Chengxuan Qiu

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Medial temporal lobe is vulnerable to vascular risk factors in men: a population-based study
    C Qiu
    Department of Neurobiology, Karolinska Institutet Stockholm University, Stockholm, Sweden
    Eur J Neurol 19:876-83. 2012
  2. doi request reprint Preventing Alzheimer's disease by targeting vascular risk factors: hope and gap
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet Stockholm University, Stockholm, Sweden
    J Alzheimers Dis 32:721-31. 2012
  3. doi request reprint Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet Stockholm University, Stockholm, Sweden
    Neurology 80:1888-94. 2013
  4. pmc Cerebral microbleeds and age-related macular degeneration: the AGES-Reykjavik Study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 33:2935-7. 2012
  5. ncbi request reprint Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Olivecronas vag 4, S 113 82 Stockholm, Sweden
    Arch Intern Med 166:1003-8. 2006
  6. doi request reprint Association of blood pressure and hypertension with the risk of Parkinson disease: the National FINRISK Study
    Chengxuan Qiu
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, S 11330 Stockholm, Sweden
    Hypertension 57:1094-100. 2011
  7. pmc Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study
    C Qiu
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD, USA
    Neurology 75:2221-8. 2010
  8. ncbi request reprint The epidemiology of the dementias: an update
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Caring Sciences and Society NVS, Karolinska Institutet and the Stockholm Gerontology Research Center, Stockholm, Sweden
    Curr Opin Psychiatry 20:380-5. 2007
  9. ncbi request reprint Vascular and psychosocial factors in Alzheimer's disease: epidemiological evidence toward intervention
    Chengxuan Qiu
    Aging Research Center, Karolinska Institutet Stockholm University, Stockholm, Sweden
    J Alzheimers Dis 20:689-97. 2010
  10. ncbi request reprint Vascular risk profiles for dementia and Alzheimer's disease in very old people: a population-based longitudinal study
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Karolinska Institutet, Stockholm University, Stockholm, Sweden
    J Alzheimers Dis 20:293-300. 2010

Detail Information

Publications42

  1. doi request reprint Medial temporal lobe is vulnerable to vascular risk factors in men: a population-based study
    C Qiu
    Department of Neurobiology, Karolinska Institutet Stockholm University, Stockholm, Sweden
    Eur J Neurol 19:876-83. 2012
    ..We investigate whether an aggregation of VRFs is associated with volume of hippocampus and entorhinal cortex in elderly people living in the community...
  2. doi request reprint Preventing Alzheimer's disease by targeting vascular risk factors: hope and gap
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet Stockholm University, Stockholm, Sweden
    J Alzheimers Dis 32:721-31. 2012
    ..To bridge the gap, the multifactorial nature of AD and the proper time-window for intervention should be taken into account in the future when designing preventative interventions against this devastating disorder...
  3. doi request reprint Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet Stockholm University, Stockholm, Sweden
    Neurology 80:1888-94. 2013
    ..To explore whether prevalence, survival, and incidence of dementia have changed from 1987-1994 to 2001-2008 in Stockholm, Sweden...
  4. pmc Cerebral microbleeds and age-related macular degeneration: the AGES-Reykjavik Study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 33:2935-7. 2012
    ..85 (0.89-3.87, p = 0.100) for nonlobar CMB. This study provides no evidence that amyloid deposits in the brain and AMD are correlated. However, the suggestive association of geographic atrophy with CMB warrants further investigation...
  5. ncbi request reprint Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Olivecronas vag 4, S 113 82 Stockholm, Sweden
    Arch Intern Med 166:1003-8. 2006
    ..We sought to examine the hypothesis that heart failure is a risk factor for dementia and Alzheimer disease...
  6. doi request reprint Association of blood pressure and hypertension with the risk of Parkinson disease: the National FINRISK Study
    Chengxuan Qiu
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, S 11330 Stockholm, Sweden
    Hypertension 57:1094-100. 2011
    ..Optimal control of blood pressure in women may reduce the incidence of PD...
  7. pmc Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study
    C Qiu
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD, USA
    Neurology 75:2221-8. 2010
    ..To determine whether microvascular damage, indicated by cerebral microbleeds (CMBs) and retinal microvascular signs, is associated with cognitive function and dementia in older persons...
  8. ncbi request reprint The epidemiology of the dementias: an update
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Caring Sciences and Society NVS, Karolinska Institutet and the Stockholm Gerontology Research Center, Stockholm, Sweden
    Curr Opin Psychiatry 20:380-5. 2007
    ..The epidemiology of dementia is one of the priority fields in aging research. This review aims to highlight the most relevant findings over last years concerning occurrence, risk factors, and prevention of dementia and its major subtypes...
  9. ncbi request reprint Vascular and psychosocial factors in Alzheimer's disease: epidemiological evidence toward intervention
    Chengxuan Qiu
    Aging Research Center, Karolinska Institutet Stockholm University, Stockholm, Sweden
    J Alzheimers Dis 20:689-97. 2010
    ....
  10. ncbi request reprint Vascular risk profiles for dementia and Alzheimer's disease in very old people: a population-based longitudinal study
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Karolinska Institutet, Stockholm University, Stockholm, Sweden
    J Alzheimers Dis 20:293-300. 2010
    ..Severe cerebral atherosclerosis and insufficient perfusion are involved in the development of dementia including AD...
  11. ncbi request reprint Low diastolic pressure and risk of dementia in very old people: a longitudinal study
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet Stockholm University, Stockholm, Sweden
    Dement Geriatr Cogn Disord 28:213-9. 2009
    ..Midlife high blood pressure is linked to late-life dementia. We sought to investigate the temporal relation of blood pressure to the risk of dementia and Alzhei-mer's disease (AD) among older adults...
  12. doi request reprint Epidemiological findings of vascular risk factors in Alzheimer's disease: implications for therapeutic and preventive intervention
    Chengxuan Qiu
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, S 113 30 Stockholm, Sweden
    Expert Rev Neurother 11:1593-607. 2011
    ....
  13. pmc Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
    Chengxuan Qiu
    Aging Research Center, Karolinska Institutet Stockholm, Sweden
    Dialogues Clin Neurosci 11:111-28. 2009
    ....
  14. doi request reprint Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Diabetes 57:1645-50. 2008
    ..We sought to examine whether microvascular lesions in the retina and in the brain are associated and whether this association differs among people with and without diabetes...
  15. ncbi request reprint Pulse pressure and risk of Alzheimer disease in persons aged 75 years and older: a community-based, longitudinal study
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Stroke 34:594-9. 2003
    ..Elevated blood pressure has been found to increase the risk of dementia, including Alzheimer disease. We sought to investigate whether pulse pressure was predictive of Alzheimer disease and dementia...
  16. ncbi request reprint Lifetime principal occupation and risk of Alzheimer's disease in the Kungsholmen project
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institute and the Stockholm Gerontology Research Center, Sweden
    Am J Ind Med 43:204-11. 2003
    ..Some studies suggest that manual work is associated with dementia. This study is aimed at identifying the specific occupational categories that may be related to dementia...
  17. pmc Accelerated progression from mild cognitive impairment to dementia in people with diabetes
    Weili Xu
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
    Diabetes 59:2928-35. 2010
    ..We sought to examine whether diabetes and pre-diabetes are associated with MCI and accelerate the progression from MCI to dementia...
  18. doi request reprint Diabetes, markers of brain pathology and cognitive function: the Age, Gene/Environment Susceptibility-Reykjavik Study
    Chengxuan Qiu
    Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD Aging Research Center, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet Stockholm University, Stockholm, Sweden
    Ann Neurol 75:138-46. 2014
    ..We investigated whether, and the extent to which, vascular and degenerative lesions in the brain mediate the association of diabetes with poor cognitive performance...
  19. doi request reprint How can elderly apolipoprotein E ε4 carriers remain free from dementia?
    Camilla Ferrari
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
    Neurobiol Aging 34:13-21. 2013
    ..The ε4 carriers with these characteristics appear to have similar dementia-free survival time to non-ε4 carriers...
  20. pmc Microvascular lesions in the brain and retina: The age, gene/environment susceptibility-Reykjavik study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Ann Neurol 65:569-76. 2009
    ..To investigate whether the severity and location of cerebral white matter hyperintensities (WMHs) and brain infarcts are correlated with the signs of retinal microvascular abnormalities in the elderly...
  21. ncbi request reprint APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study
    Wenyong Huang
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, Stockholm Gerontology Research Center, corrected Stockholm, Sweden
    Arch Neurol 61:1930-4. 2004
    ..Both family aggregation and apolipoprotein E (APOE) epsilon4 allele are well-known risk factors for dementia, but the relation between these two factors remains unclear...
  22. ncbi request reprint Cerebrovascular disease, APOE epsilon4 allele and cognitive decline in a cognitively normal population
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurol Res 28:650-6. 2006
    ..To investigate whether cerebrovascular disease (CVD) and apolipoprotein E (APOE) epsilon4 allele were associated with cognitive decline and whether the relationship between CVD and cognitive decline varied by APOE epsilon4 status...
  23. ncbi request reprint The age-dependent relation of blood pressure to cognitive function and dementia
    Chengxuan Qiu
    Aging Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institute and Stockholm Gerontology Research Centre, Stockholm, Sweden
    Lancet Neurol 4:487-99. 2005
    ....
  24. ncbi request reprint Combined effects of APOE genotype, blood pressure, and antihypertensive drug use on incident AD
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and the Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurology 61:655-60. 2003
    ..To study the hypotheses that APOE-epsilon4 allele may interact with blood pressure to affect Alzheimer's disease (AD) occurrence and that antihypertensive therapy could modify such an effect...
  25. ncbi request reprint Occupational exposure to electromagnetic fields and risk of Alzheimer's disease
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, S 113 82 Stockholm, Sweden
    Epidemiology 15:687-94. 2004
    ..Extremely-low-frequency magnetic field (ELF-MF) exposure is suspected to increase the risk of Alzheimer's disease. Such fields are present in the vicinity of electrical motors and other electric appliances containing coils...
  26. pmc Lifestyle, social factors, and survival after age 75: population based study
    Debora Rizzuto
    Aging Research Center, Department of Neurobiology, Health Care Sciences and Society, Karolinska Institutet and Stockholm University, 113 30 Stockholm, Sweden
    BMJ 345:e5568. 2012
    ..To identify modifiable factors associated with longevity among adults aged 75 and older...
  27. ncbi request reprint Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease
    Anita Karp
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Am J Epidemiol 159:175-83. 2004
    ..In conclusion, the association between low education and increased AD risk was not mediated by adult SES or socioeconomic mobility. This suggests that early life factors may be relevant...
  28. ncbi request reprint The effect of borderline diabetes on the risk of dementia and Alzheimer's disease
    Weili Xu
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Diabetes 56:211-6. 2007
    ..Borderline diabetes may interact with severe systolic hypertension to multiply the risk of Alzheimer's disease...
  29. doi request reprint Prevention of common neurodegenerative disorders in the elderly
    Laura Fratiglioni
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm Gerontology Research Center, Gavlegatan 16, S 113 30, Stockholm, Sweden
    Exp Gerontol 44:46-50. 2009
    ....
  30. ncbi request reprint Heterogeneity in risk factors for cognitive impairment, no dementia: population-based longitudinal study from the Kungsholmen Project
    Roberto Monastero
    Aging Research Center, Division of Geriatric Epidemiology, Department for Neurobiology, Health Care Sciences, and Society, Karolinska Institutet, Stockholm Gerontology Research Center, Stockholm, Sweden
    Am J Geriatr Psychiatry 15:60-9. 2007
    ....
  31. ncbi request reprint Decline in blood pressure over time and risk of dementia: a longitudinal study from the Kungsholmen project
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Stroke 35:1810-5. 2004
    ..Low blood pressure has been related to an increased risk of dementia. We sought to verify blood pressure variations before and after a dementia diagnosis and to relate blood pressure decline to subsequent Alzheimer disease and dementia...
  32. doi request reprint Acceleration of hippocampal atrophy in a non-demented elderly population: the SNAC-K study
    Yi Zhang
    Department of Clinical Science, Intervention and Technology, Division of Radiology, Karolinska Institutet, Stockholm, Sweden
    Int Psychogeriatr 22:14-25. 2010
    ..The aim is to study the aging atrophy speed and acceleration of brain atrophy in a cross-sectional database, to identify the age at which acceleration of hippocampal atrophy starts in non-demented elderly persons...
  33. pmc Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study
    Weili Xu
    Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Diabetes 58:71-7. 2009
    ..We aimed to verify the association between diabetes and the risk of dementia, Alzheimer's disease, and vascular dementia in twins and to explore whether genetic and early-life environmental factors could contribute to this association...
  34. ncbi request reprint Alcohol consumption and incidence of dementia in a community sample aged 75 years and older
    Wenyong Huang
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and the Stockholm Gerontology Research Center, Olivecronas vag 4, Box 6401, S 113 82 Stockholm, Sweden
    J Clin Epidemiol 55:959-64. 2002
    ....
  35. ncbi request reprint Low blood pressure and risk of dementia in the Kungsholmen project: a 6-year follow-up study
    Chengxuan Qiu
    Aging Research Center, Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 60:223-8. 2003
    ..Previous studies have reported a higher prevalence of dementia in persons with low blood pressure...
  36. pmc Association of cardiovascular burden with mobility limitation among elderly people: a population-based study
    Anna Karin Welmer
    Aging Research Center ARC, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
    PLoS ONE 8:e65815. 2013
    ..We seek to examine to what extent individual and aggregated CRFs and cardiovascular diseases (CVDs) are associated with mobility limitation...
  37. ncbi request reprint Epidemiology of cerebrovascular disease related cognitive decline
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Karolinska Institute, Stockholm, Sweden
    Int Psychogeriatr 15:105-10. 2003
    ..Early treatment and prevention of cerebrovascular disease may be the major measures for preventing and postponing the progression of the vascular disease related cognitive decline...
  38. ncbi request reprint Dementing disorders in the elderly: evolution of disease severity over 7 years
    Hedda Aguero-Torres
    Division of Geriatric Epidemiology, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Gerontology Research Center, Sweden
    Alzheimer Dis Assoc Disord 16:221-7. 2002
    ..Long-term survivors in dementia are not rare, and as the absolute number of demented people is increasing, expanding our knowledge of these persons is of high public health importance...
  39. doi request reprint Atrial fibrillation, stroke and dementia in the very old: a population-based study
    Alessandra Marengoni
    Aging Research Center, NVS Department, Karolinska Institutet, Gavlegatan 16, Stockholm, Sweden
    Neurobiol Aging 32:1336-7. 2011
    ..3, 52.2, and 52.2 in persons with AF and 63.8, 54.6 and 30.6 in those without AF, respectively. AF was associated with the hazard ratio of 1.8 (95%CI, 1.0-3.4) for first-ever stroke, but not significantly associated with dementia or AD...
  40. doi request reprint Brain aging: lessons from community studies
    Laura Fratiglioni
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Nutr Rev 68:S119-27. 2010
    ..Presented here is an overview of the main findings of epidemiological studies on nutritional factors and nutrition-related pathological conditions, as related to dementia and Alzheimer's disease...
  41. ncbi request reprint Vascular risk factor burden, atherosclerosis, and functional dependence in old age: a population-based study
    Anna Karin Welmer
    Aging Research Center ARC, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Gavlegatan 16, SE 113 30, Stockholm, Sweden
    Int J Behav Med 21:597-604. 2014
    ..Vascular risk factors such as hypertension and obesity have been associated with physical limitations among older adults...
  42. doi request reprint Time trends in prevalence of activities of daily living (ADL) disability and survival: comparing two populations (aged 78+ years) living in a rural area in Sweden
    Britt Marie Sjölund
    Aging Research Center ARC, Karolinska Institutet Stockholm University, Gavlegatan 16, 113 30 Stockholm, Sweden University of Gävle, 801 76 Gävle, Sweden Electronic address
    Arch Gerontol Geriatr 58:370-5. 2014
    ..The time trends for ADL disability found in the study show that ADL disability had increased in women but not in men. More studies are needed to identify risk factors for ADL disability with a view to preventing it in time. ..