A Ortqvist

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Non-response to specific serotypes likely cause for failure to 23-valent pneumococcal polysaccharide vaccine in the elderly
    A Ortqvist
    Department of Communicable Diseases Control and Prevention, Stockholm County, Sweden
    Vaccine 25:2445-50. 2007
  2. doi request reprint Effectiveness of the monovalent AS03-adjuvanted influenza A(H1N1)pdm09 vaccine against hospitalization in children because of influenza
    Ake Ortqvist
    Karolinska Institutet, Department of Medicine, Unit of Infectious Diseases, Karolinska Solna, Sweden
    Vaccine 30:5699-702. 2012
  3. pmc Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in Sweden 2000-2003, increasing incidence and regional differences
    Mikael Stenhem
    Department of Epidemiology, Swedish Institute for Infectious Disease Control, Karolinska Institutet, Solna, Sweden
    BMC Infect Dis 6:30. 2006
  4. ncbi request reprint Streptococcus pneumoniae: epidemiology, risk factors, and clinical features
    Ake Ortqvist
    Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    Semin Respir Crit Care Med 26:563-74. 2005
  5. ncbi request reprint Influenza vaccination and mortality: prospective cohort study of the elderly in a large geographical area
    A Ortqvist
    Department of Communicable Diseases Control and Prevention Smittskyddsenheten, Norrbacka, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur Respir J 30:414-22. 2007
  6. doi request reprint Effectiveness of an adjuvanted monovalent vaccine against the 2009 pandemic strain of influenza A(H1N1)v, in Stockholm County, Sweden
    Ake Ortqvist
    Department of Communicable Diseases Control and Prevention, Stockholm County, Sweden
    Clin Infect Dis 52:1203-11. 2011
  7. ncbi request reprint Additive preventive effect of influenza and pneumococcal vaccines in elderly persons
    B Christenson
    Dept of Communicable Disease Control and Prevention, Stockholm County, Sweden
    Eur Respir J 23:363-8. 2004
  8. ncbi request reprint Effects of a large-scale intervention with influenza and 23-valent pneumococcal vaccines in adults aged 65 years or older: a prospective study
    B Christenson
    Department of Communicable Disease Control and Prevention, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Lancet 357:1008-11. 2001
  9. ncbi request reprint Prospective study of prognostic factors in community-acquired bacteremic pneumococcal disease in 5 countries
    M Kalin
    Department of Medicine, Section of Infectious Diseases, Karolinska Hospital, 171 76 Stockholm, Sweden
    J Infect Dis 182:840-7. 2000
  10. ncbi request reprint Randomised trial of 23-valent pneumococcal capsular polysaccharide vaccine in prevention of pneumonia in middle-aged and elderly people. Swedish Pneumococcal Vaccination Study Group
    A Ortqvist
    Division of Infectious Diseases, Karolinska Institutet, Danderyd Hospital, Sweden
    Lancet 351:399-403. 1998

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Non-response to specific serotypes likely cause for failure to 23-valent pneumococcal polysaccharide vaccine in the elderly
    A Ortqvist
    Department of Communicable Diseases Control and Prevention, Stockholm County, Sweden
    Vaccine 25:2445-50. 2007
    ..In conclusion, the 23-valent pneumococcal vaccine should be regarded as 23 different vaccines, rather than one. Older persons who fail to respond to one serotype may well be protected against infection by the other 22 serotypes...
  2. doi request reprint Effectiveness of the monovalent AS03-adjuvanted influenza A(H1N1)pdm09 vaccine against hospitalization in children because of influenza
    Ake Ortqvist
    Karolinska Institutet, Department of Medicine, Unit of Infectious Diseases, Karolinska Solna, Sweden
    Vaccine 30:5699-702. 2012
    ..The reason for the increased rate of hospitalizations with confirmed influenza in children just following immunization is unclear and should be studied further...
  3. pmc Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in Sweden 2000-2003, increasing incidence and regional differences
    Mikael Stenhem
    Department of Epidemiology, Swedish Institute for Infectious Disease Control, Karolinska Institutet, Solna, Sweden
    BMC Infect Dis 6:30. 2006
    ..During the late 1990s, Sweden experienced a large health-care associated outbreak which with resolute efforts was overcome. Subsequently, MRSA was made a notifiable diagnosis in Sweden in 2000...
  4. ncbi request reprint Streptococcus pneumoniae: epidemiology, risk factors, and clinical features
    Ake Ortqvist
    Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    Semin Respir Crit Care Med 26:563-74. 2005
    ....
  5. ncbi request reprint Influenza vaccination and mortality: prospective cohort study of the elderly in a large geographical area
    A Ortqvist
    Department of Communicable Diseases Control and Prevention Smittskyddsenheten, Norrbacka, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur Respir J 30:414-22. 2007
    ..Vaccination remains the most important measure for prevention of influenza complications in elderly people, although the effectiveness in reducing all-cause mortality in elderly persons is lower than previously thought...
  6. doi request reprint Effectiveness of an adjuvanted monovalent vaccine against the 2009 pandemic strain of influenza A(H1N1)v, in Stockholm County, Sweden
    Ake Ortqvist
    Department of Communicable Diseases Control and Prevention, Stockholm County, Sweden
    Clin Infect Dis 52:1203-11. 2011
    ..Vaccination against the pandemic influenza A(H1N1)v was performed in many countries during 2009, but population-based data on vaccine effectiveness are lacking...
  7. ncbi request reprint Additive preventive effect of influenza and pneumococcal vaccines in elderly persons
    B Christenson
    Dept of Communicable Disease Control and Prevention, Stockholm County, Sweden
    Eur Respir J 23:363-8. 2004
    ..There was a strong indication that pneumococcal vaccination alone, was effective not only in the prevention of invasive pneumococcal disease, but also of pneumonia overall, although to a low degree...
  8. ncbi request reprint Effects of a large-scale intervention with influenza and 23-valent pneumococcal vaccines in adults aged 65 years or older: a prospective study
    B Christenson
    Department of Communicable Disease Control and Prevention, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Lancet 357:1008-11. 2001
    ..We have therefore examined the effects of influenza and pneumococcal vaccination in individuals aged 65 years and older in a 3-year prospective study, between Dec 1, 1998 and May 31, 1999...
  9. ncbi request reprint Prospective study of prognostic factors in community-acquired bacteremic pneumococcal disease in 5 countries
    M Kalin
    Department of Medicine, Section of Infectious Diseases, Karolinska Hospital, 171 76 Stockholm, Sweden
    J Infect Dis 182:840-7. 2000
    ..Differences of disease severity and of frequencies and impact of underlying chronic conditions were factors of probable importance for different outcomes...
  10. ncbi request reprint Randomised trial of 23-valent pneumococcal capsular polysaccharide vaccine in prevention of pneumonia in middle-aged and elderly people. Swedish Pneumococcal Vaccination Study Group
    A Ortqvist
    Division of Infectious Diseases, Karolinska Institutet, Danderyd Hospital, Sweden
    Lancet 351:399-403. 1998
    ..We assessed the effectiveness of a 23-valent pneumococcal vaccine in the prevention of pneumococcal pneumonia and of pneumonia overall in non-immunocompromised middle-aged and elderly people...
  11. ncbi request reprint Clinical isolates of Streptococcus pneumoniae that exhibit tolerance of vancomycin
    B Henriques Normark
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institutet, Solna, Sweden
    Clin Infect Dis 32:552-8. 2001
    ....
  12. ncbi request reprint Effects of a large-scale intervention with influenza and 23-valent pneumococcal vaccines in elderly people: a 1-year follow-up
    J Hedlund
    Department of Infectious Diseases, Karolinska Institutet, Karolinska Hospital, S 17176 Stockholm, Sweden
    Vaccine 21:3906-11. 2003
    ..68), pneumonia (RR 0.78), and invasive pneumococcal disease (RR 0.46). In the vaccinated cohort, the in-hospital mortality was lower for pneumonia (RR 0.55), COPD (RR 0.53) and cardiac failure (RR 0.72)...
  13. ncbi request reprint Pneumococcal vaccination: current and future issues
    A Ortqvist
    Karolinska Institutet and Dept of Infectious Diseases, Karolinska Hospital, Stockholm, Sweden
    Eur Respir J 18:184-95. 2001
    ..However, the included serotypes correspond to those most often associated with penicillin resistance and vaccination is, therefore, a possible tool in limiting the spread of antibiotic-resistant pneumococci...
  14. ncbi request reprint Dynamics of penicillin-susceptible clones in invasive pneumococcal disease
    B Henriques Normark
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna, Sweden
    J Infect Dis 184:861-9. 2001
    ..These results illustrate the ability of virulent penicillin-susceptible pneumococcal clones to emerge and spread rapidly within a country...
  15. ncbi request reprint Addition of a macrolide to a ss-lactam in bacteremic pneumococcal pneumonia
    R Dwyer
    Department of Medicine, Infectious Disease Unit, Karolinska University Hospital, 14186 Stockholm, Sweden
    Eur J Clin Microbiol Infect Dis 25:518-21. 2006
    ..Identified predictors of death in a multivariate regression model were age >65 years (OR=2.6), two or more lung lobes affected (OR=2.2), and severity of disease as estimated using the acute physiology score (APS)>8...
  16. ncbi request reprint Negligible adjuvant effect for antibody responses and frequent adverse events associated with IL-12 treatment in humans vaccinated with pneumococcal polysaccharide
    J Hedlund
    Department of Infectious Diseases, Karolinska Institute, Karolinska Hospital, S 17176, Stockholm, Sweden
    Vaccine 20:164-9. 2001
    ..The rhIL-12 recipients had a high incidence of local and systemic side effects. Given the lack of convincing evidence that rhIL-12 enhances the antibody response to PPV, the frequency and severity of the side effects was unacceptable...
  17. ncbi request reprint Prognostic score systems and community-acquired bacteraemic pneumococcal pneumonia
    C Spindler
    Unit of Infectious Diseases, Dept of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden
    Eur Respir J 28:816-23. 2006
    ..The pneumonia severity index was the most sensitive, but CURB-65 was easier to use...
  18. pmc Forecasting drug utilization and expenditure in a metropolitan health region
    Björn Wettermark
    Department of Drug Management and Informatics, Stockholm County Council, Stockholm, Sweden
    BMC Health Serv Res 10:128. 2010
    ..The aim of this paper is to present the forecasting model and the predicted growth in all therapeutic areas in 2010 and 2011...
  19. ncbi request reprint Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen
    K Sjostrom
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, Karolinska University Hospital, Solna, Sweden
    Clin Infect Dis 42:451-9. 2006
    ..Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide. The role of the different capsular and clonal types in invasive disease severity remains to be defined...
  20. ncbi request reprint Validity of routine surveillance data: a case study on Swedish notifications of methicillin-resistant Staphylococcus aureus
    M Stenhem
    Department of Epidemiology, Swedish Institute for Infectious Disease Control, Karolinska Institutet, Solna, Sweden
    Euro Surveill 14:19281. 2009
    ..This should be taken into account when interpreting routine surveillance figures. Whether or not the case definition includes cases of MRSA colonisation may have a significant impact on population-wide estimates of MRSA occurrence...
  21. ncbi request reprint Endocarditis and pericarditis complicating pneumococcal bacteraemia, with special reference to the adhesive abilities of pneumococci: results from a prospective study
    B Kan
    Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden
    Clin Microbiol Infect 12:338-44. 2006
    ..However, non-encapsulated S. pneumoniae showed higher hydrophobicity and increased adherence to human epithelial cells...
  22. ncbi request reprint Swedish guidelines for the management of community-acquired pneumonia in immunocompetent adults
    Jonas Hedlund
    Department of Infectious Diseases, Karolinska University Hospital, S 17176 Stockholm, Sweden
    Scand J Infect Dis 37:791-805. 2005
    ..Recommended measures for prevention of CAP include influenza -- and pneumococcal -- vaccination to risk groups and efforts for smoking cessation...
  23. ncbi request reprint Revaccination with the 23-valent pneumococcal polysaccharide vaccine in middle-aged and elderly persons previously treated for pneumonia
    Jan Törling
    Department of Medicine, Unit of Infectious Diseases, Karolinska Hospital, Karolinska Institutet, S 17176 Stockholm, Sweden
    Vaccine 22:96-103. 2003
    ..We conclude that revaccination of elderly with PPV after 5-10 years is safe and induce a significant immune response in a majority of persons...
  24. ncbi request reprint Quantitative detection of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in lower respiratory tract samples by real-time PCR
    Madeleine Kais
    Clinical Microbiology, Microbiology and Tumor Biology Center, Karolinska Institutet, Karolinska University Hospital Solna, SE 17176 Stockholm, Sweden
    Diagn Microbiol Infect Dis 55:169-78. 2006
    ..In the group of patients with LRTI, significant pathogens (>/=10(5) CFU/mL) were found in 32/135 samples (23.7%) with culture, in 51/135 (37.7%) with RQ-PCR, and in 59/135 (43.7%) when combining the methods...
  25. doi request reprint Effects of a large-scale introduction of the pneumococcal polysaccharide vaccine among elderly persons in Stockholm, Sweden
    Carl Spindler
    Karolinska Institutet, Department of Medicine Solna, Infectious Diseases Unit, Karolinska University Hospital, Stockholm, Sweden
    Vaccine 26:5541-6. 2008
    ..The incidence of vaccine-type IPD in Stockholm declined significantly during the study period (1997-2001) in elderly persons, from 50 to 28.9/100,000, but not in other age groups in Stockholm, nor in any age group in Skåne...
  26. ncbi request reprint Management of patients with community-acquired pneumonia treated in hospital in Sweden
    Jonas Hedlund
    Department of Infectious Diseases, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Scand J Infect Dis 34:887-92. 2002
    ..These findings suggest that a majority of patients who are hospitalized with moderately severe pneumonia can be treated initially with penicillin alone...
  27. ncbi request reprint [Management of adult patients with community-acquired pneumonia. Evidence-based guidelines from the Swedish Infectious Diseases Association]
    Kristoffer Stralin
    Infektionskliniken, Universitetssjukhuset, Orebro
    Lakartidningen 105:2582-7. 2008
  28. ncbi request reprint Morbidity, mortality and clinical presentation of nursing home-acquired pneumonia in a Swedish population
    Märtha Sund-Levander
    Department of Medicine and Care, Faculty of Health Sciences, University of Linkoping, Linkoping, Sweden
    Scand J Infect Dis 35:306-10. 2003
    ..In order not to delay treatment, it is necessary to be aware that specific symptoms of pneumonia may be lacking in the clinical presentation in the nursing-home setting...
  29. ncbi request reprint Bacteraemic pneumococcal pneumonia: impact of HIV on clinical presentation and outcome
    Charles Feldman
    Division of Pulmonology, Department of Medicine, Johannesburg Hospital, University of the Witwatersrand, Medical School, 7 York Road, Parktown 2193, Johannesburg, South Africa
    J Infect 55:125-35. 2007
    ....
  30. pmc Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies
    Carmen Giefing
    Intercell AG, 1030 Vienna, Austria
    J Exp Med 205:117-31. 2008
    ..A vaccine containing PcsB and StkP is intended for the prevention of infections caused by all serotypes of pneumococcus in the elderly and in children...
  31. ncbi request reprint Gram-negative bacteria from patients seeking medical advice in Stockholm after the tsunami catastrophe
    Owe Källman
    Department of Clinical Microbiology, MTC, Karolinska Institute, Karolinska University Hospital, Solna, Sweden
    Scand J Infect Dis 38:448-50. 2006
    ..but not for Pseudomonas aeruginosa, probably reflecting that the resistant isolates were nosocomially acquired in Asia...
  32. ncbi request reprint Limited value of routine microbiological diagnostics in patients hospitalized for community-acquired pneumonia
    Christer Lidman
    Division of Infectious Diseases, University Hospital Huddinge, Stockholm, Sweden
    Scand J Infect Dis 34:873-9. 2002
    ..Improved diagnostics in CAP are urgently needed, as establishing an aetiological diagnosis carries a potential for optimizing the antibiotic therapy...
  33. ncbi request reprint [Modern health care requires well-functioning infection clinics. It must be possible to isolate infected patients and to maintain basic hygiene routines]
    Ake Ortqvist
    Smittskyddsenheten, Stockholms Iän
    Lakartidningen 101:2980-2. 2004
  34. ncbi request reprint An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome
    Victor L Yu
    Division of Infectious Disease, University of Pittsburgh, PA, USA
    Clin Infect Dis 37:230-7. 2003
    ..beta-Lactam antibiotics should still be useful for treatment of pneumococcal infections that do not involve cerebrospinal fluid, regardless of in vitro susceptibility, as determined by current NCCLS breakpoints...
  35. ncbi request reprint [Rare bacteria species found in wounds of tsunami patients. Predominance of gram-negative rods, increased antibiotic resistance]
    Owe Källman
    Avdelningen för klinisk mikrobiologi, Karolinska Universitetslaboratoriet, Karolinska Universitetssjukhuset Solna, Stockholm, Sweden
    Lakartidningen 102:3660, 3663, 3665. 2005
    ..Possibly, this reflects that the resistant isolates were nosocomially acquired in Asia...