Johan K Sandberg

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development
    Edwin Leeansyah
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    Nat Commun 5:3143. 2014
  2. pmc Innate and adaptive immune responses both contribute to pathological CD4 T cell activation in HIV-1 infected Ugandans
    Michael A Eller
    Makerere University Walter Reed Project, Kampala, Uganda
    PLoS ONE 6:e18779. 2011
  3. pmc HIV-1 Vpu interference with innate cell-mediated immune mechanisms
    Johan K Sandberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr HIV Res 10:327-33. 2012
  4. pmc Rebound of residual plasma viremia after initial decrease following addition of intravenous immunoglobulin to effective antiretroviral treatment of HIV
    Tomas Mellberg
    Department of Infectious Diseases, University of Gothenburg, Sahlgrenska University Hospital, Sweden
    AIDS Res Ther 8:21. 2011
  5. pmc Reduction of the HIV-1 reservoir in resting CD4+ T-lymphocytes by high dosage intravenous immunoglobulin treatment: a proof-of-concept study
    Annica Lindkvist
    Department of Infectious Diseases, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden
    AIDS Res Ther 6:15. 2009
  6. doi request reprint Chronic immune activation in the T cell compartment of HCV/HIV-1 co-infected patients
    Johan K Sandberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Virulence 1:177-9. 2010
  7. pmc High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment
    Veronica D Gonzalez
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    J Virol 83:11407-11. 2009
  8. ncbi request reprint Expansion of CD56- NK cells in chronic HCV/HIV-1 co-infection: reversion by antiviral treatment with pegylated IFNalpha and ribavirin
    Veronica D Gonzalez
    Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186, Stockholm, Sweden
    Clin Immunol 128:46-56. 2008
  9. doi request reprint Expansion of functionally skewed CD56-negative NK cells in chronic hepatitis C virus infection: correlation with outcome of pegylated IFN-alpha and ribavirin treatment
    Veronica D Gonzalez
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Immunol 183:6612-8. 2009
  10. ncbi request reprint Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection
    Niklas K Björkström
    Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Immunol 181:4219-28. 2008

Collaborators

Detail Information

Publications39

  1. pmc Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development
    Edwin Leeansyah
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    Nat Commun 5:3143. 2014
    ..Establishment of this arm of immunity before birth may help protect the newborn from a range of pathogenic microbes. ..
  2. pmc Innate and adaptive immune responses both contribute to pathological CD4 T cell activation in HIV-1 infected Ugandans
    Michael A Eller
    Makerere University Walter Reed Project, Kampala, Uganda
    PLoS ONE 6:e18779. 2011
    ....
  3. pmc HIV-1 Vpu interference with innate cell-mediated immune mechanisms
    Johan K Sandberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr HIV Res 10:327-33. 2012
    ....
  4. pmc Rebound of residual plasma viremia after initial decrease following addition of intravenous immunoglobulin to effective antiretroviral treatment of HIV
    Tomas Mellberg
    Department of Infectious Diseases, University of Gothenburg, Sahlgrenska University Hospital, Sweden
    AIDS Res Ther 8:21. 2011
    ..abstract:..
  5. pmc Reduction of the HIV-1 reservoir in resting CD4+ T-lymphocytes by high dosage intravenous immunoglobulin treatment: a proof-of-concept study
    Annica Lindkvist
    Department of Infectious Diseases, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden
    AIDS Res Ther 6:15. 2009
    ..We propose that IVIG should be further evaluated as an adjuvant to effective ART...
  6. doi request reprint Chronic immune activation in the T cell compartment of HCV/HIV-1 co-infected patients
    Johan K Sandberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Virulence 1:177-9. 2010
    ..Here, we briefly summarize these findings and discuss them in context of the emerging roles of the gut barrier and the liver in chronic immune activation and viral disease progression...
  7. pmc High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment
    Veronica D Gonzalez
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    J Virol 83:11407-11. 2009
    ..High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients...
  8. ncbi request reprint Expansion of CD56- NK cells in chronic HCV/HIV-1 co-infection: reversion by antiviral treatment with pegylated IFNalpha and ribavirin
    Veronica D Gonzalez
    Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186, Stockholm, Sweden
    Clin Immunol 128:46-56. 2008
    ..Together, our data suggest that the high HCV loads in HCV/HIV-1 co-infection alter the NK cell compartment in a way not observed in HCV mono-infection...
  9. doi request reprint Expansion of functionally skewed CD56-negative NK cells in chronic hepatitis C virus infection: correlation with outcome of pegylated IFN-alpha and ribavirin treatment
    Veronica D Gonzalez
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Immunol 183:6612-8. 2009
    ..Furthermore, high levels of these cells reveal a disturbance in innate cellular immunity that is associated with an impaired ability to respond to antiviral treatment with IFN-alpha and ribavirin...
  10. ncbi request reprint Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection
    Niklas K Björkström
    Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Immunol 181:4219-28. 2008
    ..Our data suggest that CD8 T cells, during chronic HCV infection in humans, continue to differentiate beyond defined stages of terminal effector cells, acquiring CD16 and NK cell-like functional properties...
  11. pmc Severe functional impairment and elevated PD-1 expression in CD1d-restricted NKT cells retained during chronic HIV-1 infection
    Markus Moll
    Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Eur J Immunol 39:902-11. 2009
    ..The data demonstrate a severe functional impairment in the remaining NKT-cell compartment in HIV-1-infected patients, which limits the prospects to mobilize these cells in immunotherapy approaches in patients...
  12. pmc Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets
    Veronica D Gonzalez
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Immunol Methods 330:64-74. 2008
    ..We discuss the importance of this technology for detailed investigations of lymphocyte subsets in studies of infectious diseases and cancer...
  13. pmc NKG2D performs two functions in invariant NKT cells: direct TCR-independent activation of NK-like cytolysis and co-stimulation of activation by CD1d
    Carlotta Kuylenstierna
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Eur J Immunol 41:1913-23. 2011
    ..NKG2D thus plays both a direct and a co-stimulatory role in the activation of NKT cells...
  14. pmc Differential loss of invariant natural killer T cells and FoxP3⁺ regulatory T cells in HIV-1 subtype A and subtype D infections
    Britta Flach
    Makerere University Walter Reed Project, Kampala, Uganda
    J Acquir Immune Defic Syndr 63:289-93. 2013
    ..Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response...
  15. pmc Human immunodeficiency virus type 1 infection is associated with increased NK cell polyfunctionality and higher levels of KIR3DL1+ NK cells in ugandans carrying the HLA-B Bw4 motif
    Michael A Eller
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    J Virol 85:4802-11. 2011
    ..These results indicate that chronic HIV-1 infection is associated with increased NK cell polyfunctionality and elevated levels of KIR3DL1(+) NK cells in Ugandans carrying the HLA-B Bw4 motif...
  16. pmc Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments
    Markus Moll
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Blood 116:1876-84. 2010
    ....
  17. doi request reprint HCV/HIV co-infection at a large HIV outpatient clinic in Sweden: feasibility and results of hepatitis C treatment
    Karolin Falconer
    Department of Medicine Solna, Infectious Diseases Unit, Karolinska Institutet, Stockholm, Sweden
    Scand J Infect Dis 41:881-5. 2009
    ..Thus, 11 patients were treated, and HCV kinetics were measured during early treatment. The overall treatment response rate was surprisingly high (73%) and correlated to early virological response...
  18. pmc Contact-dependent interference with invariant NKT cell activation by herpes simplex virus-infected cells
    Lidija Bosnjak
    Department of Medicine, Center for Infectious Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    J Immunol 188:6216-24. 2012
    ..Thus, interference with activation of human iNKT cells by HSV-1 may represent a novel immunoevasive strategy used by the virus to avoid immune clearance...
  19. pmc Impaired natural killer cell responses are associated with loss of the highly activated NKG2A+CD57+CD56dim subset in HIV-1 subtype D infection in Uganda
    Prossy Naluyima
    aMakerere University Walter Reed Project, Kampala, Uganda bCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden cUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring dHenry M Jackson Foundation for the Advancement of Military Medicine eLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda fSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA gSchool of Public Health, Makerere University College of Health Sciences, Kampala hRakai Health Sciences Program, Uganda Virus Research Institute, Entebbe iFaculty of Medicine, Makerere University College of Health Sciences, Kampala, Uganda jBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS 28:1273-8. 2014
    ..Here, we studied NK cell activation and function in Ugandans with chronic untreated HIV-1 subtype D infection in comparison to uninfected community matched controls...
  20. pmc Quality monitoring of HIV-1-infected and uninfected peripheral blood mononuclear cell samples in a resource-limited setting
    Robert E Olemukan
    Makerere University Walter Reed Project, Kampala, Uganda
    Clin Vaccine Immunol 17:910-8. 2010
    ....
  21. ncbi request reprint Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response
    Kim Blom
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    J Immunol 190:2150-8. 2013
    ....
  22. doi request reprint Innate immunity and chronic immune activation in HCV/HIV-1 co-infection
    Veronica D Gonzalez
    Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    Clin Immunol 135:12-25. 2010
    ....
  23. doi request reprint CD56 negative NK cells: origin, function, and role in chronic viral disease
    Niklas K Björkström
    Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Trends Immunol 31:401-6. 2010
    ..We discuss current knowledge of CD56(neg) NK cells, with a particular emphasis on their accumulation during chronic infection and the possible consequences of this for the host...
  24. doi request reprint Elevated natural killer cell activity despite altered functional and phenotypic profile in Ugandans with HIV-1 clade A or clade D infection
    Michael A Eller
    Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Acquir Immune Defic Syndr 51:380-9. 2009
    ..We here aimed to determine the state of the NK cell compartment in Ugandans with untreated HIV-1 clade A or D infection in comparison with matched uninfected controls...
  25. pmc IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcgammaRIIa
    Anna Smed-Sorensen
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Blood 111:5037-46. 2008
    ..Our data demonstrate an important role for FcgammaRIIa in regulating the CD1 antigen presentation machinery of human DCs...
  26. pmc Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection
    Edwin Leeansyah
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Blood 121:1124-35. 2013
    ....
  27. doi request reprint Analysis of the KIR repertoire in human NK cells by flow cytometry
    Niklas K Björkström
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Methods Mol Biol 612:353-64. 2010
    ..Finally, we discuss possibilities as well as limitations with the application of multi-color flow cytometry techniques to future studies of human NK cells...
  28. ncbi request reprint Spontaneous HCV clearance in HCV/HIV-1 coinfection associated with normalized CD4 counts, low level of chronic immune activation and high level of T cell function
    Karolin Falconer
    Karolinska Institutet, Department of Medicine Solna, Infectious Diseases Unit, SE 17176 Stockholm, Sweden
    J Clin Virol 41:160-3. 2008
    ..The search for immune correlates of spontaneous clearance is important for the understanding of pathogenesis as well as for the development of possible new treatment strategies...
  29. pmc Technical advance. Measurement of iNKT cell responses at the single-cell level against rare HIV-1-infected dendritic cells in a mixed culture
    Sofia K Andersson
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Leukoc Biol 93:449-55. 2013
    ..This microscopy assay, based on full-length HIV-1 modified to express eGFP, thus allows detailed evaluation of HIV-1 immune-evasion mechanisms in rare virus-infected live DCs...
  30. doi request reprint Single-cell level response of HIV-specific and cytomegalovirus-specific CD4 T cells correlate with viral control in chronic HIV-1 subtype A infection
    Michael A Eller
    U S Military HIV Research Program, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Acquir Immune Defic Syndr 61:9-18. 2012
    ..To study the possible role of T cells associated with better outcome, we examined CD4 and CD8 T-cell responses against HIV-1 and cytomegalovirus (CMV) in Ugandans infected with subtype A HIV-1...
  31. ncbi request reprint CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles
    Maire F Quigley
    Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Eur J Immunol 37:3352-62. 2007
    ..The finding that a subset of early effector memory CD8 T cells use CXCR5 to locate to B cell follicles indicates that MHC class I-restricted CD8 T cells are part of the follicular T cell population...
  32. pmc Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin-2
    Markus Moll
    CIM, Department of Medicine, F59, Karolinska Institute, Karolinska University Hospital, Huddinge, 14186 Stockholm, Sweden
    Blood 107:3081-3. 2006
    ..These data indicate that IL-2 treatment in combination with effective ART is beneficial for the restoration of innate NKT cell immunity in patients with primary HIV-1 infection...
  33. pmc IVIg immune reconstitution treatment alleviates the state of persistent immune activation and suppressed CD4 T cell counts in CVID
    Dominic Paquin-Proulx
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS ONE 8:e75199. 2013
    ..These findings help our understanding of the immunopathogenesis of primary immunodeficiency, as well as acquired immunodeficiency caused by HIV-1 infection. ..
  34. doi request reprint Soluble biomarkers of HIV transmission, disease progression and comorbidities
    Edwin Leeansyah
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Opin HIV AIDS 8:117-24. 2013
    ..The purpose of this study is to survey and synthesize recent progress in soluble biomarkers relevant to HIV-1 disease stages, progression and comorbidities...
  35. doi request reprint IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema
    Sara M Lind
    Clinical Allergy Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    Eur J Immunol 39:2293-301. 2009
    ..Based on these findings, we propose that IL-18-mediated activation and subsequent dysregulation of the CD1d-restricted iNKT-cells plays a role in the pathogenesis of human AE...
  36. ncbi request reprint Development and function of CD1d-restricted NKT cells: influence of sphingolipids, SAP and sex
    Johan K Sandberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    Trends Immunol 26:347-9. 2005
    ..Clinical implications of these findings are briefly touched on...
  37. doi request reprint Exosomes from breast milk inhibit HIV-1 infection of dendritic cells and subsequent viral transfer to CD4+ T cells
    Tanja I Näslund
    aKarolinska Institutet, Department of Medicine, Translational Immunology Unit L2 04, Karolinska University Hospital Solna bKarolinska Institutet, Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    AIDS 28:171-80. 2014
    ..To investigate whether exosomes derived from human breast milk or plasma confer protection against HIV-1 infection of monocyte-derived dendritic cells (MDDCs) and subsequent viral transfer to CD4 T cells...
  38. pmc Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection
    Maire F Quigley
    Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Virol 80:3083-7. 2006
    ..These findings demonstrate the presence of a robust perforin-positive response in gastrointestinal CD8 T cells during acute, but not chronic, SIV infection...
  39. ncbi request reprint A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses
    Adnane Achour
    Microbiology and Tumor Biology Center, Karolinska Institutet, Royal School of Technology, S 106 91 Stockholm, Sweden
    Immunity 17:757-68. 2002
    ..Importantly, the peptide's N-terminal residue p1K protrudes from the binding cleft in H-2K(b). We present structural evidence that explains the functional consequences of single mutations found in escape variants...