Genomes and Genes
Affiliation: Karolinska Institutet
- ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytesJosefin Skogsberg
The Computational Medicine Group, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
PLoS ONE 3:e3771. 2008..Whether there also exists a reciprocal metabolic arm affecting energy metabolism in white adipose tissue is unknown...
- Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genesJosefin Skogsberg
The Computational Medicine Group, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
PLoS Genet 4:e1000036. 2008..This network should be of interest for the development of novel atherosclerosis therapies...
- Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) studySara Hägg
The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
PLoS Genet 5:e1000754. 2009..Thus, the A-module appears to be important for atherosclerosis development and, together with LDB2, merits further attention in CAD research...
- Blood levels of dual-specificity phosphatase-1 independently predict risk for post-operative morbidities causing prolonged hospitalization after coronary artery bypass graftingSara Hägg
The Cardiovascular Genomics Group, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Stockholm, Sweden
Int J Mol Med 27:851-7. 2011....
- Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulinSara Hägg
The Cardiovascular Genomics Group, Department of Medical Biochemistry and Biophysics, Solna, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e18248. 2011..We took advantage of the atmospheric (14)C-declination curve (a result of the atomic bomb tests in the 1950s and 1960s) to determine the average biological age of carotid plaques...
- PPARdelta increases expression of the human apolipoprotein A-II gene in human liver cellsPetra Thulin
Atherosclerosis Research Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
Int J Mol Med 21:819-24. 2008..In conclusion, PPARdelta increases the expression of the human apoA-II gene in liver cells via a PPRE in the proximal promoter...
- MMP-2 and MMP-9 are prominent matrix metalloproteinases during atherosclerosis development in the Ldlr(-/-)Apob(100/100) mouseDick Wågsäter
Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Solna, Stockholm, Sweden
Int J Mol Med 28:247-53. 2011..The study suggests that MMP-2 and MMP-9 are the main proteases involved in atherogenesis in this mouse model...
- Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor deltaDavid Kitz Krämer
Department of Surgical Science, Karolinska Institute, Stockholm, Sweden
Diabetes 54:1157-63. 2005..Moreover, we provide biological validation of PPARdelta as a potential target for antidiabetic therapy...
- The low density lipoprotein receptor prevents secretion of dense apoB100-containing lipoproteins from the liverSofia L Larsson
Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Institutet, Karolinska Hospital, 17176 Stockholm, Sweden
J Biol Chem 279:831-6. 2004..In addition, these results suggest that very low levels of MTP are insufficient to mediate the second step but sufficient for the first step of VLDL assembly...
- Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Multi-organ whole-genome measurements and reverse engineering to uncover gene networks underlying complex traitsJesper Tegner
The CoCenter for Molecular Medicine, King Gustaf V Research Institute, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
J Lipid Res 48:267-77. 2007..We also address how gene networks will probably play a key role in the development of early diagnostics and treatments for complex disorders in the coming era of individualized medicine...
- PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cellsBjorn Glinghammar
King Gustaf V Research Institute, Karolinska Institutet, Karolinska Hospital, S 171 76 Stockholm, Sweden
Biochem Biophys Res Commun 308:361-8. 2003..These results may suggest that PPARdelta plays an important role in the development of HCC by modulating expression of COX-2...
- Troglitazone stimulates IGF-binding protein-1 by a PPAR gamma-independent mechanismAgneta Hilding
Department of Molecular Medicine, Karolinska Institutet and Hospital, Stockholm, Sweden
Biochem Biophys Res Commun 303:693-9. 2003..We conclude that the effect of troglitazone on IGFBP-1 production by HepG2 cells is independent of PPAR and may involve PXR...