Jin Jing Pei

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint mTOR-dependent signalling in Alzheimer's disease
    Jin Jing Pei
    Karolinska Institute, Department of Neurobiology, Care Sciences and Society, KI ADRC, Stockholm, Sweden
    J Cell Mol Med 12:2525-32. 2008
  2. doi request reprint Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets
    Jin Jing Pei
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, KI ADRC, Novum, Stockholm, Sweden
    Curr Opin Psychiatry 21:555-61. 2008
  3. ncbi request reprint Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2
    Wen Lin An
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
    Brain Res Mol Brain Res 135:40-7. 2005
  4. ncbi request reprint Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Huddinge, Sweden
    J Neurochem 92:1104-15. 2005
  5. ncbi request reprint Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
    Xin Wen Zhou
    Karolinska Institutet, Department of Neurotec, Geriatric lab, Novum Plan 5, S 14157, Huddinge, Sweden
    Neurobiol Dis 22:657-68. 2006
  6. pmc Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease
    Jin Jing Pei
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Huddinge, Sweden
    Am J Pathol 163:845-58. 2003
  7. ncbi request reprint Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease
    Jin Jing Pei
    Karolinska Institutet, Neurotec, Division of Experimental Geriatrics, Novum, KFC Plan 4, Novum, S 141 86, Huddinge, Sweden
    Brain Res Mol Brain Res 109:45-55. 2002
  8. ncbi request reprint Zinc induces neurofilament phosphorylation independent of p70 S6 kinase in N2a cells
    Cecilia Bjorkdahl
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, S 141 86 Huddinge, Sweden
    Neuroreport 16:591-5. 2005
  9. pmc Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
    Am J Pathol 163:591-607. 2003
  10. doi request reprint Interactions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cells
    Xin Wen Zhou
    Karolinska Institutet, KI Alzheimer Disease Research Center KI ADRC, Novum, Huddinge, Sweden
    J Alzheimers Dis 17:929-37. 2009

Collaborators

Detail Information

Publications22

  1. doi request reprint mTOR-dependent signalling in Alzheimer's disease
    Jin Jing Pei
    Karolinska Institute, Department of Neurobiology, Care Sciences and Society, KI ADRC, Stockholm, Sweden
    J Cell Mol Med 12:2525-32. 2008
    ....
  2. doi request reprint Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets
    Jin Jing Pei
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, KI ADRC, Novum, Stockholm, Sweden
    Curr Opin Psychiatry 21:555-61. 2008
    ....
  3. ncbi request reprint Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2
    Wen Lin An
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
    Brain Res Mol Brain Res 135:40-7. 2005
    ..These results indicate that a zinc-induced anti-apoptotic response in SH-SY5Y cells likely occurs through ERK1/2...
  4. ncbi request reprint Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Huddinge, Sweden
    J Neurochem 92:1104-15. 2005
    ..Thus, 100 microM zinc might activate PKB, GSK-3beta, ERK1/2, JNK, p38 and p70S6K, that are consequently involved in tau changes in SH-SY5Y cells...
  5. ncbi request reprint Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
    Xin Wen Zhou
    Karolinska Institutet, Department of Neurotec, Geriatric lab, Novum Plan 5, S 14157, Huddinge, Sweden
    Neurobiol Dis 22:657-68. 2006
    ..Assessments of levels of these abnormal proteins by dot blots may serve as a useful complement to the morphological evaluations in diagnosis of AD...
  6. pmc Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease
    Jin Jing Pei
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Huddinge, Sweden
    Am J Pathol 163:845-58. 2003
    ....
  7. ncbi request reprint Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease
    Jin Jing Pei
    Karolinska Institutet, Neurotec, Division of Experimental Geriatrics, Novum, KFC Plan 4, Novum, S 141 86, Huddinge, Sweden
    Brain Res Mol Brain Res 109:45-55. 2002
    ..These data provide direct in situ evidence consistent with the possible involvement of MAP kinase pathway in the hyperphosphorylation of tau and the presence of this lesion before deposition of beta-amyloid in AD...
  8. ncbi request reprint Zinc induces neurofilament phosphorylation independent of p70 S6 kinase in N2a cells
    Cecilia Bjorkdahl
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, S 141 86 Huddinge, Sweden
    Neuroreport 16:591-5. 2005
    ..Although zinc could induce cell proliferation and cell growth, and increased phosphorylation of neurofilaments, only cell growth appeared to be related to p7056kinase activation...
  9. pmc Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
    Am J Pathol 163:591-607. 2003
    ..A p70 S6 kinase modulated up-regulation of tau translation might contribute to PHF-tau accumulation in neurons with neurofibrillary changes...
  10. doi request reprint Interactions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cells
    Xin Wen Zhou
    Karolinska Institutet, KI Alzheimer Disease Research Center KI ADRC, Novum, Huddinge, Sweden
    J Alzheimers Dis 17:929-37. 2009
    ..The final phosphorylation state of tau is possibly caused by the synergic action of the three enzymes...
  11. ncbi request reprint Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration
    Jin Jing Pei
    Karolinska Institutet, Neurotec, Section of Experimental Geriatrics, KFC Plan 4, Novum, 141 86 Huddinge, Sweden
    Acta Neuropathol 104:369-76. 2002
    ....
  12. pmc Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease
    Zhi Tang
    KI Alzheimer Disease Research Center, Karolinska Institutet, Novum, SE 14186 Stockholm, Sweden
    J Biol Chem 288:15556-70. 2013
    ..These results implicate mTor in promoting an imbalance of tau homeostasis, a condition required for neurons to maintain physiological function...
  13. ncbi request reprint Role of protein kinase B in Alzheimer's neurofibrillary pathology
    Jin Jing Pei
    Neurotec, Section for Experimental Geriatrics, Novum, Karolinska Institutet, KFC Plan 4, 141 86 Huddinge, Sweden
    Acta Neuropathol 105:381-92. 2003
    ..These studies suggest the involvement of PKB/GSK-3 signaling in Alzheimer neurofibrillary degeneration...
  14. ncbi request reprint P70 S6 kinase mediates tau phosphorylation and synthesis
    Jin Jing Pei
    Department of Neurotec, Division of Experimental Geriatrics, Karolinska Institutet, KFC Novum, Plan 4, SE 141 86, Huddinge, Sweden
    FEBS Lett 580:107-14. 2006
    ..These suggested that p70S6K might contribute to tau related pathologies in AD brains...
  15. ncbi request reprint Small heat shock proteins Hsp27 or alphaB-crystallin and the protein components of neurofibrillary tangles: tau and neurofilaments
    Cecilia Bjorkdahl
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI Alzheimer s Disease Research Center, Novum, Huddinge, Sweden
    J Neurosci Res 86:1343-52. 2008
    ..Furthermore, Hsp27 might also be involved in AD pathology by aggravating MT disruption by tau phosphorylation...
  16. ncbi request reprint Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproduction
    Xin Wen Zhou
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society NVS, KI Alzheimer s Disease Research Center, Geriatrics lab, Novum, Huddinge, Sweden
    FEBS Lett 582:159-64. 2008
    ..Our results suggest that the Abeta deposition in senile plaques in Alzheimer disease brains might be a primary event that activates p70S6K and phosphorylates tau at S262, resulting in microtubule disruption...
  17. ncbi request reprint Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain
    Xu Li
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, KFC Plan 4, Novum, S 141 86 Huddinge, Sweden
    Neuroreport 15:2237-40. 2004
    ..Level of eIF4E phosphorylation is significantly correlated with total- and Alzheimer hyperphosphorylated taus. These data suggest that the increase of eIF4E phosphorylation is involved in formation of Alzheimer neurofibrillary changes...
  18. doi request reprint Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells
    Erika Bereczki
    Department of Neurobiology, Care Sciences and Society, KI Alzheimer Disease Research Center KI ADRC Karolinska Institutet, Stockholm, Sweden
    Nanomedicine 7:560-71. 2011
    ..We also detected rescue of the imbalance of GSK-3β and PP2A activity, and reduction in tau phosphorylation. Thus, these liposomes appear particularly suitable for implementing further therapeutic strategies for AD...
  19. ncbi request reprint p70 S6 kinase and tau in Alzheimer's disease
    Jin Jing Pei
    Karolinska Institutet, KI Alzheimer Disease Research Center, Novum, Huddinge, Sweden
    J Alzheimers Dis 14:385-92. 2008
    ..This process provides the opportunity for the newly synthesized tau to be phosphorylated by p70S6K and by other tau kinases. This hyperphosphorylated tau then aggregates and is progressively deposited in neurons...
  20. ncbi request reprint Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain
    Xu Li
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
    FEBS J 272:4211-20. 2005
    ....
  21. doi request reprint Interplay between glycogen synthase kinase-3β and tau in the cerebellum of Hsp27 transgenic mouse
    Shan Wang
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI Alzheimer s Disease Research Center, Novum, Huddinge, Sweden
    J Neurosci Res 89:1267-75. 2011
    ..This suggests that the increased tau phosphorylation at S396/404 and S262 sites may be induced by Hsp27 through enhancement of GSK3β activity in the mouse cerebellum...
  22. ncbi request reprint Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
    Xin Wen Zhou
    Karolinska Institutet, KI Alzheimer Disease Research Center KI ADRC, Novum, Huddinge, Sweden
    Neurobiol Dis 31:386-94. 2008
    ....