Alain Fourquet
  • Morgane Le Bras
  • Michel Barrois
  • Christine Mallard
  • Philippe Vielh

Detail Information

Publications31

  1. ncbi request reprint Shaping genetic alterations in human cancer: the p53 mutation paradigm
    Thierry Soussi
    Université P M Curie, 4 place Jussieu, 75005 Paris, France
    Cancer Cell 12:303-12. 2007
    ....
  2. ncbi request reprint p53 alterations in human cancer: more questions than answers
    T Soussi
    Department of Life Sciences, Université Pierre et Marie Curie Paris, Paris, France
    Oncogene 26:2145-56. 2007
    ..Finally, the possible clinical applications of p53 will be discussed...
  3. doi request reprint Advances in carcinogenesis: a historical perspective from observational studies to tumor genome sequencing and TP53 mutation spectrum analysis
    Thierry Soussi
    Karolinska Institute, Dept of Oncology Pathology Cancer Center Karolinska CCK, SE 171 76 Stockholm, Sweden
    Biochim Biophys Acta 1816:199-208. 2011
    ....
  4. doi request reprint MUT-TP53 2.0: a novel versatile matrix for statistical analysis of TP53 mutations in human cancer
    Thierry Soussi
    Karolinska Institute Department of Oncology Pathology Cancer Center Karolinska, Stockholm, Sweden
    Hum Mutat 31:1020-5. 2010
    ..Furthermore, using functional and statistical information issued from the UMD p53 database, it allows to assess the biological activity and the likelihood of every p53 mutant...
  5. doi request reprint When mutant p53 plays hide and seek: a new challenge for diagnosis and therapy?
    Thierry Soussi
    Department of Oncology Pathology, Cancer Centre Karolinska CCK, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Trends Mol Med 15:1-4. 2009
    ..In light of these observations, targeting the MDM2-p53 interaction for therapy of human cancer could be more complicated than previously anticipated...
  6. ncbi request reprint Rapid and sensitive p53 alteration analysis in biopsies from lung cancer patients using a functional assay and a universal oligonucleotide array: a prospective study
    Coralie Fouquet
    EA3493, UPMC IC of corrected Laboratoire de génotoxicologie des tumeurs, Paris, France
    Clin Cancer Res 10:3479-89. 2004
    ..Identifying tumor mutations in such samples will require a sensitive and robust technology to overcome signal from excess amounts of normal DNA...
  7. ncbi request reprint Analysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination
    Hanna Berglind
    Karolinska Institute, Department of Oncology Pathology, Cancer Center Karolinska CCK, Stockholm, Sweden
    Cancer Biol Ther 7:699-708. 2008
    ..The p53 web site has been updated with new sections describing the p53 status in the majority of cell lines and a special section devoted to cell lines with controversial p53 status...
  8. ncbi request reprint Locus-specific mutation databases: pitfalls and good practice based on the p53 experience
    Thierry Soussi
    Université P M Curie, 4 place Jussieu, 75005 Paris, France
    Nat Rev Cancer 6:83-90. 2006
    ..However, there are several biases in this database that can lead to serious erroneous interpretations. We describe several rules for mutation database management that could benefit the entire scientific community...
  9. ncbi request reprint Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations
    Thierry Soussi
    Laboratoire de Génotoxicologie des tumeurs, Departement de Pneumologie, Hopital Tenon, Paris, France
    Hum Mutat 25:6-17. 2005
    ....
  10. ncbi request reprint Meta-analysis of the p53 mutation database for mutant p53 biological activity reveals a methodologic bias in mutation detection
    Thierry Soussi
    Laboratoire de Génotoxicologie des tumeurs, UPMC, Dpt Pneumologie, Hopital Tenon, Paris, France
    Clin Cancer Res 12:62-9. 2006
    ..We were concerned by the inclusion of dubious reports in the p53 databases that could lead to controversial analysis prejudicial to the scientific community...
  11. ncbi request reprint Quantitative fish determination of chromosome 3 arm imbalances in lung tumors by automated image cytometry
    Khuong Truong
    Instabilité du Génome et Cancer, FRE 2584 CNRS Institut Curie and 2 IMSTAR, Paris, France
    Med Sci Monit 10:BR426-32. 2004
    ..In addition, detection of pre-neoplastic lesions with only a few cells involved may improve the diagnosis of such lesions and their precocious treatment...
  12. pmc The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis
    Bernard Leroy
    Universite Pierre et Marie Curie PARIS6, 75005 Paris, France
    Nucleic Acids Res 41:D962-9. 2013
    ..For several hot spot mutants, multiple gain of function activities are also included. The database can be easily browsed via a graphical user interface...
  13. ncbi request reprint Significance of TP53 mutations in human cancer: a critical analysis of mutations at CpG dinucleotides
    Thierry Soussi
    Institut Curie and Université P and M Curie, EA3493, Laboratoire de Génotoxicologie des tumeurs, Paris, France
    Hum Mutat 21:192-200. 2003
    ..Overall, these data indicate that great caution is required when analyzing the significance of p53 mutations...
  14. doi request reprint TP53 mutations in human cancer: database reassessment and prospects for the next decade
    Thierry Soussi
    Department of Oncology Pathology, Cancer Center Karolinska CCK, Karolinska Institute, Stockholm, Sweden
    Adv Cancer Res 110:107-39. 2011
    ..We will also discuss how the genetic data will be stored and handled in the future and the consequences for database management...
  15. ncbi request reprint ThinPrep-processed fine-needle samples of breast are effective material for RNA- and DNA-based molecular diagnosis: application to p53 mutation analysis
    Pascaline Tisserand
    Laboratoire de Génotoxicologie des tumeurs, Institut Curie, Paris, France
    Cancer 99:223-32. 2003
    ..The aim of the current study was to assess the accuracy of molecular diagnosis techniques using fine-needle sample (FNS) material stored in PreservCyt (Cytyc Corp., Boxborough, MA)...
  16. ncbi request reprint [Immunochemistry and genotype analysis of tumors. Second part: What future for the molecular diagnosis of tumors?]
    Thierry Soussi
    Laboratoire de Génotoxicologie des tumeurs, Institut Curie, Universite Pierre and Marie Curie, 26 Rue d Ulm, 75005 Paris, France
    Ann Pathol 22:113-20. 2002
    ..Furthermore, the relation between genotype and phenotype is not straightforward and can be influence by various parameters such as the localization of the mutation, the alterations of other genes or the expression of modifier genes...
  17. ncbi request reprint Assessing TP53 status in human tumours to evaluate clinical outcome
    T Soussi
    Institut Curie, Universite P and M Curie, Laboratoire de Génotoxicologie des tumeurs, Paris, France
    Nat Rev Cancer 1:233-40. 2001
    ..What simple steps can be taken to ensure that patients benefit from our understanding of TP53?..
  18. ncbi request reprint The p53 pathway and human cancer
    T Soussi
    Hopital Tenon, 26 Rue d Ulm, 75005 Paris, France, and Cancer Centre Karolinska, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Br J Surg 92:1331-2. 2005
  19. ncbi request reprint The p53 tumor suppressor gene: from molecular biology to clinical investigation
    T Soussi
    Institut Curie, Laboratoire de Génotoxicologie des tumeurs, Paris, France
    Ann N Y Acad Sci 910:121-37; discussion 137-9. 2000
    ..Several studies have shown that p53 mutations are associated with short survival in colorectal cancer, but the use of p53 as a tumoral marker is still a matter of debate...
  20. ncbi request reprint p53 Antibodies in the sera of patients with various types of cancer: a review
    T Soussi
    Laboratoire de Génotoxicologie des tumeurs, Institut Curie, Paris, France
    Cancer Res 60:1777-88. 2000
    ..The finding of p53-Abs in the sera of individuals who are at high risk of cancer, such as exposed workers or heavy smokers, indicates that they have promising potential in the early detection of cancer...
  21. ncbi request reprint p53 mutation heterogeneity in cancer
    T Soussi
    Laboratoire de Génotoxicologie des tumeurs, EA3493 IC UPMC, Hopital Tenon, Dpt Pneumologie, 26 Rue d Ulm, 75005 Paris, France
    Biochem Biophys Res Commun 331:834-42. 2005
    ..The fact that the apoptotic and antiproliferative functions of p53 can be dissociated in certain mutants also suggests another level of complexity in the relationships between p53 inactivation and neoplasia...
  22. ncbi request reprint p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis
    T Soussi
    Institut Curie, UMR 218 CNRS, Paris, France
    Hum Mutat 15:105-13. 2000
    ..This software includes an optimized structure to assist and secure data entry and to allow the input of various clinical data...
  23. ncbi request reprint UMD (Universal mutation database): a generic software to build and analyze locus-specific databases
    C Beroud
    INSERM U383, Hopital Necker Enfants Malades, Clinique Maurice Lamy, Paris, France
    Hum Mutat 15:86-94. 2000
    ..Four new LSDBs are under construction (VLCAD, MCAD, KIR6, and COL4A5). Finally, the data can be transferred to core databases...
  24. ncbi request reprint Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors
    Zhi Ping Ren
    Department of Genetics and Pathology, Uppsala University, University Hospital, Uppsala, Sweden
    J Neuropathol Exp Neurol 66:944-54. 2007
    ..Our results are of importance for a further understanding of the molecular mechanisms behind failure to treat glioma patients...
  25. ncbi request reprint Change of conformation of the DNA-binding domain of p53 is the only key element for binding of and interference with p73
    Karim Bensaad
    Laboratoire de Génotoxicologie des tumeurs, Institut Curie, 26 Rue d Ulm, 75005 Paris, France
    J Biol Chem 278:10546-55. 2003
    ..These results reinforce the notion that mutant p53 with a conformational change can act as a down-regulator of the p73 pathway in human cancer and could confer a selective advantage to the tumor...
  26. ncbi request reprint Focus on the p53 gene and cancer: advances in TP53 mutation research
    Thierry Soussi
    Hum Mutat 21:173-5. 2003
  27. ncbi request reprint The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment
    Antonio Russo
    Universita di Palermo, Department of Oncology, Italy
    J Clin Oncol 23:7518-28. 2005
    ....
  28. ncbi request reprint UMD (Universal Mutation Database): 2005 update
    Christophe Beroud
    Laboratoire de Genetique Moleculaire, IURC, Montpellier, France
    Hum Mutat 26:184-91. 2005
    ....
  29. ncbi request reprint p53 mutations and resistance to chemotherapy: A stab in the back for p73
    Thierry Soussi
    Cancer Cell 3:303-5. 2003
    ..p73 is essential for apoptosis induced by many cytotoxic agents, but this function can be blocked by a particular category of p53 mutations that have consequently acquired a gain of function...
  30. ncbi request reprint [p53 mutations and resistance to chemotherapy: a stab in the back for p73?]
    Thierry Soussi
    Bull Cancer 90:383-6. 2003
    ..Such discovery will be important for a better understanding of the signaling pathway that lead to resistance to chemotherapy...
  31. ncbi request reprint Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors
    Pascaline Tisserand
    Laboratoire de Genotoxicololgie des Tumeurs Paris, France
    Cancer Biol Ther 2:559-63. 2003
    ..Medullary carcinoma of the breast should therefore be considered to be a unique entity defined by specific histologic and molecular traits...