Research Topics
| Anna Smed-SorensenSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Detail Information
Publications
Targeting dendritic cells for improved HIV-1 vaccinesAnna Smed-Sorensen
Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Adv Exp Med Biol 762:263-88. 2013..The susceptibility and responses of DCs to recombinant adenovirus vectors are reviewed, as well as the strategy of directly targeting DCs by using DC marker-specific monoclonal antibodies coupled to an antigen...
Influenza A virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cellsAnna Smed-Sorensen
Genentech, South San Francisco, California, USA
PLoS Pathog 8:e1002572. 2012..Our results suggest that cross-presentation by uninfected mDCs is a preferred mechanism of antigen-presentation for the activation and expansion of CD8 T cells during IAV infection...- Dendritic cells at the interface of innate and adaptive immunity to HIV-1Anna Smed-Sorensen
Department of Microbiology, Tumor and Cell Biology bCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Curr Opin HIV AIDS 6:405-10. 2011..This review summarizes recent findings on how HIV-1 infection affects dendritic cells in their ability to elicit innate and adaptive immune responses... 
HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulationAnna Smed-Sorensen
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, F59 Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
Blood 104:2810-7. 2004..These observations suggest that HIV-1 infection disables DC function, a phenomenon that may be relevant for optimal induction of HIV-1-specific immune responses...- IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naïve B cell differentiationCornelia Gujer
Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
J Leukoc Biol 89:811-21. 2011..In summary, PDCs, via their production of IFN-α, may render B cells more responsive to T cell contact, which in turn, facilitates B cell proliferation and differentiation to antibody-producing cells... - Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cellsAnna Smed-Sorensen
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, F59 Huddinge University Hospital, S 141 86 Stockholm, Sweden
J Virol 79:8861-9. 2005..The difference in susceptibility of PDCs and MDCs to HIV-1 may have implications for HIV-1 transmission and DC-mediated transfer of HIV-1 to T cells... - Plasma and mucosal fluid from HIV type 1-infected patients but not from HIV type 1-exposed uninfected subjects prevent HIV type 1-exposed DC from infecting other target cellsJohan Söderlund
Infectious Diseases Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
AIDS Res Hum Retroviruses 23:101-6. 2007..However, they readily neutralized HIV-1 infection of PBMC alone. This may suggest that protection against HIV-1 infection in HEPS individuals occurs prior to interaction between HIV-1-exposed DC and other target cells... - Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartmentsMarkus Moll
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Blood 116:1876-84. 2010.... - Triggering of dendritic cell responses after exposure to activated, but not resting, apoptotic PBMCsUlrika Johansson
Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
J Immunol 179:1711-20. 2007..Together, these findings show that activated apoptotic PBMCs per se provide an activation/maturation signal to DCs, suggesting that activated apoptotic PBMCs possess endogenous adjuvant properties... - Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentationLillian Cohn
Genentech, South San Francisco, CA 94080
J Exp Med 210:1049-63. 2013..Thus, multiple DC populations may be comparably effective at presenting exogenous antigens to CD8(+) T cells as long as the antigen is delivered to early endocytic compartments... - Plasmacytoid dendritic cells infiltrate the skin in positive tuberculin skin test indurationsEmily Bond
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
J Invest Dermatol 132:114-23. 2012.... - Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cellsIyadh Douagi
Swedish Institute for Infectious Disease Control, Stockholm, Sweden
J Immunol 182:1991-2001. 2009..These data help decipher the different roles of PDCs and MDCs for modulating human B cell responses and can contribute to selection of specific TLR ligands as vaccine adjuvants... - IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcgammaRIIaAnna Smed-Sorensen
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Blood 111:5037-46. 2008..Our data demonstrate an important role for FcgammaRIIa in regulating the CD1 antigen presentation machinery of human DCs... - Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacityEmily Bond
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
J Immunol Methods 348:42-56. 2009..These methods offer potency for various applications addressing antigen uptake, microbial DC interactions or other antigenic stimulation targeting the skin and can enhance our knowledge of basic DC biology in human skin...