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Genomes and GenesSpecies | M PeterssonSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Cardiovascular effects of oxytocinMaria Petersson
Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet, S 171 77 Stockholm, Sweden
Prog Brain Res 139:281-8. 2002..Oxytocin may also cause cardiovascular effects by affecting other mediators, such as atrial natriuretic peptide (ANP), nitric oxide (NO) and alpha 2-adrenoreceptors...- Oxytocin decreases carrageenan induced inflammation in ratsM Petersson
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Peptides 22:1479-84. 2001..c.) responded differently to nociceptive mechanical stimulation (P < 0.05) and had a reduced amount of myeloperoxidase (marker for neutrophil recruitment) in the paw (P < 0.01)... - Oxytocin enhances the effects of clonidine on blood pressure and locomotor activity in ratsM Petersson
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
J Auton Nerv Syst 78:49-56. 1999..These findings imply that alpha 2-adrenoreceptors are involved in the effects of oxytocin treatment on blood pressure and spontaneous motor activity... - Oxytocin stimulates proliferation of human osteoblast-like cellsMaria Petersson
Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet and Karolinska Hospital, S 171 76, Stockholm, Sweden
Peptides 23:1121-6. 2002..Oxytocin 100 pmol/l decreased interleukin-6 (IL-6) production of the hOB cells (23.4+/-1.96 versus 33.4+/-2.65 pg/well; P<0.001). These findings indicate that oxytocin may affect bone metabolism in humans... - Oxytocin causes a sustained decrease in plasma levels of corticosterone in ratsM Petersson
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Neurosci Lett 264:41-4. 1999..Dexamethasone decreased corticosterone to equal levels in both groups. Thus, OXT seems to be able to stimulate as well as to inhibit the activity within the HPA-axis within a short- and a long-term perspective, respectively... - Long-term changes in gastrin, cholecystokinin and insulin in response to oxytocin treatmentM Petersson
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Neuroendocrinology 69:202-8. 1999..These effects may be mediated by changes in vagal nerve activity... - Steroid dependent effects of oxytocin on spontaneous motor activity in female ratsM Petersson
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Brain Res Bull 45:301-5. 1998..These results show that the effects of OXY on motor activity in female rats are modified by female sex steroid hormones... - Oxytocin decreases blood pressure in male but not in female spontaneously hypertensive ratsM Petersson
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
J Auton Nerv Syst 66:15-8. 1997..These results show that oxytocin may cause a sustained decrease in blood pressure, without affecting heart rate, in male but not in female SHR... - Systemic oxytocin treatment modulates glucocorticoid and mineralocorticoid receptor mRNA in the rat hippocampusMaria Petersson
Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet Karolinska Hospital, S 171 77 Stockholm, Sweden
Neurosci Lett 343:97-100. 2003..Thus, oxytocin may modulate the activity of the hypothalamic-pituitary-adrenal-axis also at the hippocampal level in rats... - Prolyl-leucyl-glycinamide shares some effects with oxytocin but decreases oxytocin levelsMaria Petersson
Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet Karolinska Hospital, S 171 76 Stockholm, Sweden
Physiol Behav 83:475-81. 2004..In addition, PLG also induced some other effects similar to those induced by oxytocin treatment but when administered in high doses it decreased oxytocin levels... - Oxytocin/alpha(2)-Adrenoceptor interactions in feeding responsesZ Diaz-Cabiale
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Neuroendocrinology 71:209-18. 2000.... 
Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cellsE Z Wolpert
Microbiology and Tumor Biology Center, Karolinska Institute, Box 280, S 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 94:11496-501. 1997..These findings are discussed in relation to the biochemical nature of MHC class I dependent CTL epitopes associated with impaired TAP function, as well as implications for immunotherapy and autoimmunity...- The effects of arg-vasopressin on osteoblast-like cells in endothelial nitric oxide synthase-knockout mice and their wild type counterpartsA Lagumdzija
Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet and Karolinska University Hospital, S-17176 Stockholm, Sweden
Peptides 26:1661-6. 2005..In conclusion, this study indicates that NO is involved in the effects of AVP on cell proliferation in osteoblast-like cells... - Antagonistic oxytocin/alpha2-adrenoreceptor interactions in the nucleus tractus solitarii: relevance for central cardiovascular controlZ Diaz-Cabiale
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
J Neuroendocrinol 12:1167-73. 2000.... - Systemic oxytocin treatment modulates alpha 2-adrenoceptors in telencephalic and diencephalic regions of the ratZ Diaz-Cabiale
Department of Neuroscience BZ lab, Karolinska Institute, S 171 77 Stockholm, Sweden
Brain Res 887:421-5. 2000..These results suggest that long-term modulation of autonomic and neuroendocrine functions and emotional behaviours elicited by brain oxytocin may involve enhancement of central alpha 2-adrenoceptor function... - Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10F Salazar-Onfray
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
J Immunol 159:3195-202. 1997.... - Effects of an acute stressor on blood pressure and heart rate in rats pretreated with intracerebroventricular oxytocin injectionsMaria Petersson
Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
Psychoneuroendocrinology 32:959-65. 2007..No such effect was observed in the control group. Thus repeated oxytocin treatment can, in spite of decreasing blood pressure during basal conditions, increase cardiovascular reactivity to some types of stressors... - Effects of arginine-vasopressin and parathyroid hormone-related protein (1-34) on cell proliferation and production of YKL-40 in cultured chondrocytes from patients with rheumatoid arthritis and osteoarthritisM Petersson
Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet and Karolinska University Hospital, S 171 76 Stockholm, Sweden
Osteoarthritis Cartilage 14:652-9. 2006..We therefore investigated the effects of AVP and PTHrP (1-34) on cell proliferation and secretion of the glycoprotein YKL-40 in human chondrocytes derived from healthy subjects as well as from patients with RA or osteoarthritis (OA)... - [Oxytocin, a mediator of anti-stress, well-being, social interaction, growth and healing]Kerstin Uvnas-Moberg
Swedish University of Agricultural Sciences, Department of Animal Physiology, PO Box 7045, S 75007 Uppsala, Sweden
Z Psychosom Med Psychother 51:57-80. 2005..In addition, various types of psychotherapy involving transfer of support, warmth and empathy are likely to induce similar effects, which thus contribute to the positive effects of these kinds of therapies... - Oxytocin decreases plasma levels of thyroid-stimulating hormone and thyroid hormones in ratsMaria Petersson
Endocrine and Diabetes Unit, Department of Molecular Medicine, Karolinska Institutet, S 171 77, Stockholm, Sweden
Regul Pept 108:83-7. 2002..c. did not affect plasma levels of TSH, fT3 or fT4. Thus, the effect seems to have been mediated within the central nervous system, and TSH and the thyroid hormones may be involved in some of the metabolic effects in response to oxytocin... - [Oxytocin--biochemical link for human relations. Mediator of antistress, well-being, social interaction, growth, healing...]Kerstin Uvnas-Moberg
Institutionen för anatomi och fysiologi, Statens Lantbruksuniversitet, Uppsala
Lakartidningen 101:2634-9. 2004 - Tumor-induced immune dysfunctionR Kiessling
Cancer Center Karolinska, Immune and Genetherapy Laboratory, KS ringen R8 01, Karolinska Hospital, S 171 76 Stockholm, Sweden
Cancer Immunol Immunother 48:353-62. 1999.... - Plasma galanin, vasopressin, and oxytocin in patients with Addison's diseaseE Grenbäck
Department of Molecular Medicine and Surgery, Endocrine and Diabetes Unit, Karolinska Institutet, Stockholm, Sweden
Horm Metab Res 39:589-95. 2007..In conclusion, increased plasma ACTH was not reflected in elevated plasma galanin or vasopressin. In contrast, elevated ACTH levels were accompanied by higher oxytocin levels... - T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversityJ K Sandberg
Microbiology and Tumor Biology Center and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
J Immunol 165:25-33. 2000..We interpret these data, together with results previously published by others, in an avidity pit model based on avidity thresholds for maintenance of both maximal diversity and optimal self tolerance in the CD8+ T cell repertoire... - Arg-vasopressin increases proliferation of human osteoblast-like cells and decreases production of interleukin-6 and macrophage colony-stimulating factorAlena Lagumdzija
Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet Hospital, S 171 76 Stockholm, Sweden
Regul Pept 121:41-8. 2004..We suggest that the effect was mediated through the V1-receptor. Additionally, AVP decreased production of IL-6 and M-CSF from the hOB cells. Moreover, the V1a-receptor seems to be expressed in hOB cells... 
Postnatal oxytocin treatment of spontaneously hypertensive male rats decreases blood pressure and body weight in adulthoodMaria Petersson
Department of Molecular Medicine and Surgery, Endocrine and Diabetes Unit, Karolinska Institutet, SE 171 76 Stockholm, Sweden
Neurosci Lett 440:166-9. 2008..128; p=0.10). Heart rate was equal in the two groups. The postnatally oxytocin-treated male SHR had a significantly lower body weight at the age of 5-8 weeks compared to the controls (ANOVA p=0.014)...- Inhibited anabolic effect of insulin-like growth factor-I on stromal bone marrow cells in endothelial nitric oxide synthase-knockout miceA Lagumdzija
Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden
Acta Physiol Scand 182:29-35. 2004..The results indicate that the effect of IGF-I is dependent on NO production. The impaired IGF-I response may contribute to the bone defect formation seen in eNOSKO animals... - Opposite effects of oxytocin on proliferation of osteosarcoma cell linesMaria Petersson
Department of Molecular Medicine and Surgery, Endocrine and Diabetes Unit, Karolinska Institutet Karolinska University Hospital, S 171 76 Stockholm, Sweden
Regul Pept 150:50-4. 2008..001). Thus oxytocin has the capacity to both stimulate and inhibit cell proliferation of osteosarcoma cells. This effect might be dependent on the stage of differentiation of the cancer cells... - Oxytocin decreases corticosterone and nociception and increases motor activity in OVX ratsMaria Petersson
Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet Karolinska University Hospital, S 171 77 Stockholm, Sweden
Maturitas 51:426-33. 2005..c.) or intravaginally (i.vag.) on spontaneous motor activity, nociceptive thresholds and plasma corticosterone levels were examined in female ovariectomized (OVX) rats... - Oxytocin increases the density of high affinity alpha(2)-adrenoceptors within the hypothalamus, the amygdala and the nucleus of the solitary tract in ovariectomized ratsMaria Petersson
Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet Karolinska Hospital, S 171 76 Stockholm, Sweden
Brain Res 1049:234-9. 2005.... - Peptides associated with hyperphagia in adults with Prader-Willi syndrome before and during GH treatmentCharlotte Hoybye
Department of Endocrinology and Diabetology, Karolinska Hospital, Stockholm SE 171 76, Sweden
Growth Horm IGF Res 13:322-7. 2003..GH treatment of PWS patients did not change ghrelin, leptin or NPY. We suggest that both oxytocin and ghrelin are involved in the pathogenesis of hyperphagia seen in PWS... - Postnatal oxytocin treatment and postnatal stroking of rats reduce blood pressure in adulthoodSarah Holst
Department of Animal Physiology, Swedish University of Agricultural Sciences, Uppsala
Auton Neurosci 99:85-90. 2002..No changes in heart rate were found. In conclusion, both postnatal OT treatment and postnatal stroking reduced blood pressure in adulthood. In addition, in female rats, OT reduced the increase in blood pressure caused by prenatal stress... - Massage-like stroking influences plasma levels of gastrointestinal hormones, including insulin, and increases weight gain in male ratsSarah Holst
Swedish University of Agriculture Sciences, Department of Anatomy and Physiology, P O Box 7045, S 13247 Uppsala, Sweden
Auton Neurosci 120:73-9. 2005..In conclusion, repeated massage-like stroking decreased plasma levels of gastrin, insulin and somatostatin, increased plasma levels of glucose and promoted weight gain. The effects were influenced by the number of treatments...