S Norgren

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Orlistat treatment in obese prepubertal children: a pilot study
    S Norgren
    National Childhood Obesity Center and Pediatric Endocrine Research Unit, Department of Pediatrics, Karolinska Institutet and Huddinge University Hospital, Stockholm, Sweden
    Acta Paediatr 92:666-70. 2003
  2. ncbi request reprint Glutathione synthetase deficiency: is gamma-glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione?
    E Ristoff
    Department of Paediatrics, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Inherit Metab Dis 25:577-84. 2002
  3. ncbi request reprint Lack of mutations in the TSHr and Gsalpha genes in TSHr antibody negative Graves' disease
    A Elgadi
    Department of Pediatrics, Endocrine Research Unit, B 62, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    Exp Clin Endocrinol Diabetes 113:516-21. 2005
  4. ncbi request reprint Pathophysiological and genetic characterization of the major diabetes locus in GK rats
    J Galli
    Karolinska Institute, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Diabetes 48:2463-70. 1999
  5. ncbi request reprint Cooperative binding of gamma-glutamyl substrate to human glutathione synthetase
    R Njalsson
    Department of Pediatrics, Karolinska Institute, Huddinge University Hospital, 141 86 Huddinge, Sweden
    Biochem Biophys Res Commun 289:80-4. 2001
  6. pmc Quantitative determination of mdr1 gene expression in leukaemic cells from patients with acute leukaemia
    A Gruber
    Division of Medicine, Karolinska Hospital, Stockholm, Sweden
    Br J Cancer 66:266-72. 1992
  7. ncbi request reprint Effects of growth hormone treatment on the leptin system and body composition in obese prepubertal boys
    A Elimam
    Department of Paediatrics, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    Acta Paediatr 90:520-5. 2001
  8. ncbi request reprint Clinical, histopathologic, and genetic investigation in two large families with dentinogenesis imperfecta type II
    B Malmgren
    Department of Pediatrics, Pediatric Endocrine Research Unit, B62, Huddinge University Hospital, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Hum Genet 114:491-8. 2004
  9. ncbi request reprint Type 1 diabetic serum interferes with pancreatic beta-cell Ca2+-handling
    N Dekki
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, L1, Stockholm, 171 76, Sweden
    Biosci Rep 27:321-6. 2007
  10. pmc Kinetic properties of missense mutations in patients with glutathione synthetase deficiency
    R Njalsson
    Department of Paediatrics, B57, Karolinska Institutet, Huddinge University Hospital, S 141 86 Huddinge, Sweden
    Biochem J 349:275-9. 2000

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Orlistat treatment in obese prepubertal children: a pilot study
    S Norgren
    National Childhood Obesity Center and Pediatric Endocrine Research Unit, Department of Pediatrics, Karolinska Institutet and Huddinge University Hospital, Stockholm, Sweden
    Acta Paediatr 92:666-70. 2003
    ..This study investigated orlistat treatment in obese prepubertal children with regard to tolerance, safety and psychological well-being...
  2. ncbi request reprint Glutathione synthetase deficiency: is gamma-glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione?
    E Ristoff
    Department of Paediatrics, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Inherit Metab Dis 25:577-84. 2002
    ..7-51.4), we propose that the cultured fibroblasts may have a mechanism to regulate in a coordinated way the levels of GSH and gamma-GC; for instance, by both compounds acting as feedback inhibitors of gamma-GC synthetase...
  3. ncbi request reprint Lack of mutations in the TSHr and Gsalpha genes in TSHr antibody negative Graves' disease
    A Elgadi
    Department of Pediatrics, Endocrine Research Unit, B 62, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    Exp Clin Endocrinol Diabetes 113:516-21. 2005
    ..The results also confirm that somatic gain-of-function TSHr mutations are present in hyperfunctioning follicular adenomas and goiters, but not in non-functioning thyroid lesions...
  4. ncbi request reprint Pathophysiological and genetic characterization of the major diabetes locus in GK rats
    J Galli
    Karolinska Institute, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Diabetes 48:2463-70. 1999
    ....
  5. ncbi request reprint Cooperative binding of gamma-glutamyl substrate to human glutathione synthetase
    R Njalsson
    Department of Pediatrics, Karolinska Institute, Huddinge University Hospital, 141 86 Huddinge, Sweden
    Biochem Biophys Res Commun 289:80-4. 2001
    ..75, indicating negative cooperativity. Our studies, for the first time, show that human glutathione synthetase is an allosteric enzyme with cooperative binding for gamma-glutamyl substrate...
  6. pmc Quantitative determination of mdr1 gene expression in leukaemic cells from patients with acute leukaemia
    A Gruber
    Division of Medicine, Karolinska Hospital, Stockholm, Sweden
    Br J Cancer 66:266-72. 1992
    ..Expression of the mdr1 gene could be one of several equally important factors contributing to drug resistance in acute leukaemia...
  7. ncbi request reprint Effects of growth hormone treatment on the leptin system and body composition in obese prepubertal boys
    A Elimam
    Department of Paediatrics, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    Acta Paediatr 90:520-5. 2001
    ..Whether GH affects leptin production or metabolism needs further study...
  8. ncbi request reprint Clinical, histopathologic, and genetic investigation in two large families with dentinogenesis imperfecta type II
    B Malmgren
    Department of Pediatrics, Pediatric Endocrine Research Unit, B62, Huddinge University Hospital, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Hum Genet 114:491-8. 2004
    ..The clinical and radiographic disturbances and DDS were more severe in Family B. The data indicate the presence of a genotype-phenotype correlation in DI type II...
  9. ncbi request reprint Type 1 diabetic serum interferes with pancreatic beta-cell Ca2+-handling
    N Dekki
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, L1, Stockholm, 171 76, Sweden
    Biosci Rep 27:321-6. 2007
    ..In a defined subgroup of patients with type 1 diabetes and first-degree relatives a defect Ca(2+)-handling may aggravate development of beta-cell destruction...
  10. pmc Kinetic properties of missense mutations in patients with glutathione synthetase deficiency
    R Njalsson
    Department of Paediatrics, B57, Karolinska Institutet, Huddinge University Hospital, S 141 86 Huddinge, Sweden
    Biochem J 349:275-9. 2000
    ..Thus our data indicate that different mutations can affect the catalytic capacity of GS by decreasing substrate affinity, maximal velocity or enzyme stability...