Leonid Padyukov

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Arthritis Rheum 54:38-46. 2006
  2. ncbi request reprint A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis
    Leonid Padyukov
    Karolinska Institutet, Stockholm, Sweden, and Mechnikov Research Institute, Stockholm, Sweden
    Arthritis Rheum 50:3085-92. 2004
  3. ncbi request reprint Polymorphism in promoter region of IL10 gene is associated with rheumatoid arthritis in women
    Leonid Padyukov
    Rheumatology Unit, Institute of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Rheumatol 31:422-5. 2004
  4. pmc Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis
    L Padyukov
    Unit of Rheumatology, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 62:526-9. 2003
  5. pmc Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis
    Maria Seddighzadeh
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Eur J Hum Genet 18:821-6. 2010
  6. pmc Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region
    Bo Ding
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:30-8. 2009
  7. doi request reprint Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis
    Emeli Lundström
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:924-30. 2009
  8. pmc Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis
    Mauro D'Amato
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e9315. 2010
  9. doi request reprint Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile
    Karin Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm 171 76, Sweden
    Ann Rheum Dis 72:652-8. 2013
  10. pmc Genetic variation in the transforming growth factor-beta1 gene is associated with susceptibility to IgA nephropathy
    Mai Tuyet Vuong
    Department of Medicine, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 24:3061-7. 2009

Detail Information

Publications70

  1. ncbi request reprint A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Arthritis Rheum 54:38-46. 2006
    ..To investigate whether smoking and HLA-DR shared epitope (SE) genes may interact in triggering immune reactions to citrulline-modified proteins...
  2. ncbi request reprint A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis
    Leonid Padyukov
    Karolinska Institutet, Stockholm, Sweden, and Mechnikov Research Institute, Stockholm, Sweden
    Arthritis Rheum 50:3085-92. 2004
    ..We studied a potential gene-environment interaction between SE genes and smoking in the etiology of the 2 major subgroups of RA: rheumatoid factor (RF)-seropositive and RF-seronegative disease...
  3. ncbi request reprint Polymorphism in promoter region of IL10 gene is associated with rheumatoid arthritis in women
    Leonid Padyukov
    Rheumatology Unit, Institute of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Rheumatol 31:422-5. 2004
    ..We investigated IL10 and TNFA gene polymorphisms in a group of Swedish women and men with RA compared with healthy individuals to estimate combinations of alleles specific for the disease...
  4. pmc Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis
    L Padyukov
    Unit of Rheumatology, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 62:526-9. 2003
    ..This is the case with the tumour necrosis factor (TNF) blocking agents, where 20-40% of patients have been described as non-responders. No predictive markers exist as yet for the prognosis of response...
  5. pmc Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis
    Maria Seddighzadeh
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Eur J Hum Genet 18:821-6. 2010
    ..This finding may lead to the development of treatment based on enhancing the protective features of 5-HT2A in individuals with a certain HLA genotype...
  6. pmc Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region
    Bo Ding
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:30-8. 2009
    ....
  7. doi request reprint Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis
    Emeli Lundström
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:924-30. 2009
    ....
  8. pmc Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis
    Mauro D'Amato
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e9315. 2010
    ..We sought to determine whether genetic variability at the NPSR1 locus influences the susceptibility and clinical manifestation of rheumatoid arthritis (RA)...
  9. doi request reprint Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile
    Karin Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm 171 76, Sweden
    Ann Rheum Dis 72:652-8. 2013
    ....
  10. pmc Genetic variation in the transforming growth factor-beta1 gene is associated with susceptibility to IgA nephropathy
    Mai Tuyet Vuong
    Department of Medicine, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 24:3061-7. 2009
    ..Among several candidate genes related to immunological regulation in renal tissue, TGFB1 is known to be a contributor to proliferation and the development of fibrosis...
  11. doi request reprint Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis
    Hiba Mahdi
    Rheumatology Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden
    Nat Genet 41:1319-24. 2009
    ..We conclude that citrullinated alpha-enolase is a specific citrullinated autoantigen that links smoking to genetic risk factors in the development of RA...
  12. pmc Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important
    Emeli Lundström
    Karolinska Institutet, Rheumatology Unit, Department of Medicine, Stockholm, Sweden
    Arthritis Rheum 60:1597-603. 2009
    ..We aimed to further investigate this interaction between distinct SE alleles and smoking regarding the risk of developing RA with and without anti-citrullinated protein antibodies (ACPAs)...
  13. pmc Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis
    Henrik Kallberg
    Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Hum Genet 80:867-75. 2007
    ..The data extend the basis for a pathogenetic hypothesis for RA involving genetic and environmental factors. The study also raises and illustrates principal questions concerning ways to define interactions in complex diseases...
  14. pmc Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA)
    Chun Lai Too
    Rheumatology Unit, Department of Medicine, Center of Molecular Medicine L8 04, Karolinska University Hospital, 17176 Stockholm, Sweden
    Arthritis Res Ther 14:R89. 2012
    ....
  15. doi request reprint Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis
    Judit Laki
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 64:2078-84. 2012
    ....
  16. doi request reprint Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations
    Maria Seddighzadeh
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Rheumatol 39:1509-16. 2012
    ..We investigated the association of STAT3 and STAT4 polymorphisms with serologically distinct subgroups of rheumatoid arthritis (RA)...
  17. ncbi request reprint Genetically determined imbalance between serum levels of tumour necrosis factor (TNF) and interleukin (IL)-10 is associated with anti-Jo-1 and anti-Ro52 autoantibodies in patients with poly- and dermatomyositis
    Adla B Hassan
    Department of Medicine, Rheumatology Unit, CMM L8 O4, Karolinska University Hospital, Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Autoimmun 27:62-8. 2006
    ..negative, p=0.041). Our data suggest that a genetically programmed cytokine imbalance exists in patients with poly- or dermatomyositis and that this imbalance is related to the presence of disease-associated autoantibodies...
  18. doi request reprint HLA-DRB1*04/*13 alleles are associated with vascular disease and antiphospholipid antibodies in systemic lupus erythematosus
    Emeli Lundström
    Department of Medicine, Rheumatology Unit, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 72:1018-25. 2013
    ..Since HLA class II genotypes have been linked to the presence of pro-thrombotic aPL, we investigated the relationship between HLA-DRB1 alleles, aPL and vascular events in SLE patients...
  19. doi request reprint Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1
    Johanna Sundqvist
    Department of Women s and Children s Health, Division of Obstetrics and Gynecology, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Fertil Steril 95:437-40. 2011
    ..This study investigates the association of rheumatoid arthritis-associated single nucleotide polymorphisms in endometriosis. We found an association of CCL21 (rs2812378) and HLA-DRB1 (rs660895) with moderate to severe endometriosis...
  20. doi request reprint Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy
    Mai T Vuong
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital at Solna, Stockholm, Sweden
    Kidney Int 78:1281-7. 2010
    ..Thus, we found an association between the levels of sCD89-IgA complexes in serum and the severity of IgAN, and a possible genetic component in regulating the production or expression of sCD89...
  21. pmc Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke
    Henrik Kallberg
    Correspondence to Dr Henrik Källberg, Institute of Environmental Medicine, Box 210, Karolinska Institutet, 171 77 Stockholm, Sweden
    Ann Rheum Dis 70:508-11. 2011
    ..Less is known on how smoking contributes to RA in the context of genetic variability, and what proportion of RA may be caused by smoking...
  22. pmc A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
    Leonid Padyukov
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 70:259-65. 2011
    ..The aim of the current study is to provide and compare GWAS data for both subsets...
  23. pmc Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis
    Marina Korotkova
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Eur J Hum Genet 19:908-14. 2011
    ..Genetically predisposed individuals may develop earlier and more active disease owing to this mechanism...
  24. doi request reprint A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus
    Elisabet Svenungsson
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, SE 17176 Stockholm, Sweden
    Ann Rheum Dis 69:834-40. 2010
    ....
  25. doi request reprint Genetic evidence for involvement of adaptive immunity in the development of IgA nephropathy: MHC class II alleles are protective in a Caucasian population
    Mai Tuyet Vuong
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Hum Immunol 74:957-60. 2013
    ..Our data replicates finding from other Caucasian populations and suggest that involvement of adaptive immunity may be of importance in the development of the disease...
  26. pmc Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis
    Marcus Ronninger
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 7:e32861. 2012
    ..Since a biological link between products of these genes is evident, the genetic contribution from CIITA and class II antigens in the autoimmune process may involve additional unidentified factors...
  27. pmc Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case-control study
    Berit Sverdrup
    Department of Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Arthritis Res Ther 7:R1296-303. 2005
    ..The findings are of particular interest since the same mineral oils can induce polyarthritis in rats...
  28. pmc Shared epitope alleles remain a risk factor for anti-citrullinated proteins antibody (ACPA)--positive rheumatoid arthritis in three Asian ethnic groups
    Too Chun-Lai
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e21069. 2011
    ..To investigate the associations between HLA-DRB1 shared epitope (SE) alleles and rheumatoid arthritis in subsets of rheumatoid arthritis defined by autoantibodies in three Asian populations from Malaysia...
  29. pmc Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, D2 01, 17176 Stockholm, Sweden
    Arthritis Res Ther 13:R65. 2011
    ....
  30. doi request reprint Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis
    Lars Klareskog
    Department of Medicine, Karolinska Institutet Karolinska University Hospital, Solna, Stockholm, Sweden
    Semin Immunol 23:92-8. 2011
    ....
  31. doi request reprint Immunity to citrullinated proteins in rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, SE 171 76, Stockholm, Sweden
    Annu Rev Immunol 26:651-75. 2008
    ..The model provides a new basis for molecular studies on the pathogenesis of ACPA-positive arthritis...
  32. ncbi request reprint MICA4/HLA-DRB1*04/TNF1 haplotype is associated with mixed connective tissue disease in Swedish patients
    Adla B Hassan
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska Hospital S 171 76, Stockholm, Sweden
    Hum Immunol 64:290-6. 2003
    ..1 genotype. Mixed connective tissue disease was also associated with shared epitope genes, which in RA has been associated with a more severe disease. Whether these genotypes affect the clinical phenotype of MCTD needs to be determined...
  33. ncbi request reprint Genes, environment and immunity in the development of rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Curr Opin Immunol 18:650-5. 2006
    ....
  34. ncbi request reprint Mechanisms of disease: Genetic susceptibility and environmental triggers in the development of rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Nat Clin Pract Rheumatol 2:425-33. 2006
    ..Increased knowledge about these and other events involved in the development of RA should enable the design of new tools for suppressing RA pathogenesis before the onset of disease...
  35. doi request reprint Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis
    Thierry Dervieux
    Exagen Diagnostics, Inc, Albuquerque, New Mexico, USA
    Pharmacogenet Genomics 22:1-9. 2012
    ..We sought to elucidate architecture of methotrexate response in three cohorts of patients with RA treated with methotrexate...
  36. pmc Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap
    Mai Tuyet Vuong
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e10559. 2010
    ..The aim of this study was to compare genetic variants from the TGFB1, IRF5, STAT4 genes and TRAF1-C5 locus with susceptibility to IgAN and lupus nephritis in two Swedish cohorts...
  37. ncbi request reprint Smoking as a trigger for inflammatory rheumatic diseases
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
    Curr Opin Rheumatol 19:49-54. 2007
    ....
  38. pmc Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE)
    Anna Hellquist
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    PLoS ONE 4:e8037. 2009
    ..Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with multiple susceptibility genes. We have previously reported suggestive linkage to the chromosomal region 14q21-q23 in Finnish SLE families...
  39. pmc Effects of GSTM1 in rheumatoid arthritis; results from the Swedish EIRA study
    Emeli Lundström
    Department of Rheumatology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e17880. 2011
    ....
  40. ncbi request reprint The A-1087IL-10 allele is associated with cardiovascular disease in SLE
    Guo Zhong Fei
    Rheumatology Unit, Department of Medicine at Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 177:409-14. 2004
    ..Furthermore, the IL-10 AA genotype is associated with reduced ratio of atheroprotective to atherogenic cytokines in SLE patients with CVD...
  41. ncbi request reprint Association of arthritis with a gene complex encoding C-type lectin-like receptors
    Johnny C Lorentzen
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, S 17176 Stockholm, Sweden
    Arthritis Rheum 56:2620-32. 2007
    ..To identify susceptibility genes in a rat model of rheumatoid arthritis (RA) and to determine whether the corresponding human genes are associated with RA...
  42. doi request reprint A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis
    Maja Jagodic
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Sci Transl Med 1:10ra21. 2009
    ..We conclude that VAV1 plays a central role in controlling central nervous system immune-mediated disease and proinflammatory cytokine production critical for disease pathogenesis...
  43. pmc GEIRA: gene-environment and gene-gene interaction research application
    Bo Ding
    Institute of Environmental Medicine, Karolinska Institutet, SE 171 77, Box 210, Stockholm, Sweden
    Eur J Epidemiol 26:557-61. 2011
    ..The algorithm is coded in both SAS and R. GEIRA is freely available to non-commercial users at http://www.epinet.se. Additional information, including user's manual and example datasets is available online at http://www.epinet.se...
  44. ncbi request reprint Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus
    Karin Popovic
    Department of Dermatology, Karolinska Institutet at Danderyd Hospital, S 182 88 Stockholm, Sweden
    Arthritis Rheum 52:3639-45. 2005
    ..To investigate the role of the novel cytokine high mobility group box chromosomal protein 1 (HMGB-1) in the pathogenesis of cutaneous lupus erythematosus (CLE)...
  45. pmc Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06
    Josefin Lysell
    Department of Dermatology and Venereology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Invest Dermatol 133:411-7. 2013
    ..ERAP1 single-nucleotide polymorphism rs26653, which, to our knowledge, has not previously been reported in psoriasis, is nonsynonymous, has suggestive functional consequences, and herein displays strong association with disease...
  46. ncbi request reprint MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
    Maria Swanberg
    Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
    Nat Genet 37:486-94. 2005
    ..We conclude that polymorphisms in Mhc2ta and MHC2TA result in differential MHC molecule expression and are associated with susceptibility to common complex diseases with inflammatory components...
  47. pmc GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma
    Karin E Smedby
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
    PLoS Genet 7:e1001378. 2011
    ..These findings suggest that the HLA class II region plays a complex yet important role in NHL...
  48. pmc A Research Study of the Association between Maternal Microchimerism and Systemic Lupus Erythematosus in Adults: A Comparison between Patients and Healthy Controls Based on Single-Nucleotide Polymorphism Using Quantitative Real-Time PCR
    Anna Maria Jonsson Kanold
    Department of Obstetrics and Gynecology, Center for Fetal Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e74534. 2013
    ..Systemic Lupus erythematosus (SLE) is an autoimmune disorder with a resemblance to graft-versus-host disease. The aim of this study was to investigate the association between maternal microchimerism in the blood and SLE...
  49. pmc The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls
    Marcus Ronninger
    Department of Medicine, Rheumatology Unit, CMM L8 04, Karolinska Institutet and Karolinska Universitetssjukhuset, Stockholm, S 17176, Sweden
    Genome Med 4:2. 2012
    ....
  50. pmc Genes and environment in arthritis: can RA be prevented?
    Lars Klareskog
    Rheumatology Unit, Department of Medicine at Karolinska Hospital, Stockholm, Sweden
    Arthritis Res 4:S31-6. 2002
    ..Taken together, our data support the notion that concepts and data on gene-environment interactions in arthritis can now be taken from induced animal models of arthritis to generate new etiological hypotheses for RA...
  51. ncbi request reprint Fcgamma receptor type IIIA genotype and response to tumor necrosis factor alpha-blocking agents in patients with rheumatoid arthritis
    Alf Kastbom
    Linkoping University, Linkoping, Sweden
    Arthritis Rheum 56:448-52. 2007
    ....
  52. pmc A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis
    Ewa Berglin
    Department of Public Health and Clinical Medicine, Division of Rheumatology, University Hospital, Umea, Sweden
    Arthritis Res Ther 6:R303-8. 2004
    ..9, 95% confidence interval 0.9-4.2). This study showed that the presence of anti-CCP antibodies together with SE gene carriage is associated with a very high relative risk for future development of RA...
  53. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...
  54. ncbi request reprint Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope
    Ludmila Prokunina
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 50:1770-3. 2004
    ..To study the frequency of allele A of polymorphism PD-1.3 of the PDCD1 gene in patients with rheumatoid arthritis (RA) and its subsets, based on the presence of rheumatoid factor (RF) and the shared epitope (SE) alleles...
  55. ncbi request reprint Association of the proinflammatory haplotype (MICA5.1/TNF2/TNFa2/DRB1*03) with polymyositis and dermatomyositis
    Adla B Hassan
    Arthritis Rheum 50:1013-5. 2004
  56. ncbi request reprint Association of the -1087 IL 10 gene polymorphism with severe chronic periodontitis in Swedish Caucasians
    Tord Berglundh
    Department of Periodontology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Clin Periodontol 30:249-54. 2003
    ..Severe forms of periodontitis are suggested to have a genetic basis...
  57. ncbi request reprint Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia
    Ulf Thunberg
    Department of Oncology, Uppsala University, Uppsala, Sweden
    Lancet 360:1935-9. 2002
    ....
  58. ncbi request reprint Local expression of interleukin-10 and mCD14 in relation to the -1087 IL-10 and -159 CD14 gene polymorphisms in chronic periodontitis
    Mauro Donati
    Department of Periodontology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Periodontol 79:517-24. 2008
    ..The aim of the present investigation was to study the local expression of interleukin (IL)-10 and membrane-bound CD14 (mCD14) in relation to the -1087 IL-10 and -159 CD14 gene polymorphisms in subjects with chronic periodontitis...
  59. ncbi request reprint Impaired kidney graft survival is associated with the TNF-alpha genotype
    Lars G Wramner
    Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Transplantation 78:117-21. 2004
    ..The purpose was to study the association of this gene polymorphism with rejection episodes and graft survival after kidney transplantation...
  60. pmc A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity
    Lina M Olsson
    Medical Inflammation Research, Lund University, BMC I11, 221 84, Lund, Sweden
    Arthritis Res Ther 9:R98. 2007
    ....
  61. ncbi request reprint Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis
    Snaevar Sigurdsson
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 56:2202-10. 2007
    ..To determine whether genetic variants of the interferon regulatory factor 5 (IRF-5) and Tyk-2 genes are associated with rheumatoid arthritis (RA)...
  62. pmc Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4
    Robert M Plenge
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Am J Hum Genet 77:1044-60. 2005
    ....
  63. pmc TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study
    Robert M Plenge
    Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA
    N Engl J Med 357:1199-209. 2007
    ..We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheumatoid arthritis...
  64. ncbi request reprint Association of the -159 CD14 gene polymorphism and lack of association of the -308 TNFA and Q551R IL-4RA polymorphisms with severe chronic periodontitis in Swedish Caucasians
    Mauro Donati
    Department of Periodontology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Clin Periodontol 32:474-9. 2005
    ..Severe forms of periodontitis are suggested to have a genetic basis...
  65. doi request reprint A 3'-untranslated region polymorphism in the TBX21 gene encoding T-bet is a risk factor for genital herpes simplex virus type 2 infection in humans
    Alexandra Svensson
    Department of Rheumatology and Inflammation Research, University of Gothenburg, and Department of Dermatovenerology, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Gen Virol 89:2262-8. 2008
    ..These results indicate that the host genetic background may affect susceptibility to HSV-2 infection in humans, with TBX21 as a strong candidate gene...
  66. pmc STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    N Engl J Med 357:977-86. 2007
    ..Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q...
  67. pmc A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis
    Fina A S Kurreeman
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Med 4:e278. 2007
    ..We therefore aimed to investigate whether this locus would play a role in RA...
  68. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  69. ncbi request reprint Cytokines in the placenta of Pakistani newborns with and without intrauterine growth retardation
    Sylvie Amu
    Department of Clinical Immunolgy, Gothenburg University, Sweden
    Pediatr Res 59:254-8. 2006
    ..We propose that the low IL-10 in the placenta may be involved in the pathogenesis of IUGR and might possibly be treatable...
  70. ncbi request reprint Common variations in the IL4R gene affect splicing and influence natural expression of the soluble isoform
    Ann Marie Bergin
    Department of Clinical Immunology, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Hum Mutat 27:990-8. 2006
    ..Together these results show sequence variations as a possible way of altering alternative splicing selection of IL4R in vivo...