Ute Romling

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Cyclic di-GMP: the first 25 years of a universal bacterial second messenger
    Ute Romling
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Microbiol Mol Biol Rev 77:1-52. 2013
  2. ncbi Biofilm infections, their resilience to therapy and innovative treatment strategies
    U Romling
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 272:541-61. 2012
  3. ncbi Cyclic di-GMP, an established secondary messenger still speeding up
    Ute Romling
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Environ Microbiol 14:1817-29. 2012
  4. ncbi Roles of curli, cellulose and BapA in Salmonella biofilm morphology studied by atomic force microscopy
    Kristina Jonas
    Swedish Institute for Infectious Disease Control, Solna, Sweden
    BMC Microbiol 7:70. 2007
  5. ncbi Prevailing concepts of c-di-GMP signaling
    Ute Romling
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Contrib Microbiol 16:161-81. 2009
  6. ncbi Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea
    Ute Romling
    Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology, FE280, SE 171 77 Stockholm, Sweden
    Sci Signal 1:pe39. 2008
  7. ncbi Cyclic di-GMP as a second messenger
    Ute Romling
    Karolinska Institutet, Microbiology and Tumor Biology Center MTC, Box 280, SE 171 77 Stockholm, Sweden
    Curr Opin Microbiol 9:218-28. 2006
  8. ncbi Complex regulatory network encompassing the Csr, c-di-GMP and motility systems of Salmonella Typhimurium
    Kristina Jonas
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Environ Microbiol 12:524-40. 2010
  9. ncbi Unphosphorylated CsgD controls biofilm formation in Salmonella enterica serovar Typhimurium
    Katherina Zakikhany
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, FE 280, 17177 Stockholm, Sweden
    Mol Microbiol 77:771-86. 2010
  10. ncbi GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility
    Roger Simm
    Microbiology and Tumorbiology Center MTC, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    Mol Microbiol 53:1123-34. 2004

Collaborators

Detail Information

Publications31

  1. ncbi Cyclic di-GMP: the first 25 years of a universal bacterial second messenger
    Ute Romling
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Microbiol Mol Biol Rev 77:1-52. 2013
    ..We also identify unresolved questions and highlight new directions in c-di-GMP research that will give us a deeper understanding of this truly universal bacterial second messenger...
  2. ncbi Biofilm infections, their resilience to therapy and innovative treatment strategies
    U Romling
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 272:541-61. 2012
    ..Their conserved structures sensed by the eukaryotic host have a widespread effect on the immune system. Thus, cyclic di-nucleotides are also potential immunotherapeutic agents to treat antibiotic-resistant bacterial infections...
  3. ncbi Cyclic di-GMP, an established secondary messenger still speeding up
    Ute Romling
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Environ Microbiol 14:1817-29. 2012
    ....
  4. ncbi Roles of curli, cellulose and BapA in Salmonella biofilm morphology studied by atomic force microscopy
    Kristina Jonas
    Swedish Institute for Infectious Disease Control, Solna, Sweden
    BMC Microbiol 7:70. 2007
    ....
  5. ncbi Prevailing concepts of c-di-GMP signaling
    Ute Romling
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Contrib Microbiol 16:161-81. 2009
    ..However, the exact molecular mechanisms of c-di-GMP action remain to be discovered...
  6. ncbi Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea
    Ute Romling
    Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology, FE280, SE 171 77 Stockholm, Sweden
    Sci Signal 1:pe39. 2008
    ..To elucidate the biological importance and molecular mechanisms of action for c-di-AMP and the recently recognized second messenger c-di-GMP will require a multidisciplinary approach...
  7. ncbi Cyclic di-GMP as a second messenger
    Ute Romling
    Karolinska Institutet, Microbiology and Tumor Biology Center MTC, Box 280, SE 171 77 Stockholm, Sweden
    Curr Opin Microbiol 9:218-28. 2006
    ..Besides its role as an intracellular signaling molecule in bacteria, c-di-GMP also acts as an intercellular signaling molecule between prokaryotes and also has effects in eukaryotes that could provide a perspective in cancer treatment...
  8. ncbi Complex regulatory network encompassing the Csr, c-di-GMP and motility systems of Salmonella Typhimurium
    Kristina Jonas
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Environ Microbiol 12:524-40. 2010
    ..Altogether, our data reveal that the concerted and complex regulation of several genes encoding GGDEF/EAL domain proteins allows CsrA to control the motility-sessility switch in S. Typhimurium at multiple levels...
  9. ncbi Unphosphorylated CsgD controls biofilm formation in Salmonella enterica serovar Typhimurium
    Katherina Zakikhany
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, FE 280, 17177 Stockholm, Sweden
    Mol Microbiol 77:771-86. 2010
    ..In summary, our findings suggest that the response regulator CsgD functions in its unphosphorylated form under the conditions of biofilm formation investigated in this study...
  10. ncbi GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility
    Roger Simm
    Microbiology and Tumorbiology Center MTC, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    Mol Microbiol 53:1123-34. 2004
    ..Thus, the data suggest that c-di-GMP is a novel global second messenger in bacteria the metabolism of which is controlled by GGDEF and EAL domain proteins...
  11. ncbi Characterization of cellulose production in Escherichia coli Nissle 1917 and its biological consequences
    Claudia Monteiro
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    Environ Microbiol 11:1105-16. 2009
    ..The role of cellulose in this strain is in contrast to the role of cellulose in the commensal strain E. coli TOB1. Consequently, the role of cellulose in bacterial-host interaction is dependent on the E. coli strain background...
  12. ncbi Cyclic di-GMP signalling controls virulence properties of Salmonella enterica serovar Typhimurium at the mucosal lining
    Agaristi Lamprokostopoulou
    Department of Microbiology, Tumor and Cell Biology, FE number 280, Karolinska Institutet, 17177 Stockholm, Sweden
    Environ Microbiol 12:40-53. 2010
    ..Our results suggest that transition between biofilm formation and virulence in S. typhimurium at the epithelial cell lining is mediated by c-di-GMP signalling through CsgD and cellulose expression...
  13. ncbi The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins
    Kristina Jonas
    Swedish Institute for Infectious Disease Control, SE 17182, Solna and Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE 17177 Stockholm, Sweden
    Mol Microbiol 70:236-57. 2008
    ..All together, these data demonstrate a global role for CsrA in the regulation of c-di-GMP metabolism by regulating the expression of GGDEF proteins at the post-transcriptional level...
  14. ncbi Complex c-di-GMP signaling networks mediate transition between virulence properties and biofilm formation in Salmonella enterica serovar Typhimurium
    Irfan Ahmad
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e28351. 2011
    ..Our findings show that c-di-GMP signaling is at least equally important in the regulation of Salmonella-host interaction as in the regulation of biofilm formation at ambient temperature...
  15. ncbi Characteristics of biofilms from urinary tract catheters and presence of biofilm-related components in Escherichia coli
    Xiaoda Wang
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, FE 280, SE 171 77, Stockholm, Sweden
    Curr Microbiol 60:446-53. 2010
    ....
  16. ncbi Hfq and Hfq-dependent small RNAs are major contributors to multicellular development in Salmonella enterica serovar Typhimurium
    Claudia Monteiro
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    RNA Biol 9:489-502. 2012
    ..curli fimbriae surface-attachment at ambient temperature. Consequently, ArcZ is a major regulator of rdar biofilm development...
  17. ncbi A role for the EAL-like protein STM1344 in regulation of CsgD expression and motility in Salmonella enterica serovar Typhimurium
    Roger Simm
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    J Bacteriol 191:3928-37. 2009
    ..Consequently, although STM1344 has not retained a direct role in c-di-GMP metabolism, it still participates in the regulation of c-di-GMP turnover and has a role in the transition between sessility and motility...
  18. ncbi Bistable expression of CsgD in biofilm development of Salmonella enterica serovar typhimurium
    Nina Grantcharova
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, Stockholm, Sweden
    J Bacteriol 192:456-66. 2010
    ..Consequently, bistability at the level of CsgD expression leads to a corresponding pattern of task distribution in S. Typhimurium biofilms...
  19. ncbi Regulatory components at the csgD promoter--additional roles for OmpR and integration host factor and role of the 5' untranslated region
    Ulrich Gerstel
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    FEMS Microbiol Lett 261:109-17. 2006
    ..Furthermore, the role of the 174 bp long 5'-untranslated region on transcriptional activity was defined...
  20. ncbi Quantitative determination of cyclic diguanosine monophosphate concentrations in nucleotide extracts of bacteria by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry
    Roger Simm
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Anal Biochem 386:53-8. 2009
    ..We describe the use of the methodology to assess the change in c-di-GMP concentration during the growth phase and the contribution of a point mutation in S. typhimurium to the overall cellular c-di-GMP concentration...
  21. ncbi The role of c-di-GMP signaling in an Aeromonas veronii biovar sobria strain
    Mokhlasur Rahman
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    FEMS Microbiol Lett 273:172-9. 2007
    ..On the other hand, overexpression of the EAL domain protein YhjH decreased biofilm formation and increased motility...
  22. ncbi Role of EAL-containing proteins in multicellular behavior of Salmonella enterica serovar Typhimurium
    Roger Simm
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    J Bacteriol 189:3613-23. 2007
    ..Consequently, this work has shown that several EAL and GGDEF-EAL domain proteins, which act as phosphodiesterases, play a determinative role in the expression level of multicellular behavior of Salmonella enterica serovar Typhimurium...
  23. ncbi Uropathogenic Escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide LL-37
    Ylva Kai-Larsen
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    PLoS Pathog 6:e1001010. 2010
    ..Taken together, our data demonstrate that biofilm components are involved in the pathogenesis of urinary tract infections by E. coli and can be a target of local immune defense mechanisms...
  24. ncbi C-di-GMP: the dawning of a novel bacterial signalling system
    Ute Romling
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, SE 17177 Stockholm, Sweden
    Mol Microbiol 57:629-39. 2005
    ..The accumulated data clearly indicate that a novel ubiquitous signalling system in bacteria has been discovered...
  25. ncbi Regulation of c-di-GMP metabolism in biofilms
    Kristina Jonas
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Future Microbiol 4:341-58. 2009
    ....
  26. ncbi Regulation of biofilm components in Salmonella enterica serovar Typhimurium by lytic transglycosylases involved in cell wall turnover
    Claudia Monteiro
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, FE28017177, Stockholm, Sweden
    J Bacteriol 193:6443-51. 2011
    ..These findings reveal, for the first time, a specific function of lytic transglycosylases in S. Typhimurium and suggest the existence of a new signaling pathway that links cell wall turnover to biofilm formation...
  27. ncbi Opposing contributions of polynucleotide phosphorylase and the membrane protein NlpI to biofilm formation by Salmonella enterica serovar Typhimurium
    Syed Fazle Rouf
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    J Bacteriol 193:580-2. 2011
    ..Polynucleotide phosphorylase and NlpI also had opposite effects on the expression of yjcC, which codes for a cyclic-3',5'-di-guanylate phosphodiesterase affecting CsgD expression...
  28. ncbi Proteome analysis reveals adaptation of Pseudomonas aeruginosa to the cystic fibrosis lung environment
    Dinesh Diraviam Sriramulu
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Proteomics 5:3712-21. 2005
    ..Altogether, our results elucidate adaptive strategies of P. aeruginosa towards the nutrient-rich CF lung habitat during the course of chronic colonization...
  29. ncbi Worldwide distribution of Pseudomonas aeruginosa clone C strains in the aquatic environment and cystic fibrosis patients
    Ute Romling
    Microbiology and Tumorbiology Center MTC, Karolinska Institutet, Stockholm, Sweden
    Environ Microbiol 7:1029-38. 2005
    ..Elucidation of the mechanisms which lead to the prevalence of clone C strain in patients and the environment requires the investigation of additional phenotypes...
  30. ncbi Occurrence and regulation of the multicellular morphotype in Salmonella serovars important in human disease
    Ute Romling
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    Int J Med Microbiol 293:273-85. 2003
    ..Therefore, the expression pattern of the rdar morphotype is serovar specific and correlates with a disease phenotype breaching the intestinal epithelial cell lining...
  31. ncbi Complex regulation of csgD promoter activity by global regulatory proteins
    Ulrich Gerstel
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden
    Mol Microbiol 49:639-54. 2003
    ..A complex regulatory network involving IHF, H-NS and OmpR is proposed whereby the nucleo-complex composition in the csgD-csgBA intergenic region is altered in response to oxygen tension...