Birgitta Sander

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma
    Xiao Wang
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS ONE 5:e14085. 2010
  2. ncbi request reprint The reliability of immunohistochemical analysis of the tumor microenvironment in follicular lymphoma: a validation study from the Lunenburg Lymphoma Biomarker Consortium
    Birgitta Sander
    Haematologica 99:715-25. 2014
  3. ncbi request reprint Mantle cell lymphoma: recent insights into pathogenesis, clinical variability, and new diagnostic markers
    Birgitta Sander
    Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Semin Diagn Pathol 28:245-55. 2011
  4. ncbi request reprint Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma
    Kristin Gustafsson
    Department of Laboratory Medicine, Division of Pathology, Karolinska University Hospital Huddinge, F 46, SE 14186 Stockholm, Sweden
    Mol Pharmacol 70:1612-20. 2006
  5. doi request reprint Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation
    Kristin Gustafsson
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital Huddinge, F 46, SE 14186 Stockholm, Sweden
    Int J Cancer 123:1025-33. 2008
  6. doi request reprint The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival
    Xiao Wang
    Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
    Br J Haematol 143:248-52. 2008
  7. pmc Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism
    Kristin Gustafsson
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
    Mol Cancer Res 7:1086-98. 2009
  8. doi request reprint Expression of PTEN and SHP1, investigated from tissue microarrays in pediatric acute lymphoblastic, leukemia
    Fredrika Gauffin
    Department of Clinical Science, Intervention and Technology CLINTEC, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden
    Pediatr Hematol Oncol 26:48-56. 2009
  9. doi request reprint Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma
    Lina Nygren
    Department of Laboratory Medicine, Division of Pathology Center for Haematology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Blood 119:4215-23. 2012
  10. pmc High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes
    Yilmaz Mahshid
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    BMC Immunol 10:2. 2009

Collaborators

Detail Information

Publications31

  1. pmc Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma
    Xiao Wang
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS ONE 5:e14085. 2010
    ..In summary we have identified a number of genes influenced by SOX11 expression in MCL cell lines and primary MCL. Among these genes, DBN1, SETMAR and HIG2 are direct transcriptional targets of the SOX11 protein...
  2. ncbi request reprint The reliability of immunohistochemical analysis of the tumor microenvironment in follicular lymphoma: a validation study from the Lunenburg Lymphoma Biomarker Consortium
    Birgitta Sander
    Haematologica 99:715-25. 2014
    ..We recommend a more objective measurement, such as computer-assisted scoring, in future studies of the prognostic impact of microenvironment in follicular lymphoma patients. ..
  3. ncbi request reprint Mantle cell lymphoma: recent insights into pathogenesis, clinical variability, and new diagnostic markers
    Birgitta Sander
    Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Semin Diagn Pathol 28:245-55. 2011
    ..In situ MCL, MCL with an indolent clinical course, and cyclin D1-negative MCL are other topics of this review...
  4. ncbi request reprint Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma
    Kristin Gustafsson
    Department of Laboratory Medicine, Division of Pathology, Karolinska University Hospital Huddinge, F 46, SE 14186 Stockholm, Sweden
    Mol Pharmacol 70:1612-20. 2006
    ..The present data suggest that targeting CB(1)/CB(2) may have therapeutic potential for the treatment of mantle cell lymphoma...
  5. doi request reprint Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation
    Kristin Gustafsson
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital Huddinge, F 46, SE 14186 Stockholm, Sweden
    Int J Cancer 123:1025-33. 2008
    ..Together, our results suggest that therapies using cannabinoid receptor ligands will have efficiency in reducing tumor burden in malignant lymphoma overexpressing CB1 and CB2...
  6. doi request reprint The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival
    Xiao Wang
    Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
    Br J Haematol 143:248-52. 2008
    ..These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL...
  7. pmc Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism
    Kristin Gustafsson
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
    Mol Cancer Res 7:1086-98. 2009
    ..Furthermore, this is the first study were the cytotoxic effect of a cannabinoid is enhanced by modulation of ceramide metabolism...
  8. doi request reprint Expression of PTEN and SHP1, investigated from tissue microarrays in pediatric acute lymphoblastic, leukemia
    Fredrika Gauffin
    Department of Clinical Science, Intervention and Technology CLINTEC, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden
    Pediatr Hematol Oncol 26:48-56. 2009
    ..Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors...
  9. doi request reprint Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma
    Lina Nygren
    Department of Laboratory Medicine, Division of Pathology Center for Haematology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Blood 119:4215-23. 2012
    ..001), and p53 expression (P = .001) remained significant, and SOX11 lost significance. We conclude that most indolent MCLs are SOX11(+) and that SOX11 cannot be used for predicting an indolent disease course...
  10. pmc High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes
    Yilmaz Mahshid
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    BMC Immunol 10:2. 2009
    ..In order to better understand and define the role of 5-LO in B cells, we investigated the expression of 5-LO mRNA and protein in subsets of B cells from human tonsils and different types of B cell lymphoma...
  11. doi request reprint Late-onset neutropenia associated with rituximab therapy: evidence for a maturation arrest at the (pro)myelocyte stage of granulopoiesis
    Daniel Tesfa
    Department of Medicine and Hematology Center, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, 14186, Sweden
    Med Oncol 25:374-9. 2008
    ..Nevertheless, our data suggest that rituximab-related LON and congenital neutropenia might share similar neutropenia-causing mechanisms resulting in maturation arrest...
  12. doi request reprint Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times
    Björn E Wahlin
    Division of Haematology, Department of Medicine at Huddinge, Karolinska Institutet, Stockholm, Sweden
    Br J Haematol 156:225-33. 2012
    ..We conclude that follicular lymphoma grade 1-3A is indolent and incurable with conventional therapy. Grade 3B appears to be an aggressive but curable disease...
  13. doi request reprint Late-onset neutropenia following rituximab therapy in rheumatic diseases: association with B lymphocyte depletion and infections
    Daniel Tesfa
    Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Arthritis Rheum 63:2209-14. 2011
    ..The purpose of this study was to define the incidence, clinical features, and some of the underlying mechanisms of late-onset neutropenia in relation to rituximab use in several rheumatic diseases...
  14. doi request reprint Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy
    Lena von Bahr
    Haematology Centre, Department of Clinical Immunology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Biol Blood Marrow Transplant 18:557-64. 2012
    ..01). We conclude that treatment with early-passage MSCs improved survival in patients with therapy-resistant GVHD. Death from infection was common in MSC-treated patients, but there was no increase in leukemia relapse...
  15. doi request reprint A unifying microenvironment model in follicular lymphoma: outcome is predicted by programmed death-1--positive, regulatory, cytotoxic, and helper T cells and macrophages
    Björn Engelbrekt Wahlin
    Division of Hematology, Department of Internal Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Cancer Res 16:637-50. 2010
    ..Our hypothesis was that several immune cell subsets are important for disease outcome and their individual prognostic importance should be demonstrable in the same analysis and in competition with clinical factors...
  16. ncbi request reprint Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
    Jenny Flygare
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Karolinska University Hospital Huddinge, F 46, SE 141 86 Stockholm, Sweden
    FEBS Lett 579:6885-9. 2005
    ..Induction of apoptosis, as measured by FACS/Annexin V-FITC, contributed to the growth suppressive effect of Win-55,212-2. Our data suggest that cannabinoid receptors may be considered as potential therapeutic targets in MCL...
  17. doi request reprint Higher World Health Organization grades of follicular lymphoma correlate with better outcome in two Nordic Lymphoma Group trials of rituximab without chemotherapy
    Björn Engelbrekt Wahlin
    Department of Medicine at Huddinge, Division of Hematology, Karolinska Institutet and The Hematology Center, Karolinska University Hospital, Stockholm, Sweden
    Leuk Lymphoma 55:288-95. 2014
    ..00005). In conclusion, WHO grade 1 follicular lymphoma correlates with inferior outcome after rituximab monotherapy. WHO grading might provide a clinically useful tool for personalized therapy...
  18. pmc SOXC transcription factors in mantle cell lymphoma: the role of promoter methylation in SOX11 expression
    Agata Magdalena Wasik
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital, SE 141 86 Stockholm
    Sci Rep 3:1400. 2013
    ..Furthermore, 5-azacytidine treatment of the SOX11 negative MCL cell line, JVM2, induced SOX4 but not SOX11...
  19. doi request reprint Treatment of familial hemophagocytic lymphohistiocytosis with third-party mesenchymal stromal cells
    Dimitrios Mougiakakos
    Division of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Stem Cells Dev 21:3147-51. 2012
    ..If these transient effects of MSCs can be confirmed in future-controlled clinical trials, adoptive MSC therapy could represent a salvage agent in FHL acting as a bridge to definitive treatment with stem cell transplantation...
  20. doi request reprint The role of cannabinoid receptors and the endocannabinoid system in mantle cell lymphoma and other non-Hodgkin lymphomas
    Agata M Wasik
    Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Semin Cancer Biol 21:313-21. 2011
    ..The possible role for the endocannabinoid system in the immune microenvironment of lymphoma is discussed...
  21. doi request reprint The endocannabinoid system in cancer-potential therapeutic target?
    Jenny Flygare
    Department of Laboratory Medicine, Divison of Pathology, F46, Karolinska Institutet and Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Semin Cancer Biol 18:176-89. 2008
    ..In this review we discuss various means by which the endocannabinoid system may be targeted in cancer and the current knowledge considering the regulation of the endocannabinoid system in malignancy...
  22. ncbi request reprint CD8+ T-cell content in diagnostic lymph nodes measured by flow cytometry is a predictor of survival in follicular lymphoma
    Björn Engelbrekt Wahlin
    Division of Hematology, Department of Internal Medicine at Huddinge, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden
    Clin Cancer Res 13:388-97. 2007
    ..Follicular lymphoma is a heterogeneous disease with variable prognosis and clinical course. We hypothesized that the presence of nonmalignant T cells in the microenvironment of the tumor may affect the outcome...
  23. ncbi request reprint Mantle cell lymphomas with low levels of cyclin D1 long mRNA transcripts are highly proliferative and can be discriminated by elevated cyclin A2 and cyclin B1
    Birgitta Sander
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Int J Cancer 117:418-30. 2005
    ..Several of the upregulated genes, such as TOP2A, AURORA A and RRM2 may influence a response to therapy. Identification of MCL with low cyclin D1 3'UTR is important because it seems to be associated with shorter overall survival...
  24. ncbi request reprint Characterization of genetic changes in MCL by interphase FISH on tissue sections
    Birgitta Sander
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
    Leuk Lymphoma 48:1344-52. 2007
    ..One fourth of MCL had none of the investigated additional aberrations and these tumours were in general less proliferative and some of these patients had a very long survival...
  25. ncbi request reprint Inhibition of lymphoma vascularization and dissemination by estrogen receptor β agonists
    Konstantin Yakimchuk
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    Blood 123:2054-61. 2014
    ..These results suggest that targeting ERβ with agonists may be valuable in the treatment of some lymphomas, affecting several aspects of the malignant process, including proliferation, vascularization, and dissemination. ..
  26. pmc Inhibition of the intrinsic but not the extrinsic apoptosis pathway accelerates and drives MYC-driven tumorigenesis towards acute myeloid leukemia
    Kari Högstrand
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 7:e31366. 2012
    ..In conclusion, our findings provide direct evidence that BCL-X(L) and BCL-2 but not FLIP(L) acts in synergy with MYC to drive AML development...
  27. doi request reprint T cells in tumors and blood predict outcome in follicular lymphoma treated with rituximab
    Björn Engelbrekt Wahlin
    Division of Hematology, Department of Medicine at Huddinge, Division of Hematology, Department of Medicine at Solna, Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Norway
    Clin Cancer Res 17:4136-44. 2011
    ..T cells influence outcome in follicular lymphoma, but their contributions seem to be modified by therapy. Their impact in patients receiving rituximab without chemotherapy is unknown...
  28. doi request reprint Maintenance of remission with cyclosporine in paediatric patients with Kimura's disease - two case reports
    Sandra Soeria-Atmadja
    Department of Hematology, Astrid Lindgren Children s Hospital, Karolinska University Hospital, Stockholm, Sweden
    Acta Paediatr 100:e186-9. 2011
    ..Initial response to prednisolone was excellent but both relapsed as medication was tapered or discontinued. Adding cyclosporine to the regimen resulted in prolonged remission in both patients...
  29. doi request reprint Expression of VEGF and VEGF receptors in childhood precursor B-cell acute lymphoblastic leukemia evaluated by immunohistochemistry
    Eva Diffner
    Department of Laboratory Medicine, Clinical Research Center, Lund University, Sweden
    J Pediatr Hematol Oncol 31:696-701. 2009
    ..These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL...
  30. ncbi request reprint Posttransplant lymphoma--a single-center experience of 500 liver transplantations
    Stefan Norin
    Department of Hematology, Huddinge University Hospital, Karolinska Institutet, 141 86 Stockholm, Sweden
    Med Oncol 21:273-84. 2004
    ..The incidence of PTLD ranges from 1% to 10%, depending on the type of organ transplanted and the immunosuppressive regimens used...
  31. ncbi request reprint Elevated p53 protein expression; a predictor of relapse in rare chronic myeloid malignancies in children?
    Emma Honkaniemi
    1Department of Pediatrics, Astrid Lindgren Children s Hospital, Karolinska University Hospital Huddinge, Department of Clinical Science Intervention and Technology CLINTEC, Karolinska Institutet, Stockholm, Sweden
    Pediatr Hematol Oncol 31:327-39. 2014
    ....