Nancy Pedersen

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint The Swedish Twin Registry in the third millennium
    Nancy L Pedersen
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Twin Res 5:427-32. 2002
  2. ncbi request reprint The influence of mortality on twin models of change: addressing missingness through multiple imputation
    Nancy L Pedersen
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Behav Genet 33:161-9. 2003
  3. ncbi request reprint Multiple-threshold models for genetic influences on age of onset for Alzheimer disease: findings in Swedish twins
    N L Pedersen
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Am J Med Genet 105:724-8. 2001
  4. ncbi request reprint No evidence for heritability of Parkinson disease in Swedish twins
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurology 63:305-11. 2004
  5. ncbi request reprint Risk and protective factors for Parkinson's disease: a study in Swedish twins
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 181 77 Stockholm, Sweden
    Ann Neurol 57:27-33. 2005
  6. pmc Accounting for the relationship between low education and dementia: a twin study
    Margaret Gatz
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    Physiol Behav 92:232-7. 2007
  7. ncbi request reprint Obesity and hormone-dependent tumors: cohort and co-twin control studies based on the Swedish Twin Registry
    Fredrik Jonsson
    Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 106:594-9. 2003
  8. ncbi request reprint Asthma, eczema, rhinitis and the risk for dementia
    Ulrika K Eriksson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 25:148-56. 2008
  9. pmc Lifestyle factors and risk for symptomatic gastroesophageal reflux in monozygotic twins
    Zongli Zheng
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels vag 12a, SE 171 77 Stockholm, Sweden
    Gastroenterology 132:87-95. 2007
  10. pmc Genetic and environmental influence on lung function impairment in Swedish twins
    Jenny Hallberg
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Respir Res 11:92. 2010

Detail Information

Publications91

  1. ncbi request reprint The Swedish Twin Registry in the third millennium
    Nancy L Pedersen
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Twin Res 5:427-32. 2002
    ....
  2. ncbi request reprint The influence of mortality on twin models of change: addressing missingness through multiple imputation
    Nancy L Pedersen
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Behav Genet 33:161-9. 2003
    ..Results indicated that twin similarity for slopes decreases when mortality is accounted for, but that considerable age-related covariation remains...
  3. ncbi request reprint Multiple-threshold models for genetic influences on age of onset for Alzheimer disease: findings in Swedish twins
    N L Pedersen
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Am J Med Genet 105:724-8. 2001
    ..We interpret the findings to suggest that models with free thresholds confound influences on longevity with influences for the disease. Multiple-threshold models, however, do not confound age effects with shared environmental influences...
  4. ncbi request reprint No evidence for heritability of Parkinson disease in Swedish twins
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurology 63:305-11. 2004
    ..Although several genes are implicated in Parkinson disease (PD), they explain only a small fraction of cases. The etiology of most cases is yet unknown...
  5. ncbi request reprint Risk and protective factors for Parkinson's disease: a study in Swedish twins
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 181 77 Stockholm, Sweden
    Ann Neurol 57:27-33. 2005
    ..We confirm the protective effect of smoking on Parkinson's disease and establish that the association is only partially explained by genetic and familial environmental factors...
  6. pmc Accounting for the relationship between low education and dementia: a twin study
    Margaret Gatz
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    Physiol Behav 92:232-7. 2007
    ..Low education is confirmed as a risk factor for dementia. Findings from three different analytic approaches showed that genetic influences did not explain this association...
  7. ncbi request reprint Obesity and hormone-dependent tumors: cohort and co-twin control studies based on the Swedish Twin Registry
    Fredrik Jonsson
    Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 106:594-9. 2003
    ..78). No association was found for prostate cancer. We conclude that age is an important effect modifier of cancer risk associated with obesity and that obesity and overweight in young adult life may affect cancer risk also later in life...
  8. ncbi request reprint Asthma, eczema, rhinitis and the risk for dementia
    Ulrika K Eriksson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 25:148-56. 2008
    ..Inflammation is associated with Alzheimer's disease (AD) and dementia. In light of the chronic inflammatory properties of the atopic disorders asthma, eczema and rhinitis, we hypothesized an association with dementia...
  9. pmc Lifestyle factors and risk for symptomatic gastroesophageal reflux in monozygotic twins
    Zongli Zheng
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels vag 12a, SE 171 77 Stockholm, Sweden
    Gastroenterology 132:87-95. 2007
    ..We investigated associations between lifestyle factors and gastroesophageal reflux (GER) symptoms, with and without controlling for genetic predisposition...
  10. pmc Genetic and environmental influence on lung function impairment in Swedish twins
    Jenny Hallberg
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Respir Res 11:92. 2010
    ..Therefore, the objective was to evaluate heritability for different aspects of lung function, and to investigate how the estimates are affected by adjustments for smoking and respiratory symptoms...
  11. ncbi request reprint Data modeling and data communication in GenomEUtwin
    Jan Eric Litton
    Department of Medical Epidemiology and Biostatistics, Karolinska Insitutet, Stockholm, Sweden
    Twin Res 6:383-90. 2003
    ..In the following we describe the preliminary strategy being implemented in the Database Core of GenomEUtwin...
  12. doi request reprint Genetic susceptibility of myocardial infarction
    Slobodan Zdravkovic
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Twin Res Hum Genet 10:848-52. 2007
    ..In conclusion, liability to first occurrence of acute myocardial infarction is moderately influenced by genetic variants in both sexes. The familial influence on phenotypic variance is exclusively explained by additive genetic factors...
  13. ncbi request reprint Sensitivity and specificity of dementia coding in two Swedish disease registries
    Ya Ping Jin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Neurology 63:739-41. 2004
    ..Specificity was 98% for the Inpatient Discharge Registry and 100% for the Cause of Death Registry...
  14. pmc Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: Swedish population based cohort study
    Per Hall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, PO Box 281, SE 171 77 Stockholm, Sweden
    BMJ 328:19. 2004
    ..To determine whether exposure to low doses of ionising radiation in infancy affects cognitive function in adulthood...
  15. ncbi request reprint How heritable is Alzheimer's disease late in life? Findings from Swedish twins
    Nancy L Pedersen
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Ann Neurol 55:180-5. 2004
    ..Although these genetic estimates for incident disease are lower than those for prevalent disease, the importance of genetic factors for liability to Alzheimer's disease is considerable even late in life...
  16. ncbi request reprint Accounting for depressive symptoms in women: a twin study of associations with interpersonal relationships
    Erica L Spotts
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    J Affect Disord 82:101-11. 2004
    ..This study examined how interpersonal relationships, specifically marital quality and adequacy of social support, are associated with depressive symptoms among women...
  17. ncbi request reprint Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease
    Mia E L Blomqvist
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Neurogenetics 5:115-9. 2004
    ..Results were consistent between AD and PD, suggesting the presence of equivalent detrimental and protective alleles. These data highlight a genomic region in the proximity of IDE that may contribute to AD and PD in a similar manner...
  18. doi request reprint Genome-wide search for QTLs for apolipoprotein A-I level in elderly Swedish DZ twins: evidence of female-specific locus on 15q11-13
    Patrik K E Magnusson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Eur J Hum Genet 16:1103-10. 2008
    ....
  19. ncbi request reprint Remembered parental bonding in adult twins: genetic and environmental influences
    Paul Lichtenstein
    Department of Medical Epidemiology, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    Behav Genet 33:397-408. 2003
    ..However, other explanations such as personality characteristics influencing how experiences with parents are interpreted or circumstances in adult life that affect the recall of experiences could not be ruled out...
  20. ncbi request reprint Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system
    Anastasia Iliadou
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Hypertens 20:1543-50. 2002
    ..However, many studies have not been able to replicate findings of association between specific polymorphisms and diastolic and systolic blood pressure...
  21. ncbi request reprint The Swedish Twin Registry in the third millennium: an update
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Twin Res Hum Genet 9:875-82. 2006
    ..In particular, we describe recent efforts to screen all twins born between 1959 and 1985, and young twin pairs when they turn 9 and 12 years of age. For these studies, we present initial frequencies of common conditions and exposures...
  22. ncbi request reprint Occupational magnetic field exposure and neurodegenerative disease
    Maria Feychting
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 14:413-9; discussion 427-8. 2003
    ..Several studies have identified occupational exposure to extremely low-frequency electromagnetic fields (EMF) as a potential risk factor for neurodegenerative disease, but the evidence is contradictory and inconclusive...
  23. ncbi request reprint Genetic and shared environmental factors do not confound the association between birth weight and hypertension: a study among Swedish twins
    Niklas Bergvall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE 171 77 Stockholm, Sweden
    Circulation 115:2931-8. 2007
    ..Studies have found associations between low birth weight and increased risks of cardiovascular diseases in adulthood. However, these associations could be due to confounding by genetic or socioeconomic factors...
  24. ncbi request reprint Shared rearing environment in migraine: results from twins reared apart and twins reared together
    Dan A Svensson
    Division of Neurology, Neurotec Department, Karolinska Institutet, Stockholm, Sweden
    Headache 43:235-44. 2003
    ..Studies of twins who are separated from each other early in life and are reared in different environments offer the opportunity to resolve variation in liability to disease...
  25. ncbi request reprint No linkage to obesity in candidate regions of chromosome 2 and 10 in a selected sample of Swedish twins
    Anastasia Iliadou
    Department of Medical Epidemiology, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden
    Twin Res 6:162-9. 2003
    ..However, the results were sensitive to issues related to power, minor effects of the genes, ethnic differences and the complex mechanism underlying obesity...
  26. pmc Complete ascertainment of Parkinson disease in the Swedish Twin Registry
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 29:1765-73. 2008
    ..Overall prevalence rate for PD was 496 per 100,000 individuals. Among the 132 PD cases identified, there were only three concordant twin pairs. In total 7.2% of PD cases reported a first degree relative with PD...
  27. ncbi request reprint Self-rated health in a longitudinal perspective: a 9-year follow-up twin study
    Pia Svedberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
    J Gerontol B Psychol Sci Soc Sci 60:S331-S340. 2005
    ..This study first considers age and cohort explanations for age-related changes in mean values and variance in self-rated health. Second, it evaluates the contributions of genes and environments to self-rated health measured longitudinally...
  28. ncbi request reprint Premorbid predictors of chronic fatigue
    Kenji Kato
    Department of Medical Epidemiology and Biostatistics, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Arch Gen Psychiatry 63:1267-72. 2006
    ..Moreover, subjects with chronic fatiguing illness may have distinctive personality traits, although this finding could reflect confounding by other mechanisms...
  29. ncbi request reprint Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism
    Hagit Katzov
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Hum Mutat 23:358-67. 2004
    ..Results indicate that variants of ABCA1 may affect the risk of AD, providing further support for a genetic link between AD and cholesterol metabolism...
  30. ncbi request reprint A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity
    Hagit Katzov
    Center for Genomics and Bioinformatics, Karolinska Institute, Berzelius väg 35 171 77, Stockholm, Sweden
    Hum Mol Genet 13:2647-57. 2004
    ....
  31. doi request reprint Risk of urinary incontinence symptoms in oral contraceptive users: a national cohort study from the Swedish Twin Register
    Anastasia Iliadou
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Fertil Steril 92:428-33. 2009
    ..To assess the impact of oral contraceptives on lower urinary tract dysfunction in premenopausal women...
  32. doi request reprint Genetic dominance influences blood biomarker levels in a sample of 12,000 Swedish elderly twins
    Iffat Rahman
    1 Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Twin Res Hum Genet 12:286-94. 2009
    ..The study highlights the importance of acknowledging nonadditive genes underlying the risk of developing cardiovascular diseases...
  33. ncbi request reprint Sex differences in genetic risk for dementia
    Margaret Gatz
    University of Southern California, Los Angeles, California, USA Karolinska Institutet, Stockholm, Sweden
    Behav Genet 33:95-105. 2003
    ..We conclude that women are not at higher risk of developing dementia, but there is a hint that different genetic processes may be involved for women than for men...
  34. ncbi request reprint A prospective study of health, life-style and psychosocial predictors of self-rated health
    Pia Svedberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Eur J Epidemiol 21:767-76. 2006
    ..Genetic and familial factors are of importance only for some of these associations...
  35. ncbi request reprint Likelihood ratio tests in behavioral genetics: problems and solutions
    Annica Dominicus
    Department of Mathematics, Stockholm University, Stockholm, Sweden
    Behav Genet 36:331-40. 2006
    ..Similar results for tests of the AE, DE and E models against the ADE model are also derived. Failing to use the appropriate reference distribution can lead to invalid conclusions...
  36. pmc Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study
    Weili Xu
    Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Diabetes 58:71-7. 2009
    ..We aimed to verify the association between diabetes and the risk of dementia, Alzheimer's disease, and vascular dementia in twins and to explore whether genetic and early-life environmental factors could contribute to this association...
  37. pmc Postmenopausal hormone therapy as a risk factor for gastroesophageal reflux symptoms among female twins
    Helena Nordenstedt
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 134:921-8. 2008
    ..We investigated the relationship of oral contraceptives and postmenopausal hormone therapy (HT) to risk of reflux symptoms, controlling for genetic factors and body mass...
  38. ncbi request reprint Bias in variance components due to nonresponse in twin studies
    Annica Dominicus
    Department of Mathematics, Stockholm University, Stockholm, Sweden
    Twin Res Hum Genet 9:185-93. 2006
    ....
  39. ncbi request reprint Genetic and environmental influences on expression of recurrent headache as a function of the reporting age in twins
    Dan A Svensson
    Division of Neurology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Twin Res 5:277-86. 2002
    ..While total variance showed a positive age trend, genetic variance tended to be stable across age groups, whereas individual specific environmental variance was significantly lower in adolescent women as compared to older women...
  40. ncbi request reprint The association between low birth weight and type 2 diabetes: contribution of genetic factors
    Stefan Johansson
    Departments of Medical Epidemiology, and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 19:659-65. 2008
    ..Poor fetal nutrition has been suggested to explain this association. Our objective was to determine whether genetic factors contribute to the association between low birth weight and subsequent risk of type 2 diabetes...
  41. ncbi request reprint Genetic influences on CHD-death and the impact of known risk factors: comparison of two frailty models
    Slobodan Zdravkovic
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Behav Genet 34:585-92. 2004
    ..Although the outcome phenotype used in the present study is not behavioral, the analyses demonstrate the potential of frailty models for quantitative genetic analyses of categorical phenotypes...
  42. ncbi request reprint Lifetime prevalence and concordance risk of cluster headache in the Swedish twin population
    Karl Ekbom
    Department of Neurology, Karolinska Institutet, Stockholm, Sweden
    Neurology 67:798-803. 2006
    ..To examine the lifetime prevalence and the concordance risk of cluster headache (CH) in a twin sample representative of the Swedish general population...
  43. pmc Risk prediction measures for case-cohort and nested case-control designs: an application to cardiovascular disease
    Andrea Ganna
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Am J Epidemiol 175:715-24. 2012
    ....
  44. ncbi request reprint Genetic influences on angina pectoris and its impact on coronary heart disease
    Slobodan Zdravkovic
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Eur J Hum Genet 15:872-7. 2007
    ..In conclusion, our data imply genetic influences for AP and CHD death among both sexes and that AP is important as a risk factor for CHD death in both males and females, due in part to shared genetic pathways...
  45. ncbi request reprint Telomere length predicts survival independent of genetic influences
    Stephanie L Bakaysa
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Aging Cell 6:769-74. 2007
    ..Twins with the shortest telomeres had a three times greater risk of death during the follow-up period than their co-twins with the longest telomere measurements [hazard ratio (RR) = 2.8, 95% confidence interval 1.1-7.3, P = 0.03]...
  46. doi request reprint Genetic and environmental mediation of the associations between self-rated health and cognitive abilities
    Pia Svedberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Exp Aging Res 35:178-201. 2009
    ..In the oldest age group (>or=67 years), associations between self-rated health and spatial reasoning, perceptual speed, and visual memory were entirely due to genetic factors...
  47. ncbi request reprint The epidemiology of chronic fatigue in the Swedish Twin Registry
    Birgitta Evengard
    Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Psychol Med 35:1317-26. 2005
    ..Chronic fatigue syndrome (CFS) remains an idiopathic and controversial entity...
  48. ncbi request reprint Personality and coping: a study of twins reared apart and twins reared together
    Kenji Kato
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Behav Genet 35:147-58. 2005
    ..Multivariate model fitting indicated that genetic influences on adults' coping differentially reflect genetic factors in common with personality traits. The sources of covariation also showed significant gender differences...
  49. pmc Evidence that the gene encoding insulin degrading enzyme influences human lifespan
    Mun Gwan Hong
    Department of Medical Epidemiology and Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Hum Mol Genet 17:2370-8. 2008
    ....
  50. pmc Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans
    Hasse Walum
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:14153-6. 2008
    ..These results suggest an association between a single gene and pair-bonding behavior in humans, and indicate that the well characterized influence of AVP on pair-bonding in voles may be of relevance also for humans...
  51. doi request reprint No evidence of sex differences in heritability of irritable bowel syndrome in Swedish twins
    Pia Svedberg
    Section of Personal Injury Prevention, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Twin Res Hum Genet 11:197-203. 2008
    ..We found no evidence for sex differences in heritability in any of the age groups, however, models allowing prevalences of irritable bowel syndrome to differ between sexes and age groups fitted best...
  52. ncbi request reprint Chronic widespread pain and its comorbidities: a population-based study
    Kenji Kato
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Arch Intern Med 166:1649-54. 2006
    ..Few studies have examined the comorbidities of CWP in the general population. Furthermore, little is known about the importance of familial (genetic and family environmental) factors in the etiology of co-occurrence...
  53. ncbi request reprint Importance of genetic influences on chronic widespread pain
    Kenji Kato
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 54:1682-6. 2006
    ..To estimate the relative importance of genetic and environmental factors in chronic widespread pain, and to assess whether there are sex differences in the type or magnitude of these influences...
  54. doi request reprint Association between CYP2C19 polymorphism and depressive symptoms
    Sarah C Sim
    Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Am J Med Genet B Neuropsychiatr Genet 153:1160-6. 2010
    ..0001). Our results suggest for the first time that the CYP2C19 polymorphism might be of importance for depressive symptoms, as here shown for older European adults...
  55. pmc MAOA haplotypes associated with thrombocyte-MAO activity
    Marten Jansson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Genet 6:46. 2005
    ..3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals)...
  56. doi request reprint Low levels of antibodies against phosphorylcholine in Alzheimer's disease
    Ulrika K Eriksson
    Deparment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden
    J Alzheimers Dis 21:577-84. 2010
    ..Further attention is merited to elucidate the role of anti-PC in AD development and the usefulness of anti-PC as a part of risk prediction, prognosis, diagnosis, or treatment...
  57. ncbi request reprint Twin pair resemblance for psychiatric hospitalization in the Swedish Twin Registry: a 32-year follow-up study of 29,602 twin pairs
    Carol A Prescott
    Department of Psychology, University of Southern California, 3620 S McClintock Ave, SGM 501, Los Angeles, CA 90089 1061, USA
    Behav Genet 37:547-58. 2007
    ..The present report updates the prior results by using 17 additional years of follow-up, including members of opposite-sex twin pairs, and addressing biases arising from cohort effects and from excluding pairs with unknown zygosity...
  58. ncbi request reprint Irritable bowel syndrome: a co-twin control analysis
    Mary K Wojczynski
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Gastroenterol 102:2220-9. 2007
    ..Therefore, we aimed to examine if there is a genetic component to the co-occurrence of MDD and IBS in participants from the population-based Swedish Twin Registry...
  59. pmc Interaction between smoking and genetic factors in the development of chronic bronchitis
    Jenny Hallberg
    Department of Occupational and Environmental Health, Norrbacka, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 177:486-90. 2008
    ....
  60. ncbi request reprint Gastroesophageal reflux disease in monozygotic and dizygotic twins
    Alan J Cameron
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 122:55-9. 2002
    ..Gastroesophageal reflux disease (GERD) interferes with the quality of life and carries an increased risk for esophageal adenocarcinoma. We investigated genetic influence in the development of reflux...
  61. ncbi request reprint Age changes in processing speed as a leading indicator of cognitive aging
    Deborah Finkel
    Department of Psychology, Indiana University Southeast, 5201 Grant Line Road, New Albany, IN 47150, USA
    Psychol Aging 22:558-68. 2007
    ..The results suggest that, as predicted by the processing speed theory of cognitive aging, processing speed is a leading indicator of age changes in memory and spatial ability, but not verbal ability...
  62. ncbi request reprint Personality and major depression: a Swedish longitudinal, population-based twin study
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 63:1113-20. 2006
    ..Prior studies suggest that the personality traits of neuroticism and extroversion may be related to the liability to major depression (MD)...
  63. ncbi request reprint Personality and risk of cognitive impairment 25 years later
    Michael Crowe
    Department of Psychology, University of Alabama, 35294 2100, USA
    Psychol Aging 21:573-80. 2006
    ..Findings are discussed in the context of theories related to personality, psychological distress, arousal, and cognitive function...
  64. ncbi request reprint Quantitative genetic analysis of latent growth curve models of cognitive abilities in adulthood
    Chandra A Reynolds
    Department of Psychology, University of California, 1344 Olmstead Hall, Riverside, CA 92521, USA
    Dev Psychol 41:3-16. 2005
    ..The present findings provide support for theories of the increasing influence of the environment with age on cognitive abilities...
  65. ncbi request reprint Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Neurobiol Aging 26:439-47. 2005
    ..Among monozygotic twins where both twins had Alzheimer's disease, the within pair difference in age of onset ranged from both becoming demented in the same year to 7 years difference in onset...
  66. ncbi request reprint The genetics of middle-age spread in middle-class males
    James C Romeis
    Health Services Research, Department of Health Management and Policy, School of Public Health, Saint Louis University, St Louis, Missouri 63104, USA
    Twin Res 7:596-602. 2004
    ..The data analysis suggests that treatments and public health interventions need to recognize the magnitude of genetic factors if short-term and long-term interventions are to be effective...
  67. ncbi request reprint Type 2 diabetes mellitus contributes to cognitive decline in old age: a longitudinal population-based study
    Linda B Hassing
    Department of Psychology, Goteborg University, Goteborg, Sweden
    J Int Neuropsychol Soc 10:599-607. 2004
    ..These findings points to the conclusion that type 2 diabetes is associated with accelerated cognitive decline in old age that may result in dementia...
  68. ncbi request reprint The metabolic syndrome mediates the relationship between cynical hostility and cardiovascular disease
    Tracy L Nelson
    Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado 80523, USA
    Exp Aging Res 30:163-77. 2004
    ..Results were adjusted for baseline CVD, smoking, and age. These findings suggest that a clustering of CVD risk factors partially mediate the association between cynicism and CVD in an older population...
  69. ncbi request reprint Birth order, sibship size, and housing density in relation to tooth loss and periodontal disease: a cohort study among Swedish twins
    Lorelei A Mucci
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 159:499-506. 2004
    ..65, 95% CI: 0.48, 0.89). These findings are compatible with the hypotheses that adult oral diseases are associated with the probability of exposure in childhood and that earlier age at exposure lowers risk...
  70. ncbi request reprint Stroke research in GenomEUtwin
    David Gaist
    Danish Twin Registry, University of Southern Denmark, Denmark
    Twin Res 6:442-7. 2003
    ..This information illustrates that the number of affected sib pairs for linkage studies is relatively limited, but the sample sizes are promising for association studies...
  71. ncbi request reprint Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Twin Res 6:322-4. 2003
    ..Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs...
  72. ncbi request reprint Does participation in leisure activities lead to reduced risk of Alzheimer's disease? A prospective study of Swedish twins
    Michael Crowe
    Department of Psychology Leonard Davis School of Gerontology, University of Southern California, Los Angeles 90089 1061, USA
    J Gerontol B Psychol Sci Soc Sci 58:P249-55. 2003
    ..Greater participation in intellectual-cultural activities was associated with lower risk of Alzheimer's disease for women, although not for men...
  73. ncbi request reprint Three-state frailty model for age at onset of dementia and death in Swedish twins
    Samuli Ripatti
    Rolf Nevanlinna Institute, University of Helsinki, Länsisatamankatu 14 B 26, 00180 Helsinki, Finland
    Genet Epidemiol 24:139-49. 2003
    ..More data, however, are needed to gain precision in these estimates...
  74. ncbi request reprint Sources of influence on rate of cognitive change over time in Swedish twins: an application of latent growth models
    Chandra A Reynolds
    Department of Psychology, University of California Riverside, Riverside, California 92521, USA
    Exp Aging Res 28:407-33. 2002
    ..These same forces may overlap with those that influence higher or lower educational attainment or those leading to better or worse pulmonary functioning...
  75. ncbi request reprint Heritabilities of apolipoprotein and lipid levels in three countries
    Marian Beekman
    Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Center, Leiden, The Netherlands
    Twin Res 5:87-97. 2002
    ..Although sample specific effects are present, we have shown that genes play a major role in determining the variance of apolipoprotein and lipid levels in four independent twin samples from three different countries...
  76. ncbi request reprint Endogenous and exogenous hormone exposure and risk of cognitive impairment in Swedish twins: a preliminary study
    Natalie L Rasgon
    Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, 401 Quarry Road, Room 2360, Palo Alto, CA 94305 5723, USA
    Psychoneuroendocrinology 30:558-67. 2005
    ..To analyze the risk of cognitive impairment among female Swedish Twins with regard to endogenous and exogenous hormone exposure...
  77. ncbi request reprint Comparative rating measures of health and environmental exposures: how well do twins agree?
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, Riverside, California 92521, United States of America
    Twin Res Hum Genet 8:113-9. 2005
    ..Comparative ratings appear most accurate for smoking and alcohol use, and less consistent for mental health symptoms and self-rated health...
  78. ncbi request reprint Chronic fatigue in a population sample: definitions and heterogeneity
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
    Psychol Med 35:1337-48. 2005
    ..Numerous nosological decisions are made when moving from the common human symptom of unusual fatigue to the rare chronic fatigue syndrome (CFS). These decisions have infrequently been subjected to rigorous evaluation...
  79. ncbi request reprint Lifestyle risk and delaying factors
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Alzheimer Dis Assoc Disord 20:S84-8. 2006
    ..Such findings point to the importance of taking a life-course perspective to designing interventions to delay or to prevent dementia...
  80. ncbi request reprint Surprising lack of sex differences in normal cognitive aging in twins
    Deborah Finkel
    Indiana University Southeast, New Albany 47150, USA
    Int J Aging Hum Dev 62:335-57. 2006
    ..Despite differential longevity and susceptibility to disease, there are no consistent indications that men and women show different patterns of cognitive aging...
  81. ncbi request reprint Sex differences after all those years? Heritability of cognitive abilities in old age
    Sanna Read
    Institute of Gerontology, School of Health Sciences, PO Box 1026, 551 11 Jönköping, Sweden
    J Gerontol B Psychol Sci Soc Sci 61:P137-43. 2006
    ..We found no sex-specific genetic influences. In other words, the same genetic effects were operating for men and women. Furthermore, the magnitude of genetic effect was similar for men and women...
  82. ncbi request reprint Alcohol, tobacco and caffeine use: spouse similarity processes
    Chandra A Reynolds
    University of California, Riverside, USA
    Behav Genet 36:201-15. 2006
    ..Social homogamy may be more important for some substance use traits such as alcohol consumption and tobacco use status but not others...
  83. ncbi request reprint A twin study of lifetime Generalized Anxiety Disorder (GAD) in older adults: genetic and environmental influences shared by neuroticism and GAD
    Margaret Anne Mackintosh
    Department of Psychology, University of Southern California, Los Angeles, California 90089 1061, USA
    Twin Res Hum Genet 9:30-7. 2006
    ..Analyses of sex effects suggested that men and women differed in the frequency of lifetime GAD and level of neuroticism; however, no sex differences for genetic and environmental influences for either trait were identified...
  84. ncbi request reprint Heritability of an age-dependent categorical phenotype: cognitive dysfunction
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, 92521, USA
    Twin Res Hum Genet 9:17-23. 2006
    ..The findings emphasize the extent to which research is needed to uncover nonfamilial environmental influences on cognitive dysfunction in later life...
  85. ncbi request reprint Prevalence, heritability, and prospective risk factors for anorexia nervosa
    Cynthia M Bulik
    Department of Psychiatry, School of Public Health, University of North Carolina at Chapel Hill, 27599, USA
    Arch Gen Psychiatry 63:305-12. 2006
    ..Anorexia nervosa (AN) is a serious mental illness with marked morbidity and mortality...
  86. ncbi request reprint Role of genes and environments for explaining Alzheimer disease
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    Arch Gen Psychiatry 63:168-74. 2006
    ..Twin studies using selected samples have shown high heritability for Alzheimer disease (AD)...
  87. ncbi request reprint Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes
    Chandra A Reynolds
    Department of Psychology, University of California Riverside, 92521, USA
    Behav Genet 36:185-94. 2006
    ..There were no significant findings for LRP. Dominance, often untested in previous studies, was important in the current study's findings...
  88. ncbi request reprint A Swedish national twin study of lifetime major depression
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:109-14. 2006
    ..It is not known whether genetic effects on major depression are constant across historical cohorts...
  89. ncbi request reprint Longitudinal change in memory performance associated with HTR2A polymorphism
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, 1344 Olmsted Hall, Riverside, CA 92521 0426, USA
    Neurobiol Aging 27:150-4. 2006
    ..These findings imply a role for the 5-HT2A serotonin receptor on the formation of episodic memories in older adults...
  90. ncbi request reprint Age at onset and familial risk for major depression in a Swedish national twin sample
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 35:1573-9. 2005
    ..In many biomedical disorders, early age at onset (AAO) is an index of high liability to illness which is manifest by an increased risk of illness in relatives. Most but not all prior studies report such a pattern for major depression (MD)...
  91. ncbi request reprint Lifestyle factors and pancreatic cancer risk: a cohort study from the Swedish Twin Registry
    Bengt Isaksson
    Int J Cancer 98:480-2. 2002

Research Grants22

  1. A Twin Study of Chronic Fatigue Syndrome in Sweden
    Nancy Pedersen; Fiscal Year: 2003
    ..The current proposal has several unique aims and represents a cost-effective means to extend this work in an epidemiological sample that is arguably the best twin registry in the world. ..
  2. Environmental Factors for Parkinson's in Swedish Twins
    Nancy Pedersen; Fiscal Year: 2004
    ..there interactions between candidate genes and exposures? 5) To what extent is liability to PD influenced by the same latent shared and non-shared environmental influences as dementia and depression, which are often co-morbid with PD? ..
  3. Genetic & Environmental Influences-Biobehavioral Aging
    Nancy Pedersen; Fiscal Year: 2006
    ..abstract_text> ..
  4. Interstitial Cystitis in Swedish Twins
    Nancy Pedersen; Fiscal Year: 2007
    ..abstract_text> ..
  5. GENETIC & ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGING
    Nancy Pedersen; Fiscal Year: 2002
    ..abstract_text> ..
  6. Gene-Environment Interplay of Social Contexts and Aging-Related Outcomes
    Nancy L Pedersen; Fiscal Year: 2010
    ....