G Schulte

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation
    Carina Halleskog
    Dept Physiology and Pharmacology, Sec Receptor Biology and Signaling, Karolinska Institutet, Nanna Svartz vag 2, Stockholm, S 17177, Sweden
    J Neuroinflammation 9:111. 2012
  2. doi request reprint International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptors
    Gunnar Schulte
    Section of Receptor Biology and Signaling, Dept of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Pharmacol Rev 62:632-67. 2010
  3. pmc beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?
    Gunnar Schulte
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Br J Pharmacol 159:1051-8. 2010
  4. ncbi request reprint The Frizzled family of unconventional G-protein-coupled receptors
    Gunnar Schulte
    Section of Receptor Biology and Signaling, Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Trends Pharmacol Sci 28:518-25. 2007
  5. ncbi request reprint Novel aspects of G-protein-coupled receptor signalling--different ways to achieve specificity
    G Schulte
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 190:33-8. 2007
  6. doi request reprint Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice
    L Li
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, S 171 77 Stockholm, Sweden
    Neuroscience 170:923-8. 2010
  7. doi request reprint The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia
    Malin Jonsson Fagerlund
    Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1270-9. 2010
  8. pmc Molecular reorganization of endocannabinoid signalling in Alzheimer's disease
    Jan Mulder
    European Neuroscience Institute at Aberdeen, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Brain 134:1041-60. 2011
  9. ncbi request reprint Modulation of glial cell functions by adenosine receptors
    Elisabetta Daré
    Karolinska Institute, Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Nanna Svartz vag 2, S 171 77 Stockholm, Sweden
    Physiol Behav 92:15-20. 2007
  10. doi request reprint Recombinant WNTs differentially activate β-catenin-dependent and -independent signalling in mouse microglia-like cells
    M B C Kilander
    Section Receptor Biology and Signalling, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 203:363-72. 2011

Collaborators

  • Patrik Ernfors
  • Vitezslav Bryja
  • Ernest Arenas
  • B B Fredholm
  • Robert Edwards
  • Elisabetta Daré
  • Fernanda Ledda
  • Masahiko Watanabe
  • K A Jacobson
  • Wolfgang Hartig
  • Dietmar Gradl
  • Peter P Mager
  • Jessica Kåhlin
  • Tibor Harkany
  • Paul Berghuis
  • Ken Mackie
  • Carina Halleskog
  • A Wiklund
  • Marton B Dobszay
  • Kyle M Sousa
  • Jan Mulder
  • M B C Kilander
  • L Li
  • Malin Jonsson Fagerlund
  • Maria Lindqvist
  • Frank Brand
  • Yuri Zilberter
  • Jan Lynge
  • Christian Hammarberg
  • Michaela Brita Christina Kilander
  • E Sundman
  • D Gustavsson
  • L I Eriksson
  • Javier Becerril-Ortega
  • Eva Lindgren
  • Jacomijn Petronella Dijksterhuis
  • M Jonsson Fagerlund
  • A Ebberyd
  • Juan Carlos Villaescusa
  • Attila Köfalvi
  • Misha Zilberter
  • Susana J Pasquaré
  • Alan Alpar
  • Samira G Ferreira
  • Heikki Tanila
  • C Halleskog
  • Maria L De Ceballos
  • Ana M Martín-Moreno
  • Tibor Hortobagyi
  • Erik Keimpema
  • Cecilia Dyberg
  • Rieko Ajima
  • Hugo Lagercrantz
  • Souren Mkrtchian
  • Anette Ebberyd
  • Terry P Yamaguchi
  • Thomas Ringstedt
  • J X Hao
  • Panagiotis Papachristou
  • Lars I Eriksson
  • X J Xu
  • Zachi Horn
  • Z Wiesenfeld-Hallin
  • Athena M Klutz
  • Xinyu Wang
  • Sabrina Spano
  • Yasmin L Hurd
  • Gustavo Paratcha
  • Jon Storm-Mathisen
  • Tayyaba Qureshi
  • Carl Holmgren
  • Tamás J Görcs
  • Robert T Fremeau
  • Farrukh A Chaudhry
  • Nikolai Nordsborg
  • Ylva Hellsten

Detail Information

Publications29

  1. pmc Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation
    Carina Halleskog
    Dept Physiology and Pharmacology, Sec Receptor Biology and Signaling, Karolinska Institutet, Nanna Svartz vag 2, Stockholm, S 17177, Sweden
    J Neuroinflammation 9:111. 2012
    ..WNT-5A, however, generally recruits β-catenin-independent signaling. Thus, we aim here to characterize the role of WNT-5A and downstream signaling pathways for the inflammatory transformation of the brain's macrophages, the microglia...
  2. doi request reprint International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptors
    Gunnar Schulte
    Section of Receptor Biology and Signaling, Dept of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Pharmacol Rev 62:632-67. 2010
    ....
  3. pmc beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?
    Gunnar Schulte
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Br J Pharmacol 159:1051-8. 2010
    ....
  4. ncbi request reprint The Frizzled family of unconventional G-protein-coupled receptors
    Gunnar Schulte
    Section of Receptor Biology and Signaling, Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Trends Pharmacol Sci 28:518-25. 2007
    ..Here, we outline the current state of knowledge on FZDs and FZD signal transduction and pinpoint aspects of debate and future directions...
  5. ncbi request reprint Novel aspects of G-protein-coupled receptor signalling--different ways to achieve specificity
    G Schulte
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 190:33-8. 2007
    ....
  6. doi request reprint Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice
    L Li
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, S 171 77 Stockholm, Sweden
    Neuroscience 170:923-8. 2010
    ..The results indicate that activation of peripheral adenosine A(2A) receptors during inflammation is associated with mechanical hyperalgesia, and that this effect is more prominent in females than in males...
  7. doi request reprint The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia
    Malin Jonsson Fagerlund
    Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1270-9. 2010
    ....
  8. pmc Molecular reorganization of endocannabinoid signalling in Alzheimer's disease
    Jan Mulder
    European Neuroscience Institute at Aberdeen, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Brain 134:1041-60. 2011
    ..Thus, enhanced endocannabinoid signalling, particularly around senile plaques, can exacerbate synaptic failure in Alzheimer's disease...
  9. ncbi request reprint Modulation of glial cell functions by adenosine receptors
    Elisabetta Daré
    Karolinska Institute, Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Nanna Svartz vag 2, S 171 77 Stockholm, Sweden
    Physiol Behav 92:15-20. 2007
    ..Microglial cells appear to be important in regulating adenosine formation from ATP and adenosine can affect many microglial signaling pathways. Adenosine receptors on oligodendrocytes regulate white matter development...
  10. doi request reprint Recombinant WNTs differentially activate β-catenin-dependent and -independent signalling in mouse microglia-like cells
    M B C Kilander
    Section Receptor Biology and Signalling, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 203:363-72. 2011
    ....
  11. doi request reprint Prolonged attenuation of acetylcholine-induced phosphorylation of extracellular signal-regulated kinase 1/2 following sevoflurane exposure
    A Wiklund
    Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden
    Acta Anaesthesiol Scand 56:608-15. 2012
    ..Perturbation of cholinergic signalling can cause cognitive deficits. In this study, we wanted to evaluate acetylcholine-induced intracellular signalling following sevoflurane exposure...
  12. ncbi request reprint Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation
    V Bryja
    Department of Medical Biochemistry and Biophysics, Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 190:55-61. 2007
    ..Therefore, we investigated the effects of endocytosis inhibition on Frizzled4-green fluorescent protein (FZD(4)-GFP) localization, dishevelled levels and Wnt-3a signalling to beta-catenin...
  13. pmc Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways
    Vitezslav Bryja
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles v ag 1, S 171 77 Stockholm, Sweden
    EMBO Rep 9:1244-50. 2008
    ..Thus, our results indicate that the balance between beta-arr and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated...
  14. ncbi request reprint Signalling from adenosine receptors to mitogen-activated protein kinases
    Gunnar Schulte
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Cell Signal 15:813-27. 2003
    ..Although each of the adenosine receptors can activate one or more of the MAPKs, the mechanisms appear to differ substantially, both between receptor subtypes in the same cell type and between the same receptor in different cell types...
  15. ncbi request reprint Evidence for functional adenosine A3 receptors in microglia cells
    Christian Hammarberg
    Karolinska Institutet, Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Stockholm, Sweden
    J Neurochem 86:1051-4. 2003
    ..The involvement of the A3R in Cl-IB-MECA-induced ERK1/2 phosphorylation was confirmed by demonstrating that those effects are absent in primary mouse microglia cells isolated from mice lacking the gene for the A3R...
  16. ncbi request reprint Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism
    Vitezslav Bryja
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Cell Sci 120:586-95. 2007
    ....
  17. ncbi request reprint Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin
    Vitezslav Bryja
    Karolinska Institutet, Department Medical Biochemistry and Biophysics, Laboratory Molecular Neurobiology, S 171 77 Stockholm, Sweden
    Cell Signal 19:610-6. 2007
    ..Thus, our results show that Wnt-3a rapidly induce a partial activation of beta-catenin in the absence of PS-Dvl at low doses, while at high doses induce a full activation of beta-catenin in a PS-Dvl-dependent manner...
  18. ncbi request reprint Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation
    Gunnar Schulte
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Neurochem 92:1550-3. 2005
    ..Furthermore, we identify dishevelled as a key player in transducing both Wnt canonical and non-canonical signals in dopaminergic cells...
  19. ncbi request reprint Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2
    Gunnar Schulte
    Section of Molecular Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Mol Pharmacol 62:1137-46. 2002
    ..In conclusion, the adenosine A(3) receptor recruits a pathway that involves betagamma release from G(i/o), PI3K, Ras, and MEK to induce ERK1/2 phosphorylation and activation, whereas signaling is independent of Ca(2+), PKC, and c-Src...
  20. pmc Vang-like protein 2 and Rac1 interact to regulate adherens junctions
    Maria Lindqvist
    Neonatal Unit, Department of Woman and Child Health, SE 171 76, Stockholm, Sweden
    J Cell Sci 123:472-83. 2010
    ..We propose that Vangl2 affects cell adhesion and the cytoskeleton by recruiting Rac1 and targeting its activity in the cell to adherens junctions...
  21. ncbi request reprint The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38
    Gunnar Schulte
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Exp Cell Res 290:168-76. 2003
    ..ERK1/2 activation was dependent on PI3K but not on PKA. p38 activation by NECA was instead independent of PI3K but required cAMP and PKA. The potent activation of both MAPKs suggests a physiological role...
  22. pmc Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC
    Frank Brand
    Karolinska Institutet, Department of Physiology and Pharmacology, Sect Receptor Biology and Signaling, S 171 77 Stockholm, Sweden
    Eur J Pharmacol 590:36-42. 2008
    ..The basic characterization of Alexa488-APEC described here showed that it provides a useful tool for tracing adenosine A(2A) receptors in vitro...
  23. ncbi request reprint Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists
    Gunnar Schulte
    Section of Molecular Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Cell Signal 14:109-13. 2002
    ....
  24. ncbi request reprint A Nordic meeting on G-protein-coupled receptors: from molecular aspects to novel therapy
    Gunnar Schulte
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 190:1. 2007
  25. pmc Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo
    Vitezslav Bryja
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:6690-5. 2007
    ....
  26. pmc Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
    Paul Berghuis
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:19115-20. 2005
    ..Moreover, eCBs use TrkB receptor-dependent signaling pathways to regulate subtype-selective interneuron migration and specification...
  27. ncbi request reprint Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons
    Paul Berghuis
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 20:1290-306. 2004
    ..Our results show that BDNF, along with membrane depolarization, is critical for FS cells to establish inhibitory circuitries during corticogenesis...
  28. ncbi request reprint Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3
    Tibor Harkany
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Neurosci 24:4978-88. 2004
    ....
  29. ncbi request reprint Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells
    Jan Lynge
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, August Krogh Institute, Copenhagen University, Universitetsparken 13, Copenhagen Ø, DK 2100, Denmark
    Biochem Biophys Res Commun 307:180-7. 2003
    ....