Linda Söderberg

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site
    Linda Söderberg
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center, Neurotec, Novum, SE 141 57 Huddinge, Sweden
    J Biol Chem 280:1007-15. 2005
  2. ncbi CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation
    Hiroyoshi Kakuyama
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Karolinska Institutet, SE 141 57 Huddinge, Sweden
    Biochemistry 44:15602-9. 2005
  3. ncbi Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates
    Linda Söderberg
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Novum, Huddinge, Sweden
    FEBS J 272:2231-6. 2005
  4. ncbi Analysis of single Alzheimer solid plaque cores by laser capture microscopy and nanoelectrospray/tandem mass spectrometry
    Linda Söderberg
    Karolinska Institutet and Dainippon Sumitomo Pharma Alzheimer Center KASPAC, Neurotec, Novum
    Biochemistry 45:9849-56. 2006

Detail Information

Publications4

  1. ncbi Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site
    Linda Söderberg
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center, Neurotec, Novum, SE 141 57 Huddinge, Sweden
    J Biol Chem 280:1007-15. 2005
    ..These findings may be useful for future therapeutic interventions aimed at finding compounds that modulate the binding of CLAC to Abeta deposits...
  2. ncbi CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation
    Hiroyoshi Kakuyama
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Karolinska Institutet, SE 141 57 Huddinge, Sweden
    Biochemistry 44:15602-9. 2005
    ..Taken together, we suggest that CLAC becomes involved at an intermediate stage in the pathogenesis by binding to Abeta fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth...
  3. ncbi Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates
    Linda Söderberg
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Novum, Huddinge, Sweden
    FEBS J 272:2231-6. 2005
    ..Therefore, CLAC assembles Abeta fibrils into fibril bundles that have an increased resistance to proteases. We suggest that CLAC may act in a similar way in vivo...
  4. ncbi Analysis of single Alzheimer solid plaque cores by laser capture microscopy and nanoelectrospray/tandem mass spectrometry
    Linda Söderberg
    Karolinska Institutet and Dainippon Sumitomo Pharma Alzheimer Center KASPAC, Neurotec, Novum
    Biochemistry 45:9849-56. 2006
    ....