Research Topics
Species | I SavicSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Detail Information
Publications
Brain imaging studies of the functional organization of human olfactionIvanka Savic
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Neuroscientist 8:204-11. 2002..New data from brain imaging studies suggest that this is not the case and that the specific characteristics of the sense of smell can be attributed to the engagement of limbic structures at an early stage in the signal processing...- Brain response to putative pheromones in homosexual menIvanka Savic
Department of Clinical Neuroscience, Karolinska University Hospital, 171 76 Stockholm, Sweden
Proc Natl Acad Sci U S A 102:7356-61. 2005..These findings show that our brain reacts differently to the two putative pheromones compared with common odors, and suggest a link between sexual orientation and hypothalamic neuronal processes... - Odor processing in multiple chemical sensitivityLena Hillert
Department of Public Health Sciences, Division of Occupational Medicine, Karolinska Institutet, Stockholm, Sweden
Hum Brain Mapp 28:172-82. 2007..One possible explanation for the observed pattern of activation in MCS is a top-down regulation of odor-response via cingulate cortex... - Imaging of odor perception delineates functional disintegration of the limbic circuits in mesial temporal lobe epilepsyCarolina Ciumas
Department of Clinical Neuroscience, Division of Neurology, Karolinska University Hospital, Karolinska Institutet, Sweden
Neuroimage 39:578-92. 2008..It shows an altered response in several regions, which may underlie some interictal behavioral problems associated with this condition... - Androstenol--a steroid derived odor activates the hypothalamus in womenIvanka Savic
Stockholm Brain Institute, Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
PLoS ONE 5:e8651. 2010..A further issue was to evaluate whether the pattern of activation resembles the pattern of common odors... - Sex differences in patients with mesial temporal lobe epilepsyI Savic
Department of Human Brain Research, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
J Neurol Neurosurg Psychiatry 65:910-2. 1998..0052) and an ictal spread to the contralateral temporal lobe (p=0.0097). These findings suggest sex differences in spatial distribution of brain dysfunction in MTLE, perhaps reflecting sexual dimorphism in regional cerebral connectivity... - Brain imaging studies of the functional organization of human olfactionIvanka Savic
Department of Neuroscience, Division of Human Brain Mapping, Karolinska Institute, Stockholm, Sweden
Chem Senses 30:i222-3. 2005 - Limbic reductions of 5-HT1A receptor binding in human temporal lobe epilepsyI Savic
Division of Human Brain Research, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Neurology 62:1343-51. 2004.... - Passive perception of odors and semantic circuitsIvanka Savic
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Hum Brain Mapp 21:271-8. 2004..Already the most elemental form of odor processing, passive perception thus seems to engage semantic circuits. This is achieved by the ability of odorants to immediately elicit associations and judgments of odor characteristics... - MRS shows syndrome differentiated metabolite changes in human-generalized epilepsiesI Savic
Division of Human Brain Research, Department of Neuroscience, Sweden
Neuroimage 21:163-72. 2004..The present follow-up study investigates if similar or other types of changes exist in subjects with pure primarily generalized tonic clonic epilepsy (GTCS)... - Odorant differentiated pattern of cerebral activation: comparison of acetone and vanillinIvanka Savic
Division of Human Brain Research, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Hum Brain Mapp 17:17-27. 2002..Acetone's limited activation of the olfactory cortex may result from a cross-modal interaction, with inhibition of acetone's odor component by its trigeminal component... - Imaging of brain activation by odorants in humansIvanka Savic
Department of Neuroscience, Karolinska Institute, Retziusvag 8, 17177, Stockholm, Sweden
Curr Opin Neurobiol 12:455-61. 2002.... - Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humansI Savic
Division of Human Brain Research, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Neuron 31:661-8. 2001..This sex-dissociated hypothalamic activation suggests a potential physiological substrate for a sex-differentiated behavioral response in humans... - Processing of odorous signals in humansI Savic
Department of Neuroscience, Division of Human Brain Mapping, Karolinska Institute, Stockholm, Sweden
Brain Res Bull 54:307-12. 2001..The present chapter gives a short overview over the major components of these processes in humans... - Right-nostril dominance in discrimination of unfamiliar, but not familiar, odoursI Savic
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Chem Senses 25:517-23. 2000..Future studies on odour processing should therefore take into account odour familiarity and side of presentation... - In vivo measurements of glutamine + glutamate (Glx) and N-acetyl aspartate (NAA) levels in human partial epilepsyI Savic
Dept of Neurology, UCLA, Los Angeles, USA
Acta Neurol Scand 102:179-88. 2000..To investigate whether cerebral levels of N-acetyl aspartate (NAA), and glutamine + glutamate (Glx), are interictally altered in the epileptogenic regions of patients with partial seizures... - MR spectroscopy shows reduced frontal lobe concentrations of N-acetyl aspartate in patients with juvenile myoclonic epilepsyI Savic
Department of Neurology, Huddinge University Hospital, Stockholm, Sweden
Epilepsia 41:290-6. 2000..In this study we investigated whether an underlying mechanism could be a regional neuronal damage not visible with structural magnetic resonance (MR), but detectable with magnetic resonance spectroscopy (MRS)... - Olfactory functions are mediated by parallel and hierarchical processingI Savic
Department of Neuroscience, Uppsala University, Sweden
Neuron 26:735-45. 2000..These findings indicate that olfactory functions are organized in a parallel and hierarchical manner... - Brain activation during odor perception in males and femalesS Bengtsson
Division of Human Brain Research, Department of Neuroscience, Huddinge University Hospital, Karolinska Institute, Berzelius v. 3, S-171 77 Stockholm, Sweden
Neuroreport 12:2027-33. 2001..The reported female superiority in assessing olfactory information including odor identification is probably an effect of a difference at a cognitive, rather than perceptive level of olfactory processing... - Chronic stress is linked to 5-HT(1A) receptor changes and functional disintegration of the limbic networksH Jovanovic
Stockholm Brain Institute, Dept of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
Neuroimage 55:1178-88. 2011..These changes support the notion of an impaired top-down regulation of stress stimuli, and identify potential targets for early treatment... - Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patientsAdám Vas
Chemical Works of Gedeon Richter Ltd, Gyomroi ut 19 21, H 1103 Budapest, Hungary
J Neurol Sci 264:9-17. 2008..The comparative analysis of the two ligands indicate that [(11)C]vinpocetine shows a number of characteristics favourable in comparison with [(11)C]PK11195... - Increased thalamus levels of glutamate and glutamine (Glx) in patients with idiopathic generalised epilepsyG Helms
Department of Clinical Neuroscience, Karolinska Institute, MR Centre, S-171 77 Stockholm, Sweden
J Neurol Neurosurg Psychiatry 77:489-94. 2006..The observed elevation of Glx levels together with reductions in NAA levels and grey matter fractions are consistent with epilepsy related excitoxicity as a possible underlying mechanism... - Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroidsH Berglund
Department of Medicine, Division of Neurology, Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska University Hospital, Karolinska Institute, MR Centre, Stockholm, Sweden
Cereb Cortex 18:1900-8. 2008..Instead, the data implicate that transsexuality may be associated with sex-atypical physiological responses in specific hypothalamic circuits, possibly as a consequence of a variant neuronal differentiation... - Reduced dopamine transporter binding in patients with juvenile myoclonic epilepsyC Ciumas
Department of Clinical Neuroscience, Division of Neurology, Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
Neurology 71:788-94. 2008.... - Pheromone signal transduction in humans: what can be learned from olfactory lossIvanka Savic
Stockholm Brain Institute, Department of Clinical Neuroscience, Karolinska University Hospital, MR Centre, Sweden
Hum Brain Mapp 30:3057-65. 2009..The anosmics inability to activate the hypothalamus with EST, therefore, suggests that in healthy men EST signals were primarily transmitted via the olfactory system... - Brain response to putative pheromones in lesbian womenHans Berglund
Department of Medicine, and Stockholm Brain Institute, Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
Proc Natl Acad Sci U S A 103:8269-74. 2006..These data support our previous results about differentiated processing of pheromone-like stimuli in humans and further strengthen the notion of a coupling between hypothalamic neuronal circuits and sexual preferences... - Smelling human sex hormone-like compounds affects face gender judgment of menGyula Kovacs
Center for Cognitive Sciences, Budapest University of Technology and Economics, Budapest, H 1111, Hungary
Neuroreport 15:1275-7. 2004..Our results provide evidence for specific cross-sensory effects of the gender-specific chemosensory cues on the categorization of visual face gender... - PET and MRI show differences in cerebral asymmetry and functional connectivity between homo- and heterosexual subjectsIvanka Savic
Stockholm Brain Institute, Department of Clinical Neuroscience, Karolinska Institute, 171 76 Stockholm, Sweden
Proc Natl Acad Sci U S A 105:9403-8. 2008..The present study shows sex-atypical cerebral asymmetry and functional connections in homosexual subjects. The results cannot be primarily ascribed to learned effects, and they suggest a linkage to neurobiological entities... - Migraine and olfactory stimuliChristina Sjöstrand
Headache Research Centre, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Curr Pain Headache Rep 14:244-51. 2010..Migraine pathophysiology likely explains this particular vulnerability. We discuss these pathophysiologic mechanisms and hypotheses relating odour intolerances and migraine... - Regional reductions in serotonin 1A receptor binding in juvenile myoclonic epilepsyAnna Meschaks
Division of Neurology, Neurotec, Stockholm, Sweden
Arch Neurol 62:946-50. 2005.... - Structural changes in patients with primary generalized tonic and clonic seizuresCarolina Ciumas
Department of Clinical Neuroscience, Division of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Neurology 67:683-6. 2006..The thalamus and cerebellum also showed reduced volumes, as did the caudate and putamen. Contrary to current diagnostic criteria, regional tissue abnormalities may be present in IGE... - Preparation of highly specific radioactivity [18F]flumazenil and its evaluation in cynomolgus monkey by positron emission tomographyNikolaj N Ryzhikov
Institute of Human Brain, Russian Academy of Science, 9, Pavlov str, 197376, Saint Petersburg, Russia
Nucl Med Biol 32:109-16. 2005..In blocking experiments, almost all radioactivity was inhibited by the addition of unlabeled flumazenil. [18F]Flumazenil is a suitable radioligand for PET assessment of the BZR...