Kristian Pietras

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis
    Imke Albrecht
    Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
    PLoS ONE 5:e14109. 2010
  2. pmc miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
    Jelena Polajeva
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    BMC Cancer 12:378. 2012
  3. ncbi request reprint Hallmarks of cancer: interactions with the tumor stroma
    Kristian Pietras
    Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Scheeles vag 2, SE 171 77 Stockholm
    Exp Cell Res 316:1324-31. 2010
  4. pmc Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination
    Charlotte Anderberg
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Exp Med 210:563-79. 2013
  5. ncbi request reprint Vascular endothelial growth factor B controls endothelial fatty acid uptake
    Carolina E Hagberg
    Tissue Biology Group, Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nature 464:917-21. 2010
  6. pmc Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments
    Monika Ehnman
    Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 73:2139-49. 2013
  7. pmc ALK1 as an emerging target for antiangiogenic therapy of cancer
    Sara I Cunha
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden
    Blood 117:6999-7006. 2011
  8. pmc Of mice and men: a comparative study of cancer-associated fibroblasts in mammary carcinoma
    Pernilla Roswall
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Scheeles vag 2, Stockholm, Sweden
    Ups J Med Sci 117:196-201. 2012
  9. pmc Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts
    Charlotte Anderberg
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Nobels väg 3, Stockholm, Sweden
    Cancer Res 69:369-78. 2009
  10. pmc Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression
    Marcela Franco
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden
    Blood 118:2906-17. 2011

Collaborators

Detail Information

Publications11

  1. pmc Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis
    Imke Albrecht
    Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
    PLoS ONE 5:e14109. 2010
    ..Herein, we investigate the function of VEGF-B by the generation of mouse models of cancer with transgenic expression of VEGF-B or homozygous deletion of Vegfb...
  2. pmc miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
    Jelena Polajeva
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    BMC Cancer 12:378. 2012
    ..We decided to investigate the expression of the oncogenic miR-21 during normal mouse development and glioma, focusing on PDGF signaling as a potential regulator of miR-21...
  3. ncbi request reprint Hallmarks of cancer: interactions with the tumor stroma
    Kristian Pietras
    Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Scheeles vag 2, SE 171 77 Stockholm
    Exp Cell Res 316:1324-31. 2010
    ..Moreover, we discuss emerging fields of research which need to be further explored in order to fulfil the promise of stroma-targeted therapies for cancer...
  4. pmc Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination
    Charlotte Anderberg
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Exp Med 210:563-79. 2013
    ....
  5. ncbi request reprint Vascular endothelial growth factor B controls endothelial fatty acid uptake
    Carolina E Hagberg
    Tissue Biology Group, Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nature 464:917-21. 2010
    ..The involvement of VEGF-B in lipid uptake may open up the possibility for novel strategies to modulate pathological lipid accumulation in diabetes, obesity and cardiovascular diseases...
  6. pmc Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments
    Monika Ehnman
    Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 73:2139-49. 2013
    ..In summary, the study shows a clinically relevant distinction in PDGF signaling in human rhabdomyosarcoma and also suggests continued exploration of the influence of stromal PDGFRs on sarcoma progression...
  7. pmc ALK1 as an emerging target for antiangiogenic therapy of cancer
    Sara I Cunha
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden
    Blood 117:6999-7006. 2011
    ..Herein, we will summarize the current view of ALK1 regulation of endothelial cell phenotype in vitro and in vivo as well as provide an outlook for the ongoing clinical trials of ALK1 inhibitors in malignant disease...
  8. pmc Of mice and men: a comparative study of cancer-associated fibroblasts in mammary carcinoma
    Pernilla Roswall
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Scheeles vag 2, Stockholm, Sweden
    Ups J Med Sci 117:196-201. 2012
    ..However, there is a paucity of comparative studies between mouse and human tumours in order to validate the use of mouse models as discovery tools...
  9. pmc Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts
    Charlotte Anderberg
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Nobels väg 3, Stockholm, Sweden
    Cancer Res 69:369-78. 2009
    ..In conclusion, we establish paracrine signaling by PDGF-CC as a potential drug target to reduce stromal support in malignant melanoma...
  10. pmc Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression
    Marcela Franco
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden
    Blood 118:2906-17. 2011
    ..Our elucidation of pericyte-derived pro-survival signaling in tumor ECs has potentially important implications for clinical development of antiangiogenic drugs, and suggests new therapeutic targets for rational multitargeting of cancer...
  11. pmc Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis
    Sara I Cunha
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institutet, Stockholm SE 171 77, Sweden
    J Exp Med 207:85-100. 2010
    ..We delineate a decisive role for signaling by TGF-beta family members in tumor angiogenesis and offer mechanistic insight for the forthcoming clinical development of drugs blocking ALK1 in oncology...