Carlos A Rubio

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Mucous gland metaplasia in the esophagus and gastric mucosa in baboons
    Carlos A Rubio
    Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Anticancer Res 31:2187-90. 2011
  2. ncbi An additional case of gastric serrated adenoma
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    Anticancer Res 34:3007-10. 2014
  3. ncbi Fabry disease simulating Crohn's ileitis
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 34:2437-41. 2014
  4. ncbi Advanced microtubular colorectal adenomas: a 10-year survey at a single hospital
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 33:5471-6. 2013
  5. doi Lymphoid aggregates in Crohn's colitis and mucosal immunity
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Virchows Arch 463:637-42. 2013
  6. doi Paucity of synaptophysin-expressing cells in Barrett's mucosa
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Histopathology 63:208-16. 2013
  7. ncbi Traditional serrated adenoma in a patient with Barrett's esophagus
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Anticancer Res 33:1743-5. 2013
  8. ncbi Pitfall in assessing the size of tumor phantoms on mammograms
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 33:1131-4. 2013
  9. ncbi A method to assess the distribution and frequency of plasma cells and plasma cell precursors in autoimmune hepatitis
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 33:665-9. 2013
  10. ncbi Lysozyme is up-regulated in columnar-lined Barrett's mucosa: a possible natural defence mechanism against Barrett's esophagus-associated pathogenic bacteria
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 32:5115-9. 2012

Detail Information

Publications119 found, 100 shown here

  1. pmc Mucous gland metaplasia in the esophagus and gastric mucosa in baboons
    Carlos A Rubio
    Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Anticancer Res 31:2187-90. 2011
    ..In a previous study of entire esophagi, the majority of baboons showed MGM. The gastric mucosa was not investigated...
  2. ncbi An additional case of gastric serrated adenoma
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    Anticancer Res 34:3007-10. 2014
    ....
  3. ncbi Fabry disease simulating Crohn's ileitis
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 34:2437-41. 2014
    ..It is submitted that the gastrointestinal phenotype of Fabry disease may concur with symptoms resembling abdominal Crohn's disease. ..
  4. ncbi Advanced microtubular colorectal adenomas: a 10-year survey at a single hospital
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 33:5471-6. 2013
    ..In 1997, we reported a novel histological phenotype, the microtubular adenoma (MTA), epitomized by dysplastic epithelium arranged in closed rings (microtubules), with sideways-elongated outgrowth...
  5. doi Lymphoid aggregates in Crohn's colitis and mucosal immunity
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Virchows Arch 463:637-42. 2013
    ..These precursors would eventually migrate into the lamina propria to differentiate into aT/cB/PC, complying thereby with the immunological mucosal demands generated by the on-going chronic inflammation...
  6. doi Paucity of synaptophysin-expressing cells in Barrett's mucosa
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Histopathology 63:208-16. 2013
    ..To assess synaptophysin expression in columnar-lined oesophageal mucosa showing either goblet cells, known as intestinal metaplasia, or with accompanying oxyntic glands or pyloric glands...
  7. ncbi Traditional serrated adenoma in a patient with Barrett's esophagus
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Anticancer Res 33:1743-5. 2013
    ..In non-dysplastic subjacent glands with intestinal metaplasia, goblet cells contained sialomucins (alcian blue pH 2.5) and mucopolysaccharides (periodic acid Schiff). The TSA was found at the border of an invasive adenocarcinoma...
  8. ncbi Pitfall in assessing the size of tumor phantoms on mammograms
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 33:1131-4. 2013
    ..Tumor size is crucial for clinical management and prognosis of breast malignancies...
  9. ncbi A method to assess the distribution and frequency of plasma cells and plasma cell precursors in autoimmune hepatitis
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 33:665-9. 2013
    ..It is suggested that MUM1 may be of help in the histological differential diagnosis between autoimmune liver diseases and other liver ailments...
  10. ncbi Lysozyme is up-regulated in columnar-lined Barrett's mucosa: a possible natural defence mechanism against Barrett's esophagus-associated pathogenic bacteria
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 32:5115-9. 2012
    ..Pathogenic microbes have recently been identified in the esophageal mucosa in patients with Barrett's esophagus (BE). Lysozyme expression was evaluated in biopsies from patients with BE...
  11. doi The frequency of advanced adenoma in consulting patients: a nationwide survey in Iceland (2003-2006)
    C A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Colorectal Dis 14:e595-602. 2012
    ..To assess the frequency of advanced colorectal adenomas in consulting patients in Iceland...
  12. ncbi An easy method to quantify plasma cells/plasma cell precursors in normal colonic mucosa, collagenous colitis and Crohn's colitis
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Anticancer Res 32:3723-6. 2012
    ....
  13. ncbi An easy method to quantify plasma cells in caeliac disease
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    In Vivo 26:859-62. 2012
    ..Recently it was also noticed that an antibody against multiple myeloma oncogene 1/IRF4 (MUM1) stained plasma cells and their precursors...
  14. ncbi Chaperon normal goblet cells intercalated with dysplastic cells in duodenal adenomas express synaptophysin
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 32:3411-4. 2012
    ..In this work, we investigated whether goblet cells in duodenal adenomas express synaptophysin...
  15. pmc The length of the Barrett's mucosa in baboons, revisited
    Carlos A Rubio
    Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Anticancer Res 32:3115-8. 2012
    ..In humans, this histological constellation is called Barrett's mucosa type 2 (BMT2)...
  16. ncbi Classification of gastritis in first-degree relatives of patients with gastric cancer in a high cancer-risk area in Italy
    Calogero Saieva
    Department of Molecular and Nutritional Epidemiology Unit, Cancer Prevention and Research Institute, Florence, Italy
    Anticancer Res 32:1711-6. 2012
    ..Screening gastroscopic examinations were performed in a cohort of individuals at high risk for developing gastric carcinoma (GC)...
  17. ncbi Detecting plasma cell precursors in autoimmune hepatitis
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    In Vivo 26:319-21. 2012
    ..In many cases, however, only lymphocytes and occasional granulocytes are found. It was recently noticed that the antibody to multiple myeloma oncogene 1/IRF4 (MUM1), stained plasma cells and their precursors...
  18. ncbi Squamous-cell carcinoma of the anus with high intratumoral lymphocytosis and its clinical implications
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    Anticancer Res 28:2469-72. 2008
    ..It has been claimed that patients with squamous cell carcinoma of the anal canal (SCCAC) showing intraepithelial lymphocytes have a poor prognosis...
  19. ncbi Incidence of lymphocytic esophagitis in baboons
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, 78245 0549, USA
    In Vivo 22:613-5. 2008
    ..The aim of the present study was to explore the possible occurrence of lymphocytic esophagitis in baboons...
  20. ncbi Colorectal cancer in Crohn's disease--review of a 56-year experience in Karolinska Institute University Hospital
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    J Environ Pathol Toxicol Oncol 27:257-66. 2008
    ....
  21. pmc The frequency of histological features mimicking reflux esophagitis: a study in non-human primates
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    In Vivo 22:721-4. 2008
    ..The frequency of histological changes mimicking those described for reflux esophagitis in humans was assessed in a cohort of non-human primates (NHP)...
  22. pmc The prevalence of colonic amyloidosis in baboons. A 22-year survey at a large primate facility
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    In Vivo 22:725-7. 2008
    ..The aim of the present work was to assess the prevalence of colonic amyloidosis at the Southwest National Primate Research Center since 1986...
  23. pmc The columnar-lined mucosa in the distal esophagus. A preliminary study in baboons
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    In Vivo 23:273-5. 2009
    ....
  24. ncbi Assessing the size of polyp phantoms in tandem colonoscopies
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Building P1 03 057, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    Anticancer Res 29:1539-45. 2009
    ..The size of colorectal neoplastic polyps is important for their clinical management...
  25. ncbi Arrest of cell proliferation in budding tumor cells ahead of the invading edge of colonic carcinomas. A preliminary report
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 28:2417-20. 2008
    ..Tumor budding is claimed to correlate with lymph node metastasis and local recurrence...
  26. ncbi The frequency of lymphocytic gastritis in baboons
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    In Vivo 22:101-4. 2008
    ..The disease, subsequently called lymphocytic gastritis (LG) is a rare form of gastritis (0.8%-1.6% of cases), with unclear pathogenesis. More recently, LG was recorded in pigs and in non-human primates...
  27. ncbi Serrated neoplasias and de novo carcinomas in ulcerative colitis: a histological study in colectomy specimens
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    J Gastroenterol Hepatol 22:1024-31. 2007
    ....
  28. ncbi Qualitative DNA differences between two structurally different lesions: high-grade dysplasia and carcinoma in situ in colorectal adenomas
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 27:2881-5. 2007
    ..Differences between CIS and HGD in colorectal adenomas are reported...
  29. ncbi Further studies on the arrest of cell proliferation in tumor cells at the invading front of colonic adenocarcinoma
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    J Gastroenterol Hepatol 22:1877-81. 2007
    ..The aim of this study was to audit cell proliferation and p53 mutation in flat tumor cells and in tumor cells at the tip of glandular pores at the leading invading front of colonic carcinomas...
  30. ncbi Luminal histological outline and colonic adenoma phenotypes
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 27:3555-9. 2007
    ..These two modalities were compared to the size, the histological phenotype and the degree of epithelial neoplasia...
  31. ncbi Difference in cell proliferation between two structurally different lesions in colorectal adenomas: high-grade dysplasia and carcinoma in situ
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 27:4321-4. 2007
    ..Despite the fact that most Western pathologists diagnose carcinoma in situ (CIS) in many organs the same pathologists generally diagnose similar histological aberrations in colorectal adenomas, as high-grade dysplasia (HGD)...
  32. ncbi Further studies on serrated neoplasias of the cardia: a review and case report
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Anticancer Res 27:4431-4. 2007
    ..Serrated adenomas of the cardia seem to have a particular proclivity to evolve into invasive carcinomas...
  33. ncbi Morphological events found at the invading edge of colorectal carcinomas in baboons
    Carlos A Rubio
    Department of Pathology, Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Anticancer Res 28:193-6. 2008
    ....
  34. ncbi The frequency of gastric pyloric cells with glassy cytoplasm in baboons. A comparison with human subjects
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    In Vivo 22:9-12. 2008
    ..These pyloric cells, called glassy cells (GCs) show a homogeneous, eosinophilic material that pushes the nucleous towards the free border of the cell...
  35. ncbi "Glassy" cells in Barrett's mucosa
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital 17176, Stockholm, Sweden
    Anticancer Res 29:4145-6. 2009
    ..In 1991 we detected glandular cells with "glassy" cytoplasm (GCs) in human gastric mucosa having intestinal metaplasia (IM). GCs were subsequently found in the gastric mucosa of baboons...
  36. ncbi Further studies on the frequency of colorectal cancer in Crohn's colitis: an 11-year survey in the Northwest Stockholm County
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 29:4291-5. 2009
    ..The frequency of colorectal carcinomas (CRC) evolving in patients with Crohn's colitis (CC) was assessed at the Danderyds University Hospital (DUH), one of two large hospitals in Northwest Stockholm County (NWSC)...
  37. ncbi Paneth cells and goblet cells express the neuroendocrine peptide synaptophysin. I. Normal duodenal mucosa
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    In Vivo 26:135-8. 2012
    ..The finding that synaptophysin is also produced by Paneth cells adds new information which might help to unravel the riddle of the ultimate biological significance of these puzzling cells...
  38. doi Lysozyme-rich mucus metaplasia in duodenal crypts supersedes Paneth cells in celiac disease
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Virchows Arch 459:339-46. 2011
    ..The molecular mechanism(s) behind the abrogation of Paneth cells in duodenal crypts and its substitution by LPMMC in celiac disease remains to be elucidated...
  39. ncbi Fundic gland polyps
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Anticancer Res 31:1789-93. 2011
    ..The aim was to assess the cellular components in sections stained with Giemsa or toluidine blue: two stains that easily differentiate parietal from chief cells...
  40. doi Qualitative and quantitative alterations in the parietal cell domain in chronic gastritis
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Building P1 03 057, Stockholm, Sweden
    Virchows Arch 458:733-9. 2011
    ..Future studies might elucidate whether qualitative and quantitative studies of toluidine blue-stained sections of the fundic mucosa are useful in monitoring the results of therapy in individual patients with chronic gastritis...
  41. doi Lysozyme expression in microscopic colitis
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    J Clin Pathol 64:510-5. 2011
    ..Results were compared with those recorded in patients with inflammatory bowel disease (IBD) of the colon (ulcerative colitis (UC) or Crohn's colitis)...
  42. ncbi An easy method to highlight chief cells in gastric biopsies
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    In Vivo 25:137-40. 2011
    ..Hematoxylin and eosin (H&E) is not an optimal stain to discriminate chief cells from parietal cells in gastric biopsies..
  43. pmc Further studies on Barretts mucosa in baboons: metaplastic glandular cells produce sialomucin
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, 78245 0549, USA
    Anticancer Res 30:4123-6. 2010
    ..Alcian blue stain (AB) is used to evidence sialomucin-producing goblet cells in human BM...
  44. pmc A simple method to record parietal cells in the fundic mucosa in baboons
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    In Vivo 24:705-7. 2010
    ..Gastric parietal cells in a baboon were recently found to be auto-fluorescent. Aim: To study gastric sections with a fluorescent microscope in a cohort of baboons...
  45. ncbi Protruding and non-protruding colon carcinomas originating in gut-associated lymphoid tissue
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 30:3019-22. 2010
    ..Histology demonstrated a protruding GALTC. The surgical specimen showed four additional carcinomas: 2 GALTC (non-protruding) and 2 carcinomas in lymphoid-free colonic mucosa (LFCMC)...
  46. ncbi An easy method to identify parietal cells in gastric biopsies
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    In Vivo 24:599-602. 2010
    ..Sections from gastric biopsies are usually stained with hematoxylin and eosin (H&E), a stain that is not optimal for the recognition of many parietal cells. This paper describes a more suitable routine stain to identify parietal cells...
  47. ncbi Lysozyme overexpression in fundic gland polyps
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 30:1021-4. 2010
    ..We recently found that FGPs express lysozyme, one of the natural defence substances against infection. We aimed to assess the degree of lysozyme expression in a cohort of consecutive FGPs...
  48. ncbi Massive fundic gland polyposis in a patient receiving protracted proton-pump inhibitor medication
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    Anticancer Res 30:261-3. 2010
    ..This case substantiates the notion that protracted PPI medication may encourage the development of MFGPsis in susceptible individuals...
  49. ncbi Fundic gland cysts in Atp4a-/- mice mimic fundic gland polyps in humans
    Carlos A Rubio
    Department of Environemnt, University of Cincinnati Medical Center, Cincinnati, OH, USA
    In Vivo 23:979-81. 2009
    ..Innumerable fundic gland cysts (FGCs) develop in mice lacking the gene Atp4a (Atp4a((-/-))), that encodes the enzyme ATPase. The aim was to monitor the evolution of FGCs in Atp4a((-/-)) mice...
  50. pmc The frequency of glassy cells in Barrett's mucosa: a study in Baboons
    Carlos A Rubio
    Southwest Foundation Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    In Vivo 23:925-7. 2009
    ..Similar GGCs were more recently detected in a baboon having glandulo-metaplastic esophageal mucosa (GMEM). The aim was to assess the frequency of baboons with GMEM having GGCs...
  51. pmc Plugs clog the glandular outlets in fundic gland polyps
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Int J Clin Exp Pathol 3:69-74. 2009
    ..Thus, the blocking of the glandular outflow by plugs of anucleated structures with eosinophilic granules is the most likely cause for the cystic accumulation of "normal" glandular secretions...
  52. ncbi The size of colon polyps revisited: intra- and inter-observer variations
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 30:2419-23. 2010
    ..In this work, the size of a large cohort of endoscopically-resected colon polyps was assessed with a novel method...
  53. pmc Frequency of epithelioid granulomas in colonoscopic biopsy specimens from paediatric and adult patients with Crohn's colitis
    C A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    J Clin Pathol 60:1268-72. 2007
    ..To test the assumption that epithelioid granulomas found in colonoscopic biopsy specimens in patients with Crohn's colitis are markers of a different clinical behaviour...
  54. pmc The frequency of gastric amyloidosis in baboons. A 22-year survey at a large primate facility
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    In Vivo 22:663-5. 2008
    ..Systemic amyloidosis, caused by abnormal tissue accretion of plasma proteins, affects several organs of the gastrointestinal (GI) tract. Gastric amyloidosis, rare in humans, has only been reported once in animals...
  55. ncbi Cell proliferation at the leading invasive front of colonic carcinomas. Preliminary observations
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Anticancer Res 26:2275-8. 2006
    ..It is not inconceivable that this unexpected paradoxical biological behaviour of flat tumour cells might be connected with the formation of glandular pores at the level of advancing invasion in colonic carcinomas...
  56. pmc Gastric duodenal metaplasia in duodenal adenomas
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology Karolinska Institute and University Hospital, Stockholm, Sweden
    J Clin Pathol 60:661-3. 2007
    ..In cases of known aetiology, gastric duodenal metaplasia (GMD) is a reversible lesion. In cases of unknown aetiology, the fate of GMD remains elusive. GMD was recently found in a duodenal adenoma...
  57. pmc My approach to reporting a gastric biopsy
    Carlos A Rubio
    Department of Pathology, Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute, Sweden
    J Clin Pathol 60:160-6. 2007
    ..This knowledge is crucial, considering that environmental diseases are theoretically preventable...
  58. ncbi Quantitative assessment of the subepithelial collagen band does not increase the accuracy of diagnosis of collagenous colitis
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Am J Clin Pathol 130:375-81. 2008
    ..In agreement with Lazenby's statement: "Focusing solely on the collagen band can result in both over- and underdiagnosis"..
  59. ncbi Further studies support the participation of stem cells in the cell turnover of duodenal adenomas
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    Anticancer Res 29:657-60. 2009
    ..The position of the Paneth cells within duodenal adenomas was investigated...
  60. doi Endogenous estrogen exposure in relation to distribution of histological type and estrogen receptors in gastric adenocarcinoma
    Evangelos Chandanos
    Unit of Esophageal and Gastric Research, Section of Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Gastric Cancer 11:168-74. 2008
    ..Estrogen might protect women against gastric adenocarcinoma of the intestinal histological type. We addressed this hypothesis and proposed that gastric estrogen receptors (ERs) are involved...
  61. ncbi Colorectal carcinoma in ulcerative colitis is decreasing in Scandinavian countries
    C A Rubio
    Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 21:2921-4. 2001
    ..A review of the present literature indicated that the ris for colorectal carcinoma in pancolitics is presently decreasing, not only in Sweden but also in other Scandinavian countries...
  62. ncbi Adenomas and carcinomas may be histologically detected in apparently normal colonic mucosa. A study of carcinogen-treated rats
    C A Rubio
    Departments of Pathology and Endoscopic Gastroenterology, Karolinska Institute and Hospital, Stockholm, Sweden
    In Vivo 15:299-301. 2001
    ..0% (n = 4) were invasive carcinomas. Experimentally-induced colonic neoplasias may be overlooked even after a careful scrutiny of the colonic mucosa using high-power optical devices...
  63. ncbi A method for the detection of eosinophilic granulocytes in colonoscopic biopsies from IBD patients
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Pathol Res Pract 199:145-50. 2003
    ..Focal eosinophilic mucosal infiltration in CD is more common than epithelioid cell granulomas, and emerges as an important parameter in the histologic differential diagnosis between colonic CD and UC...
  64. ncbi Do stem cells participate in cell turnover in duodenal adenomas? A preliminary study on Paneth cells
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 28:1571-3. 2008
    ..In the normal duodenum, Paneth cells migrate from the stem cells downwards, towards the bottom of the crypts of Lieberkuhn...
  65. pmc Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype
    Zhanquan Shi
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Int J Cancer 127:2334-50. 2010
    ..This oral BaP mouse paradigm represents an example of "gene-environment interactions" in which the same exposure of carcinogen results in altered target organ and tumor type, as a function of just 1 or 2 globally absent genes...
  66. ncbi Lymphocytic esophagitis: a histologic subset of chronic esophagitis
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital and Institute, Stockholm, Sweden
    Am J Clin Pathol 125:432-7. 2006
    ....
  67. doi Tamoxifen exposure in relation to gastric adenocarcinoma development
    Evangelos Chandanos
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Cancer 44:1007-14. 2008
    ....
  68. pmc Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden
    E Chandanos
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Br J Cancer 95:118-22. 2006
    ..We concluded that there might be a link between tamoxifen and risk of non-cardia gastric adenocarcinoma...
  69. ncbi Neoplasias of the colorectal crypts
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 25:4551-8. 2005
    ..The awareness that colorectal neoplasias may evolve from that particular cellular domain may cast more light on the understanding of the complex mechanisms of colorectal carcinogenesis...
  70. pmc Gastric ciliated metaplasia. A study of 3406 gastrectomy specimens from dwellers of the Atlantic and the Pacific basins
    C A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
    J Clin Pathol 58:605-10. 2005
    ..Ciliated cells in gastrectomies from patients dwelling in the Pacific and Atlantic basins have been reported previously...
  71. pmc The frequency of lymphocytic and reflux esophagitis in non-human primates
    Carlos A Rubio
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research San Antonio, TX 78245 0549, USA
    Int J Clin Exp Pathol 1:531-5. 2008
    ..The antigenic agent(s) responsible for the marked immunological reaction in lymphocytic esophagitis in non-human primates (and in humans) remains unknown...
  72. ncbi Different biological materials are found in neoplastic glands with pores at the invading edge of sporadic colonic carcinomas
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    Anticancer Res 29:1745-8. 2009
    ..Studying the invading edge of colorectal carcinomas it was previously noticed that the neoplastic glands with pores could contain mucin, inflammatory cells and/or necrotic material...
  73. ncbi A single method to document the size of endoscopically-excised colorectal polyps
    Carlos A Rubio
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    In Vivo 21:1103-6. 2007
    ..Using polyp-phantoms we previously found a wide inter- and intra-observer variation in size assessment...
  74. ncbi Colorectal adenomas: time for reappraisal
    Carlos A Rubio
    Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Pathol Res Pract 198:615-20. 2002
    ..To compare the frequency of these adenoma phenotypes, we suggest that serrated and microtubular adenomas be included in future reports on the histologic characteristics of colorectal polyps...
  75. ncbi Colorectal adenomas produce lysozyme
    C A Rubio
    Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 23:5165-71. 2003
    ..Lysozyme overexpression (+++) also occurred in 2 of the 21 hyperplastic polyps, suggesting that intense lysozyme production might herald a possible dysplastic evolution in some hyperplastic polyps...
  76. ncbi Possible mechanism pertinent to mucosal invasion in sporadic colonic adenomas
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 24:2033-6. 2004
    ..The release of proteolytic secretions through glandular pores in some colonic adenomas disrupt the surrounding matrix, a mechanism that would facilitate neoplastic cell penetration into the lamina propria...
  77. pmc A simple method to demonstrate duodenal gastric metaplasia
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    J Clin Pathol 55:520-3. 2002
    ..Recently, groups of duodenal columnar cells were seen to be autofluorescent in haematoxylin and eosin (H&E) stained sections from a patient with DGM...
  78. ncbi Nonprotruding colorectal neoplasms: epidemiologic viewpoint
    C A Rubio
    Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    World J Surg 24:1098-103. 2000
    ....
  79. pmc Serrated adenoma of the duodenum
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    J Clin Pathol 57:1219-21. 2004
    ..Increased awareness of the existence of serrated neoplasms in the duodenum may result in similar cases being reported in the future...
  80. ncbi Serrated and microtubular adenomas of the colon and rectum. An 8-year histological survey
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 23:1693-6. 2003
    ....
  81. ncbi Gastric carcinomas of intestinal type concur with distant changes in the gastric mucosa. A multicenter study in the Atlantic basin
    C A Rubio
    Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute, 17176 Stockholm, Sweden
    Anticancer Res 21:813-8. 2001
    ..Thus, DMCs seem to provide the adequate "soil" for the development of gastric carcinomas of intestinal type, independently of the future localization of that tumor in the stomach...
  82. ncbi The chronological appearance of flat colonic neoplasias in rats
    J Shetye
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    In Vivo 18:197-202. 2004
    ..These experimental results seem to substantiate previous observations in humans suggesting that, in the colonic mucosa, flat and protruding adenomas follow different pathways of neoplastic transformation...
  83. pmc Extensive intestinal metaplasia in gastric carcinoma and in other lesions requiring surgery: a study of 3,421 gastrectomy specimens from dwellers of the Atlantic and Pacific basins
    C A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    J Clin Pathol 58:1271-7. 2005
    ..Extensive intestinal metaplasia (EIM) has been reported in gastrectomies from patients dwelling in the Pacific and Atlantic basins...
  84. ncbi Macrophage-associated chronic diarrhea of unknown origin. Preliminary observations
    C A Rubio
    Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    In Vivo 19:927-9. 2005
    ....
  85. ncbi Possible mechanism connected with the progression of submucosal invasion in colorectal neoplasias
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 25:2503-7. 2005
    ....
  86. pmc Prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma in relation to anatomical site of the tumour
    Hedvig E Löfdahl
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e46538. 2012
    ....
  87. ncbi Reliability of the reported size of removed colorectal polyps
    Carlos A Rubio
    Department of Pathology Karolinska University Hospital, Stockholm, Solna, Sweden
    Anticancer Res 26:4895-9. 2006
    ..The size of colorectal polyps is important in the clinical management of these lesions...
  88. ncbi Assessing polyp size by improved digitalized computed tomography (CT)
    Chikako Suzuki
    Department of Diagnostic Radiology, Institution for Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    Anticancer Res 28:1911-5. 2008
    ..The aim of this study was to assess the size of 12 phantom polyps by computed tomography (CT)...
  89. ncbi Colorectal carcinomas. Possible mechanisms of local tumor progression
    C A Rubio
    Gastointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 23:347-50. 2003
    ..The malignant cells surrounding those glandular "pores" would eventually grow around the secreted products, thus guaranteeing a stepwise but everlasting tumor progression in untreated cases...
  90. ncbi Classification of colorectal polyps: guidelines for the endoscopist
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Endoscopy 34:226-36. 2002
  91. ncbi Possible mechanism of local tumor progression in experimentally-induced colorectal carcinomas in rats
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    In Vivo 17:97-100. 2003
    ..The remodelling of the glands will guarantee a stepwise but everlasting tumor progression deeper into the host...
  92. ncbi Adenocarcinoma in inflammatory colorectal disease. Histological features pertinent to local tumour progression
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 23:4313-8. 2003
    ..To restore the continuity of those incomplete glands, new cancer cells would grow around mucin "lakes" or inflammatory-necrotic aggregates in the stroma. This mechanism will guarantee a life-long tumour progression in untreated patients...
  93. pmc Serrated neoplasia of the stomach: a new entity
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    J Clin Pathol 54:849-53. 2001
    ..The aim of this paper is to report a novel histological phenotype of gastric adenoma with early invasive growth...
  94. ncbi Further studies on the histological characteristics linked to local tumour invasion in colorectal carcinomas
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    Anticancer Res 23:3555-60. 2003
    ..Since preoperative irradiation was administered only to patients carrying rectal tumours, it is apparent that the histological features here described are neither evoked nor abrogated by irradiation...
  95. ncbi Villous and serrated adenomatous growth bordering carcinomas in inflammatory bowel disease
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute, 171 76 Stockholm, Sweden
    Anticancer Res 20:4761-4. 2000
    ..It would appear that villous and serrated AGs are the most common non-invasive neoplastic lesions from which IBD carcinomas originate...
  96. ncbi Extended intestinal metaplasia. A survey of 1392 gastrectomies from dwellers of the Pacific basin
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    Anticancer Res 24:3185-92. 2004
    ..To assess the extent of gastric intestinal metaplasia (IM) in gastrectomy specimens in populations of the Pacific basin having different incidence of gastric carcinoma...
  97. ncbi Histologic phenotypes of colonic carcinoma in Sweden and in Japan
    C A Rubio
    Department of Pathology, Karolinska Institute, Stockholm, Sweden
    Anticancer Res 18:2649-55. 1998
    ....
  98. ncbi Hyperplastic polyposis coli syndrome and colorectal carcinoma
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    Endoscopy 38:266-70. 2006
    ..Patients with hyperplastic polyposis coli syndrome (HPCS) have a propensity to develop colorectal carcinoma (CRC)...
  99. pmc Increased lysozyme expression in gastric biopsies with intestinal metaplasia and pseudopyloric metaplasia
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology and Department of Gastroenterology, Karolinska Institute and University Hospital 17176 Stockholm, Sweden
    Int J Clin Exp Med 2:248-53. 2009
    ..The Helicobacter pylori did not proliferate in areas with IM or with PpM. The lysozyme production in IM and in PpM might be upregulated to eradicate ingested, proliferating bacteria in acid-deficient stomachs...
  100. ncbi A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden
    In Vivo 17:67-71. 2003
    ..The present method will improve the enumeration of the actual number of normal and metaplastic Paneth cells both in experimental research and in clinical trials...
  101. ncbi The detection of bile ducts in liver biopsies by cytokeratin 7
    C A Rubio
    Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    In Vivo 12:183-6. 1998
    ....