Inger Ohman

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Plasma concentrations of lamotrigine and its 2-N-glucuronide metabolite during pregnancy in women with epilepsy
    Inger Ohman
    Department of Medicine, Clinical Pharmacology Unit, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    Epilepsia 49:1075-80. 2008
  2. doi request reprint Effects of pregnancy and contraception on lamotrigine disposition: new insights through analysis of lamotrigine metabolites
    Inger Ohman
    Department of Medicine, Solna, Clinical Pharmacology Unit, Karolinska Institutet, Stockholm, Sweden
    Seizure 17:199-202. 2008
  3. doi request reprint Pharmacokinetics of topiramate during pregnancy
    Inger Ohman
    Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
    Epilepsy Res 87:124-9. 2009
  4. ncbi request reprint Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation
    Torbjorn Tomson
    Deparatment of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Epilepsia 48:1111-6. 2007
  5. doi request reprint Age and comedications influence levetiracetam pharmacokinetics in children
    Maria G Dahlin
    Department of Neuropediatrics, Astrid Lindgren Children s Hospital, Karolinska University Hospital, Stockholm, Sweden
    Pediatr Neurol 43:231-5. 2010
  6. doi request reprint Are lamotrigine kinetics altered in menopause? Observations from a drug monitoring database
    Torbjorn Tomson
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Epilepsy Behav 19:86-8. 2010
  7. doi request reprint Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety
    Maria G Dahlin
    Department of Neuropediatrics, Astrid Lindgren Children s Hospital, Karolinska University Hospital, Stockholm, Sweden
    Neuropediatrics 43:264-70. 2012
  8. ncbi request reprint Determination of lamotrigine and its metabolites in human plasma by liquid chromatography-mass spectrometry
    Olof Beck
    Department of Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Sweden
    Ther Drug Monit 28:603-7. 2006
  9. ncbi request reprint Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy?
    Inger Ohman
    Department of Internal Medicine, Division of Clinical Pharmacology, Karolinska Institute at Karolinska University Hospital, Stockholm, Sweden
    Epilepsia 46:1621-4. 2005
  10. ncbi request reprint Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse
    Catharina Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska Hospital L8 00, 171 76 Stockholm, Sweden
    Neurobiol Dis 24:374-83. 2006

Detail Information

Publications14

  1. ncbi request reprint Plasma concentrations of lamotrigine and its 2-N-glucuronide metabolite during pregnancy in women with epilepsy
    Inger Ohman
    Department of Medicine, Clinical Pharmacology Unit, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    Epilepsia 49:1075-80. 2008
    ..To further characterize pregnancy-induced alterations in the pharmacokinetics of lamotrigine (LTG)...
  2. doi request reprint Effects of pregnancy and contraception on lamotrigine disposition: new insights through analysis of lamotrigine metabolites
    Inger Ohman
    Department of Medicine, Solna, Clinical Pharmacology Unit, Karolinska Institutet, Stockholm, Sweden
    Seizure 17:199-202. 2008
    ..To investigate possible underlying mechanisms for alterations in lamotrigine (LTG) kinetics by gestation and use of contraceptives...
  3. doi request reprint Pharmacokinetics of topiramate during pregnancy
    Inger Ohman
    Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
    Epilepsy Res 87:124-9. 2009
    ..To study the effects of pregnancy on plasma concentrations of topiramate (TPM)...
  4. ncbi request reprint Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation
    Torbjorn Tomson
    Deparatment of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Epilepsia 48:1111-6. 2007
    ..To study pharmacokinetics of levetiracetam (LEV) during pregnancy, delivery, lactation, and in the neonatal period...
  5. doi request reprint Age and comedications influence levetiracetam pharmacokinetics in children
    Maria G Dahlin
    Department of Neuropediatrics, Astrid Lindgren Children s Hospital, Karolinska University Hospital, Stockholm, Sweden
    Pediatr Neurol 43:231-5. 2010
    ..In conclusion, younger age and comedication with an enzyme inducer increased levetiracetam clearance. This finding should be taken into account when treating individual patients...
  6. doi request reprint Are lamotrigine kinetics altered in menopause? Observations from a drug monitoring database
    Torbjorn Tomson
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Epilepsy Behav 19:86-8. 2010
    ..05). Our data suggest that there may be a transient decline in clearance of LTG in conjunction with presumed menopause...
  7. doi request reprint Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety
    Maria G Dahlin
    Department of Neuropediatrics, Astrid Lindgren Children s Hospital, Karolinska University Hospital, Stockholm, Sweden
    Neuropediatrics 43:264-70. 2012
    ..Seizure response after 2 to 3 months on RUF treatment was found in 12 of 51 children (23.5%), at mean plasma level of 36.9 ± 22.0 µmol/L. Adverse events were reported in 41% of the patients of which fatigue was most frequent (24%)...
  8. ncbi request reprint Determination of lamotrigine and its metabolites in human plasma by liquid chromatography-mass spectrometry
    Olof Beck
    Department of Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Sweden
    Ther Drug Monit 28:603-7. 2006
    ..11 (range, <0.01 to 0.64). In conclusion, this liquid chromatographic-mass spectrometric method is suitable for simultaneous determination of lamotrigine and its metabolites in human plasma...
  9. ncbi request reprint Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy?
    Inger Ohman
    Department of Internal Medicine, Division of Clinical Pharmacology, Karolinska Institute at Karolinska University Hospital, Stockholm, Sweden
    Epilepsia 46:1621-4. 2005
    ..To study the pharmacokinetics of gabapentin (GBP) during delivery, lactation, and in the neonatal period...
  10. ncbi request reprint Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse
    Catharina Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska Hospital L8 00, 171 76 Stockholm, Sweden
    Neurobiol Dis 24:374-83. 2006
    ..These observations and the effect of CBZ in utero suggest that CBZ treatment might be advantageous in some types of human idiopathic megalencephaly...
  11. ncbi request reprint Direct and efficient liquid chromatographic-tandem mass spectrometric method for opiates in urine drug testing - importance of 6-acetylmorphine and reduction of analytes
    Maria Andersson
    Division of Clinical Pharmacology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Drug Test Anal 6:317-24. 2014
    ..The method might be further developed by reducing the number of analytes to morphine-3-glucuronide, codeine-6-glucuronide and 6-acetylmorphine without compromising test performance. Copyright © 2013 John Wiley & Sons, Ltd. ..
  12. ncbi request reprint Oral contraceptives induce lamotrigine metabolism: evidence from a double-blind, placebo-controlled trial
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Epilepsia 48:484-9. 2007
    ..This study evaluates the effect of oral contraceptives on lamotrigine (LTG) plasma concentrations and urine excretion of LTG metabolites in a double-blind, placebo-controlled, crossover study in patients with epilepsy...
  13. ncbi request reprint Oral contraceptives reduce lamotrigine plasma levels
    Anne Sabers
    Danish Epilepsy Hospital, University of Aarhus, Denmark
    Neurology 61:570-1. 2003
    ..0001), indicating that LTG plasma levels are reduced by >50% during OC co-medication. It is advisable to monitor LTG plasma levels in conjunction with initiation or withdrawal of OC in women on LTG therapy...
  14. ncbi request reprint Topiramate kinetics during delivery, lactation, and in the neonate: preliminary observations
    Inger Ohman
    Departments of Internal Medicine, Division of Clinical Pharmacology and Clinical Neuroscience, Karolinska Hospital, and Department of Neuroscience and Locomotion, Linkoping University, Stockholm and Linköping, Sweden
    Epilepsia 43:1157-60. 2002
    ..To study the pharmacokinetics of topiramate (TPM) during delivery, lactation, and in the neonate...