Carlos A Rubio

Summary

Affiliation: Karolinska Institute and Hospital
Country: Sweden

Publications

  1. ncbi Further studies support the participation of stem cells in the cell turnover of duodenal adenomas
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    Anticancer Res 29:657-60. 2009
  2. pmc The frequency of lymphocytic and reflux esophagitis in non-human primates
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research San Antonio, TX 78245 0549, USA
    Int J Clin Exp Pathol 1:531-5. 2008
  3. pmc Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors
    H Fischer
    Dept Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    BMC Physiol 1:1. 2001
  4. pmc COL11A1 in FAP polyps and in sporadic colorectal tumors
    H Fischer
    Department Molecular Medicine, Karolinska Institute, S 171 76 Stockholm, Sweden
    BMC Cancer 1:17. 2001
  5. ncbi Serrated and microtubular colorectal adenomas in Italian patients. A 5-year survey
    C A Rubio
    Dipartimento di Patologia Umana ed Oncologia, Universita degli Studi di Firenze, Florence, Italy
    Anticancer Res 25:1353-9. 2005
  6. ncbi Bronchogenic gastric cyst. A case report
    C A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    In Vivo 19:383-5. 2005
  7. ncbi Paneth cell adenoma of the ileum
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 24:4187-90. 2004
  8. ncbi Extended intestinal metaplasia. A survey of 1392 gastrectomies from dwellers of the Pacific basin
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 24:3185-92. 2004
  9. pmc Serrated adenoma of the duodenum
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    J Clin Pathol 57:1219-21. 2004
  10. pmc Serrated adenomas of the appendix
    C A Rubio
    J Clin Pathol 57:946-9. 2004

Detail Information

Publications90

  1. ncbi Further studies support the participation of stem cells in the cell turnover of duodenal adenomas
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    Anticancer Res 29:657-60. 2009
    ..The position of the Paneth cells within duodenal adenomas was investigated...
  2. pmc The frequency of lymphocytic and reflux esophagitis in non-human primates
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research San Antonio, TX 78245 0549, USA
    Int J Clin Exp Pathol 1:531-5. 2008
    ..The antigenic agent(s) responsible for the marked immunological reaction in lymphocytic esophagitis in non-human primates (and in humans) remains unknown...
  3. pmc Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors
    H Fischer
    Dept Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    BMC Physiol 1:1. 2001
    ..In order to identify differentially expressed genes in colorectal tumors and normal colorectal epithelium, a differential display experiment was used to compare RNA expression in normal and tumor tissue samples...
  4. pmc COL11A1 in FAP polyps and in sporadic colorectal tumors
    H Fischer
    Department Molecular Medicine, Karolinska Institute, S 171 76 Stockholm, Sweden
    BMC Cancer 1:17. 2001
    ..Most colorectal carcinomas are suggested to be a result of an activated Wnt- pathway, most often involving an inactivation of the APC gene or activation of beta-catenin...
  5. ncbi Serrated and microtubular colorectal adenomas in Italian patients. A 5-year survey
    C A Rubio
    Dipartimento di Patologia Umana ed Oncologia, Universita degli Studi di Firenze, Florence, Italy
    Anticancer Res 25:1353-9. 2005
    ..In the light of the present results, it is proposed that SAs and MTAs are included in future reports of colorectal adenomas in order to compare their frequency worldwide...
  6. ncbi Bronchogenic gastric cyst. A case report
    C A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    In Vivo 19:383-5. 2005
    ..Congenital bronchogenic cysts should be differentiated from acquired gastric cysts lined with ciliated metaplastic cells that evolve as a result of environmental factors...
  7. ncbi Paneth cell adenoma of the ileum
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 24:4187-90. 2004
    ..A review of the literature indicates that this is the first reported case of Paneth cell adenoma of the small intestine...
  8. ncbi Extended intestinal metaplasia. A survey of 1392 gastrectomies from dwellers of the Pacific basin
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 24:3185-92. 2004
    ..To assess the extent of gastric intestinal metaplasia (IM) in gastrectomy specimens in populations of the Pacific basin having different incidence of gastric carcinoma...
  9. pmc Serrated adenoma of the duodenum
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    J Clin Pathol 57:1219-21. 2004
    ..Increased awareness of the existence of serrated neoplasms in the duodenum may result in similar cases being reported in the future...
  10. pmc Serrated adenomas of the appendix
    C A Rubio
    J Clin Pathol 57:946-9. 2004
    ..The aim was to explore the possible occurrence of serrated adenomas of the appendix at the department of pathology, Karolinska Institute and University Hospital, Stockholm, Sweden...
  11. ncbi Serrated adenomas of the cardia
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 24:2113-6. 2004
    ..Metastases were also demonstrated in two additional cases. In similarity with other adenoma phenotypes, serrated adenomas of the cardia have a propensity to evolve into invasive carcinoma, a phenomenon that appears to be size-dependent...
  12. ncbi Possible mechanism pertinent to mucosal invasion in sporadic colonic adenomas
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 24:2033-6. 2004
    ..The release of proteolytic secretions through glandular pores in some colonic adenomas disrupt the surrounding matrix, a mechanism that would facilitate neoplastic cell penetration into the lamina propria...
  13. ncbi Histological changes pertinent to local tumor progression in hereditary nonpolyposis colorectal cancer (HNPCC). A preliminary report
    C A Rubio
    Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 24:1765-8. 2004
    ....
  14. ncbi Colorectal adenomas produce lysozyme
    C A Rubio
    Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 23:5165-71. 2003
    ..Lysozyme overexpression (+++) also occurred in 2 of the 21 hyperplastic polyps, suggesting that intense lysozyme production might herald a possible dysplastic evolution in some hyperplastic polyps...
  15. ncbi Adenocarcinoma in inflammatory colorectal disease. Histological features pertinent to local tumour progression
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 23:4313-8. 2003
    ..To restore the continuity of those incomplete glands, new cancer cells would grow around mucin "lakes" or inflammatory-necrotic aggregates in the stroma. This mechanism will guarantee a life-long tumour progression in untreated patients...
  16. ncbi Histological features pertinent to local tumour progression in Barrett's adenocarcinoma
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 23:3015-8. 2003
    ..The presence of cell-free mucin "lakes" within the tissues of the host in signet ring cell Barrett's adenocarcinomas suggest a similar mechanism of tumour progression...
  17. ncbi Further studies on the histological characteristics linked to local tumour invasion in colorectal carcinomas
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 23:3555-60. 2003
    ..Since preoperative irradiation was administered only to patients carrying rectal tumours, it is apparent that the histological features here described are neither evoked nor abrogated by irradiation...
  18. pmc Gastric ciliated metaplasia. A study of 3406 gastrectomy specimens from dwellers of the Atlantic and the Pacific basins
    C A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    J Clin Pathol 58:605-10. 2005
    ..Ciliated cells in gastrectomies from patients dwelling in the Pacific and Atlantic basins have been reported previously...
  19. ncbi Do stem cells participate in cell turnover in duodenal adenomas? A preliminary study on Paneth cells
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 28:1571-3. 2008
    ..In the normal duodenum, Paneth cells migrate from the stem cells downwards, towards the bottom of the crypts of Lieberkuhn...
  20. ncbi A single method to document the size of endoscopically-excised colorectal polyps
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    In Vivo 21:1103-6. 2007
    ..Using polyp-phantoms we previously found a wide inter- and intra-observer variation in size assessment...
  21. ncbi Reliability of the reported size of removed colorectal polyps
    Carlos A Rubio
    Department of Pathology Karolinska University Hospital, Stockholm, Solna, Sweden
    Anticancer Res 26:4895-9. 2006
    ..The size of colorectal polyps is important in the clinical management of these lesions...
  22. ncbi The Vienna classification applied to colorectal adenomas
    Carlos A Rubio
    Department of Pathology and Oncology, University of Florence, Florence, Italy
    J Gastroenterol Hepatol 21:1697-703. 2006
    ..In 1999, a group of Western and Asian pathologists gathered in Vienna reached consensus regarding the classification of gastrointestinal epithelial neoplasia. In this study, that classification is applied to colorectal adenomas...
  23. ncbi Hyperplastic polyposis coli syndrome and colorectal carcinoma
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    Endoscopy 38:266-70. 2006
    ..Patients with hyperplastic polyposis coli syndrome (HPCS) have a propensity to develop colorectal carcinoma (CRC)...
  24. ncbi Apoptosis versus polemosis. Different mechanisms leading to non-necrotic cell death
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 26:183-6. 2006
    ..This would satisfy the avidity of the DNA of rapidly proliferating dysplastic cells, a process that takes place, unremittingly, at any given time...
  25. ncbi Gastric glassy cells: a study of 3202 gastrectomy specimens from dwellers of the Atlantic and Pacific basins
    C A Rubio
    Gatrointestinal and Liver Pathology Research Laboratory, Department of Pathology of Karolinska Institute and University Hospital, Stockholm, Sweden
    J Environ Pathol Toxicol Oncol 24:281-9. 2005
    ..Hence, the difference in the frequencies of GCs appears to be a new indication that dissimilar environmental exposures in the two basins might have influenced the histological make-up of the gastric mucosa...
  26. ncbi Neoplasias of the colorectal crypts
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 25:4551-8. 2005
    ..The awareness that colorectal neoplasias may evolve from that particular cellular domain may cast more light on the understanding of the complex mechanisms of colorectal carcinogenesis...
  27. pmc Extensive intestinal metaplasia in gastric carcinoma and in other lesions requiring surgery: a study of 3,421 gastrectomy specimens from dwellers of the Atlantic and Pacific basins
    C A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    J Clin Pathol 58:1271-7. 2005
    ..Extensive intestinal metaplasia (EIM) has been reported in gastrectomies from patients dwelling in the Pacific and Atlantic basins...
  28. ncbi Mott cell (Russell bodies) Barrett's oesophagitis
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    In Vivo 19:1097-100. 2005
    ..Increased awareness of the existence of this subgroup of Barrett's oesophagitis may result in similar cases being reported in the future...
  29. ncbi Macrophage-associated chronic diarrhea of unknown origin. Preliminary observations
    C A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    In Vivo 19:927-9. 2005
    ....
  30. ncbi Intraductal serrated adenoma of the pancreas. A case report
    C A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    Anticancer Res 25:3099-102. 2005
    ..An area with early invasive carcinoma was found. The tumour had progressed slowly during the 2.7 years of surveillance. Serrated neoplasia in the duodenum may result in similar cases in the future...
  31. ncbi Possible mechanism connected with the progression of submucosal invasion in colorectal neoplasias
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 25:2503-7. 2005
    ....
  32. ncbi Serrated and microtubular adenomas of the colon and rectum. An 8-year histological survey
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 23:1693-6. 2003
    ....
  33. ncbi A method for the detection of eosinophilic granulocytes in colonoscopic biopsies from IBD patients
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Pathol Res Pract 199:145-50. 2003
    ..Focal eosinophilic mucosal infiltration in CD is more common than epithelioid cell granulomas, and emerges as an important parameter in the histologic differential diagnosis between colonic CD and UC...
  34. ncbi Ethnic or environmental differences in disparate geographic regions may influence the histology of flat colorectal neoplasias
    C A Rubio
    Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 18:651-5. 1998
    ..Ethnic and/or environmental differences seem to play a crucial role in the evolution of flat colorectal neoplasic polyps from LGD and HGD, to intramucosal and to invasive carcinoma...
  35. pmc Serrated neoplasia of the stomach: a new entity
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    J Clin Pathol 54:849-53. 2001
    ..The aim of this paper is to report a novel histological phenotype of gastric adenoma with early invasive growth...
  36. ncbi Gastric carcinomas of intestinal type concur with distant changes in the gastric mucosa. A multicenter study in the Atlantic basin
    C A Rubio
    Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute, 17176 Stockholm, Sweden
    Anticancer Res 21:813-8. 2001
    ..Thus, DMCs seem to provide the adequate "soil" for the development of gastric carcinomas of intestinal type, independently of the future localization of that tumor in the stomach...
  37. ncbi Apoptotic colonic disease: a new entity in a primate
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute, Stockholm, Sweden
    In Vivo 15:35-7. 2001
    ..The term apoptotic colonic disease is proposed for this previously unreported condition...
  38. ncbi Chronic colitis in baboons: similarities with chronic colitis in humans
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute, Stockholm, Sweden
    In Vivo 15:109-16. 2001
    ..Only then would it be feasible to systematically initiate the search for the corresponding etiologic agent(s), aiming to tailor specific therapeutic strategies in those animals...
  39. ncbi Villous and serrated adenomatous growth bordering carcinomas in inflammatory bowel disease
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute, 171 76 Stockholm, Sweden
    Anticancer Res 20:4761-4. 2000
    ..It would appear that villous and serrated AGs are the most common non-invasive neoplastic lesions from which IBD carcinomas originate...
  40. pmc Qualitative and quantitative differences between bile ducts in chronic hepatitis and in primary biliary cirrhosis
    C A Rubio
    Department of Pathology, Karolinska Institute, Stockholm, Sweden
    J Clin Pathol 53:765-9. 2000
    ..The aim was to assess the number and the characteristics of the bile ducts in those diseases with the aid of an antibody to cytokeratin 7 (CK7)...
  41. ncbi Nonprotruding colorectal neoplasms: epidemiologic viewpoint
    C A Rubio
    Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    World J Surg 24:1098-103. 2000
    ....
  42. ncbi Cryptal lymphocytic colitis: a new entity in baboons
    C A Rubio
    Department of Pathology, Karolinska Institute, Stockholm, Sweden
    In Vivo 14:485-6. 2000
    ..At histology, marked lymphocytic infiltration within the colonic epithelium covering the crypts was found. The term cryptal lymphocytic colitis is proposed for this previously unreported disease in baboons...
  43. ncbi Cytotoxic intraepithelial lymphocytes in colorectal polyps and carcinomas
    C A Rubio
    Department of Pathology, Gastroenterology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 19:3221-7. 1999
    ..The upregulation of CD3-T, MHC class II molecules, and TIA 1 in IELs of neoplastic colorectal lesions suggests that they are activated and cytotoxic; however, they undergo apoptosis due to the downregulation of the FAS molecules...
  44. ncbi A new phenotype of gastric pyloric cells. A study in baboons
    C A Rubio
    Department of Pathology, Karolinska Institute, Stockholm, Sweden
    In Vivo 12:543-6. 1998
    ..The same cells are now found in the gastric antrum of baboons. "Glassy" pyloric cells showed a moderate positivity with PAS stain but they were negative after diastase treatment, suggesting that the glassy material may be a glycoprotein...
  45. ncbi Histologic phenotypes of colonic carcinoma in Sweden and in Japan
    C A Rubio
    Department of Pathology, Karolinska Institute, Stockholm, Sweden
    Anticancer Res 18:2649-55. 1998
    ....
  46. ncbi A comparative study between the gastric mucosa of west Canadians and other dwellers of the Pacific Basin
    C A Rubio
    Department of Anatomical Pathology, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Canada
    Anticancer Res 18:2463-70. 1998
    ..Environmental factors acting in that basin may account for the results obtained...
  47. ncbi The detection of bile ducts in liver biopsies by cytokeratin 7
    C A Rubio
    Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    In Vivo 12:183-6. 1998
    ....
  48. ncbi Adenomas and carcinomas may be histologically detected in apparently normal colonic mucosa. A study of carcinogen-treated rats
    C A Rubio
    Departments of Pathology and Endoscopic Gastroenterology, Karolinska Institute and Hospital, Stockholm, Sweden
    In Vivo 15:299-301. 2001
    ..0% (n = 4) were invasive carcinomas. Experimentally-induced colonic neoplasias may be overlooked even after a careful scrutiny of the colonic mucosa using high-power optical devices...
  49. ncbi Re-adaptation of the gastroduodenal mucosa to DNA synthesis during protracted stress
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Eur J Clin Invest 31:1054-9. 2001
    ..The possibility that this DS adaptation (DSA) could be maintained beyond 8 weeks in animals allowed to subsequent resting (stress-free) weeks, was now explored...
  50. ncbi Colorectal carcinomas. Possible mechanisms of local tumor progression
    C A Rubio
    Gastointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 23:347-50. 2003
    ..The malignant cells surrounding those glandular "pores" would eventually grow around the secreted products, thus guaranteeing a stepwise but everlasting tumor progression in untreated cases...
  51. ncbi Possible mechanism of local tumor progression in experimentally-induced colorectal carcinomas in rats
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    In Vivo 17:97-100. 2003
    ..The remodelling of the glands will guarantee a stepwise but everlasting tumor progression deeper into the host...
  52. ncbi A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    In Vivo 17:67-71. 2003
    ..The present method will improve the enumeration of the actual number of normal and metaplastic Paneth cells both in experimental research and in clinical trials...
  53. ncbi Re-adaptation of the colonic mucosa following protracted stress in rats
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, Stockholm, Sweden
    Eur J Clin Invest 33:406-11. 2003
    ..We previously found that DNA synthesis of the colonic mucosa rises under protracted physical stress. At 8 stress weeks DNA values regained those of untreated animals, and was regarded as DNA adaptation to stress...
  54. ncbi Colorectal adenomas: time for reappraisal
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Pathol Res Pract 198:615-20. 2002
    ..To compare the frequency of these adenoma phenotypes, we suggest that serrated and microtubular adenomas be included in future reports on the histologic characteristics of colorectal polyps...
  55. ncbi Apoptotic colon disease: a new clinico-pathological entity
    C A Rubio
    Research Laboratory, Karolinska Institute, 17176 Stockholm, Sweden
    In Vivo 16:235-7. 2002
    ..That phenomenon was designated apoptotic colonic disease. We propose a similar denomination for this previously unreported finding in a human subject...
  56. ncbi Chronic colitis in Macaca fascicularis: similarities with chronic colitis in humans
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute, 17176 Stocholm, Sweden
    In Vivo 16:191-5. 2002
    ....
  57. pmc A simple method to demonstrate duodenal gastric metaplasia
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    J Clin Pathol 55:520-3. 2002
    ..Recently, groups of duodenal columnar cells were seen to be autofluorescent in haematoxylin and eosin (H&E) stained sections from a patient with DGM...
  58. ncbi The subepithelial band in collagenous colitis is autofluorescent a study in H&E stained sections
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    In Vivo 16:123-6. 2002
    ..The results suggest that the simple observation of H&E--stained biopsies with ILF may be sufficient to diagnose CC. Re-sectioning for special staining can be avoided, thus reducing final diagnosis-time and laboratory costs...
  59. pmc Cryptal lymphocytic coloproctitis: a new phenotype of lymphocytic colitis?
    C A Rubio
    Department of Pathology, Karolinska Hospital, 171 76 Stockholm, Sweden
    J Clin Pathol 55:138-40. 2002
    ..This report describes two patients with symptoms similar to those of lymphocytic colitis and an increased number of IELs, but within the cryptal epithelium...
  60. ncbi Classification of colorectal polyps: guidelines for the endoscopist
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Endoscopy 34:226-36. 2002
  61. ncbi Protruding and non-protruding adenomas of the stomach
    C A Rubio
    Department of Pathology, Karolinska Institute, Stockholm, Sweden
    Anticancer Res 21:3037-40. 2001
    ..Thus, similarly to colorectal adenomas, gastric adenomas may be classified into protruding and non-protruding. Micrometric measurements permit the correct assessment of the type of adenoma...
  62. ncbi Lysozyme-rich muciphages surrounding colorectal adenomas
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 22:879-81. 2002
    ..Such a mechanism would prevent the lateral expansion of the dysplastic epithelium of the adenoma into the surrounding normal mucosa of the stalk...
  63. ncbi Colorectal carcinoma in ulcerative colitis is decreasing in Scandinavian countries
    C A Rubio
    Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 21:2921-4. 2001
    ..A review of the present literature indicated that the ris for colorectal carcinoma in pancolitics is presently decreasing, not only in Sweden but also in other Scandinavian countries...
  64. pmc The frequency of glassy cells in Barrett's mucosa: a study in Baboons
    Carlos A Rubio
    Southwest Foundation Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    In Vivo 23:925-7. 2009
    ..Similar GGCs were more recently detected in a baboon having glandulo-metaplastic esophageal mucosa (GMEM). The aim was to assess the frequency of baboons with GMEM having GGCs...
  65. ncbi Lysozyme overexpression in fundic gland polyps
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 30:1021-4. 2010
    ..We recently found that FGPs express lysozyme, one of the natural defence substances against infection. We aimed to assess the degree of lysozyme expression in a cohort of consecutive FGPs...
  66. doi Lysozyme-rich mucus metaplasia in duodenal crypts supersedes Paneth cells in celiac disease
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Virchows Arch 459:339-46. 2011
    ..The molecular mechanism(s) behind the abrogation of Paneth cells in duodenal crypts and its substitution by LPMMC in celiac disease remains to be elucidated...
  67. ncbi Arrest of cell proliferation in budding tumor cells ahead of the invading edge of colonic carcinomas. A preliminary report
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 28:2417-20. 2008
    ..Tumor budding is claimed to correlate with lymph node metastasis and local recurrence...
  68. ncbi The size of colon polyps revisited: intra- and inter-observer variations
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 30:2419-23. 2010
    ..In this work, the size of a large cohort of endoscopically-resected colon polyps was assessed with a novel method...
  69. ncbi Serrated neoplasias and de novo carcinomas in ulcerative colitis: a histological study in colectomy specimens
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    J Gastroenterol Hepatol 22:1024-31. 2007
    ....
  70. ncbi Luminal histological outline and colonic adenoma phenotypes
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 27:3555-9. 2007
    ..These two modalities were compared to the size, the histological phenotype and the degree of epithelial neoplasia...
  71. ncbi Colorectal cancer in Crohn's disease--review of a 56-year experience in Karolinska Institute University Hospital
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    J Environ Pathol Toxicol Oncol 27:257-66. 2008
    ....
  72. ncbi Assessing the size of polyp phantoms in tandem colonoscopies
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Building P1 03 057, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    Anticancer Res 29:1539-45. 2009
    ..The size of colorectal neoplastic polyps is important for their clinical management...
  73. ncbi Protruding and non-protruding colon carcinomas originating in gut-associated lymphoid tissue
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 30:3019-22. 2010
    ..Histology demonstrated a protruding GALTC. The surgical specimen showed four additional carcinomas: 2 GALTC (non-protruding) and 2 carcinomas in lymphoid-free colonic mucosa (LFCMC)...
  74. doi Quantitative assessment of the subepithelial collagen band does not increase the accuracy of diagnosis of collagenous colitis
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Am J Clin Pathol 130:375-81. 2008
    ..In agreement with Lazenby's statement: "Focusing solely on the collagen band can result in both over- and underdiagnosis"..
  75. ncbi Further studies on the frequency of colorectal cancer in Crohn's colitis: an 11-year survey in the Northwest Stockholm County
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 29:4291-5. 2009
    ..The frequency of colorectal carcinomas (CRC) evolving in patients with Crohn's colitis (CC) was assessed at the Danderyds University Hospital (DUH), one of two large hospitals in Northwest Stockholm County (NWSC)...
  76. pmc Plugs clog the glandular outlets in fundic gland polyps
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Int J Clin Exp Pathol 3:69-74. 2009
    ..Thus, the blocking of the glandular outflow by plugs of anucleated structures with eosinophilic granules is the most likely cause for the cystic accumulation of "normal" glandular secretions...
  77. ncbi Lymphocytic esophagitis: a histologic subset of chronic esophagitis
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital and Institute, Stockholm, Sweden
    Am J Clin Pathol 125:432-7. 2006
    ....
  78. ncbi Further studies on serrated neoplasias of the cardia: a review and case report
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Anticancer Res 27:4431-4. 2007
    ..Serrated adenomas of the cardia seem to have a particular proclivity to evolve into invasive carcinomas...
  79. ncbi An easy method to identify parietal cells in gastric biopsies
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    In Vivo 24:599-602. 2010
    ..Sections from gastric biopsies are usually stained with hematoxylin and eosin (H&E), a stain that is not optimal for the recognition of many parietal cells. This paper describes a more suitable routine stain to identify parietal cells...
  80. ncbi "Glassy" cells in Barrett's mucosa
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital 17176, Stockholm, Sweden
    Anticancer Res 29:4145-6. 2009
    ..In 1991 we detected glandular cells with "glassy" cytoplasm (GCs) in human gastric mucosa having intestinal metaplasia (IM). GCs were subsequently found in the gastric mucosa of baboons...
  81. ncbi Further studies on the arrest of cell proliferation in tumor cells at the invading front of colonic adenocarcinoma
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    J Gastroenterol Hepatol 22:1877-81. 2007
    ..The aim of this study was to audit cell proliferation and p53 mutation in flat tumor cells and in tumor cells at the tip of glandular pores at the leading invading front of colonic carcinomas...
  82. ncbi Assessing polyp size by improved digitalized computed tomography (CT)
    Chikako Suzuki
    Department of Diagnostic Radiology, Institution for Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    Anticancer Res 28:1911-5. 2008
    ..The aim of this study was to assess the size of 12 phantom polyps by computed tomography (CT)...
  83. pmc My approach to reporting a gastric biopsy
    Carlos A Rubio
    Department of Pathology, Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute, Sweden
    J Clin Pathol 60:160-6. 2007
    ..This knowledge is crucial, considering that environmental diseases are theoretically preventable...
  84. ncbi Morphological events found at the invading edge of colorectal carcinomas in baboons
    Carlos A Rubio
    Department of Pathology, Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Anticancer Res 28:193-6. 2008
    ....
  85. ncbi Gastric achlorhydria in H/K-ATPase-deficient (Atp4a(-/-)) mice causes severe hyperplasia, mucocystic metaplasia and upregulation of growth factors
    Louise M Judd
    Department of Medicine, University of Melbourne, Western Hospital, Melbourne, Victoria, Australia
    J Gastroenterol Hepatol 20:1266-78. 2005
    ..To study this, mice lacking the gastric H/K-ATPase (Atp4a(-/-) mice) were used to determine whether chronic loss of acid secretion, with attendant hypergastrinemia, predisposes to cancer phenotype...
  86. ncbi The frequency of gastric pyloric cells with glassy cytoplasm in baboons. A comparison with human subjects
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    In Vivo 22:9-12. 2008
    ..These pyloric cells, called glassy cells (GCs) show a homogeneous, eosinophilic material that pushes the nucleous towards the free border of the cell...
  87. doi Tamoxifen exposure in relation to gastric adenocarcinoma development
    Evangelos Chandanos
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Cancer 44:1007-14. 2008
    ....
  88. ncbi The frequency of lymphocytic gastritis in baboons
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    In Vivo 22:101-4. 2008
    ..The disease, subsequently called lymphocytic gastritis (LG) is a rare form of gastritis (0.8%-1.6% of cases), with unclear pathogenesis. More recently, LG was recorded in pigs and in non-human primates...
  89. ncbi Somatostatinoma: clinico-pathological features of three cases and literature reviewed
    Gabriella Nesi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    J Gastroenterol Hepatol 23:521-6. 2008
    ..A comparison between our three cases and those in the literature provides useful insights into the clinical management of these patients. Interestingly, the jejunal somatostatinoma described here is the second case ever reported...
  90. ncbi Squamous-cell carcinoma of the anus with high intratumoral lymphocytosis and its clinical implications
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    Anticancer Res 28:2469-72. 2008
    ..It has been claimed that patients with squamous cell carcinoma of the anal canal (SCCAC) showing intraepithelial lymphocytes have a poor prognosis...