Jin Jing Pei

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
    Am J Pathol 163:591-607. 2003
  2. ncbi Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproduction
    Xin Wen Zhou
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society NVS, KI Alzheimer s Disease Research Center, Geriatrics lab, Novum, Huddinge, Sweden
    FEBS Lett 582:159-64. 2008
  3. ncbi Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration
    Jin Jing Pei
    Karolinska Institutet, Neurotec, Section of Experimental Geriatrics, KFC Plan 4, Novum, 141 86 Huddinge, Sweden
    Acta Neuropathol 104:369-76. 2002
  4. ncbi P70 S6 kinase mediates tau phosphorylation and synthesis
    Jin Jing Pei
    Department of Neurotec, Division of Experimental Geriatrics, Karolinska Institutet, KFC Novum, Plan 4, SE 141 86, Huddinge, Sweden
    FEBS Lett 580:107-14. 2006
  5. ncbi Role of protein kinase B in Alzheimer's neurofibrillary pathology
    Jin Jing Pei
    Neurotec, Section for Experimental Geriatrics, Novum, Karolinska Institutet, KFC Plan 4, 141 86 Huddinge, Sweden
    Acta Neuropathol 105:381-92. 2003
  6. ncbi p70 S6 kinase and tau in Alzheimer's disease
    Jin Jing Pei
    Karolinska Institutet, KI Alzheimer Disease Research Center, Novum, Huddinge, Sweden
    J Alzheimers Dis 14:385-92. 2008
  7. ncbi Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease
    Jin Jing Pei
    Karolinska Institutet, Neurotec, Division of Experimental Geriatrics, Novum, KFC Plan 4, Novum, S 141 86, Huddinge, Sweden
    Brain Res Mol Brain Res 109:45-55. 2002
  8. ncbi Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2
    Wen Lin An
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
    Brain Res Mol Brain Res 135:40-7. 2005
  9. ncbi Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
    Xin Wen Zhou
    Karolinska Institutet, Department of Neurotec, Geriatric lab, Novum Plan 5, S 14157, Huddinge, Sweden
    Neurobiol Dis 22:657-68. 2006
  10. ncbi Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Huddinge, Sweden
    J Neurochem 92:1104-15. 2005

Collaborators

Detail Information

Publications26

  1. pmc Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
    Am J Pathol 163:591-607. 2003
    ..A p70 S6 kinase modulated up-regulation of tau translation might contribute to PHF-tau accumulation in neurons with neurofibrillary changes...
  2. ncbi Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproduction
    Xin Wen Zhou
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society NVS, KI Alzheimer s Disease Research Center, Geriatrics lab, Novum, Huddinge, Sweden
    FEBS Lett 582:159-64. 2008
    ..Our results suggest that the Abeta deposition in senile plaques in Alzheimer disease brains might be a primary event that activates p70S6K and phosphorylates tau at S262, resulting in microtubule disruption...
  3. ncbi Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration
    Jin Jing Pei
    Karolinska Institutet, Neurotec, Section of Experimental Geriatrics, KFC Plan 4, Novum, 141 86 Huddinge, Sweden
    Acta Neuropathol 104:369-76. 2002
    ....
  4. ncbi P70 S6 kinase mediates tau phosphorylation and synthesis
    Jin Jing Pei
    Department of Neurotec, Division of Experimental Geriatrics, Karolinska Institutet, KFC Novum, Plan 4, SE 141 86, Huddinge, Sweden
    FEBS Lett 580:107-14. 2006
    ..These suggested that p70S6K might contribute to tau related pathologies in AD brains...
  5. ncbi Role of protein kinase B in Alzheimer's neurofibrillary pathology
    Jin Jing Pei
    Neurotec, Section for Experimental Geriatrics, Novum, Karolinska Institutet, KFC Plan 4, 141 86 Huddinge, Sweden
    Acta Neuropathol 105:381-92. 2003
    ..These studies suggest the involvement of PKB/GSK-3 signaling in Alzheimer neurofibrillary degeneration...
  6. ncbi p70 S6 kinase and tau in Alzheimer's disease
    Jin Jing Pei
    Karolinska Institutet, KI Alzheimer Disease Research Center, Novum, Huddinge, Sweden
    J Alzheimers Dis 14:385-92. 2008
    ..This process provides the opportunity for the newly synthesized tau to be phosphorylated by p70S6K and by other tau kinases. This hyperphosphorylated tau then aggregates and is progressively deposited in neurons...
  7. ncbi Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease
    Jin Jing Pei
    Karolinska Institutet, Neurotec, Division of Experimental Geriatrics, Novum, KFC Plan 4, Novum, S 141 86, Huddinge, Sweden
    Brain Res Mol Brain Res 109:45-55. 2002
    ..These data provide direct in situ evidence consistent with the possible involvement of MAP kinase pathway in the hyperphosphorylation of tau and the presence of this lesion before deposition of beta-amyloid in AD...
  8. ncbi Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2
    Wen Lin An
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
    Brain Res Mol Brain Res 135:40-7. 2005
    ..These results indicate that a zinc-induced anti-apoptotic response in SH-SY5Y cells likely occurs through ERK1/2...
  9. ncbi Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
    Xin Wen Zhou
    Karolinska Institutet, Department of Neurotec, Geriatric lab, Novum Plan 5, S 14157, Huddinge, Sweden
    Neurobiol Dis 22:657-68. 2006
    ..Assessments of levels of these abnormal proteins by dot blots may serve as a useful complement to the morphological evaluations in diagnosis of AD...
  10. ncbi Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Huddinge, Sweden
    J Neurochem 92:1104-15. 2005
    ..Thus, 100 microM zinc might activate PKB, GSK-3beta, ERK1/2, JNK, p38 and p70S6K, that are consequently involved in tau changes in SH-SY5Y cells...
  11. pmc Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease
    Jin Jing Pei
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Huddinge, Sweden
    Am J Pathol 163:845-58. 2003
    ....
  12. ncbi Small heat shock proteins Hsp27 or alphaB-crystallin and the protein components of neurofibrillary tangles: tau and neurofilaments
    Cecilia Bjorkdahl
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI Alzheimer s Disease Research Center, Novum, Huddinge, Sweden
    J Neurosci Res 86:1343-52. 2008
    ..Furthermore, Hsp27 might also be involved in AD pathology by aggravating MT disruption by tau phosphorylation...
  13. ncbi Zinc induces neurofilament phosphorylation independent of p70 S6 kinase in N2a cells
    Cecilia Bjorkdahl
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, S 141 86 Huddinge, Sweden
    Neuroreport 16:591-5. 2005
    ..Although zinc could induce cell proliferation and cell growth, and increased phosphorylation of neurofilaments, only cell growth appeared to be related to p7056kinase activation...
  14. doi Interactions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cells
    Xin Wen Zhou
    Karolinska Institutet, KI Alzheimer Disease Research Center KI ADRC, Novum, Huddinge, Sweden
    J Alzheimers Dis 17:929-37. 2009
    ..The final phosphorylation state of tau is possibly caused by the synergic action of the three enzymes...
  15. pmc Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease
    Zhi Tang
    KI Alzheimer Disease Research Center, Karolinska Institutet, Novum, SE 14186 Stockholm, Sweden
    J Biol Chem 288:15556-70. 2013
    ..These results implicate mTor in promoting an imbalance of tau homeostasis, a condition required for neurons to maintain physiological function...
  16. ncbi Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
    Xin Wen Zhou
    Karolinska Institutet, KI Alzheimer Disease Research Center KI ADRC, Novum, Huddinge, Sweden
    Neurobiol Dis 31:386-94. 2008
    ....
  17. ncbi PTEN levels in Alzheimer's disease medial temporal cortex
    Annika Rickle
    Karolinska Institutet Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Department of Neurotec, Division of Experimental Geriatrics, Neurotec, Novum Plan 5, S141 57 Huddinge, Sweden
    Neurochem Int 48:114-23. 2006
    ..The Alzheimer's disease cases had significantly lower numbers of total ( approximately 12% loss, P<0.02) and PTEN immunopositive ( approximately 15% loss, P<0.01) pyramidal neurons as compared to the control cases...
  18. ncbi Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain
    Xu Li
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, KFC Plan 4, Novum, S 141 86 Huddinge, Sweden
    Neuroreport 15:2237-40. 2004
    ..Level of eIF4E phosphorylation is significantly correlated with total- and Alzheimer hyperphosphorylated taus. These data suggest that the increase of eIF4E phosphorylation is involved in formation of Alzheimer neurofibrillary changes...
  19. doi Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets
    Jin Jing Pei
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, KI ADRC, Novum, Stockholm, Sweden
    Curr Opin Psychiatry 21:555-61. 2008
    ....
  20. doi Interplay between glycogen synthase kinase-3β and tau in the cerebellum of Hsp27 transgenic mouse
    Shan Wang
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI Alzheimer s Disease Research Center, Novum, Huddinge, Sweden
    J Neurosci Res 89:1267-75. 2011
    ..This suggests that the increased tau phosphorylation at S396/404 and S262 sites may be induced by Hsp27 through enhancement of GSK3β activity in the mouse cerebellum...
  21. ncbi Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain
    Xu Li
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
    FEBS J 272:4211-20. 2005
    ....
  22. ncbi Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays
    Khalid Iqbal
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
    J Mol Neurosci 20:425-9. 2003
    ..Development of high-throughput screening assays for potential drugs aimed at these therapeutic targets is currently under way...
  23. ncbi Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms
    Rong Liu
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 94:1225-34. 2005
    ..These data suggest that acute anoxia induces tau dephosphorylation, and that PP-2A may play a key role in tau dephosphorylation induced by acute anoxia...
  24. ncbi Effect of amyloid precursor protein 17mer peptide on microtubule structure and tau protein hyperphosphorylation in hippocampal neurons of experimental diabetic mice
    Yong Mei Zhao
    Beijing Research Laboratory or Brain Aging, Xuan Wu Hosptial, Capital University of Medical Sciences, China
    Neuroreport 14:61-6. 2003
    ..Amyloid precursor protein 17mer peptide acted as a neuroprotective agent that globally alleviates the disturbances due to impaired energy metabolism in diabetic mice...
  25. ncbi Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314 6399, USA
    J Mol Neurosci 19:95-9. 2002
    ....
  26. ncbi Decreased nicotinic receptors and cognitive deficit in rats intracerebroventricularly injected with beta-amyloid peptide(1-42) and fed a high-cholesterol diet
    Ru yu Liu
    Department of Pathology, Guiyang Medical University, Guizhou, People s Republic of China
    J Neurosci Res 86:183-93. 2008
    ..These findings may be highly relevant to the mechanisms underlying the cognitive deficits associated with AD...