Lars Savendahl

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Comparison of response to 2-years' growth hormone treatment in children with isolated growth hormone deficiency, born small for gestational age, idiopathic short stature, or multiple pituitary hormone deficiency: combined results from two large observatio
    Peter A Lee
    Penn State College of Medicine, The Milton S, Hershey Medical Center, PO Box 850, Hershey, PA, 17033 0850, USA
    Int J Pediatr Endocrinol 2012:22. 2012
  2. doi request reprint The effect of acute and chronic stress on growth
    Lars Savendahl
    Department of Women s and Children s Health, Karolinska Institutet, Stockholm SE 17176, Sweden
    Sci Signal 5:pt9. 2012
  3. doi request reprint Gender influences short-term growth hormone treatment response in children
    Lars Savendahl
    Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Horm Res Paediatr 77:188-94. 2012
  4. doi request reprint Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, The Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study
    Lars Savendahl
    Division of Pediatric Endocrinology, Karolinska University Hospital Q2 08, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 97:E213-7. 2012
  5. doi request reprint Genes of importance in the hormonal regulation of growth plate cartilage
    Andrei S Chagin
    Pediatric Endocrinology Unit, Astrid Lindgren Children s Hospital, Karolinska Institutet, Stockholm, Sweden
    Horm Res 71:41-7. 2009
  6. pmc Bortezomib is cytotoxic to the human growth plate and permanently impairs bone growth in young mice
    Emma Eriksson
    Pediatric Endocrinology Unit, Department of Women s and Childrens Health, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e50523. 2012
  7. doi request reprint Catch-up growth after dexamethasone withdrawal occurs in cultured postnatal rat metatarsal bones
    Andrei S Chagin
    Pediatric Endocrinology Laboratory, Department of Women s and Children s Health, Karolinska Institutet, Stockholm SE 17176, Sweden
    J Endocrinol 204:21-9. 2010
  8. doi request reprint Tamoxifen impairs both longitudinal and cortical bone growth in young male rats
    Elham Karimian
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    J Bone Miner Res 23:1267-77. 2008
  9. doi request reprint Pro-inflammatory cytokines produced by growth plate chondrocytes may act locally to modulate longitudinal bone growth
    Paola Fernandez-Vojvodich
    Pediatric Endocrinology, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Horm Res Paediatr 77:180-7. 2012
  10. doi request reprint Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: role of pro-apoptotic Bid
    Farasat Zaman
    Department of Women s and Children s Health, Pediatric Endocrinology Unit, Astrid Lindgren Children s Hospital, Karolinska Institutet, Stockholm 171 76, Sweden Electronic address
    Toxicol Lett 224:196-200. 2014

Detail Information

Publications38

  1. pmc Comparison of response to 2-years' growth hormone treatment in children with isolated growth hormone deficiency, born small for gestational age, idiopathic short stature, or multiple pituitary hormone deficiency: combined results from two large observatio
    Peter A Lee
    Penn State College of Medicine, The Milton S, Hershey Medical Center, PO Box 850, Hershey, PA, 17033 0850, USA
    Int J Pediatr Endocrinol 2012:22. 2012
    ..abstract:..
  2. doi request reprint The effect of acute and chronic stress on growth
    Lars Savendahl
    Department of Women s and Children s Health, Karolinska Institutet, Stockholm SE 17176, Sweden
    Sci Signal 5:pt9. 2012
    ..Further experimental and clinical studies are needed to explore these and other new potential treatment strategies that could improve bone growth in patients who do not respond to conventional therapy...
  3. doi request reprint Gender influences short-term growth hormone treatment response in children
    Lars Savendahl
    Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Horm Res Paediatr 77:188-94. 2012
    ..Gender may affect growth hormone (GH) treatment outcome. This study assessed gender-related differences in change from baseline height standard deviation scores (ΔHSDS) after 2 years' GH treatment...
  4. doi request reprint Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, The Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study
    Lars Savendahl
    Division of Pediatric Endocrinology, Karolinska University Hospital Q2 08, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 97:E213-7. 2012
    ..Recently released data from the French part of the European Union Safety and Appropriateness of GH treatments in Europe (EU SAGhE) study have raised concerns on the long-term safety of GH treatment...
  5. doi request reprint Genes of importance in the hormonal regulation of growth plate cartilage
    Andrei S Chagin
    Pediatric Endocrinology Unit, Astrid Lindgren Children s Hospital, Karolinska Institutet, Stockholm, Sweden
    Horm Res 71:41-7. 2009
    ..It is difficult to extrapolate data obtained in experimental animals, as clear species differences exist, emphasizing the need for new models that will allow studies in human growth plate cartilage...
  6. pmc Bortezomib is cytotoxic to the human growth plate and permanently impairs bone growth in young mice
    Emma Eriksson
    Pediatric Endocrinology Unit, Department of Women s and Childrens Health, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e50523. 2012
    ..We therefore propose that longitudinal bone growth should be closely monitored in ongoing clinical pediatric trials of this promising anti-cancer drug...
  7. doi request reprint Catch-up growth after dexamethasone withdrawal occurs in cultured postnatal rat metatarsal bones
    Andrei S Chagin
    Pediatric Endocrinology Laboratory, Department of Women s and Children s Health, Karolinska Institutet, Stockholm SE 17176, Sweden
    J Endocrinol 204:21-9. 2010
    ..We conclude that the phenomenon of catch-up growth after Dexa treatment is intrinsic to the growth plate and primarily mediated by an upregulation of chondrocyte proliferation...
  8. doi request reprint Tamoxifen impairs both longitudinal and cortical bone growth in young male rats
    Elham Karimian
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    J Bone Miner Res 23:1267-77. 2008
    ..Based on these rat data, we believe that Tam, if given to growing individuals, might compromise cortical bone growth, bone strength, and adult height...
  9. doi request reprint Pro-inflammatory cytokines produced by growth plate chondrocytes may act locally to modulate longitudinal bone growth
    Paola Fernandez-Vojvodich
    Pediatric Endocrinology, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Horm Res Paediatr 77:180-7. 2012
    ..So far no role of these cytokines in modulation of normal bone growth has been established...
  10. doi request reprint Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: role of pro-apoptotic Bid
    Farasat Zaman
    Department of Women s and Children s Health, Pediatric Endocrinology Unit, Astrid Lindgren Children s Hospital, Karolinska Institutet, Stockholm 171 76, Sweden Electronic address
    Toxicol Lett 224:196-200. 2014
    ..Prevention of this imbalance between pro- and anti-apoptotic Bcl-2 family proteins may provide a new strategy to protect from adverse effects of GCs on bone growth. ..
  11. ncbi request reprint GPR30 estrogen receptor expression in the growth plate declines as puberty progresses
    Andrei S Chagin
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 92:4873-7. 2007
    ..Our objective was to study whether GPR30 is expressed in the epiphyseal growth plate and its potential role as a modulator of pubertal growth...
  12. ncbi request reprint Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3'-kinase signaling pathway
    Dionisios Chrysis
    Department of Woman and Child Health, Pediatric Endocrinology Unit, Astrid Lindgren Childrens Hospital, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Endocrinology 146:1391-7. 2005
    ..Based on our in vitro data, we speculate that in vivo treatment with glucocorticoids may diminish longitudinal growth by increasing apoptosis of proliferative growth plate chondrocytes...
  13. ncbi request reprint Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones
    Andrei S Chagin
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    Bone 40:1415-24. 2007
    ..We here describe a novel mechanism of tamoxifen-induced apoptosis in chondrocytes, involving the activation of caspases and the FasL/Fas pathway, which diminishes the potential for bone growth...
  14. ncbi request reprint Glucocorticoid eye drops inhibit growth in the newborn rabbit
    Maria Kugelberg
    St Erik s Eye Hospital, Stockholm, Sweden
    Acta Paediatr 94:1096-101. 2005
    ..To investigate if postoperative treatment with dexamethasone eye drops has the capacity to affect longitudinal growth in newborn rabbits...
  15. pmc Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment
    Farasat Zaman
    Pediatric Endocrinology Unit, Department of Women s and Children s Health, Astrid Lindgren Children s Hospital, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e33168. 2012
    ..Our findings could therefore open the door for new therapeutic approaches to prevent glucocorticoid-induced bone growth impairment through specific targeting of Bax...
  16. doi request reprint Hormones and genes of importance in bone physiology and their influence on bone mineralization and growth in Turner syndrome
    Anenisia C Andrade
    Department of Women s and Children s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Horm Res Paediatr 73:161-5. 2010
    ..This paper summarizes the data and highlights the main topics and discussions related to each presentation...
  17. doi request reprint The biologics anakinra and etanercept prevent cytokine-induced growth retardation in cultured fetal rat metatarsal bones
    Paola Fernandez-Vojvodich
    Pediatric Endocrinology Unit, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Horm Res Paediatr 76:278-85. 2011
    ..Conclusion: Etanercept and anakinra efficiently and dose-dependently prevent cytokine-induced bone growth impairment, and combination with IGF-I further improves bone growth...
  18. doi request reprint Intravenous pamidronate treatment improves growth in prepubertal osteogenesis imperfecta patients
    Terhi J Heino
    Pediatric Endocrinology, Department of Women s and Children s Health, Astrid Lindgren Children s Hospital, Karolinska Institutet, Stockholm, Sweden
    Horm Res Paediatr 75:354-61. 2011
    ..Pamidronate is widely used to treat pediatric patients with osteogenesis imperfecta (OI). We aimed at delineating the effects of monthly pamidronate therapy on the growth of different body segments in prepubertal OI patients...
  19. doi request reprint Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation
    Terhi J Heino
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    Bone 42:702-9. 2008
    ..Nevertheless, based on our in vitro data, both Aln and Pam appear safe to use in growing children, at least with regard to their effects on linear bone growth...
  20. ncbi request reprint Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice
    Farasat Zaman
    Department of Woman and Child Health, Pediatric Endocrinology Unit, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Cancer Res 67:10078-86. 2007
    ..These findings could have important implications for the use of proteasome inhibitors in the treatment of childhood cancer...
  21. ncbi request reprint Oestrogen receptors and linear bone growth
    Andrei S Chagin
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    Acta Paediatr 96:1275-9. 2007
    ..We conclude that SERMs potentially could offer new possibilities to modulate bone growth by specifically targeting different oestrogen receptors within the growth plate...
  22. ncbi request reprint The 4th European Growth Plate Working Group Symposium (EUROGROP). 10th September 2004, Basel, Switzerland
    Andrei Chagin
    Pediatric Endocrinology Unit, Karolinska Institutet, Stockholm, Sweden
    J Pediatr Endocrinol Metab 18:823-7. 2005
  23. ncbi request reprint Localization of estrogen receptors-alpha and -beta and androgen receptor in the human growth plate at different pubertal stages
    Ola Nilsson
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    J Endocrinol 177:319-26. 2003
    ..05). In summary, our findings suggest that ERalpha, ERbeta and AR are expressed in the human growth plate throughout pubertal development, with no difference between the sexes...
  24. doi request reprint Estrogen signaling in growth plate cartilage
    Elham Karimian
    Pediatric Endocrinology Unit, Department of Women s and Children s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Endocr Dev 21:42-51. 2011
    ..SERMs, which display either estrogenic and/or antiestrogenic effects, bind to ERs with different affinities and subsequently recruit co-modulators of transcription in a tissue-specific manner...
  25. doi request reprint Androgen receptor modulation does not affect longitudinal growth of cultured fetal rat metatarsal bones
    Andrei S Chagin
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    Horm Res 71:219-27. 2009
    ..It is unknown if oxandrolone acts locally at the growth plate level to stimulate longitudinal bone growth...
  26. pmc The NordiNet® International Outcome Study and NovoNet® ANSWER Program®: rationale, design, and methodology of two international pharmacoepidemiological registry-based studies monitoring long-term clinical and safety outcomes of growth hormone therapy (Nor
    Charlotte Hoybye
    Department of Molecular Medicine and Surgery, Karolinska Institute and Department of Endocrinology, Metabolism and Diabetes, Stockholm, Sweden
    Clin Epidemiol 5:119-27. 2013
    ....
  27. ncbi request reprint Raloxifene acts as an estrogen agonist on the rabbit growth plate
    Ola Nilsson
    Pediatric Endocrinology Unit, Department of Women and Child Health, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Endocrinology 144:1481-5. 2003
    ..As expected, the uterus was enlarged by estrogen, but not raloxifene, treatment. We conclude that raloxifene acts as an estrogen agonist on the growth plate, accelerating growth plate senescence and thus hastening epiphyseal fusion...
  28. ncbi request reprint Estrogens and growth: review
    Andrei S Chagin
    Pediatric Endocrinology Unit, Astrid Lindgren Children s Hospital, Karolinska Institutet, Stockholm, Sweden
    Pediatr Endocrinol Rev 4:329-34. 2007
    ..It is difficult to extrapolate data obtained in experimental animals, as clear species differences exist, emphasizing the need for new models allowing studies in human growth plate cartilage...
  29. pmc Proinsulin C-peptide regulates ribosomal RNA expression
    Emma Lindahl
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Biol Chem 285:3462-9. 2010
    ..This regulation of ribosomal RNA provides a mechanism by which C-peptide can exert transcriptional effects and implies that the peptide has growth factor activity...
  30. pmc Resveratrol treatment delays growth plate fusion and improves bone growth in female rabbits
    Elham Karimian
    Pediatric Endocrinology Unit, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e67859. 2013
    ..These effects were accompanied by a profound suppression of VEGF and laminin expression suggesting that impairment of growth plate vascularization might be an underlying mechanism. ..
  31. ncbi request reprint Reduced bone mineral density and radial bone growth in young rabbits treated with dexamethasone eye drops
    Maria Kugelberg
    St Erik s Eye Hospital, Stockholm, Sweden
    Horm Res 63:165-70. 2005
    ..To investigate the effect of dexamethasone eye drops on bone metabolism in newborn rabbits...
  32. pmc Efficacy and Safety of Percutaneous Epiphysiodesis Operation around the Knee to Reduce Adult Height in Extremely Tall Adolescent Girls and Boys
    Emelie Benyi
    Pediatric Endocrinology Unit and Department of Women s and Children s Health, Karolinska Institutet, 171 76 Stockholm, Sweden
    Int J Pediatr Endocrinol 2010:740629. 2010
    ..Postoperative X-rays confirmed growth plate closure and absence of leg angulations. Conclusions. Bilateral epiphysiodesis is an effective and safe method to reduce adult height in extremely tall girls and boys...
  33. ncbi request reprint Hormonal regulation of growth plate cartilage
    Lars Savendahl
    Karolinska Institutet, Stockholm, Sweden
    Horm Res 64:94-7. 2005
    ..As new specific modulators of oestrogen receptors are developed, these could offer more specific ways to modulate longitudinal growth and growth plate fusion...
  34. doi request reprint The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone
    Terhi J Heino
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, Q2 08, SE 171 76 Stockholm, Sweden
    J Endocrinol 197:R1-6. 2008
    ..However, the functional role of GPR30 in bone tissue remains to be elucidated...
  35. pmc Genetic regulation of the growth plate
    Elham Karimian
    Pediatric Endocrinology Unit, Department of Women s and Children s Health, Karolinska Institutet Stockholm, Sweden
    Front Endocrinol (Lausanne) 2:113. 2011
    ..This may eventually help us to develop new treatment strategies of different growth disorders...
  36. ncbi request reprint Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones
    Katarina Mårtensson
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    J Bone Miner Res 19:1805-12. 2004
    ..IGF-I could partially reverse all these effects...
  37. ncbi request reprint Etanercept treatment improves longitudinal growth in prepubertal children with juvenile idiopathic arthritis
    Paola Fernandez Vojvodich
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska University Hospital, Stockholm, Sweden
    J Rheumatol 34:2481-5. 2007
    ..We studied longitudinal growth in response to etanercept treatment in prepubertal and pubertal patients with JIA...
  38. ncbi request reprint Apoptosis is developmentally regulated in rat growth plate
    Dionisios Chrysis
    Department of Woman and Child Health, Pediatric Endocrine Unit, Astrid Lindgren Children s Hospital, Karolinska Institute, Stockholm, Sweden
    Endocrine 18:271-8. 2002
    ..Our results show that apoptosis is developmentally regulated in the rat growth plate. In older animals, with decreased growth rate and growth plate height, apoptosis is significantly increased, especially in THPCs...