M Remberger

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint A high antithymocyte globulin dose increases the risk of relapse after reduced intensity conditioning HSCT with unrelated donors
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden
    Clin Transplant 27:E368-74. 2013
  2. doi request reprint Effects of different serum-levels of ATG after unrelated donor umbilical cord blood transplantation
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    Transpl Immunol 27:59-62. 2012
  3. doi request reprint Low serum levels of total rabbit-IgG is associated with acute graft-versus-host disease after unrelated donor hematopoietic stem cell transplantation: results from a prospective study
    Mats Remberger
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    Biol Blood Marrow Transplant 15:996-9. 2009
  4. doi request reprint Improved survival after allogeneic hematopoietic stem cell transplantation in recent years. A single-center study
    Mats Remberger
    Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Biol Blood Marrow Transplant 17:1688-97. 2011
  5. pmc Anti-HLA antibodies in double umbilical cord blood transplantation
    Claudio G Brunstein
    Blood and Marrow Transplantation Program, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 17:1704-8. 2011
  6. doi request reprint Second allogeneic hematopoietic stem cell transplantation: a treatment for graft failure
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Clin Transplant 25:E68-76. 2011
  7. ncbi request reprint Risk factors for acute graft-versus-host disease grades II-IV after reduced intensity conditioning allogeneic stem cell transplantation with unrelated donors: a single centre study
    M Remberger
    Department of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 41:399-405. 2008
  8. ncbi request reprint Genomic tissue typing and optimal antithymocyte globuline dose using unrelated donors results in similar survival and relapse as HLA-identical siblings in haematopoietic stem-cell transplantation for leukaemia
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation and Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Eur J Haematol 80:419-28. 2008
  9. ncbi request reprint Major ABO blood group mismatch increases the risk for graft failure after unrelated donor hematopoietic stem cell transplantation
    Mats Remberger
    Department of Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Biol Blood Marrow Transplant 13:675-82. 2007
  10. ncbi request reprint C-reactive protein levels before reduced-intensity conditioning predict outcome after allogeneic stem cell transplantation
    Mats Remberger
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Int J Hematol 92:161-7. 2010

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. doi request reprint A high antithymocyte globulin dose increases the risk of relapse after reduced intensity conditioning HSCT with unrelated donors
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden
    Clin Transplant 27:E368-74. 2013
    ..001) were correlated to relapse, and low-dose ATG was associated with improved RFS (p < 0.05). A high dose (8 mg/kg) of ATG in RIC HSCT with unrelated donors increased the risk for relapse and reduced the RFS...
  2. doi request reprint Effects of different serum-levels of ATG after unrelated donor umbilical cord blood transplantation
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    Transpl Immunol 27:59-62. 2012
    ..Low serum-levels of r-ATG early after transplantation seem to be a strong predictor for acute GVHD grades III-IV, TRM and a low incidence of relapse in patients treated with thymoglobulin before unrelated donor UCBT...
  3. doi request reprint Low serum levels of total rabbit-IgG is associated with acute graft-versus-host disease after unrelated donor hematopoietic stem cell transplantation: results from a prospective study
    Mats Remberger
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    Biol Blood Marrow Transplant 15:996-9. 2009
    ..023. Low serum levels of r-IgG seem to be a strong predictor for aGVHD grades II-IV in patients treated with Thymoglobulin before unrelated donor HSCT...
  4. doi request reprint Improved survival after allogeneic hematopoietic stem cell transplantation in recent years. A single-center study
    Mats Remberger
    Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Biol Blood Marrow Transplant 17:1688-97. 2011
    ..The problem of relapse still has to be remedied. Thus, several different developments together have resulted in significantly lower TRM and improved survival after HSCT over the last few years...
  5. pmc Anti-HLA antibodies in double umbilical cord blood transplantation
    Claudio G Brunstein
    Blood and Marrow Transplantation Program, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 17:1704-8. 2011
    ..Further studies are needed to fully understand the value of anti-HLA antibody testing in dUCB graft selection and its impact on transplantation outcomes...
  6. doi request reprint Second allogeneic hematopoietic stem cell transplantation: a treatment for graft failure
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Clin Transplant 25:E68-76. 2011
    ..005). We concluded that re-transplantation using RIC is a valid option for GF, especially in patients with non-malignant disorders...
  7. ncbi request reprint Risk factors for acute graft-versus-host disease grades II-IV after reduced intensity conditioning allogeneic stem cell transplantation with unrelated donors: a single centre study
    M Remberger
    Department of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 41:399-405. 2008
    ..1%, while it was 38.0 and 85.0% in patients with one (n=29) or two (n=10) risk factors (P<0.001). We concluded that risk factors for acute GVHD using RIC are similar as using myeloablative conditioning...
  8. ncbi request reprint Genomic tissue typing and optimal antithymocyte globuline dose using unrelated donors results in similar survival and relapse as HLA-identical siblings in haematopoietic stem-cell transplantation for leukaemia
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation and Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Eur J Haematol 80:419-28. 2008
    ..8% vs. 25.8%). There was no difference in overall survival (60% vs. 60%), transplant-related mortality (18.6% vs. 16.6%) and relapse (23% vs. 26.4%) between the two groups...
  9. ncbi request reprint Major ABO blood group mismatch increases the risk for graft failure after unrelated donor hematopoietic stem cell transplantation
    Mats Remberger
    Department of Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Biol Blood Marrow Transplant 13:675-82. 2007
    ..In patients with and without major ABO mismatch the incidence of GF was 7.5% and 0.6% (P = .02), respectively. Using an ABO major mismatched graft increases the risk for GF after unrelated donor hematopoietic stem cell transplantation...
  10. ncbi request reprint C-reactive protein levels before reduced-intensity conditioning predict outcome after allogeneic stem cell transplantation
    Mats Remberger
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Int J Hematol 92:161-7. 2010
    ..It should be analyzed before conditioning, especially in patients with coexisting infection since patients with increased CRP and infection seem to have a very poor outcome after ASCT...
  11. ncbi request reprint Similar outcome after unrelated allogeneic peripheral blood stem cell transplantation compared with bone marrow in children and adolescents
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, SE 141 86 Stockholm, Sweden
    Transplantation 84:551-4. 2007
    ..1). We found no differences in transplant-related mortality and survival in children and adolescents receiving BM or PBSC from unrelated donors. More rapid engraftment and a trend for less relapses in patients given PBSC grafts was noted...
  12. ncbi request reprint An ethnic role for chronic, but not acute, graft-versus-host disease after HLA-identical sibling stem cell transplantation
    M Remberger
    Centre for Allogeneic Stem Cell Transplantation, and Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Sweden
    Eur J Haematol 66:50-6. 2001
    ..The cumulative probabilities of relapse were 37% in the both groups. This suggests that the Scandinavian population is more homogeneous with regard to minor histocompatibility antigens important for chronic, but not acute GVHD...
  13. ncbi request reprint Peripheral blood stem cell transplantation from unrelated donors: a comparison with marrow transplantation
    O Ringden
    Center for Allogeneic Stem Cell Transplantation, Department of Clinical Immunology, Huddinge Hospital, Huddinge, Sweden
    Blood 94:455-64. 1999
    ..01). One-year transplant-related mortality was 21% and 27% and survival was 53% and 54% in the BM and PBSC groups, respectively (NS). The 2-year relapse-free survival was 41% and 46% in the two groups, respectively...
  14. ncbi request reprint Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplanta
    O Ringden
    Centre for Allogeneic Stem Cell Transplantation, and the Department of Hematology, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden
    Blood 93:2196-201. 1999
    ..01). In patients with chronic myeloid leukemia (CML) in first chronic phase, 7-year LFS was 72% and 83% in the two groups, respectively...
  15. ncbi request reprint A prospective randomized toxicity study to compare reduced-intensity and myeloablative conditioning in patients with myeloid leukaemia undergoing allogeneic haematopoietic stem cell transplantation
    O Ringden
    Division of Therapeutic Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 274:153-62. 2013
    ..To our knowledge, no randomized toxicity studies have been conducted to compare myeloablative conditioning (MAC) and reduced-intensity conditioning (RIC) in allogeneic haematopoietic stem cell transplantation (HSCT)...
  16. ncbi request reprint Outcome of haematopoietic stem cell transplantation in patients transplanted with matched unrelated donors vs allele-mismatched donors: a single centre study
    D Hauzenberger
    Department of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Tissue Antigens 72:549-58. 2008
    ..An HLA-C or -DQ mismatch had no significant impact on survival, TRM and relapse. In conclusion, compared with MUD, HLA class I allele mmUD had an increased risk of acute GVHD and TRM...
  17. ncbi request reprint BK-viruria and haemorrhagic cystitis are more frequent in allogeneic haematopoietic stem cell transplant patients receiving full conditioning and unrelated-HLA-mismatched grafts
    G Giraud
    Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    Bone Marrow Transplant 41:737-42. 2008
    ..6; P=0.03). However, when analysing HSCT performed with URD or RD grafts separately, BKV (OR 8.5; 95% CI 1.8-19.3; P=0.004) and MC (OR 5.9; 95% CI 1.3-11.3; P=0.009) increased the risk for HC only with a URD, but not with an RD graft...
  18. ncbi request reprint Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells
    K Le Blanc
    Hematology Center, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Leukemia 21:1733-8. 2007
    ..Thus, co-transplantation of MSC resulted in fast engraftment of absolute neutrophil count (ANC) and platelets and 100% donor chimerism, even in three patients regrafted for graft failure/rejection...
  19. ncbi request reprint Improved survival after bone marrow transplantation for early leukemia using busulfan-cyclophosphamide and individualized prophylaxis against graft-versus-host disease: a long-term follow-up
    J Aschan
    Centre for Allogeneic Stem Cell Transplantation, Department of Hematology, Huddinge Hospital, Stockholm, Sweden
    Clin Transplant 13:512-9. 1999
    ..However, in patients with early leukemia conditioning with BU + CY, our method of individualizing the GVHD prophylaxis might be of value, since this group had the best RFS in this study...
  20. ncbi request reprint G-CSF given after haematopoietic stem cell transplantation using HLA-identical sibling donors is associated to a higher incidence of acute GVHD II-IV
    M Remberger
    Centre for Allogeneic Stem Cell Transplantation, F79 Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    Bone Marrow Transplant 32:217-23. 2003
    ..In conclusion, G-CSF given after HLA-identical sibling HSCT was associated with a higher risk of grades II-IV acute GVHD, but not transplant-related mortality...
  21. doi request reprint Long-term salivary function after conditioning with busulfan, fractionated or single-dose TBI
    K Garming-Legert
    Division of Oral and Maxillofacial Surgery, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
    Oral Dis 17:670-6. 2011
    ..Does conditioning with fractionated total body irradiation (fTBI) or busulfan (Bu) causes less salivary dysfunction compared with single dose (sTBI) after hematopoietic stem cell transplantation (HSCT)...
  22. ncbi request reprint Norethisterone treatment, a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation
    H Hagglund
    Departments of Transplantation Surgery, Clinical Immunology, Paediatrics, and Medicine, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden
    Blood 92:4568-72. 1998
    ..02), and conditioning with busulphan (P =.02). Our conclusion is that norethisterone treatment should not be used in patients undergoing BMT and heparin prophylaxis did not affect the incidence or mortality of VOD...
  23. ncbi request reprint Transplantation of autologous and allogeneic bone marrow with liver from a cadaveric donor for primary liver cancer
    O Ringden
    Department of Clinical Immunology, Karolinska Institutet, Huddinge Hospital, Sweden
    Transplantation 69:2043-8. 2000
    ..We investigated whether it were possible to induce mixed chimerism and obtain an antitumor effect in a patient with a large primary liver cancer after combined liver and bone marrow transplantation (BMT)...
  24. ncbi request reprint Polyclonal anti-T-cell globulin as part of the preparative regimen for pediatric allogeneic stem-cell transplantation
    M Remberger
    Center for Allogeneic Stem Cell Transplantation, Department of Clinical Immunology, F79 Karolinska Institutet, Huddinge University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Pediatr Transplant 5:285-92. 2001
    ..01). Hence, the use of polyclonal ATG as part of conditioning prior to ASCT in children is safe and the survival rate encouraging...
  25. doi request reprint Increased risk of gastrointestinal acute GVHD following the addition of melphalan to busulfan/cyclophosphamide conditioning
    T Mårtensson
    Astrid Lindgren Children s Hospital and Karolinska University Hospital Huddinge, Stockholm, Sweden
    Pediatr Transplant 17:285-93. 2013
    ..5% (five of eight) in the BuCy group. In conclusion, the addition of melphalan to the BuCy conditioning regimen resulted in severe gastrointestinal complications and did not improve overall survival...
  26. doi request reprint Unrelated cord blood and mismatched unrelated volunteer donor transplants, two alternatives in patients who lack an HLA-identical donor
    O Ringden
    Centre for Allogeneic Stem Cell Transplantation and Division of Clinical Immunology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Bone Marrow Transplant 42:643-8. 2008
    ..006). Although the material is small and heterogeneous, engraftment was delayed, leukocyte chimerism was not significantly different and survival was superior using UCB rather than MM URD transplants...
  27. doi request reprint Targeted monitoring of patients at high risk of post-transplant lymphoproliferative disease by quantitative Epstein-Barr virus polymerase chain reaction
    H Omar
    Department of Medicine, Huddinge, Division of Haematology, Karolinska Institutet, Stockholm, Sweden
    Transpl Infect Dis 11:393-9. 2009
    ..The likelihood of PTLD is increased in the presence of specific risk factors. Monitoring of EBV DNA load and early administration of rituximab in patients with high EBV loads is recommended for high-risk patients...
  28. doi request reprint Cytotoxic crossmatch analysis before allo-SCT is a poor diagnostic tool for prediction of rejection
    J Mattsson
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Bone Marrow Transplant 45:235-8. 2010
    ..In conclusion, the pretransplant cytotoxic T- and/or B-crossmatch is a poor predictor of rejection after allo-SCT...
  29. ncbi request reprint Allogeneic stem cell transplantation: low immunoglobulin levels associated with decreased survival
    A C Norlin
    Department of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 41:267-73. 2008
    ..04) and an increased incidence of transplant-related mortality (27 vs 9%, P<0.01). IgG levels generally increase after SCT. Persistent low levels of IgG are a risk factor for death after SCT...
  30. ncbi request reprint Fludarabine-based disease-specific conditioning or conventional myeloablative conditioning in hematopoietic stem cell transplantation for treatment of non-malignant diseases
    O Ringden
    Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Bone Marrow Transplant 39:383-8. 2007
    ..03). Treatment-related mortality was 4 and 15%, and 5-year survival was 89 and 85% in the FBC and MC groups. Although survival was similar, FBC is a promising alternative to MC in non-malignant disorders...
  31. doi request reprint Increased costs after allogeneic haematopoietic SCT are associated with major complications and re-transplantation
    B M Svahn
    Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
    Bone Marrow Transplant 47:706-15. 2012
    ..To conclude, major complications increased the costs of HSCT. Unrelated donor transplants were more expensive than HLA-identical sibling transplants. Costs were reduced in patients treated with NMC...
  32. ncbi request reprint Fractionated TBI correlates with less T cell mixed chimerism but increased risk of relapse compared to busulphan in patients with haematological malignancies after allogeneic stem cell transplantation
    J Mattsson
    Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 32:477-83. 2003
    ..01). In multivariate analysis adjusted for diagnosis, busulphan-treated patients showed both a better survival (P=0.04) and less probability of relapse (0.03) compared to TBI-treated patients...
  33. ncbi request reprint High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients
    P Ljungman
    Department of Haematology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    Br J Haematol 111:774-81. 2000
    ..04) influenced HHV-6 DNA levels. HHV-6 viral load was significantly correlated with delayed platelet engraftment in both univariate (P < 0.01) and multivariate analysis, and to the number of platelet transfusions...
  34. ncbi request reprint No impact of NOD2/CARD15 on outcome after SCT
    D Sairafi
    Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 41:961-4. 2008
    ..On the basis of these findings we conclude that a consideration to NOD2/CARD15 mutation status is not pertinent when selecting a donor for Allo-SCT at our centre...
  35. ncbi request reprint Treatment of severe acute graft-versus-host disease with anti-thymocyte globulin
    M Remberger
    Department of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Clin Transplant 15:147-53. 2001
    ..Most patients died of GVHD, with virus or fungal infections as contributing causes of death. To conclude, treatment of severe acute GVHD is difficult and ATG, in our hands, adds nothing to conventional pharmacological treatment...
  36. ncbi request reprint GVHD prophylaxis using low-dose cyclosporine improves survival in leukaemic recipients of HLA-identical sibling transplants
    Richard Olsson
    Centre for Allogeneic Stem Cell Transplantation, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden
    Eur J Haematol 84:323-31. 2010
    ....
  37. ncbi request reprint Which donor should be chosen for hematopoietic stem cell transplantation among unrelated HLA-A, -B, and -DRB1 genomically identical volunteers?
    Olle Ringden
    Centre for Allogeneic Stem Cell Transplantation, Division of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Biol Blood Marrow Transplant 10:128-34. 2004
    ..The 5-year survival was 72%, 48%, and 30% with 0, 1, and 2 risk factors, respectively. We concluded that unrelated hematopoietic stem cell transplantation may be improved if an optimal donor and immunosuppression are chosen...
  38. ncbi request reprint Reduced risk for extensive chronic graft-versus-host disease in patients receiving transplants with human leukocyte antigen-identical sibling donors given polymerase chain reaction-based preemptive therapy against cytomegalovirus
    Kajsa Larsson
    Division for Hematology, Department of Medicine, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    Transplantation 77:526-31. 2004
    ..The aim of this study was to investigate the relationship between cytomegalovirus (CMV) and extensive chronic graft-versus-host disease (GvHD) after allogeneic stem-cell transplantation (SCT)...
  39. ncbi request reprint Home care during the pancytopenic phase after allogeneic hematopoietic stem cell transplantation is advantageous compared with hospital care
    Britt Marie Svahn
    Centre for Allogeneic Stem Cell Transplantation, Department of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Blood 100:4317-24. 2002
    ..03). To conclude, home care after SCT is a novel and safe approach. This study found it to be advantageous, compared with hospital care...
  40. ncbi request reprint Graft-versus-leukaemia effect in children: chronic GVHD has a significant impact on relapse and survival
    A Gustafsson Jernberg
    Department of Paediatrics, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    Bone Marrow Transplant 31:175-81. 2003
    ..Acute GVHD was not an independent predictor for relapse or death in this study. This study is in support of a GVL effect in childhood leukaemia related to chronic GVHD, reducing the risk of relapse and improving survival...
  41. doi request reprint Graft failure in the modern era of allogeneic hematopoietic SCT
    R Olsson
    Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 48:537-43. 2013
    ..01). In conclusion, graft failure was only associated with inferior survival in malignant disease. Non-malignant disorders, HLA match, conditioning intensity, immunosuppression regimen and cell dose all influenced graft failure risk...
  42. ncbi request reprint Disturbances in dental development and craniofacial growth in children treated with hematopoietic stem cell transplantation
    M Vesterbacka
    Division of Orthodontics and Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden
    Orthod Craniofac Res 15:21-9. 2012
    ..To investigate the correlation between age, degree of disturbances in dental development, and vertical growth of the face in children treated with hematopoietic stem cell transplantation (HSCT)...
  43. doi request reprint A prospective randomized study using N-acetyl-L-cysteine for early liver toxicity after allogeneic hematopoietic stem cell transplantation
    L Barkholt
    Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Bone Marrow Transplant 41:785-90. 2008
    ..There were two patients in the NAC group who developed VOD, as compared to three of the controls. To conclude, NAC does not improve liver toxicity after ASCT...
  44. ncbi request reprint T-cell receptor Vbeta repertoire after myeloablative and reduced intensity conditioning allogeneic haematopoietic stem cell transplantation
    P Hentschke
    Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden
    Scand J Immunol 61:285-94. 2005
    ..GVHD, infections and age are more important for immune reconstitution than type of conditioning...
  45. ncbi request reprint Cyclosporine A (CsA) 2-h concentrations vary between patients without correlation to graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
    L Barkholt
    Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Bone Marrow Transplant 40:683-9. 2007
    ..Interindividual variations in CsA uptake and metabolism may explain the wide variation of C2 levels without prediction for increased risk for severe aGVHD or infectious complication when C0 guided the CsA dosing...
  46. ncbi request reprint No difference in graft-versus-host disease, relapse, and survival comparing peripheral stem cells to bone marrow using unrelated donors
    M Remberger
    Centre for Allogeneic Stem Cell Transplantation and Department of Clinical Immunology, Huddinge University Hospital, Stockholm, Sweden
    Blood 98:1739-45. 2001
    ..PBSC from HLA-compatible unrelated donors can be used safely as an alternative to BM for stem cell transplantation...
  47. ncbi request reprint Risk factors for moderate-to-severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Biol Blood Marrow Transplant 8:674-82. 2002
    ..Patients with previous acute GVHD grades II to IV may benefit from more aggressive initial treatment. This possibility would have to be examined in clinical trials...
  48. ncbi request reprint Association between pretransplant Thymoglobulin and reduced non-relapse mortality rate after marrow transplantation from unrelated donors
    M Remberger
    Center for Allogeneic Stem Cell Transplantation, Huddinge University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 29:391-7. 2002
    ..27-0.97, P value = 0.03). No significant difference in the risk of relapse was seen (P = 0.63). This suggests that Thymoglobulin during conditioning may reduce non-relapse mortality after unrelated donor marrow transplantation...
  49. ncbi request reprint Risk factors for fatal infectious complications developing late after allogeneic stem cell transplantation
    A Bjorklund
    Hematology Center, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 40:1055-62. 2007
    ..In conclusion, infections occurring later than 6 months after HSCT are important contributors to late non-relapse mortality after HSCT. CMV infection or acute GVHD markedly increase the risk...
  50. doi request reprint Randomized PCR-based therapy and risk factors for invasive fungal infection following reduced-intensity conditioning and hematopoietic SCT
    O Blennow
    Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 45:1710-8. 2010
    ..In this study, PCR on peripheral blood was a poor indicator of IFI early after RIC HSCT. Aspergillus PCR tests performed on clinical suspicion after day 100 were insufficiently sensitive to be diagnostically useful...
  51. ncbi request reprint Clinical tolerance after allogeneic hematopoietic stem cell transplantation: a study of influencing factors
    Patrik Hentschke
    Centre for Allogeneic Stem Cell Transplantation, Huddinge University Hospital, Stockholm, Sweden Patrik Hentschke transpl hs sll se
    Transplantation 73:930-6. 2002
    ..However, this phenomenon has rarely been studied...
  52. ncbi request reprint Increased risk of extensive chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation using unrelated donors
    Mats Remberger
    Centre for Allogeneic Stem Cell Transplantation and Department of Clinical Immunology, Karolinska University Hospital, Stockholm, Sweden
    Blood 105:548-51. 2005
    ..In conclusion, PBSCs from HLA-compatible unrelated donors results in similar outcome compared to BM but implies an increased risk for extensive chronic GVHD...
  53. pmc NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation
    Andreas T Björklund
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Blood 115:2686-94. 2010
    ..Our results provide evidence against the emergence of alloreactive NK cells in HLA-identical allogeneic SCT...
  54. pmc Effect of acute and chronic GVHD on relapse and survival after reduced-intensity conditioning allogeneic transplantation for myeloma
    O Ringden
    Department of Clinical Immunology, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 47:831-7. 2012
    ..52, P=0.001). The reduction in relapse risk associated with cGVHD is consistent with a beneficial graft-vs-myeloma effect, but this did not translate into a survival advantage...
  55. ncbi request reprint The clinical importance of bronchoalveolar lavage in allogeneic SCT patients with pneumonia
    U Forslöw
    Department of Medicine, Division of Respiratory Medicine and Allergology, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Bone Marrow Transplant 45:945-50. 2010
    ..BAL resulted in a changed treatment in 32/68 (47%) episodes of pneumonia. To conclude, BAL is a safe and useful diagnostic procedure that should be performed early after the onset of pneumonia following allogeneic HSCT...
  56. ncbi request reprint Long-term follow-up of patients treated at home during the pancytopenic phase after allogeneic haematopoietic stem cell transplantation
    B M Svahn
    Center for Allogeneic Stem Cell Transplantation and the Division of Clinical Immunology, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Bone Marrow Transplant 36:511-6. 2005
    ..04). Home care after ASCT is a novel approach that resulted in less TRM, similar incidence of chronic GVHD and relapse, and improved long-term survival compared to controls treated in the hospital...
  57. ncbi request reprint The role of disease stage in the response to donor lymphocyte infusions as treatment for leukemic relapse
    S Carlens
    Centre for Allogeneic Stem Cell Transplantation, Huddinge University Hospital, Sweden
    Biol Blood Marrow Transplant 7:31-8. 2001
    ..022). This study emphasizes the importance of early disease stage and presence of chronic GVHD for effective DLI...
  58. ncbi request reprint Risk factors in pediatric stem cell transplantation for leukemia
    Asa Gustafsson Jernberg
    Department of Pediatrics, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Pediatr Transplant 8:464-74. 2004
    ..39) and death (RR 0.42). We conclude that in children with leukemia other specific donor characteristics such as HLA-matching, gender, parity, and exposure to herpes viruses were more important for outcome than relationship...
  59. ncbi request reprint A low body mass index is correlated with poor survival after allogeneic stem cell transplantation
    Katarina Le Blanc
    Center for Allogeneic Stem Cell Transplantation, Division of Clinical Immunology, F79, Karolinska Institutet, Huddinge University Hospital, SE 141 86, Stockholm, Sweden
    Haematologica 88:1044-52. 2003
    ..The purpose of this study was to determine whether body mass index (BMI, kg body weight/height (in m2) is related to survival in recipients of allogeneic stem cell transplantation (ASCT)...
  60. doi request reprint Salivary secretion in children after fractionated or single-dose TBI
    K Garming Legert
    Department of Dental Medicine, Division of Oral and Maxillofacial Surgery, Karolinska Institute, Huddinge, Sweden
    Bone Marrow Transplant 47:404-10. 2012
    ..49, 95% confidence interval (CI)=1.40-30, P=0.014) and seropositivity of the recipient for 3-4 herpesviruses (OR=6.57, 95% CI=1.26-34, P=0.021) and a low stimulated salivary secretion rate (<0.5 mL/min) was found 1 year after HSCT...
  61. ncbi request reprint Ex vivo T lymphocyte expansion for retroviral transduction: influence of serum-free media on variations in cell expansion rates and lymphocyte subset distribution
    S Carlens
    Centre for Allogeneic Stem Cell Transplantation, Huddinge University Hospital, and Departments of, Huddinge, Sweden
    Exp Hematol 28:1137-46. 2000
    ..While these sera promote cell growth and viability, they contain uncharacterized elements that may yield inconsistent results from batch to batch. Cell expansion in serum-free media would therefore be preferable...
  62. ncbi request reprint Sequential Organ Failure Assessment predicts the outcome of SCT recipients admitted to intensive care unit
    K Gilli
    Department for Anaesthesiology and Intensive Care Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Bone Marrow Transplant 45:682-8. 2010
    ..01). In multivariate analysis of death, SOFA score was the only significant factor (P<0.001). In conclusion, SOFA score predicted prognosis in ASCT patients treated at the ICU...
  63. ncbi request reprint Allogeneic haematopoietic stem cell transplantation for metastatic renal carcinoma in Europe
    L Barkholt
    Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Ann Oncol 17:1134-40. 2006
    ..An allogeneic antitumour effect has been reported for various cancers. We evaluated the experience of allogeneic haematopoietic stem cell transplantation (HSCT) for renal cell carcinoma (RCC) in 124 patients from 21 European centres...
  64. ncbi request reprint Increased levels of immune transcript in patients with acute GVHD after allogeneic stem cell transplantation
    M Jaksch
    Division of Clinical Immunology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 31:183-90. 2003
    ..In conclusion, the quantitative RT-PCR of granzyme B, perforin and FasL may serve as a guide to the clinician in diagnosing acute GVHD and monitoring treatment...
  65. ncbi request reprint The graft-versus-leukaemia effect in haematopoietic stem cell transplantation using unrelated donors
    M Remberger
    Department of Clinical Immunology, Huddinge University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 30:761-8. 2002
    ..Overall and relapse-free survival were not improved by the occurrence of acute GVHD...
  66. ncbi request reprint The significance of graft-versus-host disease and pretransplantation minimal residual disease status to outcome after allogeneic stem cell transplantation in patients with acute lymphoblastic leukemia
    M Uzunel
    Department of Clinical Immunology, Karolinska Institute at Huddinge University Hospital, Huddinge, Sweden
    Blood 98:1982-4. 2001
    ..005). In conclusion, for patients entering transplantation while they have residual disease, a combination of acute and chronic graft-versus-host disease may be needed to decrease the risk of relapse after SCT...
  67. ncbi request reprint Dose study of thymoglobulin during conditioning for unrelated donor allogeneic stem-cell transplantation
    Mats Remberger
    Department of Clinical Immunology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Transplantation 78:122-7. 2004
    ..Thymoglobulin given before allo-hematopoietic stem-cell transplantation (HSCT) from unrelated donors reduces acute graft-versus-host disease (GvHD), but the optimal dose is unknown...
  68. ncbi request reprint Allogenic stem cell transplantation for nonmalignant disorders using matched unrelated donors
    Petter Svenberg
    Centre for Allogenic Stem Cell Transplantation, Department of Paediatrics, Karolinska University Hospital, Huddinge, SE 14186 Stockholm, Sweden
    Biol Blood Marrow Transplant 10:877-82. 2004
    ..We conclude that HSCT with HLA-A, -B, and -DRbeta1 genomically matched unrelated donors in combination with antithymocyte globulin in the conditioning regimen gives encouraging results in patients with SAA or IEM...
  69. ncbi request reprint Graft-versus-host disease is associated with a lower relapse incidence after hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia
    Anna Nordlander
    Center for Allogenic Stem Cell Transplantation and Department of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Biol Blood Marrow Transplant 10:195-203. 2004
    ..01), and an HLA-matched donor (P=.01). The association between herpes simplex virus infection and a low frequency of relapse is a new observation and may indicate that viral antigens play a role in the induction of an antileukemic effect...
  70. doi request reprint Different impact of intermediate and unfavourable cytogenetics at the time of diagnosis on outcome of de novo AML after allo-SCT: a long-term retrospective analysis from a single institution
    H Nahi
    Division of Haematology, Department of Medicine, Karolinska Institutet Huddinge and Haematology Centre Karolinska, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden
    Med Oncol 29:2348-58. 2012
    ..Our study showed that outcome after allo-SCT in de novo AML differs depending on cytogenetic risk-group; however its position in post-remission therapy of eligible AML patients is not threatened...
  71. doi request reprint No increased trapping of multipotent mesenchymal stromal cells in bone marrow filters compared with other bone marrow cells
    M Sundin
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Cytotherapy 10:238-42. 2008
    ..It has been suggested that MSC may be trapped in bone marrow (BM) filters during the stem cell procurement and lost from the HSC graft...
  72. ncbi request reprint Poor oral nutrition after allogeneic stem cell transplantation correlates significantly with severe graft-versus-host disease
    J Mattsson
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Bone Marrow Transplant 38:629-33. 2006
    ..66, confidence interval 1.44-40.7, P=0.016). Poor oral intake early after SCT may be associated with an increased risk of developing severe acute GVHD...
  73. ncbi request reprint Increased immune transcript levels are correlated with acute graft-versus-host disease and cytomegalovirus response after allogeneic stem cell transplantation
    Marie Jaksch
    Division of Clinical Immunology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden
    Transplantation 77:195-200. 2004
    ..Therefore, this study evaluates the gene expression pattern in the peripheral blood of patients after allogeneic stem cell transplantation and correlates the results to acute GVHD...
  74. ncbi request reprint A comparison of nonmyeloablative and reduced-intensity conditioning for allogeneic stem-cell transplantation
    Katarina Le Blanc
    Centre for Allogeneic Stem Cell Transplantation and Division of Clinical Immunology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    Transplantation 78:1014-20. 2004
    ..Nonmyeloablative (NM) conditioning and reduced-intensity conditioning (RIC) are increasingly used for allogeneic hematopoietic stem-cell transplantation. Such regimens have not been compared...
  75. ncbi request reprint Cytokine production during myeloablative and reduced intensity therapy before allogeneic stem cell transplantation
    Mats Remberger
    Department of Clinical Immunology, Centre of Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital MR, SE 141 86 Stockholm, Sweden
    Haematologica 89:710-6. 2004
    ..The aim of this study was to elucidate the effect of the type of chemo-radio therapy given before allogeneic hematopoietic stem-cell transplantation (HSCT) on cytokine release...
  76. ncbi request reprint Rabbit-immunoglobulin G levels in patients receiving thymoglobulin as part of conditioning before unrelated donor stem cell transplantation
    Mats Remberger
    Department of Clinical Immunology, Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, SE 141 86 Stockholm, Sweden gt
    Haematologica 90:931-8. 2005
    ..The role of serum concentrations of rabbit antithymoglobulin (ATG) in the development of acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) with unrelated donors is unknown...
  77. ncbi request reprint A prospective randomized trial of a prophylactic platelet transfusion trigger of 10 x 10(9) per L versus 30 x 10(9) per L in allogeneic hematopoietic progenitor cell transplant recipients
    Beatrice Diedrich
    Department of Transfusion Medicine, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    Transfusion 45:1064-72. 2005
    ..The impact of lowering the platelet (PLT) count threshold for prophylactic PLT transfusion on bleeding and PLT use in allogeneic hematopoietic progenitor cell (HPC) transplant recipients is a matter of debate...
  78. ncbi request reprint Treatment costs and survival in patients with grades III-IV acute graft-versus-host disease after allogenic hematopoietic stem cell transplantation during three decades
    Britt Marie Svahn
    Center for Allogeneic Stem Cell Transplantation and Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Transplantation 81:1600-3. 2006
    ..It was found that the time the patients had GVHD did not differ among the three groups. In conclusion, the costs and survival rates associated with severe acute GVHD has increased in recent years...
  79. ncbi request reprint Increased gene expression of chemokine receptors is correlated with acute graft-versus-host disease after allogeneic stem cell transplantation
    Marie Jaksch
    Division of Clinical Immunology, Karolinska Institutet at Karolinska University Hospital, Huddinge, Sweden
    Biol Blood Marrow Transplant 11:280-7. 2005
    ..Although they are not specific for acute GVHD, quantitative monitoring of the gene expression of chemokine receptors may be a valuable molecular method to monitor and diagnose acute GVHD...
  80. ncbi request reprint The incidence of hemorrhagic cystitis and BK-viruria in allogeneic hematopoietic stem cell recipients according to intensity of the conditioning regimen
    Geraldine Giraud
    Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    Haematologica 91:401-4. 2006
    ..02). Finally, hemorrhagic cystitis and BK-viruria were less common in patients receiving RIC, rather than full conditioning (p<0.01 and p<0.01, respectively)...
  81. doi request reprint Incidence, risk factors, and outcome of bloodstream infections during the pre-engraftment phase in 521 allogeneic hematopoietic stem cell transplantations
    O Blennow
    Division of Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Division of Therapeutic Immunology, Karolinska Institutet, Stockholm, Sweden
    Transpl Infect Dis 16:106-14. 2014
    ..Knowledge of trends in etiology and antibiotic susceptibility of BSI is important as the time to effective antibiotic treatment is closely associated with survival in bacteremic patients with septic shock...
  82. ncbi request reprint Low-intensity conditioning and hematopoietic stem cell transplantation in patients with renal and colon carcinoma
    P Hentschke
    Center for Allogenic Stem Cell Transplantation and Division of Immunology, Microbiology and Pathology, Huddinge University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 31:253-61. 2003
    ..However, the regression of some metastases associated with GVHD provides suggestive evidence that the GVHD effect may occur in renal and colon adenocarcinoma using reduced intensity conditioning...
  83. ncbi request reprint Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation
    M Schaffer
    Department of Biosciences at Novum, Karolinska Institutet at Huddinge University Hospital, Huddinge, Sweden
    Tissue Antigens 62:243-50. 2003
    ..The awareness of HLA class I- and II-mismatches in a recipient-donor pair makes it possible to give appropriate pre- and post-transplantation treatment...
  84. pmc Association between a high BK virus load in urine samples of patients with graft-versus-host disease and development of hemorrhagic cystitis after hematopoietic stem cell transplantation
    G Bogdanovic
    Department of Oncology Pathology, Karolinska Institute, Hudding University Hospital, Stockholm, Sweden
    J Clin Microbiol 42:5394-6. 2004
    ..BKV load in combination with acute GVHD discriminated the best, while BKV and viral load alone, but not GVHD, still showed predictive ability for HC...
  85. doi request reprint N-acetyl-L-cysteine increases acute graft-versus-host disease and promotes T-cell-mediated immunity in vitro
    Helen Karlsson
    Division of Clinical Immunology, Karolinska Institutet, Stockholm, Sweden
    Eur J Immunol 41:1143-53. 2011
    ..To conclude, NAC appears to increase acute GvHD and has an immunostimulatory effect on alloantigen-specific T cells...
  86. ncbi request reprint Serum levels of cytokines correlate to donor chimerism and acute graft-vs.-host disease after haematopoietic stem cell transplantation
    Mats Remberger
    Department of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Huddinge University Hospital, Stockholm, Sweden
    Eur J Haematol 70:384-91. 2003
    ..Some patients become full donor chimeras (DC) early after stem-cell transplantation (SCT), while others remain mixed chimeras for a longer time. Little is known about the mechanism behind these phenomena...
  87. ncbi request reprint The TNFd4 allele is correlated to moderate-to-severe acute graft-versus-host disease after allogeneic stem cell transplantation
    Anna Nordlander
    Department of Clinical Immunology, and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Br J Haematol 119:1133-6. 2002
    ..01). Acute GVHD grades II-IV were more common among patients homozygous for the IL-10-1064 allele 13 (P = 0.02). Patients homozygous for the TNF-308 allele (AA) correlated with higher TNF-alpha serum levels during conditioning (P = 0.02)...
  88. ncbi request reprint Decreasing mortality rate in early pneumonia following hematopoietic stem cell transplantation
    Ulrica Forslöw
    Department of Medicine, Division of Respiratory Medicine and Allergology, Huddinge, Sweden
    Scand J Infect Dis 38:970-6. 2006
    ..8% compared to 8.9% during the first decade. We conclude that the rate of mortality related to pneumonia has decreased over time, possibly as a result of improved diagnostic, prophylactic and therapeutic methods and treatment...
  89. ncbi request reprint An association between human leucocyte antigen alleles and acute and chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
    Mats Remberger
    Department of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Br J Haematol 119:751-9. 2002
    ..These results show that major histocompatibility comlex (MHC) alleles may influence the incidence of GVHD in HSCT with HLA identical sibling donors...
  90. doi request reprint Granulocyte colony-stimulating factor induced acute and chronic graft-versus-host disease
    Olle Ringden
    Division of Clinical Immunology, Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Transplantation 90:1022-9. 2010
    ..Total body irradiation and bone marrow were found to be prerequisites for acute GVHD. This study encouraged us to perform a retrospective clinical study...
  91. ncbi request reprint Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease
    Olle Ringden
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Transplantation 81:1390-7. 2006
    ..Mesenchymal stem cells (MSC) have immunomodulatory effects. The aim was to study the effect of MSC infusion on graft-versus-host disease (GVHD)...
  92. ncbi request reprint Costs of allogeneic hematopoietic stem cell transplantation
    Britt Marie Svahn
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Transplantation 82:147-53. 2006
    ..This study aims to determine the total costs after allogeneic hematopoietic stem cell transplantation (ASCT) and factors associated with increases or decreases in costs...
  93. ncbi request reprint The role of HLA mismatch, splenectomy and recipient Epstein-Barr virus seronegativity as risk factors in post-transplant lymphoproliferative disorder following allogeneic hematopoietic stem cell transplantation
    Mikael Sundin
    Department of Laboratory Medicine, Division of Clinical Immunology F79, Karolinska Institutet, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Haematologica 91:1059-67. 2006
    ..The objective of this study was to determine risk factors in PTLD following HSCT in order to identify high-risk patients for surveillance, prophylaxis and treatment...
  94. ncbi request reprint Unrelated versus related allogeneic stem cell transplantation after reduced intensity conditioning
    Mehmet Uzunel
    Department of Clinical Immunology, Karolinska Institute at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Transplantation 82:913-9. 2006
    ..The use of reduced intensity conditioning (RIC) regimens in allogeneic hematopoietic stem cell transplantation (HSCT) has increased over the past five years...
  95. ncbi request reprint Allogeneic hematopoietic stem cell transplantation for inherited disorders: experience in a single center
    Olle Ringden
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Transplantation 81:718-25. 2006
    ..Allogeneic hematopoietic stem cell transplantation (ASCT) is a possible cure for many inherited disorders...
  96. ncbi request reprint Hemorrhagic cystitis: a retrospective single-center survey
    Zuzana Hassan
    Center for Allogenic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin Transplant 21:659-67. 2007
    ..With four risk factors, the risk of HC development was 31%. Risk factors for severe HC of grades 3-5 were aGVHD and bacteremia...
  97. ncbi request reprint Inflammatory cytokines predominate in cases of tumor regression after hematopoietic stem cell transplantation for solid cancer
    Reka Conrad
    Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Biol Blood Marrow Transplant 12:346-54. 2006
    ..01). Thus, an increased level of I cytokines possibly mirrors tumor killing induced by type 1 T-cell response. Furthermore, anti-I cytokines might inhibit cytotoxic cells from exerting the antitumor effect of allogeneic SCT...
  98. ncbi request reprint Acute neurological complications after hematopoietic stem cell transplantation in children
    Johanna Rubin
    Department of Pediatrics, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Pediatr Transplant 9:62-7. 2005
    ..Number of positive herpes group viral serologies in the recipient before transplantation and certain electrolyte disturbances may contribute to neurological complications after HSCT...
  99. doi request reprint A comparison between low intensity and reduced intensity conditioning in allogeneic hematopoietic stem cell transplantation for solid tumors
    Reka Conrad
    Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska University Hospital Huddinge F79, SE 141 86 Stockholm, Sweden
    Haematologica 93:265-72. 2008
    ..We performed a non-randomized study comparing low intensity conditioning with reduced intensity conditioning after stem cell transplantation to demonstrate the graft-versus-tumor effect...
  100. doi request reprint Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study
    Katarina Le Blanc
    Haematology Centre and Centre of Allogeneic Stem Cell Transplantation, Division of Clinical Immunology, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Lancet 371:1579-86. 2008
    ..Mesenchymal stem cells modulate immune responses in vitro and in vivo. We aimed to assess whether mesenchymal stem cells could ameliorate GVHD after haemopoietic-stem-cell transplantation...
  101. pmc Lymphocyte recovery is a major determinant of outcome after matched unrelated myeloablative transplantation for myelogenous malignancies
    Katarina Le Blanc
    Division of Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Stockholm, Sweden
    Biol Blood Marrow Transplant 15:1108-15. 2009
    ..81, P=.02) and aGVHD (HR 0.84, P=.05). These results indicate that LC30 is an independent prognostic factor for transplant outcome in matched unrelated SCT for myelogenous malignancies...