Gustavo Paratcha

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream
    Gustavo Paratcha
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S 17 177 Stockholm, Sweden
    Mol Cell Neurosci 31:505-14. 2006
  2. ncbi request reprint The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands
    Gustavo Paratcha
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, Retzius vag 8, A2 2, 17177, Stockholm, Sweden
    Cell 113:867-79. 2003
  3. ncbi request reprint GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion
    Fernanda Ledda
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    Nat Neurosci 10:293-300. 2007
  4. pmc Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth
    Shahrzad Shirazi Fard
    Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 5:e9647. 2010
  5. ncbi request reprint Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion
    Dan Sjöstrand
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Biol Chem 282:12734-40. 2007
  6. pmc Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain
    Davor Stanic
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:3610-5. 2008
  7. doi request reprint Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF
    Fernanda Ledda
    Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden
    J Neurosci 28:39-49. 2008
  8. doi request reprint GDNF and GFRalpha: a versatile molecular complex for developing neurons
    Gustavo Paratcha
    Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, S 17177 Stockholm, Sweden
    Trends Neurosci 31:384-91. 2008
  9. doi request reprint NPY and its involvement in axon guidance, neurogenesis, and feeding
    Tomas Hokfelt
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Nutrition 24:860-8. 2008
  10. pmc Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission
    Evanthia Nanou
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:20941-6. 2008

Collaborators

Detail Information

Publications14

  1. ncbi request reprint GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream
    Gustavo Paratcha
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S 17 177 Stockholm, Sweden
    Mol Cell Neurosci 31:505-14. 2006
    ..Taken together, these data demonstrate that GDNF is a direct chemoattractant factor for neuroblast cells migrating along the RMS and support the participation of NCAM during this guidance process...
  2. ncbi request reprint The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands
    Gustavo Paratcha
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, Retzius vag 8, A2 2, 17177, Stockholm, Sweden
    Cell 113:867-79. 2003
    ..These results uncover an unexpected intersection between short- and long-range mechanisms of intercellular communication and reveal a pathway for GDNF signaling that does not require the RET receptor...
  3. ncbi request reprint GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion
    Fernanda Ledda
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    Nat Neurosci 10:293-300. 2007
    ..We propose that GFRalpha1 functions as a LICAM to establish precise synaptic contacts and induce presynaptic differentiation...
  4. pmc Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth
    Shahrzad Shirazi Fard
    Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 5:e9647. 2010
    ..Taken together, these findings define a novel molecular mechanism through which Tiam1 mediates TrkA signaling and neurite outgrowth induced by NGF...
  5. ncbi request reprint Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion
    Dan Sjöstrand
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Biol Chem 282:12734-40. 2007
    ..The GDNF-NCAM interface allows complex formation with the GDNF family receptor alpha1, shedding light on the molecular architecture of a multicomponent GDNF receptor...
  6. pmc Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain
    Davor Stanic
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:3610-5. 2008
    ..These findings suggest that both NPY and CCK through their receptors help to regulate the proliferation of precursor cells, the amount of neuroblast cells in the SVZ and RMS, and influence the differentiation of OB interneurons...
  7. doi request reprint Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF
    Fernanda Ledda
    Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden
    J Neurosci 28:39-49. 2008
    ..Together, these results provide an insight into Lrig1 function and establish a new physiological mechanism to restrict signaling and biological responses induced by GDNF and Ret in neuronal cells...
  8. doi request reprint GDNF and GFRalpha: a versatile molecular complex for developing neurons
    Gustavo Paratcha
    Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, S 17177 Stockholm, Sweden
    Trends Neurosci 31:384-91. 2008
    ..Therefore, these data highlight the importance of this versatile molecular complex for nervous system development, function and regeneration...
  9. doi request reprint NPY and its involvement in axon guidance, neurogenesis, and feeding
    Tomas Hokfelt
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Nutrition 24:860-8. 2008
    ..In the present study we examined a possible role of the 36-amino acid neuropeptide Y (NPY) with regard to three functions: axon guidance and attraction/repulsion, adult neurogenesis, and control of food intake...
  10. pmc Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission
    Evanthia Nanou
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:20941-6. 2008
    ..Thus, the coupling between K(Na) channels and AMPA receptors by synaptically induced Na(+) transients represents an inherent negative feedback mechanism that scales down the magnitude of excitatory synaptic responses...
  11. ncbi request reprint Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine
    Beth Anne Sieber
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Mol Cell Neurosci 26:418-28. 2004
    ..Together, these results reveal an unexpected role for EphA/ephrin-A signaling in the normal connectivity and function of midbrain dopaminergic neurons...
  12. pmc Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field
    Fernanda Ledda
    Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, Retzius vag 8, 17177, Stockholm, Sweden
    Biomark Insights 2:45-58. 2007
    ..Here, we review the current understanding of the physiological mechanisms that attenuate RTK signaling and discuss evidence that implicates deregulation of these events in cancer...
  13. ncbi request reprint Target-derived GFRalpha1 as an attractive guidance signal for developing sensory and sympathetic axons via activation of Cdk5
    Fernanda Ledda
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    Neuron 36:387-401. 2002
    ..Together with GDNF, target-derived GFRalpha1 can function in a non-cell-autonomous fashion as a chemoattractant cue with outgrowth promoting activity for peripheral neurons...
  14. pmc Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
    Paul Berghuis
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:19115-20. 2005
    ..Moreover, eCBs use TrkB receptor-dependent signaling pathways to regulate subtype-selective interneuron migration and specification...